関連研究の成果発表一覧

平成10年度-(1998〜現在)
         

A 学術雑誌

1. Tsukumo S., Iwata M., Tohyama C., Nohara K. Skewed differentiation of thymocytes toward CD8 T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires activation of the extracellular signal-related kinase pathway. Archives of Toxicology, 2002. (in press)

2. Fujimaki H., Nohara K., Kobayashi T., Suzuki K., Eguchi-Kasai K., Tsukumo S., Kijima M. and Tohyama C. Effect of a Single Oral Dose of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Immune Function in Male NC/Nga Mice. Toxicological Sciences, 2002. (in press)

3. Ishimura R., Ohsako S., Miyabara Y., Sakaue M., Kawakami T., Aoki Y., Yonemoto J., and Tohyama C. Increase of glycogen content and glucose transporter 3 (GLUT3) mRNA level in placenta of Holtzman rats after exposure to 2,3,7,8-Tetrachrolodibenzo-p-dioxin. Toxicol Appl Pharmacol, 178; 161-171, 2002.


4. Nohara K., Fujimaki H., Tsukumo S., Inouye K., Sone H., Tohyama C. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on T cell-deriverd cytokine production in ovalbumin (OVA)-immunized C57Bl/6 mice. Toxicology, 172; 49-58, 2002.


5. Nohara K., Izumi H., Tamura S., Nagata R., Tohyama C. Effects of low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on influenza A virus-induced mortality in mice. Toxicology, 170(1-2); 131-138, 2002.

6. Ohsako S., Miyabara Y., Sakaue M., Ishimura R., Kakeyama M., Izumi H., Yonemoto J., and Tohyama C. Developmental stage-specific effects of perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive organs of the male rat offspring. Toxicol Sci, 66; 283-292, 2002.

7. Wu Q., Ohsako S., Baba T., Miyamoto K., Tohyama C. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the mouse preimplantation embryos. Toxicology, 2002. (in press)


8. Nishimura N., Miyabara Y., Sato M., Yonemoto J. and Tohyama C. Immunohistochemical localization of thyroid stimulating hormone induced by a low oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats. Toxicology, 171; 73-82, 2002.

9. Tohyama C. Low-dose exposure to Dioxin, Its toxicities and health risk assessment. Environmental Sciences, 9, 1; 37-50, 2002

10. Kakeyama M., Sone H. and Tohyama C. Changes in expression of the NMDA receptor subunit mRNA in the neocortex and hippocampus by perinatal exposure to dioxin. Neuro Report, 12(18); 4009-4012, 2001.


11. Nisimura N., Miyabara Y., Suzuki JS., Sato M., Aoki Y., Satoh M., Yonemoto J. and Tohyama C. Induction of metallothionein in the livers of female Sprague dawley rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Life Sciences, 69; 1291-1303, 2001.

12. Ohsako S., Miyabara Y., Nishimura N., Kurosawa S., Sakaue M., Ishimura R., Sato M., Aoki Y., Sone H., Tohyama C., and Yonemoto J. Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppressed the development of reproductive organs of male rats: dose-dependent increase of mRNA levels of 5
a-reductase type 2 in contrast to decrease of androgen receptor in the pubertal ventral prostate. Toxicol Sci, 60; 132-143, 2001.


13. Ishimura R., Kawakami T., Aoki Y., Yonemoto J., Tohyama C., and Ohsako S. 2,3,7,8-Tetrachrolodibenzo-p-dioxin (TCDD) affects glucose kinetics in rat placenta. Organohalogen Compounds, 53; 300-302, 2001.

14.
Fukuzawa N.H., Nagano R., Baba T., Tohyama C., and Ohsako S. Copulanar polychrolinated biphenyl (co-PCB) affects steroidgenic enzyme mRNA expression in the neonatal mouse testis in vitro. Organohalogen Compounds, 53; 368-371, 2001.

15. Wu Q., Baba T., Miyamoto K., Ohsako S., and Tohyama C. Alteration of CYP1A1, AhR and Arnt mRNA expression by TCDD in mouse preimplantation embryos developed from 8-cell to blastocyst stage. Organohalogen Compounds, 53; 372-375, 2001.

16. Ohsako S., Miyabara Y., Ishimura R., Sakaue M., Aoki Y., Yonemoto J., and Tohyama C. Impairment of ventral prostate by mid-gestational but not by late-gestational or postnatal exposure to 2,3,7,8-tetrachlorodibenzo-p-doxin (TCDD). Organohalogen Compounds (supplement), 65-68, 2001.


17. Doi H., Tsukumo S., Baba T., Tohyama C. and Nohara K. Primary lymphocytes have a function aryl hydrocarbon reseptor. Organohalogen Compounds 53; 395-397, 2001.

18. Nishimura N., Miyabara Y., Sato M., Tohyama C. and Yonemoto J. Alterations in thyroid function in Holtzman rats following gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Organohalogen Compounds 53; 14-16, 2001.

19. Nohara K., Izumi H., Tamura S. and Tohyama C. Host resistance to influenza A virus in mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Organohalogen Compounds 53; 395-397, 2001.


20. Miyabara Y., Ohsako S., Nohara K., Tohyaa C. and Yonemoto J. Fetal and infant body burden of 2,3,7,8-tetrachlorodibenzo-p-dioxin causing a short anogenital distance and immunotoxicity in male Holtzman rats. Organohalogen Compounds 53; 54-56, 2001.

21. Takanaga H., Kunimoto M., Adachi T., Tohyama C., and Aoki Y., Inhibitory effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cAMP-induced differentiation of rat C6 glial cell line. Journal of Neuroscience Research.64; 402-409, 2001.


22. Ohsako S., Miyabara Y., Nishimura N., Kurosawa S., Sakaue M., Ishimura R., Sato M., Aoki Y., Sone H., Tohyama C., and Yonemoto J. Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppressed the development of reproductive organs of male rats: dose-dependent increase of mRNA levels of 5a-reductase type 2 in contrast to decrease of androgen receptor in the pubertal ventral prostate. Toxicol Sci, 60;132-143, 2001.

23. Nohara K., Ushio H., Tsukumo S., Kobayashi T., Kijima M., Tohyama C. and Fujimaki H. Alterations of thymocyte development, thymic emigrants and peripheral T cell population in rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin, Toxicology, 145, 227-235, 2000.

24. Nohara K., Fujimaki H., Tsukumo S., Ushio H., Miyabara Y., Kijima M., Tohyama C., Yonemoto J. The effects of perinatal exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on immune oragans in rats. Toxicology 154:123-133,2000.


25. Nohara K., Ushio H., Tsukumo S., Kobayashi T., Kijima M., Tohyama C., and Fujimaki H. Alterations of thymocyte development, thymic emigrants and peripheral T cell population in rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology 145: 227-235, 2000.

26. Sarkar S., Jana N. R., Yonemoto J., Tohyama C., and Sone H. Estrogen enhances induction of cytochrome P-4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin in liver of female Long-Evans rats. International Journal of Oncology 16: 141-147, 2000.

27. Ohsako S., Ishimura R., Aoki., Tohyama C., and Yonemoto J. Decrease of androgen sensitivity in the ventral prostate of male rats exposed maternally to 2,3,7,8-tetrachlorodebenzo-p-dioxin (TCDD). Organohalogen Compounds, 49: 401-403, 2000.

28. Nishimura N., Miyabara Y., Suzuki J. S., Sato M., Yonemoto J., Satoh M., Aoki Y., Tohyama C. Metallothionein as a marker of TCDD- induced oxidative stress in the rat. Organohalogen Compounds, 49: 162-165, 2000.

29. Tsukumo S., Tohyama C. and Nohara K. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) stimulates the positive selection of CD4+CD8+ thymocytes through the activation of MKK1/2 and PKC. Organohalogen Compounds, 49, 2000.

30. Fujimaki H., Nohara K., Kobayashi T., Tsukumo S., Kijima M. and Tohyama C. Effect of a single oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin on immune function in NC/Nga mice. Organohalogen Compounds, 49, 2000.

31. Ohsako S., Miyabara Y., Sakaue M., Kurosawa S., Nishimura N., Aoki Y., Tohyama C., Sone H., Ishizuka M., Jana N.R., Sarkar S., and Yonemoto J. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the development of male reproductive organs in the rats. Organohalogen Compounds, 42: 19-21,1999

32. Nishimura N., Ohsako S., Sarkar S., Miyabara Y., Tohyama C., Sone H., and Yonemoto J. Effects of gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on pituitary and thyroid hormone levels in male rats. Organohalogen Compounds, 42: 101-103,1999

33. Sone H., Jana N.R., Sarkar S., Ishizuka M., Tohyama C., and Yonemoto J. Cross-talk between 2,3,7,8-tetrachlorodibanzo-p-dioxin and testosterone signal transduction pathways in LNCaP prostate cancer cells. Organohalogen Compounds, 42:259-262,1999

34. Nohara K., Fujimaki H., Ushio H., Kobayashi T., Tsukumo S., Kijima M., Miyabara Y., Yonemoto J., and Tohyama C. Changes in thymocyte development and thymic emigrants in rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Organohalogen Compounds, 42:353-356,1999

35. Jana N.R., Sarkar S., Ishizuka M., Yonemoto J., Tohyama C., and Sone H. Cross-talk between 2,3,7,8-tetrachlorodibenzo-p-dioxin and testosterone signal transduction pathways in LNCaP prostate cancer cells. Biochem Biophy Res Commun, 256: 462-468, 1999.

36. Jana N.R., Sarkar S., Ishizuka M., Yonemoto J., Tohyama C., and Sone H. Role of estradiol receptor-a(alpha) in differential expression of 2,3,7,8-tetrachlorodibenzo-p-dioxin inducible genes in the RL95-2 and KLE human endometrial cancer cell lines., Archives of Biochemistry and Biophysics, 368: 31-39, 1999.

37. Jana N.R., Sarkar S. , Ishizuka M., Yonemoto J., Tohyama C. and Sone H., Cross-talk between 2,3,7,8-tetrachlorodibenzo-p-dioxin and testosterone signal transduction pathways in LNCaP prostate cancer cells. Biochemical and Biophysical Research Communications, 256 : 462-468, 1999.

38. Tsutsumi O., Uechi H., Sone H., Yonemoto J., Takai Y., Momoeda M., Tohyama C., Hashimoto S., Morita M., and Taketani Y. Presence of dioxins in human follicular fluid: Their possible stage-specific action on the development of preimplantation mouse embryos Biochem. Biophys. Res. Commun., 250 : 498-501, 1998

39. Jana N.R., Sarkar S., Yonemoto J., Tohyama C. and Sone H. Strain differences in cytochrome P4501A1 gene expression caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat liver: Role of the aryl hydrocarbon receptor and its nuclear translaocator. Biochem. Biophys. Res. Commun., 248: 554-558, 1998

40. Sone H., Tohyama C., Aoki Y. and Yonemoto J. Risk assessment of the flavonoids, quercetin as an endocrine modifier: J. Risk. Res., 2: 151-166, 1999

B 総説

1. 西村典子,宮原裕一,鈴木純子,佐藤雅彦,佐藤巳喜夫,米元純三,青木康展,遠山千春,ダイオキシン投与ラット肝臓におけるメタロチオネインの誘導と重金属の変動.BIOMEDICAL RESEARCH ON TRACE ELEMENTS vol.11 No.4:387-388,2000.

2. パオロ モッカレリ,遠山 千春. セベソにおけるダイオキシン中毒の症状.治療学,34(5): 96-99, 2000.

3. 大迫誠一郎.ダイオキシンの雄性生殖機能への影響.産婦人科の実際.Vol. 49(8), 1089-1096, 2000.

4. 遠山千春,大迫誠一郎,石村隆太.内分泌攪乱物質の健康リスクアセスメント.日本臨床.Vol. 58 (12), 2393-2400, 2000.

5. 米元純三.オスの生殖影響への内分泌攪乱物質の影響.治療学;34, 485-488, 2000.

6. 米元純三,曽根秀子.ダイオキシンと性ホルモンとの相互作用.廃棄物学会誌;11, 162-172, 2000.

7. Yonemoto J. The effects of dioxin on reproduction and development. Ind. Health; 38, 259-268, 2000.

8. 宮原裕一,米元純三.ポリ塩化ビフェニル(PCBs, ダイオキシン類など).日本臨床. Vol. 58 (12), 48-53, 2000.

9. 遠山千春,曽根秀子,米元純三, ダイオキシンの健康リスク評価.臨床環境医学8(2): 51-61, 1999. 

10.
石村隆太,大迫誠一郎,遠山千春, 内分泌攪乱物質の健康リスク評価. BIO Clinica15 (2): 43-48,2000.

11.
米元純三,ダイオキシン問題と健康リスク.土木学会誌84: 60-63, 1999.

12.
遠山千春,ダイオキシンのリスク評価と不確実性.日本リスク研究学会 第12回研究発表会 予稿集,1999

13. H.Sone, Does Environmental Hormone Induce Endocrine and Reproductive Disorders in Human Female? Asian Medical Journal 42(11):487-492,1999.

14.
曽根秀子,7.化学物質の環境へのリスク 4)ダイオキシンと健康リスク.臨床検査43(11):1383-1389, 1999.

15.
宮原裕一,遠山千春,ダイオキシン類の内分泌撹乱作用と毒性.月刊エコインダストリー 8月号: 5-12, 1999.

16.
米元純三,内分泌攪乱物質(環境ホルモン)問題について.大気環境学会誌 34(1): A8-A14, 1999.

17.
曽根秀子,環境ホルモンはヒト女性の内分泌・生殖系の健康障害をおこしているか.日本医師会雑誌 121(5) : 671-674, 1999.

18.
曽根秀子,遠山千春,内分泌攪乱と健康リスク.産科と婦人科 66(2): 189-199, 1999.

19.
石塚真由美,遠山千春,環境ホルモン.日本病院薬剤師会雑誌 35(2): 127-131, 1999.

20.
米元純三,ダイオキシンの発生毒性.ファルマシア 34(5): 449-452, 1998.

21.
曽根秀子,ダイオキシンとリスクアセスメント.ファルマシア 34(5): 457-461, 1998.

22.
曽根秀子,内分泌攪乱物質の女性生殖器への影響.ホルモンと臨床 46(7): 589-597, 1998.

23.
遠山千春,食品および環境生態系における内分泌攪乱物質.ホルモンと臨床 46: 517-528, 1998.

24.
遠山千春,ダイオキシンと健康.電気評論 6月号 66-67, 1998.

25.
遠山千春,内分泌攪乱物質の健康リスクの評価 第112回日本医学学会シンポジウム記録集 72-78, 1998.

C 口頭発表

1. 田村昌士,池田雅彦,瀬谷薫,鈴木千夏,山下純子,遠山千春,富田多嘉子.ダイオキシン (2,3,7,8-tetrachlorodibenzo-p-dioxin: TCDD) の経胎盤,経母乳曝露による仔の性分化,生殖腺に対する影響.日本薬学会 122 回年会,幕張 2002.

2. 西村典子.ダイオキシン類の甲状腺機能への影響とそのメカニズム.第133回日本獣医学会,川崎 2002.

3. 大迫誠一郎,石村隆太,福澤徳穂,呉慶.ダイオキシンによる生殖機能への影響.第133回日本獣医学会,川崎 2002.

4. Nishimura N., Yonemoto J., Miyabara Y., Sone H., Ohsako S., Maeda S., Fujii-Kuriyama Y. and Tohyama C. Mechanisms of a Decrease in Circulating Levels of Thyroxine in Response to 2,3,7,8-Tetrachlorodibenzo-p-dioxin inAhR-null Mice and TTR-null Mice. Society of Toxicology: 41th Annual Meeting, Nashville. 2002.

4. Nohara K., Ito T., Inouye K., Fujimaki H. and Tohyama C. Suppressive Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Th2-Derived Cytokine Production in Primary Immune Reaction of Mice. Society of Toxicology: 41th Annual Meeting, Nashville. 2002.

5. Inouye K., Ito T., Fujimaki H., Tohyama C. and Nohara K. The Effects of TCDD on Germinal Center Formation in the Spleen of C57BL/6 Mice. Society of Toxicology: 41th Annual Meeting, Nashville. 2002.

6. Nohara K., Izumi H., Tamura S., Nagata R., Tohyama C. Effects of Low-dose 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Host Resistance. 環境ホルモン学会第4回研究発表会,つくば. 2001.

7. Nishimura N., Yonemoto J., Miyabara Y., Sone H., Ohsako S., Maeda S., Fujii-Kuriyama Y. and Tohyama C. Mechanisms of a Reduction of Thyroid Hormone Luvels in Response to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Aryl Hydrocarbon Receptor-Null Mice and Transthyretin-Null Mice. 環境ホルモン学会第4回研究発表会,つくば. 2001.

8. 青木康展,川上隆茂,大迫誠一郎,石村隆太,遠山千春.TCDD投与による妊娠ラット血中キニノーゲン分子種の変化.環境ホルモン学会第4回研究発表会,つくば. 2001.

9. 大迫誠一郎,福澤徳穂,石村隆太,曽根秀子,藤井義明,遠山千春.周産期TCDD曝露による産仔の雄性生殖機能の変調はAh受容体遺伝子依存性である.環境ホルモン学会第4回研究発表会,つくば. 2001.

10.
福澤徳穂,永野麗子,馬場忠,青木康則,遠山千春,大迫誠一郎.3,3',4,4',5-pentachlorobiphenyl のマウス新生仔精巣の器官培養系におけるステロイド合成酵素 mRNA 発現への影響. 環境ホルモン学会第4回研究発表会,つくば. 2001.

11.
石村隆太,大迫誠一郎,川上隆茂,遠山千春.TCDD曝露に伴うホルツマンラット胎盤のグルコース動態の変化.環境ホルモン学会第4回研究発表会,つくば. 2001.

12.
川上隆茂,石村隆太,遠山千春,武田健,大迫誠一郎.Sprague-Dawley 及び Holtzman ラットの胎仔・胎盤へのTCDD影響の系統差.環境ホルモン学会第4回研究発表会,つくば. 2001.

13.
呉慶,大迫誠一郎,馬場忠,遠山千春.マウス着床前胚の in vitro TCDD 曝露による遺伝子発現の変化.環境ホルモン学会第4回研究発表会,つくば. 2001.

14.
Miyabara Y., Takeuchi Y., Nishimura N., Yokoi C., Ohsako S., Sone H., Yonemoto J., and Tohyama C. Effects of Arylhydrocarbon Receptor Gene on Disposition of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin through Pregnancy and Lactation in Mice. 環境ホルモン学会第4回研究発表会,つくば. 2001.

15. Ito T., Inouye K., Fujimaki H., Tohyama C. and Nohara K. Mechanisms of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Induced Suppression of Antigen-Specific Antibody Production- Inhibition of Th2 Cell-Derived Cytokine Production in Primary Immune Reaction-.環境ホルモン学会第4回研究発表会,つくば. 2001.

16. Setani K., Ikeda M., Kakeyama M., Tamura M., Suzuki C., Yamashita J., Sone H., Tohyama C. and Tomita T. Effects of in utero and lactational exposure to TCDD on the differentiation of sexually dimorphic nucleus in the preoptic area. 環境ホルモン学会第4回研究発表会,つくば. 2001.

17. Inouye K., Ito T., Fujimaki H., Tohyama C. and Nohara K. Alteration of B cell Development in the Spleen of C57Bl/6 Mice by TCDD Treatment. 環境ホルモン学会第4回研究発表会,つくば. 2001.

18. 野原恵子,井上薫,伊藤智彦,藤巻秀和,遠山千春.ダイオキシンによる抗体産生抑制のメカニズム. 第8回免疫毒性学会,宇都宮.2001.

19. 西村典子,鈴木純子,宮原裕一,佐藤雅彦,佐藤巳喜夫,米元純三,青木康展,遠山千春.ダイオキシンによるラット肝メタロチオネインの誘導. 第3回メタロチオネイン研究会,仙台,2001.

20. 野原恵子,井上薫,藤巻秀和.Effects of 2,3,7,8-tetrachrolodibenzo-p-dioxin on the T cell-derived cytokine production in C57Bl/6 mice. 第31回日本免疫学会総会,大阪 2001.

21. 井上薫, 藤巻秀和,高橋且聖,竹森利忠,野原恵子.ダイオキシンの脾臓における胚中心形成に及ぼす影響.第31回日本免疫学会総会,大阪,2001.

22. Ikeda M., Mitsui T., Tamura M., Setani K., Kakeyama M., Sone H., Tohyama C. and Tomita T. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on sexual differentiation-influence of the in utero exposure on fetus brain aromatase activity and sexual dimorphisms in rats. 21th International Symposium on Halogenated Environmental Organic Pollutants & POPs (Dioxin 2001), Gyeongju. 2001.

23. Fukuzawa N.H., Nagano R., Baba T., Aoki Y., Tohyama C. and Ohsako S. Coplanar polychrolinated biphenyl (Co-PCB) affects steroidgenic enzyme mRNA expression in the neonatal mouse testis in vitro. 21th International Symposium on Halogenated Environmental Organic Pollutants & POPs (Dioxin 2001), Gyeongju. 2001.

24. Nishimura N., Miyabara Y., Sato M., Tohyama C. and Yonemoto J. Alterations in thyroid function in holtzman rats following gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 21th International Symposium on Halogenated Environmental Organic Pollutants & POPs (Dioxin 2001), Gyeongju. 2001.

25. Nohara K., Izumi H., Tamura S. and Tohyama C. Host resistnance to influenza a virus in mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 21th International Symposium on Halogenated Environmental Organic Pollutants & POPs (Dioxin 2001), Gyeongju. 2001.

26. Doi H., Tsukumo S., Baba T., Tohyama C. and Nohara K. Primary lymphocytes have a functional aryl hydrocarbon receptor. 21th International Symposium on Halogenated Environmental Organic Pollutants & POPs (Dioxin 2001), Gyeongju. 2001.

27. Nishimura N., Miyabara Y., Sato M., Tohyama C. and Yonemoto J. Thyroid Hyperplasia Induced by Gestational and Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. 9th International Congress of Toxicology, Brisbane. 2001.

28. Ishimura R., Ohsako S., Aoki Y. and Tohyama C. Detection and characterization of TCDD-inducible protein (HSP27) in the rat placenta. The Endocrine Society's 83rd Annual meeting, Denver. 2001.

29. Ohsako S., Kurosawa S., Ishimura R. and Tohyama C. Effect of anti-androgen flutamide on testicular function in the mature male rat. The Endocrine Society's 83rd Annual meeting, Denver. 2001.

30. 掛山正心,遠山千春,曽根秀子,脳の発達形成に対するダイオキシンの影響.第78回日本生理学会大会,京都,2001.

31. Yonemoto J., Ichiki T., Tohyama C. Reproductive effects of offspring exposed maternally to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and association of the effects with the body burdens in Dams and Fetuses / pups in Long-Evans rat. Society of Toxicology:
 40th Annual Meeting:, San Francisco. 2001.3.

32. Nishimura N., Miyabara Y., Sato M., Tohyama C., Yonemoto J. Effects of gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on thyroid in the rat. Society of Toxicology: 40th Annual Meeting, San Francisco. 2001.3.

33. Nohara K., Fujimaki H., Tsukumo S., Kijima M., Inouye K. and Tohyama C. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the Th1/Th2 cell defferentiation in C57Bl/6 mice, 40th Annual Meeting of the Society of Toxicology, San Francisco, 2001.

34.
西村典子,宮原裕一,佐藤巳喜夫,遠山千春,米元純三.2,3,7,8-Tetrachlorodibenzo-p-dioxinへの経胎盤および授乳による曝露の仔ラットの甲状腺機能への影響.第17回日本毒性病理学会,淡路,2001.1

35. Yonemoto J., Ichiki T., Tohyama C. Reproductive effects of offspring exposed maternally to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and association of the effects with the tissue concentrations in Dams and Fetuses/Pups in Long-Evans Rats.日本内分泌撹乱化学物質学会 3回研究発表会, 横浜2000.12

36. Nishimura N., Miyabara Y., Sato M., Tohyama C., Yonemoto J. Alterations in thyroid function in rat offspring transplacentally and lactationally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
.日本内分泌撹乱化学物質学会 第3回研究発表会,横浜,2000.12

37. Miyabara Y., Takeuchi Y., Ishizuka M., Nishimura N., Ishimura R., Ohsako S., Sone H., Tohyama C., Yonemoto J. Disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in pregnant rats.
日本内分泌撹乱化学物質学会 第3回研究発表会,横浜,2000.12

38. Buchanan DL., Ohsako S., Tohyama C., Cooke PS., and Taisen I. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) does not alter early estrogen-induced increases in uterine weight but inhibits epithelial mitogenic activity in mice.
第3回環境ホルモン学会,横浜2000.

39.
黒澤修一,武田健,坂上元栄,石村隆太,青木康展,遠山千春,大迫誠一郎.成熟雄ラットにおける抗アンドロゲン剤の精子形成および下垂体-性腺軸に及ぼす影響.第3回環境ホルモン学会,横浜2000.

40.
石村隆太,大迫誠一郎,青木康展,遠山千春.TCDD曝露により胎盤細胞において発現量が変化するタンパク質(Hsp27)の検出および同定.第3回環境ホルモン学会,横浜2000.

41.
福澤徳穂,石村隆太,松本理,青木康展,遠山千春,大迫誠一郎.マウス新生仔精巣の器官培養系におけるco-PCBの生殖細胞分化能への影響.第3回環境ホルモン学会,横浜2000.

42.
川上隆茂,石村隆太,大迫誠一郎,武田健,遠山千春.妊娠初期TCDD曝露によるSD系ラットの胚体外組織の変化.第3回環境ホルモン学会,横浜2000.

43.
川野道宏、中島民江、鈴木智尋、吉田 緑、米元純三、遠山千春、曽根秀子. フタル酸エステルの継世代曝露によるマウス卵巣のエストロゲン受容体発現に及ぼす影響 第3回環境ホルモン学会研究発表会、横浜, 2000.

44.
掛山正心、 遠山千春、 曽根秀子. 雄ラットの性行動に対する2,3,7,8-四塩素化ダイオキシンの経胎盤及び経母乳曝露による影響, 3回環境ホルモン学会研究発表会、横浜, 2000.

45.
久寿米木幸寛、川野道宏、米元純三、森田昌敏、遠山千春、曽根秀子. エストロゲン応答遺伝子の探索と同定, 3回環境ホルモン学会研究発表会、横浜, 2000.

46. Nohara K., Fujimaki H., Tsukumo S., Kijima M., Inouye K. and Tohyama C. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the secondary immune reaction in C57Bl/6 mice,
日本内分泌撹乱化学物質学会第3回研究発表会, 横浜, 2000

47.
土井啓利, 九十九伸一, 馬場忠, 遠山千春, 野原恵子. 2,3,7,8-Tetrachlorodibenzo-p-dioxinによるB細胞およびT細胞におけるシトクロムP4501A1遺伝子の発現誘導, 日本内分泌撹乱化学物質学会第3回研究発表会,横浜,2000

48. Ishimura R., Ohmura M., Miyabara Y., Ohsako S., Aoki Y., Nishimura N., Nohara K., Sone H., Yonemoto J., and Tohyama C. Abruption of placental maturation by mid-pregnant exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat. 38th Ann Meeting of Society of Toxicology, Philadelphia, USA. 2000.

49. Miyabara Y., Nishimura N., Ohsako S., Ishimura R., Nohara K., Sone H., Tohyama C., and Yonemoto J. Transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin through pregnancy and lactation in rats. 38th Ann Meeting of Society of Toxicology, Philadelphia, USA. 2000.

50. Nohara K., Fujimaki H., Ushio H., Kijima M., Kobayashi T., Tsukumo S., Miyabara Y., Sone H., Tohyama C. and Yonemoto J. Reduction of spleen cellularity by low-dose maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rats
39th Annual Meeting of the Society of Toxicology, Philadelphia, 2000.

51. Sato M., Miyabara Y., Yonemoto J., Matsuzaki Y., Aoki Y., Tohyama C., Nishimura N. Hypothyroxinemia caused by a Low Oral Dose of 2,3,7,8-Tetrachlorodibenso-p-dioxin in Female Sprague Dawley Rats. Society of toxicology: 39th annual meeting, Philadelphia, 2000

52. Yonemoto J., Sarkar S., Jana N.R., Tohyama C., Kusumegi T. and Sone H. Modification of 2,3,7,8-Tetrachlorodibenzo-P-dioxin Induced Cytochrome P-4501A1 by Estrogen in Liver of Female Long-Evans Rats. Society of toxicology: 39th annual meeting, Philadelphia, 2000.

53. Nishimura N., Suzuki JS., Sato M., Satoh M., Aoki Y., Ohmura M., Tohyama C. Induction of Metallothionein in Liver of Female Rats Treated with 2,3,7,8,-Tetrachlorodibenso-p-dioxin. Society of toxicology: 39th annual meeting, Philadelphia, 2000.

54. Ohsako S. Kinetics of the two 90-kDa heat shock proteins, HSP84 and HSP86, in the experimentally cryptorchid mouse testis. 30th Ann Meeting of the Society for the Study of Reproduction, Madison, USA. 2000.

55.
石村隆太,大迫誠一郎,黒澤修一,坂上元栄,遠山千春.ラット妊娠中期のTCDD投与による後期子宮内死および胎盤のグリコーゲン量の変化.第93回日本繁殖生物学会,神戸2000.

56.
黒澤修一,武田健,坂上元栄,石村隆太,遠山千春,大迫誠一郎.成熟雄ラットにおける抗アンドロゲン剤の精子形成および下垂体性腺軸に及ぼす影響.第93回日本繁殖生物学会,神戸2000.

57.
大迫誠一郎, 石村隆太, 坂上元栄, 黒沢修一, 米元純三, 遠山千春.胎仔期にTCDD曝露された雄ラットの腹側前立腺内5alpha-reductase type 2およびandrogen receptor mRNAレベルの変化.第130回日本獣医学会,大阪2000.

58.
坂上元栄,大迫誠一郎,石村隆太,黒澤修一,九郎丸正道,遠山千春,林良博.エストラジオールによるラット精巣内テストステロン産生抑制とステロイド合成酵素mRNAの減少.第130回日本獣医学会,大阪2000.

59.
大迫誠一郎.ダイオキシンの雄性生殖機能への影響.第44回日本薬学会関東支部会,千葉2000.

60. Inukai N., Ikeda M., Mitsui T., Sone H., Yonemoto J., Tohyama C. and Tomita T. Effects of TCDD on sex defferentiation 1. Influence of the in utero exposure on aromatase activity in rat fetes brain,
73回日本薬理学会年会, 横浜, 2000.

61.
藤巻秀和, 野原恵子. NC/Ngaマウスの免疫応答に対するTCDD曝露の影響, 第7回免疫毒性研究会, 千葉, 2000.

62.
野原恵子, 九十九伸一, 遠山千春. ダイオキシンによる胸腺細胞分化撹乱のメカニズム, 73回日本生化学会大会, 横浜, 2000.

63.
高永博実,足立達美,国本学,遠山千春,青木康展,ラットglioblastomaのアストロサイト様分化に及ぼすダイオキシン類の影響,第73回日本生化学会大会,横浜,2000.

64.
野原恵子,九十九伸一,遠山千春. ダイオキシンの胸腺細胞分化撹乱作用に関与するシグナル伝達経路, 23回日本分子生物学会年会, 神戸, 2000.

65. Fujimaki H., Nohara K., Kobayashi T., Tsukumo S., Kijima M. and Tohyama C. Immunosuppression in NC/Nga mice treated with a single oral dose of TCDD. XVII International Congress of Allergology and Clinical Immunology, Sydney 2000.

66.
宮原裕一,西村典子,大迫誠一郎,石村隆太,野原恵子,曽根秀子,遠山千春,米元純三.ダイオキシン類の母ラットから仔への移行に関する研究.日本薬学会第120年会,岐阜2000.4

67.
西村典子,宮原裕一,鈴木純子,佐藤雅彦,佐藤巳喜夫,米元純三,青木康展,遠山千春.ダイオキシン投与ラット肝臓における重金属およびメタロチオネインの変動.第11回日本微量元素学会,名古屋, 2000. 6

68. 西村典子,米元純三,佐藤巳喜夫,宮原裕一,大村昌子,青木康展,遠山千春,胎児期及び授乳期の低用量TCDD曝露が甲状腺機能に及ぼす影響,第27回日本トキシコロジー学術年会,横浜,2000.6

69.
米元純三.妊娠ラットに投与したTCDDの仔への影響.第6回国際先天異常学会連盟(IFTS)学術集会 第40回日本先天異常学会(JTS)学術集会,松江,2000.7

70. Nishimura N., Miyabara Y., Suzuki J S., Sato M., Yonemoto J., Satoh M., Aoki Y., Tohyama C.Metallothionein as a marker of TCDD-induced oxidative stress in the rat. 20th International Symposium on Halogenated Environmental Organic Pollutants & POPS (Dioxin 2000)
Monterey. 2000. 8

71. M.Ikeda, N.Inukai, T.Mitsui, H.Sone, J.Yonemoto, C.Tohyama and T.Tomita, Effects of TCDD on Sexual Diflerentiation -Influence of the in utero Exposure on Fetas Brain Aromatase Activity in Rats, 20th International Symposium on Halogenated environmental Organic Pollutants & POPS, California, 2000.

72.
米元純三.妊娠期TCDD曝露の仔への影響.第41回大気環境学会年会,浦和2000.9

73.
宮原裕一,米元純三.ダイオキシン類の母親から仔への移行.第41回大気環境学会年会,浦和2000.9

74. 掛山正心,遠山千春,曽根秀子,胎生期ダイオキシン曝露による雄ラットの性行動に対する影響,第23回日本神経科学大会,横浜,2000.9

75.
宮原裕一,竹内陽子,石塚真由美,西村典子,石村隆太,大迫誠一郎,曽根秀子,遠山千春,米元純三.経胎盤および授乳による2,3,7,8-Tetrachlorodibenzo-p-Dioxinの母親ラットから仔への移行.フォーラム2000:衛生薬学・環境トキシコロジー, 東京2000.10

76.
西村典子,佐藤巳喜夫,宮原裕一,大村昌子,米元純三,青木康展,遠山千春,低用量TCDDによるラット甲状腺ホルモンの変動,第16回日本毒性病理学会,岐阜,2000

77.
西村典子,佐藤雅彦,米元純三,遠山千春,ダイオキシン投与ラット肝臓におけるメタロチオネインの誘導,第70回日本衛生学会,大阪,2000

78.
西村典子,米元純三,遠山千春,低用量TCDDのラット甲状腺ホルモンに及ぼす影響,第70回日本衛生学会,大阪,2000

79. Ohsako S., Nishimura N., Miyabara Y., Ishizuka M., Aoki Y., Tohyama C, Sone H., and Yonemoto J. Changes in the reproductive organs of the male rats exposed maternally to 2,3,7,8-tetrachlorodibenzo -p-dioxin (TCDD). 38th Ann Meeting of Society of Toxicology, New Orleans, USA. 1999.

80. Miyabara Y., Nishimura N., Ohsako S., Ishimura R., Nohara K., Sone H., Tohyama C., and Yonemoto J. Transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin through pregnancy and lactation in rats. 38th Ann Meeting of Society of Toxicology, New Orleans, USA. 1999.

81. Nishimura N., Ohsako S., Ishizuka M., Tohyama C, Sone H., and Yonemoto J. Endocrine function of male rats exposed maternally to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). 38th Ann Meeting of Society of Toxicology, New Orleans, USA. 1999.

82. Ohsako S., Miyabara Y., Sakaue M., Kurosawa S., Nishimura N., Aoki Y., Tohyama C., Sone H., Ishizuka M., Jana NR., Sarkar S. and Yonemoto J. Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on the Development of Male Reproductive Organs in the rats. 19th International Symposium on Halogenated Environmental Organic Pollutants and POPs (Dioxin99), 1999.

83.
大迫誠一郎, 宮原裕一, 坂上元栄, 黒沢修一, 西村典子, 石塚真由美, 青木康展, 遠山千春, 曽根秀子, Jana N. R.,Sarkar S., 米元純三. 妊娠ラットへの低用量TCDD曝露による雄性生殖器官の変異.精巣毒性研究会,東京1999.

84.
大迫誠一郎, 宮原裕一, 坂上元栄, 黒沢修一, 西村典子, 石塚真由美, 青木康展, 遠山千春, 曽根秀子, Jana N. R.,Sarkar S., 米元純三. ダイオキシンによる雄性生殖機能の変異.日本繁殖学会,仙台1999.

85. Ohsako S., Sakaue M., Ishimura R., Kurosawa S., Yonemoto J., and Tohyama C. Effects of low-dose bisphenol-A on rat spermatogenesis. International Symposium on Environmental Endocrine Disruptors '99, Kobe, JAPAN, 1999.

86. Ishimura R., Ohmura M., Miyabara Y., Ohsako S., Nishimura N., Sakaue M., Kurosawa S., Sone H., Yonemoto J., and Tohyama C. Abruption of placental maturation by mid-pregnant exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in Holtzman rats.
2回日本外因性内分泌攪乱化学物質学会, 神戸, 1999.

87. Kurosawa S., Ohsako S., Ishimura R., Sakaue M., Kimura J., Takeda K., Yonemoto J., and Tohyama C. Analysis of mechanism for anti-androgenic effect of vinclozolin on spermatogenesis in the adult rat.
2回日本外因性内分泌攪乱化学物質学会, 神戸, 1999.

88. Nohara K., Fujimaki H., Ushio H., Kijima M., Tsukumo S., Kobayashi T., Miyabara Y., Sone H., Tohyama C. and Yonemoto J. Effects of perinatal exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on thymus and spleen lymphocytes in rats
,日本内分泌撹乱化学物質学会第2回研究発表会,神戸,1999

89. Sone H., Jana N.R., Sarkar S., Ishizuka M., Tohyama C. and Yonemoto J. Cross-Talk Between 2,3,7,8-tetrachlorodibenzo-p-dioxin and Tertosterone Signal Transduction Pathways in LNCaP Prostate Cancer cells, 19th International Symposium on Halogenated Environmental Organic Pollutants and POPs (Dioxin99), 1999.

90. Sone H., Jana N.R., Sarkar S., Ishizuka M., Tohyama C. and Yonemoto J. Cross-Talk Between 2,3,7,8-tetrachlorodibenzo-p-dioxin and Tertosterone Signal Transduction Pathways in LNCaP Prostate Cancer cells, 19th International Symposium on Halogenated Environmental Organic Pollutants and POPs (Dioxin99), 1999.

91. Kimura, S., Sasaki, M., Makiya, K., Ueda, H., Morita, M. and Tohyama, C. Fundamental Guidelines Of Japanese Government For The Promotion Of Measures To Reduce Dioxins In The Environment, 19th International Symposium on Halogenated Environmental Organic Pollutants and POPs (Dioxin99), Venice, 1999.

92. Suzuki C., Yonemoto J., Watanabe S., Kabuto M., Tohyama C. and Sone H. Analysis of CYP1A1, CYP1A2 and CYP1B1 Gene Expression Levels in Blood Using a Real-Time Reveres Transcription-PCR System, International Conference on Chytochrome P450,
仙台,1999.

93. Jana N.R., Kusumegi T., Sarkar S., Yonemoto J., Tohyama C. and Sone H. Strain difference in cytochrome P4501A1 gene expression cause by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat liver, International Conference on Cytochrome P450,
仙台, 1999.

94. Nohara K., Fujimaki H., Ushio H., Kobayashi T., Tsukumo S., Kijima M., Miyabara Y., Yonemoto J. and Tohyama C. Changes in thymocyte development and thymic emigrants in rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin, 19th International Symposium on Halogenated Environmental Organic Pollutants and POPs (Dioxin99), Venice, 1999.

95.
野原恵子,藤巻秀和. ダイオキシンとTh1/Th2バランス,第6回免疫毒性研究会, 仙台,1999

96.
野原恵子,牛尾博子,藤巻秀和. ダイオキシンが胸腺細胞の分化と末梢リンパ球構成におよぼす影響,第29回日本免疫学会総会学術集会,京都,1999.

97.
九十九伸一,木嶋美香,遠山千春,野原恵子. マウス胎仔胸腺に及ぼす2,3,7,8-TCDDの影響,第22回日本分子生物学会年会, 福岡,1999.

98.
米元純三,発生毒性-ダイオキシンを中心として-,第72回日本産業衛生学会,東京,1999

99.
米元純三,曽根秀子,大迫誠一郎,西村典子,野原恵子,藤巻秀和,牛尾博子,宮原裕一,青木康展,石塚真由美,NR JanaS Sarkar,遠山千春,TCDDの胎児期・授乳期曝露が雄ラットにおよぼす影響,第26回日本トキシコロジー学会学術年会,札幌,1999

100.
米元純三,内分泌撹乱物質のリスク評価,第39回日本臨床化学会年会,京都,1999

101. Yonemoto J., Jana N.R., Sarkar S., Kusumegi T., Tohyama C. and Sone H. Role of the Aryl Hydrocarbon Receptor and Its Nuclear Translocator in a Strain Difference of Cytochrome P4501A1 Gene Expression Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in the Rat Liver,
日本内分泌撹乱化学物質学会第2回研究発表会, 神戸, 1999.

102. Miyabara Y., Nishimura N., Ohsako S., Ishimura R., Nohara K., Sone H., Tohyama C. and Yonemoto J. Tissue Concentrations of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Dams and Pups of Rats Exposed Throughout Pregnancy and Lactation,
日本内分泌撹乱化学物質学会第2回研究発表会, 神戸, 1999

103. Nishimura N., Ohsako S., Sarkar S., Miyabara Y., Tohyama C., Sone H., Yonemoto J. Effect of Gestational and Lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on Pituitary and Thyroid Hormone Levels in Male Rats. 19th International Symposium on Halogenated Environmental organic Pollutants and POPs (Dioxin 99), Venice, 1999.

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