A 学術雑誌
1. Tsukumo S.,
Iwata M., Tohyama C., Nohara K. Skewed differentiation of thymocytes
toward CD8 T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires
activation of the extracellular signal-related kinase pathway.
Archives of Toxicology, 2002. (in press)
2. Fujimaki H., Nohara
K., Kobayashi T., Suzuki K., Eguchi-Kasai K., Tsukumo S., Kijima
M. and Tohyama C. Effect of a Single Oral Dose of 2,3,7,8-Tetrachlorodibenzo-p-dioxin
on Immune Function in Male NC/Nga Mice. Toxicological Sciences,
2002. (in press)
3. Ishimura R., Ohsako
S., Miyabara Y., Sakaue M., Kawakami T., Aoki Y., Yonemoto J.,
and Tohyama C. Increase of glycogen content and glucose transporter
3 (GLUT3) mRNA level in placenta of Holtzman rats after exposure
to 2,3,7,8-Tetrachrolodibenzo-p-dioxin. Toxicol Appl Pharmacol,
178; 161-171, 2002.
4.
Nohara K., Fujimaki H., Tsukumo S., Inouye K., Sone H., Tohyama
C. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on T
cell-deriverd cytokine production in ovalbumin (OVA)-immunized
C57Bl/6 mice. Toxicology, 172; 49-58, 2002.
5.
Nohara K., Izumi H., Tamura S., Nagata R., Tohyama C. Effects
of low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on influenza
A virus-induced mortality in mice. Toxicology, 170(1-2);
131-138, 2002.
6. Ohsako S., Miyabara
Y., Sakaue M., Ishimura R., Kakeyama M., Izumi H., Yonemoto J.,
and Tohyama C. Developmental stage-specific effects of perinatal
exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive
organs of the male rat offspring. Toxicol Sci, 66; 283-292,
2002.
7. Wu Q., Ohsako S., Baba
T., Miyamoto K., Tohyama C. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) on the mouse preimplantation embryos. Toxicology,
2002. (in press)
8.
Nishimura N., Miyabara Y., Sato M., Yonemoto J. and Tohyama C.
Immunohistochemical localization of thyroid stimulating hormone
induced by a low oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin
in female Sprague-Dawley rats. Toxicology, 171; 73-82,
2002.
9.
Tohyama C. Low-dose exposure to Dioxin, Its toxicities and health
risk assessment. Environmental Sciences, 9, 1; 37-50, 2002
10. Kakeyama M.,
Sone H. and Tohyama C. Changes in expression of the NMDA receptor
subunit mRNA in the neocortex and hippocampus by perinatal exposure
to dioxin. Neuro Report, 12(18); 4009-4012, 2001.
11.
Nisimura N., Miyabara Y., Suzuki JS., Sato M., Aoki Y., Satoh
M., Yonemoto J. and Tohyama C. Induction of metallothionein in
the livers of female Sprague dawley rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Life Sciences, 69; 1291-1303, 2001.
12. Ohsako S., Miyabara Y., Nishimura N., Kurosawa S., Sakaue
M., Ishimura R., Sato M., Aoki Y., Sone H., Tohyama C., and Yonemoto
J. Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) suppressed the development of reproductive organs of male
rats: dose-dependent increase of mRNA levels of 5a-reductase
type 2 in contrast to decrease of androgen receptor in the pubertal
ventral prostate. Toxicol Sci, 60; 132-143, 2001.
13.
Ishimura R., Kawakami T., Aoki Y., Yonemoto J., Tohyama C., and
Ohsako S. 2,3,7,8-Tetrachrolodibenzo-p-dioxin (TCDD) affects glucose
kinetics in rat placenta. Organohalogen Compounds, 53; 300-302,
2001.
14.
Fukuzawa N.H.,
Nagano R., Baba T., Tohyama C., and Ohsako S. Copulanar polychrolinated
biphenyl (co-PCB) affects steroidgenic enzyme mRNA expression
in the neonatal mouse testis in vitro. Organohalogen Compounds,
53; 368-371, 2001.
15. Wu Q., Baba T., Miyamoto
K., Ohsako S., and Tohyama C. Alteration of CYP1A1, AhR and Arnt
mRNA expression by TCDD in mouse preimplantation embryos developed
from 8-cell to blastocyst stage. Organohalogen Compounds, 53;
372-375, 2001.
16. Ohsako S., Miyabara
Y., Ishimura R., Sakaue M., Aoki Y., Yonemoto J., and Tohyama
C. Impairment of ventral prostate by mid-gestational but not by
late-gestational or postnatal exposure to 2,3,7,8-tetrachlorodibenzo-p-doxin
(TCDD). Organohalogen Compounds (supplement), 65-68, 2001.
17. Doi H., Tsukumo S., Baba T., Tohyama C. and Nohara K. Primary
lymphocytes have a function aryl hydrocarbon reseptor. Organohalogen
Compounds 53; 395-397, 2001.
18. Nishimura N., Miyabara
Y., Sato M., Tohyama C. and Yonemoto J. Alterations in thyroid
function in Holtzman rats following gestational and lactational
exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Organohalogen
Compounds 53; 14-16, 2001.
19. Nohara K., Izumi H.,
Tamura S. and Tohyama C. Host resistance to influenza A virus
in mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Organohalogen
Compounds 53; 395-397, 2001.
20.
Miyabara Y., Ohsako S., Nohara K., Tohyaa C. and Yonemoto J. Fetal
and infant body burden of 2,3,7,8-tetrachlorodibenzo-p-dioxin
causing a short anogenital distance and immunotoxicity in male
Holtzman rats. Organohalogen Compounds 53; 54-56, 2001.
21. Takanaga H., Kunimoto
M., Adachi T., Tohyama C., and Aoki Y., Inhibitory effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin
on cAMP-induced differentiation of rat C6 glial cell line. Journal
of Neuroscience Research.64; 402-409, 2001.
22. Ohsako S., Miyabara Y., Nishimura N., Kurosawa S., Sakaue
M., Ishimura R., Sato M., Aoki Y., Sone H., Tohyama C., and Yonemoto
J. Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) suppressed the development of reproductive organs of male
rats: dose-dependent increase of mRNA levels of 5a-reductase type
2 in contrast to decrease of androgen receptor in the pubertal
ventral prostate. Toxicol Sci, 60;132-143, 2001.
23. Nohara K.,
Ushio H., Tsukumo S., Kobayashi T., Kijima M., Tohyama C. and
Fujimaki H. Alterations of thymocyte development, thymic emigrants
and peripheral T cell population in rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin,
Toxicology, 145, 227-235, 2000.
24. Nohara K.,
Fujimaki H., Tsukumo S., Ushio H., Miyabara Y., Kijima M., Tohyama
C., Yonemoto J. The effects of perinatal exposure to low doses
of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on immune
oragans in rats. Toxicology 154:123-133,2000.
25. Nohara K., Ushio H., Tsukumo S., Kobayashi T., Kijima M.,
Tohyama C., and Fujimaki H. Alterations of thymocyte development,
thymic emigrants and peripheral T cell population in rats exposed
to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology 145:
227-235, 2000.
26. Sarkar S., Jana N. R., Yonemoto J., Tohyama
C., and Sone H. Estrogen enhances induction of cytochrome P-4501A1
by 2,3,7,8-tetrachlorodibenzo-p-dioxin in liver of female Long-Evans
rats. International Journal of Oncology 16: 141-147, 2000.
27. Ohsako S., Ishimura R., Aoki.,
Tohyama C., and Yonemoto J. Decrease of androgen sensitivity in
the ventral prostate of male rats exposed maternally to 2,3,7,8-tetrachlorodebenzo-p-dioxin
(TCDD). Organohalogen Compounds, 49: 401-403, 2000.
28. Nishimura N., Miyabara Y., Suzuki
J. S., Sato M., Yonemoto J., Satoh M., Aoki Y., Tohyama C. Metallothionein
as a marker of TCDD- induced oxidative stress in the rat. Organohalogen
Compounds, 49: 162-165, 2000.
29.
Tsukumo S., Tohyama C. and Nohara K. 2,3,7,8-Tetrachlorodibenzo-p-dioxin
(TCDD) stimulates the positive selection of CD4+CD8+ thymocytes
through the activation of MKK1/2 and PKC. Organohalogen Compounds,
49, 2000.
30. Fujimaki H.,
Nohara K., Kobayashi T., Tsukumo S., Kijima M. and Tohyama C.
Effect of a single oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin
on immune function in NC/Nga mice. Organohalogen Compounds,
49, 2000.
31. Ohsako S., Miyabara
Y., Sakaue M., Kurosawa S., Nishimura N., Aoki Y., Tohyama C.,
Sone H., Ishizuka M., Jana N.R., Sarkar S., and Yonemoto J. Effects
of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the development
of male reproductive organs in the rats. Organohalogen Compounds,
42: 19-21,1999
32. Nishimura N., Ohsako S., Sarkar S., Miyabara
Y., Tohyama C., Sone H., and Yonemoto J. Effects of gestational
and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
on pituitary and thyroid hormone levels in male rats. Organohalogen
Compounds, 42: 101-103,1999
33. Sone H., Jana N.R., Sarkar S., Ishizuka M.,
Tohyama C., and Yonemoto J. Cross-talk between 2,3,7,8-tetrachlorodibanzo-p-dioxin
and testosterone signal transduction pathways in LNCaP prostate
cancer cells. Organohalogen Compounds, 42:259-262,1999
34. Nohara K., Fujimaki H., Ushio H., Kobayashi
T., Tsukumo S., Kijima M., Miyabara Y., Yonemoto J., and Tohyama
C. Changes in thymocyte development and thymic emigrants in rats
exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Organohalogen
Compounds, 42:353-356,1999
35. Jana N.R., Sarkar S., Ishizuka M., Yonemoto
J., Tohyama C., and Sone H. Cross-talk between 2,3,7,8-tetrachlorodibenzo-p-dioxin
and testosterone signal transduction pathways in LNCaP prostate
cancer cells. Biochem Biophy Res Commun, 256: 462-468,
1999.
36. Jana N.R., Sarkar S., Ishizuka M., Yonemoto
J., Tohyama C., and Sone H. Role of estradiol receptor-a(alpha)
in differential expression of 2,3,7,8-tetrachlorodibenzo-p-dioxin
inducible genes in the RL95-2 and KLE human endometrial cancer
cell lines., Archives of Biochemistry and Biophysics, 368:
31-39, 1999.
37. Jana N.R., Sarkar S. , Ishizuka M., Yonemoto
J., Tohyama C. and Sone H., Cross-talk between 2,3,7,8-tetrachlorodibenzo-p-dioxin
and testosterone signal transduction pathways in LNCaP prostate
cancer cells. Biochemical and Biophysical Research Communications,
256 : 462-468, 1999.
38. Tsutsumi O., Uechi H., Sone H., Yonemoto J.,
Takai Y., Momoeda M., Tohyama C., Hashimoto S., Morita M., and
Taketani Y. Presence of dioxins in human follicular fluid: Their
possible stage-specific action on the development of preimplantation
mouse embryos Biochem. Biophys. Res. Commun., 250 : 498-501,
1998
39. Jana N.R., Sarkar S., Yonemoto J., Tohyama
C. and Sone H. Strain differences in cytochrome P4501A1 gene expression
caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat liver:
Role of the aryl hydrocarbon receptor and its nuclear translaocator.
Biochem. Biophys. Res. Commun., 248: 554-558, 1998
40. Sone H., Tohyama C., Aoki Y. and Yonemoto
J. Risk assessment of the flavonoids, quercetin as an endocrine
modifier: J. Risk. Res., 2: 151-166, 1999
B 総説
1. 西村典子，宮原裕一，鈴木純子，佐藤雅彦，佐藤巳喜夫，米元純三，青木康展，遠山千春，ダイオキシン投与ラット肝臓におけるメタロチオネインの誘導と重金属の変動．BIOMEDICAL
RESEARCH ON TRACE ELEMENTS vol.11 No.4:387-388，2000．
2. パオロ モッカレリ，遠山 千春． セベソにおけるダイオキシン中毒の症状．治療学，34(5): 96-99, 2000.
3. 大迫誠一郎．ダイオキシンの雄性生殖機能への影響．産婦人科の実際．Vol. 49(8), 1089-1096, 2000.
4. 遠山千春，大迫誠一郎，石村隆太．内分泌攪乱物質の健康リスクアセスメント．日本臨床．Vol. 58 (12), 2393-2400, 2000.
5. 米元純三．オスの生殖影響への内分泌攪乱物質の影響．治療学；34, 485-488, 2000.
6. 米元純三，曽根秀子．ダイオキシンと性ホルモンとの相互作用．廃棄物学会誌；11, 162-172, 2000.
7. Yonemoto J. The effects of dioxin on reproduction and development. Ind. Health; 38, 259-268, 2000.
8. 宮原裕一，米元純三．ポリ塩化ビフェニル（PCBs, ダイオキシン類など）．日本臨床．
Vol. 58 (12), 48-53, 2000.
9. 遠山千春,曽根秀子,米元純三, ダイオキシンの健康リスク評価．臨床環境医学8(2): 51-61, 1999.
10. 石村隆太,大迫誠一郎,遠山千春, 内分泌攪乱物質の健康リスク評価. BIO
Clinica15 (2): 43-48,2000.
11. 米元純三,ダイオキシン問題と健康リスク．土木学会誌84: 60-63, 1999.
12. 遠山千春,ダイオキシンのリスク評価と不確実性．日本リスク研究学会 第12回研究発表会 予稿集，1999．
13. H.Sone, Does Environmental Hormone Induce Endocrine and Reproductive
Disorders in Human Female? Asian Medical Journal 42(11):487-492,1999.
14. 曽根秀子，7.化学物質の環境へのリスク 4)ダイオキシンと健康リスク．臨床検査43(11):1383-1389, 1999.
15. 宮原裕一,遠山千春,ダイオキシン類の内分泌撹乱作用と毒性．月刊エコインダストリー 8月号:
5-12, 1999.
16. 米元純三，内分泌攪乱物質（環境ホルモン）問題について．大気環境学会誌 34(1): A8-A14, 1999.
17. 曽根秀子，環境ホルモンはヒト女性の内分泌・生殖系の健康障害をおこしているか．日本医師会雑誌 121(5) : 671-674, 1999.
18. 曽根秀子，遠山千春，内分泌攪乱と健康リスク．産科と婦人科 66(2): 189-199, 1999.
19. 石塚真由美，遠山千春，環境ホルモン．日本病院薬剤師会雑誌 35(2): 127-131, 1999.
20. 米元純三，ダイオキシンの発生毒性．ファルマシア 34(5): 449-452, 1998.
21. 曽根秀子，ダイオキシンとリスクアセスメント．ファルマシア 34(5): 457-461, 1998.
22. 曽根秀子，内分泌攪乱物質の女性生殖器への影響．ホルモンと臨床 46(7): 589-597, 1998.
23. 遠山千春，食品および環境生態系における内分泌攪乱物質．ホルモンと臨床 46: 517-528, 1998.
24. 遠山千春，ダイオキシンと健康．電気評論 6月号
66-67, 1998.
25. 遠山千春，内分泌攪乱物質の健康リスクの評価 第112回日本医学学会シンポジウム記録集 72-78, 1998.
C 口頭発表
1. 田村昌士，池田雅彦，瀬谷薫，鈴木千夏，山下純子，遠山千春，富田多嘉子．ダイオキシン
(2,3,7,8-tetrachlorodibenzo-p-dioxin: TCDD) の経胎盤，経母乳曝露による仔の性分化，生殖腺に対する影響．日本薬学会 122
回年会，幕張 2002.
2. 西村典子．ダイオキシン類の甲状腺機能への影響とそのメカニズム．第133回日本獣医学会，川崎 2002.
3. 大迫誠一郎，石村隆太，福澤徳穂，呉慶．ダイオキシンによる生殖機能への影響．第133回日本獣医学会，川崎 2002.
4. Nishimura N.,
Yonemoto J., Miyabara Y., Sone H., Ohsako S., Maeda S., Fujii-Kuriyama
Y. and Tohyama C. Mechanisms of a Decrease in Circulating Levels
of Thyroxine in Response to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
inAhR-null Mice and TTR-null Mice. Society of Toxicology: 41th
Annual Meeting, Nashville. 2002.
4. Nohara K., Ito T.,
Inouye K., Fujimaki H. and Tohyama C. Suppressive Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin
(TCDD) on Th2-Derived Cytokine Production in Primary Immune Reaction
of Mice. Society of Toxicology: 41th Annual Meeting, Nashville.
2002.
5. Inouye K., Ito T.,
Fujimaki H., Tohyama C. and Nohara K. The Effects of TCDD on Germinal
Center Formation in the Spleen of C57BL/6 Mice. Society of Toxicology:
41th Annual Meeting, Nashville. 2002.
6. Nohara K., Izumi H.,
Tamura S., Nagata R., Tohyama C. Effects of Low-dose 2,3,7,8-Tetrachlorodibenzo-p-dioxin
on Host Resistance. 環境ホルモン学会第４回研究発表会，つくば.
2001.
7. Nishimura N., Yonemoto
J., Miyabara Y., Sone H., Ohsako S., Maeda S., Fujii-Kuriyama
Y. and Tohyama C. Mechanisms of a Reduction of Thyroid Hormone
Luvels in Response to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Aryl
Hydrocarbon Receptor-Null Mice and Transthyretin-Null Mice. 環境ホルモン学会第４回研究発表会，つくば. 2001.
8. 青木康展，川上隆茂，大迫誠一郎，石村隆太，遠山千春．TCDD投与による妊娠ラット血中キニノーゲン分子種の変化．環境ホルモン学会第４回研究発表会，つくば.
2001.
9. 大迫誠一郎，福澤徳穂，石村隆太，曽根秀子，藤井義明，遠山千春．周産期TCDD曝露による産仔の雄性生殖機能の変調はAh受容体遺伝子依存性である．環境ホルモン学会第４回研究発表会，つくば.
2001.
10. 福澤徳穂，永野麗子，馬場忠，青木康則，遠山千春，大迫誠一郎．3,3',4,4',5-pentachlorobiphenyl
のマウス新生仔精巣の器官培養系におけるステロイド合成酵素 mRNA 発現への影響． 環境ホルモン学会第４回研究発表会，つくば.
2001.
11. 石村隆太，大迫誠一郎，川上隆茂，遠山千春．TCDD曝露に伴うホルツマンラット胎盤のグルコース動態の変化．環境ホルモン学会第４回研究発表会，つくば. 2001.
12. 川上隆茂，石村隆太，遠山千春，武田健，大迫誠一郎．Sprague-Dawley 及び Holtzman
ラットの胎仔・胎盤へのTCDD影響の系統差．環境ホルモン学会第４回研究発表会，つくば.
2001.
13. 呉慶，大迫誠一郎，馬場忠，遠山千春．マウス着床前胚の
in vitro TCDD 曝露による遺伝子発現の変化．環境ホルモン学会第４回研究発表会，つくば.
2001.
14. Miyabara
Y., Takeuchi Y., Nishimura N., Yokoi C., Ohsako S., Sone H., Yonemoto
J., and Tohyama C. Effects of Arylhydrocarbon Receptor Gene on
Disposition of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin through Pregnancy
and Lactation in Mice. 環境ホルモン学会第４回研究発表会，つくば.
2001.
15.
Ito T., Inouye K., Fujimaki H., Tohyama C. and Nohara K. Mechanisms
of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Induced Suppression
of Antigen-Specific Antibody Production- Inhibition of Th2 Cell-Derived
Cytokine Production in Primary Immune Reaction-.環境ホルモン学会第４回研究発表会，つくば.
2001.
16. Setani K., Ikeda M.,
Kakeyama M., Tamura M., Suzuki C., Yamashita J., Sone H., Tohyama
C. and Tomita T. Effects of in utero and lactational exposure
to TCDD on the differentiation of sexually dimorphic nucleus in
the preoptic area. 環境ホルモン学会第４回研究発表会，つくば.
2001.
17. Inouye K., Ito T.,
Fujimaki H., Tohyama C. and Nohara K. Alteration of B cell Development
in the Spleen of C57Bl/6 Mice by TCDD Treatment. 環境ホルモン学会第４回研究発表会，つくば. 2001.
18. 野原恵子，井上薫，伊藤智彦，藤巻秀和，遠山千春．ダイオキシンによる抗体産生抑制のメカニズム． 第８回免疫毒性学会，宇都宮．2001.
19. 西村典子，鈴木純子，宮原裕一，佐藤雅彦，佐藤巳喜夫，米元純三，青木康展，遠山千春．ダイオキシンによるラット肝メタロチオネインの誘導． 第３回メタロチオネイン研究会，仙台，2001.
20. 野原恵子，井上薫，藤巻秀和．Effects of 2,3,7,8-tetrachrolodibenzo-p-dioxin
on the T cell-derived cytokine production in C57Bl/6 mice. 第31回日本免疫学会総会，大阪 2001.
21. 井上薫， 藤巻秀和，高橋且聖，竹森利忠，野原恵子．ダイオキシンの脾臓における胚中心形成に及ぼす影響．第31回日本免疫学会総会，大阪，2001.
22. Ikeda M., Mitsui T.,
Tamura M., Setani K., Kakeyama M., Sone H., Tohyama C. and Tomita
T. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on sexual differentiation-influence
of the in utero exposure on fetus brain aromatase activity and
sexual dimorphisms in rats. 21th International Symposium on Halogenated
Environmental Organic Pollutants & POPs (Dioxin 2001), Gyeongju.
2001.
23. Fukuzawa N.H., Nagano
R., Baba T., Aoki Y., Tohyama C. and Ohsako S. Coplanar polychrolinated
biphenyl (Co-PCB) affects steroidgenic enzyme mRNA expression
in the neonatal mouse testis in vitro. 21th International Symposium
on Halogenated Environmental Organic Pollutants & POPs (Dioxin
2001), Gyeongju. 2001.
24. Nishimura N., Miyabara
Y., Sato M., Tohyama C. and Yonemoto J. Alterations in thyroid
function in holtzman rats following gestational and lactational
exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 21th International
Symposium on Halogenated Environmental Organic Pollutants &
POPs (Dioxin 2001), Gyeongju. 2001.
25. Nohara K., Izumi H.,
Tamura S. and Tohyama C. Host resistnance to influenza a virus
in mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 21th International
Symposium on Halogenated Environmental Organic Pollutants &
POPs (Dioxin 2001), Gyeongju. 2001.
26. Doi H., Tsukumo S.,
Baba T., Tohyama C. and Nohara K. Primary lymphocytes have a functional
aryl hydrocarbon receptor. 21th International Symposium on Halogenated
Environmental Organic Pollutants & POPs (Dioxin 2001), Gyeongju.
2001.
27. Nishimura N., Miyabara
Y., Sato M., Tohyama C. and Yonemoto J. Thyroid Hyperplasia Induced
by Gestational and Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin.
9th International Congress of Toxicology, Brisbane. 2001.
28. Ishimura R., Ohsako
S., Aoki Y. and Tohyama C. Detection and characterization of TCDD-inducible
protein (HSP27) in the rat placenta. The Endocrine Society's 83rd
Annual meeting, Denver. 2001.
29. Ohsako S., Kurosawa
S., Ishimura R. and Tohyama C. Effect of anti-androgen flutamide
on testicular function in the mature male rat. The Endocrine Society's
83rd Annual meeting, Denver. 2001.
30. 掛山正心，遠山千春，曽根秀子，脳の発達形成に対するダイオキシンの影響．第78回日本生理学会大会，京都，2001.
31. Yonemoto J., Ichiki T., Tohyama C. Reproductive effects of
offspring exposed maternally to 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) and association of the effects with the body burdens in
Dams and Fetuses / pups in Long-Evans rat. Society of Toxicology: 40th Annual Meeting:, San Francisco. 2001.3.
32. Nishimura N., Miyabara Y., Sato M., Tohyama C., Yonemoto J.
Effects of gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
on thyroid in the rat. Society of Toxicology: 40th Annual Meeting,
San Francisco. 2001.3.
33. Nohara K., Fujimaki H., Tsukumo S., Kijima M., Inouye K. and
Tohyama C. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
on the Th1/Th2 cell defferentiation in C57Bl/6 mice, 40th Annual
Meeting of the Society of Toxicology, San Francisco, 2001.
34. 西村典子，宮原裕一，佐藤巳喜夫，遠山千春，米元純三．2,3,7,8-Tetrachlorodibenzo-p-dioxinへの経胎盤および授乳による曝露の仔ラットの甲状腺機能への影響．第17回日本毒性病理学会，淡路，2001.1
35. Yonemoto J., Ichiki
T., Tohyama C. Reproductive effects of offspring exposed maternally
to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and association
of the effects with the tissue concentrations in Dams and Fetuses/Pups
in Long-Evans Rats．日本内分泌撹乱化学物質学会 第3回研究発表会, 横浜，2000.12
36. Nishimura N., Miyabara Y., Sato M., Tohyama C., Yonemoto J.
Alterations in thyroid function in rat offspring transplacentally
and lactationally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin．日本内分泌撹乱化学物質学会 第3回研究発表会，横浜，2000.12
37. Miyabara Y., Takeuchi Y., Ishizuka M., Nishimura N., Ishimura
R., Ohsako S., Sone H., Tohyama C., Yonemoto J. Disposition of
2,3,7,8-tetrachlorodibenzo-p-dioxin in pregnant rats. 日本内分泌撹乱化学物質学会 第3回研究発表会，横浜，2000.12
38. Buchanan DL., Ohsako S., Tohyama C., Cooke PS., and Taisen
I. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) does not alter early
estrogen-induced increases in uterine weight but inhibits epithelial
mitogenic activity in mice.
第3回環境ホルモン学会，横浜，2000.
39. 黒澤修一，武田健，坂上元栄，石村隆太，青木康展，遠山千春，大迫誠一郎．成熟雄ラットにおける抗アンドロゲン剤の精子形成および下垂体-性腺軸に及ぼす影響．第3回環境ホルモン学会，横浜，2000.
40. 石村隆太，大迫誠一郎，青木康展，遠山千春．TCDD曝露により胎盤細胞において発現量が変化するタンパク質（Hsp27）の検出および同定．第3回環境ホルモン学会，横浜，2000.
41. 福澤徳穂，石村隆太，松本理，青木康展，遠山千春，大迫誠一郎．マウス新生仔精巣の器官培養系におけるco-PCBの生殖細胞分化能への影響．第3回環境ホルモン学会，横浜，2000.
42. 川上隆茂，石村隆太，大迫誠一郎，武田健，遠山千春．妊娠初期TCDD曝露によるSD系ラットの胚体外組織の変化．第3回環境ホルモン学会，横浜，2000.
43. 川野道宏、中島民江、鈴木智尋、吉田 緑、米元純三、遠山千春、曽根秀子. フタル酸エステルの継世代曝露によるマウス卵巣のエストロゲン受容体発現に及ぼす影響 第3回環境ホルモン学会研究発表会、横浜, 2000.
44. 掛山正心、 遠山千春、 曽根秀子. 雄ラットの性行動に対する2,3,7,8-四塩素化ダイオキシンの経胎盤及び経母乳曝露による影響, 第3回環境ホルモン学会研究発表会、横浜, 2000.
45. 久寿米木幸寛、川野道宏、米元純三、森田昌敏、遠山千春、曽根秀子. エストロゲン応答遺伝子の探索と同定, 第3回環境ホルモン学会研究発表会、横浜, 2000.
46. Nohara K., Fujimaki H., Tsukumo S., Kijima M., Inouye K. and
Tohyama C. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
on the secondary immune reaction in C57Bl/6 mice, 日本内分泌撹乱化学物質学会第3回研究発表会, 横浜,
2000．
47. 土井啓利, 九十九伸一,
馬場忠, 遠山千春, 野原恵子.
2,3,7,8-Tetrachlorodibenzo-p-dioxinによるB細胞およびT細胞におけるシトクロムP4501A1遺伝子の発現誘導,
日本内分泌撹乱化学物質学会第3回研究発表会，横浜，2000．
48. Ishimura R., Ohmura M., Miyabara Y., Ohsako S., Aoki Y., Nishimura
N., Nohara K., Sone H., Yonemoto J., and Tohyama C. Abruption
of placental maturation by mid-pregnant exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
in rat. 38th Ann Meeting of Society of Toxicology, Philadelphia,
USA. 2000.
49. Miyabara Y., Nishimura N., Ohsako S., Ishimura R., Nohara
K., Sone H., Tohyama C., and Yonemoto J. Transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin
through pregnancy and lactation in rats. 38th Ann Meeting of Society
of Toxicology, Philadelphia, USA. 2000.
50. Nohara K., Fujimaki H., Ushio H., Kijima M., Kobayashi T.,
Tsukumo S., Miyabara Y., Sone H., Tohyama C. and Yonemoto J. Reduction
of spleen cellularity by low-dose maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) in the rats， 39th Annual Meeting of
the Society of Toxicology, Philadelphia, 2000.
51. Sato M., Miyabara Y., Yonemoto J., Matsuzaki Y., Aoki Y.,
Tohyama C., Nishimura N. Hypothyroxinemia caused by a Low Oral
Dose of 2,3,7,8-Tetrachlorodibenso-p-dioxin in Female Sprague
Dawley Rats. Society of toxicology: 39th annual meeting, Philadelphia,
2000
52. Yonemoto J., Sarkar S., Jana N.R., Tohyama C., Kusumegi T.
and Sone H. Modification of 2,3,7,8-Tetrachlorodibenzo-P-dioxin
Induced Cytochrome P-4501A1 by Estrogen in Liver of Female Long-Evans
Rats. Society of toxicology: 39th annual meeting, Philadelphia,
2000.
53. Nishimura N., Suzuki JS., Sato M., Satoh M., Aoki Y., Ohmura
M., Tohyama C. Induction of Metallothionein in Liver of Female
Rats Treated with 2,3,7,8,-Tetrachlorodibenso-p-dioxin. Society
of toxicology: 39th annual meeting, Philadelphia, 2000.
54. Ohsako S. Kinetics of the two 90-kDa heat shock proteins,
HSP84 and HSP86, in the experimentally cryptorchid mouse testis.
30th Ann Meeting of the Society for the Study of Reproduction,
Madison, USA. 2000.
55. 石村隆太，大迫誠一郎，黒澤修一，坂上元栄，遠山千春．ラット妊娠中期のTCDD投与による後期子宮内死および胎盤のグリコーゲン量の変化．第93回日本繁殖生物学会，神戸，2000.
56. 黒澤修一，武田健，坂上元栄，石村隆太，遠山千春，大迫誠一郎．成熟雄ラットにおける抗アンドロゲン剤の精子形成および下垂体性腺軸に及ぼす影響．第93回日本繁殖生物学会，神戸，2000.
57. 大迫誠一郎, 石村隆太,
坂上元栄, 黒沢修一,
米元純三, 遠山千春．胎仔期にTCDD曝露された雄ラットの腹側前立腺内5alpha-reductase type
2およびandrogen receptor mRNAレベルの変化．第130回日本獣医学会，大阪，2000.
58. 坂上元栄，大迫誠一郎，石村隆太，黒澤修一，九郎丸正道，遠山千春，林良博．エストラジオールによるラット精巣内テストステロン産生抑制とステロイド合成酵素mRNAの減少．第130回日本獣医学会，大阪，2000.
59. 大迫誠一郎．ダイオキシンの雄性生殖機能への影響．第44回日本薬学会関東支部会，千葉，2000.
60. Inukai N., Ikeda M., Mitsui T., Sone H., Yonemoto J., Tohyama
C. and Tomita T. Effects of TCDD on sex defferentiation 1. Influence
of the in utero exposure on aromatase activity in rat fetes brain,
第73回日本薬理学会年会, 横浜,
2000.
61. 藤巻秀和, 野原恵子.
NC/Ngaマウスの免疫応答に対するTCDD曝露の影響, 第7回免疫毒性研究会, 千葉,
2000.
62. 野原恵子, 九十九伸一,
遠山千春. ダイオキシンによる胸腺細胞分化撹乱のメカニズム, 第73回日本生化学会大会,
横浜, 2000.
63. 高永博実，足立達美，国本学，遠山千春，青木康展，ラットglioblastomaのアストロサイト様分化に及ぼすダイオキシン類の影響，第73回日本生化学会大会，横浜，2000．
64. 野原恵子,九十九伸一,遠山千春. ダイオキシンの胸腺細胞分化撹乱作用に関与するシグナル伝達経路, 第23回日本分子生物学会年会, 神戸, 2000.
65. Fujimaki H., Nohara K., Kobayashi T., Tsukumo S., Kijima M.
and Tohyama C. Immunosuppression in NC/Nga mice treated with a
single oral dose of TCDD. XVII International Congress of Allergology
and Clinical Immunology, Sydney 2000.
66. 宮原裕一，西村典子，大迫誠一郎，石村隆太，野原恵子，曽根秀子，遠山千春，米元純三.ダイオキシン類の母ラットから仔への移行に関する研究．日本薬学会第120年会，岐阜，2000.4
67. 西村典子，宮原裕一，鈴木純子，佐藤雅彦，佐藤巳喜夫，米元純三，青木康展，遠山千春.ダイオキシン投与ラット肝臓における重金属およびメタロチオネインの変動．第11回日本微量元素学会，名古屋,
2000. 6
68. 西村典子，米元純三，佐藤巳喜夫，宮原裕一，大村昌子，青木康展，遠山千春，胎児期及び授乳期の低用量TCDD曝露が甲状腺機能に及ぼす影響，第27回日本トキシコロジー学術年会，横浜，2000.6
69. 米元純三．妊娠ラットに投与したTCDDの仔への影響．第6回国際先天異常学会連盟(IFTS)学術集会 第40回日本先天異常学会(JTS)学術集会，松江，2000.7
70. Nishimura N., Miyabara Y., Suzuki J S., Sato M., Yonemoto
J., Satoh M., Aoki Y., Tohyama C.Metallothionein as a marker of
TCDD-induced oxidative stress in the rat. 20th International Symposium
on Halogenated Environmental Organic Pollutants & POPS (Dioxin
2000)，Monterey. 2000. 8
71. M.Ikeda, N.Inukai, T.Mitsui,
H.Sone, J.Yonemoto, C.Tohyama and T.Tomita, Effects of TCDD on
Sexual Diflerentiation -Influence of the in utero Exposure on
Fetas Brain Aromatase Activity in Rats, 20th International Symposium
on Halogenated environmental Organic Pollutants & POPS, California,
2000.
72. 米元純三．妊娠期TCDD曝露の仔への影響．第41回大気環境学会年会，浦和，2000.9
73. 宮原裕一，米元純三．ダイオキシン類の母親から仔への移行．第41回大気環境学会年会，浦和，2000.9
74. 掛山正心，遠山千春，曽根秀子，胎生期ダイオキシン曝露による雄ラットの性行動に対する影響，第23回日本神経科学大会，横浜，2000.9
75. 宮原裕一，竹内陽子，石塚真由美，西村典子，石村隆太，大迫誠一郎，曽根秀子，遠山千春，米元純三．経胎盤および授乳による2,3,7,8-Tetrachlorodibenzo-p-Dioxinの母親ラットから仔への移行．フォーラム2000：衛生薬学・環境トキシコロジー,
東京，2000.10
76. 西村典子，佐藤巳喜夫，宮原裕一，大村昌子，米元純三，青木康展，遠山千春，低用量TCDDによるラット甲状腺ホルモンの変動，第１６回日本毒性病理学会，岐阜，2000．
77. 西村典子，佐藤雅彦，米元純三，遠山千春，ダイオキシン投与ラット肝臓におけるメタロチオネインの誘導，第７０回日本衛生学会，大阪，2000．
78. 西村典子，米元純三，遠山千春，低用量TCDDのラット甲状腺ホルモンに及ぼす影響，第７０回日本衛生学会，大阪，2000．
79. Ohsako S., Nishimura N., Miyabara Y., Ishizuka M., Aoki Y.,
Tohyama C, Sone H., and Yonemoto J. Changes in the reproductive
organs of the male rats exposed maternally to 2,3,7,8-tetrachlorodibenzo
-p-dioxin (TCDD). 38th Ann Meeting of Society of Toxicology, New
Orleans, USA. 1999.
80. Miyabara Y., Nishimura N., Ohsako S., Ishimura R., Nohara
K., Sone H., Tohyama C., and Yonemoto J. Transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin
through pregnancy and lactation in rats. 38th Ann Meeting of Society
of Toxicology, New Orleans, USA. 1999.
81. Nishimura N., Ohsako S., Ishizuka M., Tohyama C, Sone H.,
and Yonemoto J. Endocrine function of male rats exposed maternally
to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). 38th Ann Meeting
of Society of Toxicology, New Orleans, USA. 1999.
82. Ohsako S., Miyabara Y., Sakaue M., Kurosawa S., Nishimura
N., Aoki Y., Tohyama C., Sone H., Ishizuka M., Jana NR., Sarkar
S. and Yonemoto J. Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin
(TCDD) on the Development of Male Reproductive Organs in the rats.
19th International Symposium on Halogenated Environmental Organic
Pollutants and POPs (Dioxin99), 1999.
83. 大迫誠一郎, 宮原裕一,
坂上元栄, 黒沢修一,
西村典子, 石塚真由美,
青木康展, 遠山千春,
曽根秀子, Jana N. R.,Sarkar S.,
米元純三． 妊娠ラットへの低用量TCDD曝露による雄性生殖器官の変異.精巣毒性研究会,東京，1999.
84. 大迫誠一郎, 宮原裕一,
坂上元栄, 黒沢修一,
西村典子, 石塚真由美,
青木康展, 遠山千春,
曽根秀子, Jana N. R.,Sarkar S.,
米元純三． ダイオキシンによる雄性生殖機能の変異.日本繁殖学会,仙台，1999.
85. Ohsako S., Sakaue M., Ishimura R., Kurosawa S., Yonemoto J.,
and Tohyama C. Effects of low-dose bisphenol-A on rat spermatogenesis.
International Symposium on Environmental Endocrine Disruptors
'99, Kobe, JAPAN, 1999.
86. Ishimura R., Ohmura M., Miyabara Y., Ohsako S., Nishimura
N., Sakaue M., Kurosawa S., Sone H., Yonemoto J., and Tohyama
C. Abruption of placental maturation by mid-pregnant exposure
to 2,3,7,8-tetrachlorodibenzo-p-dioxin in Holtzman rats.第2回日本外因性内分泌攪乱化学物質学会, 神戸,
1999.
87. Kurosawa S., Ohsako S., Ishimura R., Sakaue M., Kimura J.,
Takeda K., Yonemoto J., and Tohyama C. Analysis of mechanism for
anti-androgenic effect of vinclozolin on spermatogenesis in the
adult rat.第2回日本外因性内分泌攪乱化学物質学会, 神戸, 1999.
88. Nohara K., Fujimaki H., Ushio H., Kijima M., Tsukumo S., Kobayashi
T., Miyabara Y., Sone H., Tohyama C. and Yonemoto J. Effects of
perinatal exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) on thymus and spleen lymphocytes in rats，日本内分泌撹乱化学物質学会第2回研究発表会，神戸，1999．
89. Sone H., Jana N.R., Sarkar S., Ishizuka M., Tohyama C. and
Yonemoto J. Cross-Talk Between 2,3,7,8-tetrachlorodibenzo-p-dioxin
and Tertosterone Signal Transduction Pathways in LNCaP Prostate
Cancer cells, 19th International Symposium on Halogenated Environmental
Organic Pollutants and POPs (Dioxin99), 1999.
90. Sone H., Jana N.R., Sarkar S., Ishizuka M., Tohyama C. and
Yonemoto J. Cross-Talk Between 2,3,7,8-tetrachlorodibenzo-p-dioxin
and Tertosterone Signal Transduction Pathways in LNCaP Prostate
Cancer cells, 19th International Symposium on Halogenated Environmental
Organic Pollutants and POPs (Dioxin99), 1999.
91. Kimura,
S., Sasaki, M., Makiya, K., Ueda, H., Morita, M. and Tohyama,
C. Fundamental Guidelines Of Japanese Government For The Promotion
Of Measures To Reduce Dioxins In The Environment, 19th International
Symposium on Halogenated Environmental Organic Pollutants and
POPs (Dioxin99), Venice, 1999.
92. Suzuki C., Yonemoto J., Watanabe S., Kabuto M., Tohyama C.
and Sone H. Analysis of CYP1A1, CYP1A2 and CYP1B1 Gene Expression
Levels in Blood Using a Real-Time Reveres Transcription-PCR System,
International Conference on Chytochrome P450, 仙台,1999.
93. Jana N.R., Kusumegi T., Sarkar S., Yonemoto J., Tohyama C.
and Sone H. Strain difference in cytochrome P4501A1 gene expression
cause by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat liver,
International Conference on Cytochrome P450, 仙台,
1999.
94. Nohara K., Fujimaki H., Ushio H., Kobayashi T., Tsukumo S.,
Kijima M., Miyabara Y., Yonemoto J. and Tohyama C. Changes in
thymocyte development and thymic emigrants in rats exposed to
2,3,7,8-tetrachlorodibenzo-p-dioxin, 19th International Symposium
on Halogenated Environmental Organic Pollutants and POPs (Dioxin99),
Venice, 1999.
95. 野原恵子，藤巻秀和. ダイオキシンとTh1/Th2バランス，第６回免疫毒性研究会, 仙台，1999．
96. 野原恵子，牛尾博子，藤巻秀和. ダイオキシンが胸腺細胞の分化と末梢リンパ球構成におよぼす影響，第29回日本免疫学会総会学術集会,京都，1999.
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