【As of Nov 20, 2025】

ISOBE Tomohiko

Researcher Name: ISOBE Tomohiko

Div (Section) name/title: Health and Environmental Risk Division（Exposure Dynamics Research Section）／Chief Senior Researcher

Research Subject: Biomonitoring of Anthropogenic Contaminants

Degree(s): Ph D

Professional Qualification(s): Chemistry,Biology,Anatomy

Environmental Speciality Field: Persistent Organic Pollutants (POPs),Endocrine Disrupting Chemicals,Exposure Science

Keyword(s): Bioaccumulation,Biological tissue analysis,Biomonitoring

Brief Description of Research: Developing analytical methods and quality control for environmental contaminants and/or metabolites in biological specimens. Now working on exposure reconstruction to assess the exposure route and level.

URL: http://www.nies.go.jp/researchers-e/200326.html
https://researchmap.jp/isobetomohiko/?lang=english
https://orcid.org/0000-0001-9235-1227

Research Subject

Fiscal Year: 2025
- 27218 : Research project on comprehensive analysis of all substances of concern
- 27254 : Japan Environment and Children
- 27420 : Exposure Dynamics Research
- 27423 : The association between blood per and polyfluoroalkyl substances (PFAS) and cancer, metabolic diseases and death: a prospective cohort study
Fiscal Year: 2024
- 26832 : Research project on comprehensive analysis of all substances of concern
- 26877 : Japan Environment and Children
- 27116 : Exposure Dynamics Research
- 27117 : JST COI-NEXT: Establishing A Research Hub for Environmental Health/Medicine of Future Generations Utilising Digital Bio-Information and Artificial Intelligence
- 27120 : The association between blood per and polyfluoroalkyl substances (PFAS) and cancer, metabolic diseases and death: a prospective cohort study
Fiscal Year: 2023
- 26422 : Research project on comprehensive analysis of all substances of concern
- 26460 : Japan Environment and Children
- 26522 : Exposure Dynamics Research
- 26523 : JST COI-NEXT: Establishing A Research Hub for Environmental Health/Medicine of Future Generations Utilising Digital Bio-Information and Artificial Intelligence
- 26524 : The actual state of lead exposure in Japan and its impact on pediatric neurodevelopment
- 26525 : Trajectories of chemical exposure from fetal to infancy: Development of a deciduous tooth analysis method.
Fiscal Year: 2022
- 25975 : Research project on comprehensive analysis of all substances of concern
- 26024 : Japan Environment and Children
- 26058 : Exposure Dynamics Research
- 26059 : Systematic Development of Pharmacokinetic and Exposure Reconstruction Models for Chemicals of Personal Use
- 26166 : Estimation of amount and source of phthalate alternative exposure
- 26196 : JST COI-NEXT: Establishing A Research Hub for Environmental Health/Medicine of Future Generations Utilising Digital Bio-Information and Artificial Intelligence
- 26274 : The actual state of lead exposure in Japan and its impact on pediatric neurodevelopment
- 26395 : Trajectories of chemical exposure from fetal to infancy: Development of a deciduous tooth analysis method.
Fiscal Year: 2021
- 25519 : Research project on comprehensive analysis of all substances of concern
- 25557 : Japan Environment and Children
- 25598 : Systematic Development of Pharmacokinetic and Exposure Reconstruction Models for Chemicals of Personal Use
- 25639 : Exposure Dynamics Research
- 25643 : Methylmercury exposure assessment after birth
Fiscal Year: 2020
- 25097 : Sustainable Material Cycles Research Program
- 25099 : Research Program on Health and Environmental Safety
- 25123 : Japan Environment and Children
- 25132 : Assessment of Resource efficiency and Environmental Impact in the Cycles of Recyclable Materials and Accompanied Substances
- 25141 : Research Project on Health Impacts of Chemicals on Children and Future Generations
- 25142 : Project to Develop Integrated Approaches to Detecting and Assessment of Multiple and Unknown Chemicals, and Building Environmental Monitoring Networks
- 25206 : Systematic Development of Pharmacokinetic and Exposure Reconstruction Models for Chemicals of Personal Use
- 25216 : Exposure Dynamics Research
- 25348 : Determination of prenatal and postnatal exposure to toxic and trace elements using deciduous teeth and the identification of critical windows of their effects
- 25349 : Mehtylmercury exposure assessment for neonate to infant
- 25394 : Comprehensive search for organohalogen compounds in deep sea sediments of the Japan Sea by soft ionization GC×GC-HRTOFMS method using an inert gas
Fiscal Year: 2019
- 24694 : Sustainable Material Cycles Research Program
- 24696 : Research Program on Health and Environmental Safety
- 24712 : Assessment of Resource efficiency and Environmental Impact in the Cycles of Recyclable Materials and Accompanied Substances
- 24721 : Research Project on Health Impacts of Chemicals on Children and Future Generations
- 24722 : Project to Develop Integrated Approaches to Detecting and Assessment of Multiple and Unknown Chemicals, and Building Environmental Monitoring Networks
- 24755 : Japan Environment and Children's Study
- 24760 : Exposure Dynamics Research
- 24937 : Determination of prenatal and postnatal exposure to toxic and trace elements using deciduous teeth and the identification of critical windows of their effects
- 24971 : Comprehensive measurement and spatial-temporal analysis of chemical substances in sea sediment core off Hyogo prefecture by non-target analysis method
Fiscal Year: 2018
- 24295 : Assessment of resource efficiency and environmental impact in the cycles of recyclable materials and accompanied substances
- 24304 : Research project on health impacts of chemicals on children and future generations
- 24305 : Project to develop integrated approaches to detecting and assessment of multiple and unknown chemicals, and building environmental monitoring networks
- 24338 : Japan Environment and Children
- 24353 : Sustainable Material Cycles Research Program
- 24355 : Research program on health and environmental safety
- 24499 : Exposure dynamics research
- 24570 : Non-target measurement and profile analysis of environmental pollutant in deep sea sediment core of the Japan Sea by GC×GC-HRTOFMS
Fiscal Year: 2017
- 23823 : Project to develop integrated approaches to detecting and assessment of multiple and unknown chemicals, and building environmental monitoring networks
- 23824 : Research project on health impacts of chemicals on children and future generations
- 23833 : Assessment of resource efficiency and environmental impact in the cycles of recyclable materials and accompanied substances
- 23844 : Sustainable Material Cycles Research Program
- 23847 : Research program on health and environmental safety
- 23859 : Japan Environment and Children
- 24028 : Estimation of exposure factors of soil, dust and personal care products for children and pregnant women
- 24147 : Exposure dynamics research
- 24150 : Non-target analysis for organohalogen compounds in deep sea sediments of the Japan Sea and development of accurate mass spectra database.
Fiscal Year: 2016
- 23402 : Sustainable Material Cycles Research Program
- 23404 : Assessment of resource efficiency and environmental impact in the cycles of recyclable materials and accompanied substances
- 23414 : Research program on health and environmental safety
- 23415 : Research project on health impacts of chemicals on children and future generations
- 23416 : Project to develop integrated approaches to detecting and assessment of multiple and unknown chemicals, and building environmental monitoring networks
- 23441 : Japan Environment and Children's Study
- 23573 : Estimation of exposure factors of soil, dust and personal care products for children and pregnant women.
- 23579 : Establishment of multidisciplinary strategy toward comprehensive understanding of developmental neurotoxicity induced by environmental chemicals in house dust
- 23612 : Exposure dynamics research
Fiscal Year: 2015
- 23029 : Japan Environment and Children’s Study
- 23116 : Establishment of multidisciplinary strategy toward comprehensive understanding of developmental neurotoxicity induced by environmental chemicals in house dust
- 23166 : Investigation of spatiotemporal variation of marine environmental contamination and health risk of organic pollutants using stranded cetacean as a biomarker.
- 23277 : Establishment of an international cooperation for promoting arsenic research
- 23280 : Japan Environment and Children's Study
- 23281 : Estimation of exposure factors of soil, dust and personal care products for children and pregnant women.
Fiscal Year: 2014
- 22871 : Investigation of spatiotemporal variation of marine environmental contamination and health risk of organic pollutants using stranded cetacean as a biomarker.
Fiscal Year: 2004
- 8970 : Research on new analytical methods and environmental fate of endocrine disrupters
Fiscal Year: 2003
- 8687 : Research on new analytical methods and environmental fate of endocrine disrupters
Fiscal Year: 2002
- 8472 : Research on new analytical methods and environmental fate of endocrine disrupters
Fiscal Year: 2001
- 8250 : Research on new analytical methods and environmental fate of endocrine disrupters

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Research Result (Publication)

all
Original Paper
Review
Other Publications

Original Paper
Associations of PFAS exposure with obstetric and birth outcomes in the Japan Environment and Children’s Study (JECS): Is maternal endometriosis an effect modifier?

Presenter : Dionisio J., Ito Y., Hiraoka D., Ohya Y., Yamazaki S., Isobe T., Saitoh S., Sugiura-Ogasawara M., Kamijima M.
Title : , Environmental Pollution, 388(127353): (2026)
Original Paper
A benchmark dose analysis of the blood cadmium concentration in pregnant women using the Japan Environment and Children’s Study data

Presenter : Suwannarin N., Nishihama Y., Isobe T., Okubo H., Nakayama S.F.
Title : , Environment International, 208:110041 (2026)
Original Paper
Serum mercury, lead, cadmium, and arsenic and incidence of type 2 diabetes among adults: A nested case–control study

Presenter : Ito A., Yamamoto S., Iwai M., Kobayashi Y., Isobe T., Iwai K., Nakayama S.F., Konishi M., Yamamoto S., Nakagawa T., Yamazaki S., Mizoue T.
Title : , Clinical Nutrition, 57:106563 (2026)
Original Paper
A postal-based multi-matrix sampling approach for elemental human biomonitoring using ICP-MS/MS

Presenter : Iwai-Shimada M., Iwai K., Tatsuta N., Isobe T., Takagi M., Kobayashi Y., Nakayama S.F.
Title : , Metallomics Research, 6(1): (2026)
Original Paper
Associations between maternal blood lead concentration during pregnancy and trajectories of wheezing and asthma in offspring: The Japan Environment and Children's Study (JECS)

Presenter : Nishihama Y., Isobe T., Ohya Y., Murata T., Nakayama S.F.
Title : , Environment International, 210:110219 (2026)
Original Paper
Associations of maternal urinary nitrophenol concentrations with adverse birth outcomes and neurodevelopment delay at 4 years of age: The Japan environment and children's study

Presenter : Kaneko K., Ito Y., Ebara T., Yatsuya H., Sugiura-Ogasawara M., Saitoh S., Sekiyama M., Isobe T., Kamijima M.
Title : , Environmental Research, 264(1):120290 (2025)
Original Paper
Direct and indirect effects of smoking during pregnancy on child development: The Japan Environment and Children’s Study

Presenter : Tatsuta N., Nakai K., Sekiyama M., Taniguchi Y., Iwai M., Takagi M., Kobayashi Y., Isobe T., Nakayama S.F., Yamazaki S.
Title : , Scientific Reports, 15(18053): (2025)
Original Paper
Determinants of plasma poly- and perfluoroalkyl substances during pregnancy: The Japan Environment and Children's Study

Presenter : Lai Y., Nakayama S.F., Nishihama Y., Isobe T.
Title : , Ecotoxicology and Environmental Safety, 294:118107 (2025)
Original Paper
Association between exposure to perfluoroalkyl compounds during early pregnancy and risk of late miscarriage: The Japan Environment and Children’s Study

Presenter : Tatsuta N., Iwai M., Isobe T., Nakayama S.F., Sekiyama M., Takagi M., Kobayashi Y., Taniguchi Y., Yamazaki S.
Title : , International Journal of Hygiene and Environmental Health, 270(114673): (2025)
Original Paper
Cross-sectional biomonitoring of urinary deoxynivalenol, T-2 and HT-2 toxins, and zearalenone in Japanese adults

Presenter : Tajima T., Isobe T., Saito I., Kondo T., Suzuki K., Fujii R., Tsuboi Y., Sugita-Konishi Y., Ueyama J.
Title : , Environmental Health and Preventive Medicine, 30:19 (2025)
Original Paper
Determination of skin-insect repellent icaridin and DEET in human urine using solid-phase extraction and liquid chromatography with tandem mass spectrometry and its application to a sample of Japanese adults

Presenter : Nishihara N., Isobe T., Takagi M., Tajima T., Kitahara Y., Hayashi M., Saito I., Watanabe S., Iwai M., Ueyama J.
Title : , Environmental Health and Preventive Medicine, 30:18 (2025)
Original Paper
Exposure assessment of ochratoxin a using paired serum and 24-hour pooled urine samples from Japanese adults

Presenter : Tajima T., Shimizu A., Isobe T., Aoyagi R., Saito I., Nakajima M., Sugita-Konishi Y., Hirayama M., Ueyama J.
Title : , Food Additives & Contaminants: Part A, 42(8):1130-1142 (2025)
Original Paper
Concentrations of neonicotinoid insecticides and their metabolites in multiple urine samples collected from pregnant women in Japan

Presenter : Suwannarin N., Isobe T., Nishihama Y., Ito Y., Kamijima M., Ebara T., Sugiura-Ogasawara M., Nishikawa N., Nakai K., Minamikawa Y., Nakayama S.F.
Title : , Environmental Research, 240:117506 (2024)
Original Paper
Urinary concentrations and elimination half-lives of parabens, benzophenones, bisphenol and triclosan in Japanese young adults

Presenter : Nguyen T., Isobe T., Iwai M., Takagi M., Ueyama J., Oura K., Tanoue R., Kunisue T., Nakayama S.f.
Title : , Chemosphere, 349:140920 (2024)
Original Paper
Urinary concentrations of environmental phenol among pregnant women in the Japan Environment and Children’s Study

Presenter : Suwannarin N., Nishihama Y., Isobe T., Nakayama S.f.
Title : , Environment International, 183:108373 (2024)
Original Paper
Long-term monitoring of indoor, outdoor, and personal exposure to gaseous chemical compounds

Presenter : Uchiyama S., Noguchi M., Hishiki M., Shimizu M., Kunugita N., Isobe T., Nakayama S.F.
Title : , Science of The Total Environment, 906:167830 (2024)
Original Paper
Evaluating the risk of phthalate and non-phthalate plasticizers in dust samples from 100 Japanese houses

Presenter : Shinohara N., Oguri T., Takagi M., Ueyama J., Isobe T.
Title : , Environment International, 183:108399 (2024)
Original Paper
Relationship between flame retardants and respiratory health - A systematic review and meta-analysis of observational studies

Presenter : Coelho S.D., Maricoto T., Taborda-Barata L., Annesi-Maesano I., Isobe T., Sousa A.C.A.
Title : , Environmental Pollution, 347:123733 (2024)
Original Paper
Pharmaceuticals and personal care products (PPCPs) in surface water and fish from three Asian countries: Species-specific bioaccumulation and potential ecological risks

Presenter : Nozaki K., Tanoue R., Kunisue T., Tue N.M., Fujii S., Sudo N., Isobe T., Nakayama K., Sudaryanto A., Subramanian A., Bulbule K.A., Parthasarathy P., Tuyen L.H., Viet P.H., Kondo M., Tanabe S., Nomiyama K.
Title : , Science of The Total Environment, 866:161258 (2023)
Original Paper
A simultaneous, high-throughput and sensitive method for analysing 13 neonicotinoids and metabolites in urine using a liquid chromatography-tandem mass spectrometry

Presenter : Nishihama Y., Nakayama S.F., Isobe T.
Title : , MethodsX, 10:102129 (2023)
Original Paper
Effects of Pesticide Intake on Gut Microbiota and Metabolites in Healthy Adults

Presenter : Ueyama J., Hayashi M., Hirayama M., Nishiwaki H., Ito M., Saito I., Tsuboi Y., Isobe T., Ohno K.
Title : , International Journal of Environmental Research and Public Health, 20(1):213 (2023)
Original Paper
Association between maternal urinary neonicotinoid concentrations and child development in the Japan Environment and Children's Study

Presenter : Nishihama Y., Nakayama S.F., Isobe T., Kamijima M.
Title : , Environment International, 181:108267 (2023)
Review
Obesogens in the XXI century: emerging health challenges volume II

Presenter : Sousa A.C.A., Malarvannan G., Isobe T., Rato L.
Title : , Frontiers in Endocrinology, 14:1292334 (2023)
Spatial distribution of atmospheric polychlorinated biphenyls (PCBs) in Jakarta Great Area using passive air sampler

Presenter : Sudaryanto A., Ilyas M., Wahyono I.B., Aviantara D.S., Efadeswarni, Takahashi S., Isobe T., Tanabe S., Kunisue T.
Title : , IOP Conference Series: Earth and Environmental Science, 1201:012029 (2023)
Atmospheric concentrations of polybrominated diphenyl ethers (PBDEs) in passive air sampler from Batam Island, Indonesia

Presenter : Sulistia S., Ilyas M., Suciati F., Kurniawan B., Isobe T., Kunisue T., Tanabe S., Sudaryanto A.
Title : , IOP Conference Series: Earth and Environmental Science, 1201:012027 (2023)
Original Paper
Baseline Complete Blood Count and Chemistry Panel Profile from the Japan Environment and Children’s Study (JECS)

Presenter : Taniguchi Y., Yamazaki S., Nakayama S.F., Sekiyama M., Michikawa T, Isobe T., Iwai M., Kobayashi Y., Takagi M., Kamijima M
Title : , Int. J. Environ. Res. Public Health, 19(6):3277 (2022)
Review
Obesogens in the XXI century: Emerging health challenges

Presenter : Sousa A.C.A., Malarvannan G., Isobe T., Rato L.
Title : , Frontiers in Endocrinology, 13:999908 (2022)
Original Paper
Optimal method for determining the intraclass correlation coefficients of urinary biomarkers such as dialkylphosphates from imputed data

Presenter : Nishihama Y., LAI Y., Isobe T., Nakayama S.F.
Title : , Environment International, 170:107553 (2022)
Original Paper
Highly Sensitive Simultaneous Measurement of Steroid Hormone in Human Serum by Liquid Chromatography-electrospray Ionization Tandem Mass Spectrometry

Presenter : Khanh N.V., Hai N.T., Thuy N.T.D., Kido T., Nakayama S.F., Isobe T., Okuyama M., Honma S.
Title : , VNU Journal of Science: Medical and Pharmaceutical Sciences, 38(1):54-64 (2022)
Original Paper
Health risk assessment based on exposure to chemicals in air

Presenter : Sakamoto H., Uchiyama S., Sato A., Isobe T., Kunugita N., Ogura H., Nakayama S.F.
Title : , International Journal of Environmental Research and Public Health, 19(23):15813 (2022)
Original Paper
Maternal Metals Exposure and Infant Weight Trajectory: The Japan Environment and Children’s Study (JECS)

Presenter : Taniguchi Y., Yamazaki S., Nakayama S.F., Sekiyama M., Michikawa T., Isobe T., Iwai M., Kobayashi Y., Nitta H.
Title : , Environmental Health Perspectives, 130(12): (2022)
Original Paper
Exposure to heavy metals modifies optimal gestational weight gain: A large nationally representative cohort of the Japan Environment and Children’s Study

Presenter : Jung C., Nakayama S.F., Isobe T., Iwai-Shimada M., Kobayashi Y., Nishihama Y., Michikawa T., Sekiyama M., Taniguchi Y., Nitta H., Yamazaki S.
Title : , Environment International, 146:106276 (2021)
Original Paper
Occurrence, distribution, and potential exposure risk of organophosphate flame retardants in house dust in South Korea

Presenter : Gwon H.-R., Oh H.-J., Chang K.-H., Isobe T., Lee S.-Y., Kim J.-H., You S.-J., Kim J.-G., Kim J.-W.
Title : , Science of the Total Environment, 770:144571 (2021)
Original Paper
Association of prenatal maternal blood lead levels with birth outcomes in the Japan Environment and Children’s Study (JECS): a nationwide birth cohort study

Presenter : Goto Y., Mandai M., Nakayama T., Yamazaki S., Nakayama S.F., Isobe T., Sato T., Nitta H.
Title : , International Journal of Epidemiology, 50(1):156-164 (2021)
Original Paper
Comparison of Simultaneous Quantitative Analysis of Methylmercury and Inorganic Mercury in Cord Blood Using LC-ICP-MS and LC-CVAFS: The Pilot Study of the Japan Environment and Children’s Study

Presenter : Iwai-Shimada M., Kobayashi Y., Isobe T., Nakayama S.F., Sekiyama M., Taniguchi Y., Yamazaki S., Michikawa T., Oda M., Mitsubuchi H., Sanefuji M., Ohga S., Mise N., Ikegami A., Suga R., Shimono M.
Title : , Toxics, 9(82): (2021)
Original Paper
Association of prenatal exposure to cadmium with neurodevelopment in children at 2 years of age: The Japan Environment and Children's Study

Presenter : Ma C., Iwai-Shimada M., Nakayama S.F., Isobe T., Kobayashi Y., Tatsuta N., Taniguchi Y., Sekiyama M., Michikawa T., Yamazaki S., Kamijima M.
Title : , Environment International, 156(106762): (2021)
Original Paper
Anthropogenic and natural organohalogen compounds in melon-headed whales (Peponocephala electra) stranded along the Japanese coastal waters: Temporal trend analysis using archived samples in the environmental specimen bank (es-BANK)

Presenter : Kunisue T., Goto A., Sunouchi T., Egashira K., Ochiai M., Isobe T., Tajima Y., Yamada T.K., Tanabe S.
Title : , Chemosphere, 269:129401 (2021)
Original Paper
Indoor air quality of 5,000 households and its determinants. Part B: Volatile organic compounds and inorganic gaseous pollutants in the Japan Environment and Children's study

Presenter : Jung C., Nishihama Y., Nakayama S.F., Tamura K., Isobe T., Michikawa T., Iwai-Shimada M. , Kobayashi Y., Sekiyama M., Taniguchi Y., Yamazaki S.
Title : , Environmental Research, 197:111135 (2021)
Original Paper
Indoor air quality of 5,000 households and its determinants. Part A: Particulate matter (PM2.5 and PM10-2.5) concentrations in the Japan Environment and Children's Study

Presenter : Nishihama Y., Jung C., Nakayama S.F., Tamura K., Isobe T., Michikawa T., Iwai-Shimada M., Kobayashi Y., Sekiyama M., Taniguchi Y., Yamazaki S.
Title : , Environmental Research, 198:111196 (2021)
Original Paper
Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children's Study (JECS)

Presenter : Nishihama Y., Nakayama S.F., Isobe T., Jung CR., Iwai-Shimada M., Kobayashi Y., Michikawa T., Sekiyama M., Taniguchi Y., Yamazaki S.
Title : , International Journal of Environmental Research and Public Health, 18(11):5929 (2021)
Original Paper
Exposure to Organophosphate and Neonicotinoid Insecticides and Its Association with Steroid Hormones among Male Reproductive-Age Farmworkers in Northern Thailand

Presenter : Suwannarin N., Prapamontol T., Isobe T., Nishihama Y., Hashimoto Y., Mangklabruks A., Pantasri T., Chantara S., Naksen W., Nakayama S.F.
Title : , International Journal of Environmental Research and Public Health, 18(11):5599 (2021)
Original Paper
Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand

Presenter : Suwannarin N., Prapamontol T., Isobe T., Nishihama Y., Mangklabruks A., Pantasri T., Chantara S., Naksen W., Nakayama S.F.
Title : , International Journal of Environmental Research and Public Health, 18:10849 (2021)
Other Publications
Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective

Presenter : Zhang P., Carlsten C., Chaleckis R., Hanhineva K., Huang M., Isobe T., Koistinen V.M., Meister I., Papazian S., Sdougkou K., Xie H., Martin J.W., Rappaport S.M., Tsugawa H., Walker D.I., Woodruff T.J., Wright R.O., Wheelock C.E.
Title : , Environmental Science & Technology Letters, 8(10):839-852 (2021)
Original Paper
Spatial Variations of Indoor Air Chemicals in an Apartment Unit and Personal Exposure of Residents

Presenter : Sakamoto H., Uchiyama S., Isobe T., Kunugita N., Ogura H., Nakayama S.F.
Title : , International Journal of Environmental Research and Public Health, 18:11511 (2021)
Original Paper
Maternal dietary intake of vitamin A during pregnancy was inversely associated with congenital diaphragmatic hernia: the Japan Environment and Children’s Study

Presenter : Michikawa T., Yamazaki S., Sekiyama M., Kuroda T., Nakayama S.F., Isobe T., Kobayashi Y., Iwai M., Suda E., Kawamoto T., Nitta H.
Title : , British Journal of Nutrition, 122(11):1295-1302 (2020)
Original Paper
Estrogenic action by tris(2,6-dimethylphenyl) phosphate impairs the development of female reproductive functions

Presenter : Sano K., Matsukami H., Suzuki G., Htike N.T.T., Morishita M., Tin-Tin-Win-Shwe, Hashimoto S., Kawashima T., Isobe T., Nakayama S.F., Tsukahara S., Maekawa F.
Title : , Environment International, 138:105662 (2020)
Original Paper
Health Risk Assessment and Source Apportionment of Mercury, Lead, Cadmium, Selenium, and Manganese in Japanese Women: An Adjunct Study to the Japan Environment and Children’s Study

Presenter : MA C., Iwai M., Tatsuta N., Nakai K., Isobe T., Takagi M., Nishihama Y., Nakayama S.F.
Title : , International Journal of Environmental Research and Public Health, 17(7):2231 (2020)
Original Paper
Poly- and perfluoroalkyl substances in maternal serum: Method development and application in Pilot Study of the Japan Environment and Children's Study

Presenter : Nakayama S.F., Isobe T., Iwai-Shimada M., Kobayashi Y., Nishihama Y., Taniguchi Y., Sekiyama M., Michikawa T., Yamazaki S., Nitta H., Oda M., Mitsubuchi H., Sanefuji M., Ohga S., Mise N., Ikegami A., Suga R., Shimono M.
Title : , Journal of Chromatography A, 1618:460933 (2020)
Original Paper
Characteristics of Exposure of Reproductive-Age Farmworkers in Chiang Mai Province, Thailand, to Organophosphate and Neonicotinoid Insecticides: A Pilot Study

Presenter : Suwannarin N., Prapamontol T., Isobe T., Nishihama Y., Nakayama S.F.
Title : , International Journal of Environmental Research and Public Health, 17:7871 (2020)
Original Paper
Non-target and target screening of organohalogen compounds in mussels and sediments from Hiroshima Bay, Japan: Occurrence of novel bioaccumulative substances

Presenter : Goto A., Tue N.M., Isobe T., Takahashi S., Tanabe S., Kunisue T.
Title : , Environmental Science and Technology, 54(9):5480-5488 (2020)
Original Paper
Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS)

Presenter : Nishihama Y., Nakayama S.F., Tabuchi T., Isobe T., Jung C., Iwai-Shimada M., Kobayashi Y., Michikawa T., Sekiyama M., Taniguchi Y., Nitta H., Yamazaki S.
Title : , International Journal of Environmental Research and Public Health, 17(15):5537 (2020)
Original Paper
Population genetic diversity and historical dynamics of Fraser’s dolphins Lagenodelphis hosei

Presenter : Chen I., Nishida S., Chou L.S., Isobe T., Mignucci Giannoni A.A., Hoelzel A.R.
Title : , MARINE ECOLOGY PROGRESS SERIES, 643:183-195 (2020)
Original Paper
Maternal intake of one-carbon metabolism-related B vitamins and anorectal malformations in the Japan Environment and Children’s Study

Presenter : Michikawa T., Nitta H., Sekiyama M., Kuroda T., Nakayama S.F., Isobe T., Kobayashi Y., Iwai M., Suda E., Taniguchi Y., Kawamoto T., Yamazaki S.
Title : , British Journal of Nutrition, 124(8):865-873 (2020)
Original Paper
Association of blood cadmium levels in pregnant women with infant birth size and small for gestational age infants: The Japan Environment and Children's study

Presenter : Inadera H., Takamori A., Matsumura K., Tsuchida A., Cui Z.G., Hamazaki K., Tanaka T., Ito M., Kigawa M., Origasa G., Michikawa T., Nakayama S.F., Isobe T., Takeuchi A., Sato T., Nitta H., Yamazaki S.
Title : , Environmental Research, 191:110007 (2020)
Original Paper
Development of Artificial Urine Certified Reference Material for Quantification of Neonicotinoid Insecticides

Presenter : Otake T., Nakayama S.F., Isobe T., Hanari N.
Title : , Journal of AOAC INTERNATIONAL, 103(6):1469-1477 (2020)
Original Paper
Study Design and Participants’ Profile in the Sub-Cohort Study in the Japan Environment and Children’s Study (JECS)

Presenter : Sekiyama M., Yamazaki S., Michikawa T., Nakayama S.F., Nitta H., Taniguchi Y., Suda E., Isobe T., Kobayashi Y., Iwai M., Ono M., Tamura K., Yonemoto J., Kawamoto K., Kamijima M
Title : , Journal of Epidemiology (2020)
Original Paper
Evaluation of a data-processing method for target and non-target screening using comprehensive two-dimensional gas chromatography coupled with high-resolution time-of-flight mass spectrometry for environmental samples

Presenter : Ieda T., Hashimoto S., Isobe T., Kunisue T., Tanabe S.
Title : , Talanta, 194:461-468 (2019)
Original Paper
Dioxins levels in human blood after implementation of measures against dioxin exposure in Japan

Presenter : Muzembobasilua A., Iwai-Shimada M., Isobe T., Arisawa K., Shima M., Fukushima T., Nakayama S.F.
Title : , Environmental Health and Preventive Medicine, 24(6): (2019)
Original Paper
Intra-individual variations of organophosphate pesticide metabolite concentrations in repeatedly collected urine samples from pregnant women in Japan

Presenter : Hioki K., Ito Y., Oya N., Nakayama S.F., Isobe T., Ebara T., Shibata K., Nishikawa N., Nakai K., Kamida T., Ueyama J., Sugiura-Ogasawara M., Kamijima M.
Title : , Environmental Health and Preventive Medicine, 24(7): (2019)
Original Paper
Within-individual and interlaboratory variability analyses of urinary metabolites measurements of organophosphorus insecticides

Presenter : Ito Y., Ueyama J., Nakayama S.F., Isobe T., Oya N., Sato H., Ebara T., Yoshimasu K., Tsuno K., Tatsuta N., Nakai K., Kamijima M.
Title : , Journal of Exposure Science and Environmental Epidemiology, 30(4):721-729 (2019)
Original Paper
Association between blood manganese level during pregnancy and birth size: The Japan environment and children's study (JECS)

Presenter : Yamamoto M., Sakurai K., Eguchi A., Yamazaki S., Nakayama S.F., Isobe T., Takeuchi A., Sato T., Hata A., Mori C., Nitta H.
Title : , Environmental Research, 172:117-126 (2019)
Original Paper
Isoflavone Intake in Early Pregnancy and Hypospadias in the Japan Environment and Children's Study

Presenter : Michikawa T., Yamazaki S., Ono M., Kuroda T., Nakayama S.F., Suda E., Isobe T., Iwai M., Kobayashi Y., Yonemoto J., Tamura K., Kawamoto T., Nitta H.
Title : , Urology, 124:229-236 (2019)
Original Paper
Fish consumption in early pregnancy and congenital gastrointestinal tract atresia in the Japan Environment and Children’s Study

Presenter : Michikawa T., Yamazaki S., Ono M., Kuroda T., Nakayama S.F., Suda E., Isobe T., Iwai M., Kobayashi Y., Tamura K., Yonemoto J., Kawamoto T., Nitta H.
Title : , British Journal of Nutrition, 121(1):100-108 (2019)
Original Paper
Blood mercury, lead, cadmium, manganese and selenium levels in pregnant women and their determinants: the Japan Environment and Children's Study (JECS)

Presenter : Nakayama S.F., Iwai-Shimada M., Oguri T., Isobe T., Takeuchi A., Kobayashi Y., Michikawa T., Yamazaki S., Nitta H., Kawamoto T.
Title : , Journal of Exposure Science and Environmental Epidemiology, 29(5):633-647 (2019)
Review
Worldwide trends in tracing poly- and perfluoroalkyl substances (PFAS) in the environment

Presenter : Nakayama S.F., Yoshikane M., Onoda Y., Nishihama Y., Iwai-Shimada M., Takagi M., Kobayashi Y., Isobe T.
Title : , TrAC Trends in Analytical Chemistry, 121(115410): (2019)
Original Paper
Occurrence of benzotriazole ultraviolet stabilizers (BUVSs) in human breast milk from three Asian countries

Presenter : Kim J.W., Chang K.H., Prudente M., Viet P.H., Takahashi S., Tanabe S., Kunisue T., Isobe T.
Title : , Science of the Total Environment, 655:1081-1088 (2019)
Original Paper
Association of blood mercury levels during pregnancy with infant birth size by blood selenium levels in the Japan Environment and Children's Study: A prospective birth cohort

Presenter : Kobayashi S., Kishi R., Saijo Y., Ito Y., Oba K., Araki A., Miyashita C., Itoh S., Minatoya M., Yamazaki K., Ait Bamai Y., Sato T., Yamazaki S., Nakayama S.F., Isobe T., Nitta H.
Title : , Environment International, 125:418-429 (2019)
Other Publications
Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium

Presenter : Zhang P., Arora M., Chaleckis R., Isobe T., Jain M., Meister I., Melen E., Perzanowski M., Torta F., Wenk M.R., Wheelock C.E.
Title : , Metabolites, 9(6):106 (2019)
Original Paper
Does overweight before pregnancy reduce the occurrence of gastroschisis?: the Japan Environment and Children’s Study

Presenter : Michikawa T., Yamazaki S., Suda M., Kuroda T., Nakayama S.F., Isobe T., Kobayashi Y., Sekiyama M., Kawamoto T., Nitta H.
Title : , BMC Research Notes, 13: (2019)
Original Paper
Concordance between genetic diversity and marine biogeography in a highly mobile marine mammal, the Rissos dolphin

Presenter : Chen I., Nishida S., Chou L.S., Tajima Y., Yang W.C., Isobe T., Yamada T.K., Hartman K., Hoelzel A.R.
Title : , Journal of Biogeography, 2018(00):1-12 (2018)
Original Paper
Questionnaire results on exposure characteristics of pregnant women participating in the Japan Environment and Children’s Study

Presenter : Iwai-Shimada M., Nakayama S.F., Isobe T., Michikawa T., Yamazaki S., Nitta H., Takeuchi A., Kobayashi Y., Tamura K., Suda E., Ono M., Yonemoto J., Kawamoto T.
Title : , Environmental Health and Preventive Medicine, 23(1):45 (2018)
Original Paper
Levels of TBT and other selected organotin compounds in duplicate diet samples

Presenter : Sousa A.C.A., Coelho S.D., Pastorinho M.R., Taborda-Barata L., Nogueira A.J.A., Isobe T., Kunisue T., Takahashi S., Tanabe S.
Title : , Science of the Total Environment, 574:19-23 (2017)
Original Paper
Genetic diversity of bottlenose dolphin (Tursiops sp.) populations in the western North Pacific and the conservation implications

Presenter : Chen I., Nishida S., Yang W.C., Isobe T., Tajima Y., Hoelzel A.R.
Title : , Marine Biology, 164(10):202-218 (2017)
Original Paper
Spatio-temporal trends of polybrominated dibenzo-p-dioxins and dibenzofurans in archived sediments from Tokyo Bay, Japan

Presenter : Goto A., Tue N.M., Someya M., Isobe T., Takahashi S., Tanabe S., Kunisue T.
Title : , Science of The Total Environment, 599-600:340-347 (2017)
Original Paper
Polybrominated diphenyl ethers (PBDEs) and their hydroxylated and methoxylated analogues in the blood of harbor, Dalls and finless porpoises from the Japanese coastal waters

Presenter : Ochiai M., Nomiyama K., Isobe T., Yamada T.K., Tajima Y., Matsuda A., Shiozaki A., Matsuishi T., Amano M., Iwata H., Tanabe S.
Title : , Marine Environmental Research, 128:124-132 (2017)
Original Paper
Cadmium intake in women from the University of Aveiro, Portugal - A duplicate diet study

Presenter : Coelho S.D., Maricoto T., Pastorinho M.R., Itai T., Isobe T., Kunisue T., Tanabe S., Sousa A.C.A., Nogueira A.J.A.
Title : , Journal of Geochemical Exploration, 183:187-190 (2017)
Other Publications
Baseline Profile of Participants in the Japan Environment and Children

Presenter : Michikawa T., Nitta H., Nakayama S., Yamazaki S., Isobe T., Tamura K., Suda E., Ono M., Yonemoto J., Iwai M., Kobayashi Y., Suzuki G., Kawamoto T.
Title : , Journal of Epidemiology (2017)
Original Paper
Occurrence of Natural Mixed Halogenated Dibenzo-p-Dioxins: Specific Distribution and Profiles in Mussels from Seto Inland Sea, Japan

Presenter : Goto A., Tue N.M., Someya M., Isobe T., Takahashi S., Tanabe S., Kunisue T.
Title : , Environmental Science and Technology, 51(20):11771-11779 (2017)
Original Paper
In utero and Lactational Exposure to Acetamiprid Induces Abnormalities in Socio-Sexual and Anxiety-Related Behaviors of Male Mice

Presenter : Sano K., Isobe T., Yang J., Tin-Tin-Win-Shwe, Yoshikane M., Nakayama S., Kawashima T., Suzuki G., Hashimoto S., Nohara K., Tohyama C., Maekawa F.
Title : , Frontiers in Neuroscience, 10(228): (2016)
Original Paper
Brominated, chlorinated and phosphate organic contaminants in house dust from Portugal

Presenter : Coelho S.D., Sousa A.C.A., Isobe T., Kim J.W., Kunisue T., Nogueira A.J.A., Tanabe S.
Title : , Science of the Total Environment, 569-570:442-449 (2016)
Original Paper
Brominated flame retardants and organochlorine compounds in duplicate diet samples from a Portuguese academic community

Presenter : Coelho S.D., Sousa A.C.A., Isobe T., Kunisue T., Nogueira A.J.A., Tanabe S.
Title : , Chemosphere, 160:89-94 (2016)
Original Paper
Lead in duplicate diet samples from an academic community

Presenter : Coelho S.D., Pastorinho M.R., Itai T., Isobe T., Kunisue T., Nogueira A.J.A., Tanabe S., Sousa A.C.A.
Title : , Science of The Total Environment, 573:603-607 (2016)
Original Paper
Detection of glucocorticoid receptor agonists in effluents from sewage treatment plants in Japan

Presenter : Suzuki G., Sato K., Isobe T., Takigami H., Brouwer A., Nakayama K.
Title : , Science of the Total Environment, 527-528:328-334 (2015)
Original Paper
Toxic identification and evaluation of androgen receptor antagonistic activities in acid-treated liver extracts of high-trophic level wild animals from Japan

Presenter : Misaki K., Suzuki G., Tue N.M., Takahashi S., Someya M., Takigami H., Tajima Y., Yamada T.K., Amano M., Isobe T., Tanabe S.
Title : , Environmental Science and Technology, 49:11840-11848 (2015)
Original Paper
Determination of natural and synthetic glucocorticoids in effluent of sewage treatment plants using ultrahigh performance liquid chromatography-tandem mass spectrometry

Presenter : Isobe T., Sato K., Kim J.-W., Tanabe S., Suzuki G., Nakayama K.
Title : , Environmental Science and Pollution Research, 22:14127-14135 (2015)
Original Paper
Uptake and biological effects of synthetic glucocorticoids in common carp (Cyprinus carpio)

Presenter : Nakayama K., Inoue Y., Ikeda N., Hashizume N., Murakami H., Ishibashi T., Ikeda H., Isobe T., Kitamura S., Suzuki G.
Title : , Marine Pollution Bulletin, 85(2):370-375 (2014)

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Associations of PFAS exposure with obstetric and birth outcomes in the Japan Environment and Children’s Study (JECS): Is maternal endometriosis an effect modifier?

Presenter : Dionisio J., Ito Y., Hiraoka D., Ohya Y., Yamazaki S., Isobe T., Saitoh S., Sugiura-Ogasawara M., Kamijima M.
Title : , Environmental Pollution, 388(127353): (2026)
A benchmark dose analysis of the blood cadmium concentration in pregnant women using the Japan Environment and Children’s Study data

Presenter : Suwannarin N., Nishihama Y., Isobe T., Okubo H., Nakayama S.F.
Title : , Environment International, 208:110041 (2026)
Serum mercury, lead, cadmium, and arsenic and incidence of type 2 diabetes among adults: A nested case–control study

Presenter : Ito A., Yamamoto S., Iwai M., Kobayashi Y., Isobe T., Iwai K., Nakayama S.F., Konishi M., Yamamoto S., Nakagawa T., Yamazaki S., Mizoue T.
Title : , Clinical Nutrition, 57:106563 (2026)
A postal-based multi-matrix sampling approach for elemental human biomonitoring using ICP-MS/MS

Presenter : Iwai-Shimada M., Iwai K., Tatsuta N., Isobe T., Takagi M., Kobayashi Y., Nakayama S.F.
Title : , Metallomics Research, 6(1): (2026)
Associations between maternal blood lead concentration during pregnancy and trajectories of wheezing and asthma in offspring: The Japan Environment and Children's Study (JECS)

Presenter : Nishihama Y., Isobe T., Ohya Y., Murata T., Nakayama S.F.
Title : , Environment International, 210:110219 (2026)
Associations of maternal urinary nitrophenol concentrations with adverse birth outcomes and neurodevelopment delay at 4 years of age: The Japan environment and children's study

Presenter : Kaneko K., Ito Y., Ebara T., Yatsuya H., Sugiura-Ogasawara M., Saitoh S., Sekiyama M., Isobe T., Kamijima M.
Title : , Environmental Research, 264(1):120290 (2025)
Direct and indirect effects of smoking during pregnancy on child development: The Japan Environment and Children’s Study

Presenter : Tatsuta N., Nakai K., Sekiyama M., Taniguchi Y., Iwai M., Takagi M., Kobayashi Y., Isobe T., Nakayama S.F., Yamazaki S.
Title : , Scientific Reports, 15(18053): (2025)
Determinants of plasma poly- and perfluoroalkyl substances during pregnancy: The Japan Environment and Children's Study

Presenter : Lai Y., Nakayama S.F., Nishihama Y., Isobe T.
Title : , Ecotoxicology and Environmental Safety, 294:118107 (2025)
Association between exposure to perfluoroalkyl compounds during early pregnancy and risk of late miscarriage: The Japan Environment and Children’s Study

Presenter : Tatsuta N., Iwai M., Isobe T., Nakayama S.F., Sekiyama M., Takagi M., Kobayashi Y., Taniguchi Y., Yamazaki S.
Title : , International Journal of Hygiene and Environmental Health, 270(114673): (2025)
Cross-sectional biomonitoring of urinary deoxynivalenol, T-2 and HT-2 toxins, and zearalenone in Japanese adults

Presenter : Tajima T., Isobe T., Saito I., Kondo T., Suzuki K., Fujii R., Tsuboi Y., Sugita-Konishi Y., Ueyama J.
Title : , Environmental Health and Preventive Medicine, 30:19 (2025)
Determination of skin-insect repellent icaridin and DEET in human urine using solid-phase extraction and liquid chromatography with tandem mass spectrometry and its application to a sample of Japanese adults

Presenter : Nishihara N., Isobe T., Takagi M., Tajima T., Kitahara Y., Hayashi M., Saito I., Watanabe S., Iwai M., Ueyama J.
Title : , Environmental Health and Preventive Medicine, 30:18 (2025)
Exposure assessment of ochratoxin a using paired serum and 24-hour pooled urine samples from Japanese adults

Presenter : Tajima T., Shimizu A., Isobe T., Aoyagi R., Saito I., Nakajima M., Sugita-Konishi Y., Hirayama M., Ueyama J.
Title : , Food Additives & Contaminants: Part A, 42(8):1130-1142 (2025)
Concentrations of neonicotinoid insecticides and their metabolites in multiple urine samples collected from pregnant women in Japan

Presenter : Suwannarin N., Isobe T., Nishihama Y., Ito Y., Kamijima M., Ebara T., Sugiura-Ogasawara M., Nishikawa N., Nakai K., Minamikawa Y., Nakayama S.F.
Title : , Environmental Research, 240:117506 (2024)
Urinary concentrations and elimination half-lives of parabens, benzophenones, bisphenol and triclosan in Japanese young adults

Presenter : Nguyen T., Isobe T., Iwai M., Takagi M., Ueyama J., Oura K., Tanoue R., Kunisue T., Nakayama S.f.
Title : , Chemosphere, 349:140920 (2024)
Urinary concentrations of environmental phenol among pregnant women in the Japan Environment and Children’s Study

Presenter : Suwannarin N., Nishihama Y., Isobe T., Nakayama S.f.
Title : , Environment International, 183:108373 (2024)
Long-term monitoring of indoor, outdoor, and personal exposure to gaseous chemical compounds

Presenter : Uchiyama S., Noguchi M., Hishiki M., Shimizu M., Kunugita N., Isobe T., Nakayama S.F.
Title : , Science of The Total Environment, 906:167830 (2024)
Evaluating the risk of phthalate and non-phthalate plasticizers in dust samples from 100 Japanese houses

Presenter : Shinohara N., Oguri T., Takagi M., Ueyama J., Isobe T.
Title : , Environment International, 183:108399 (2024)
Relationship between flame retardants and respiratory health - A systematic review and meta-analysis of observational studies

Presenter : Coelho S.D., Maricoto T., Taborda-Barata L., Annesi-Maesano I., Isobe T., Sousa A.C.A.
Title : , Environmental Pollution, 347:123733 (2024)
Pharmaceuticals and personal care products (PPCPs) in surface water and fish from three Asian countries: Species-specific bioaccumulation and potential ecological risks

Presenter : Nozaki K., Tanoue R., Kunisue T., Tue N.M., Fujii S., Sudo N., Isobe T., Nakayama K., Sudaryanto A., Subramanian A., Bulbule K.A., Parthasarathy P., Tuyen L.H., Viet P.H., Kondo M., Tanabe S., Nomiyama K.
Title : , Science of The Total Environment, 866:161258 (2023)
A simultaneous, high-throughput and sensitive method for analysing 13 neonicotinoids and metabolites in urine using a liquid chromatography-tandem mass spectrometry

Presenter : Nishihama Y., Nakayama S.F., Isobe T.
Title : , MethodsX, 10:102129 (2023)
Effects of Pesticide Intake on Gut Microbiota and Metabolites in Healthy Adults

Presenter : Ueyama J., Hayashi M., Hirayama M., Nishiwaki H., Ito M., Saito I., Tsuboi Y., Isobe T., Ohno K.
Title : , International Journal of Environmental Research and Public Health, 20(1):213 (2023)
Association between maternal urinary neonicotinoid concentrations and child development in the Japan Environment and Children's Study

Presenter : Nishihama Y., Nakayama S.F., Isobe T., Kamijima M.
Title : , Environment International, 181:108267 (2023)
Baseline Complete Blood Count and Chemistry Panel Profile from the Japan Environment and Children’s Study (JECS)

Presenter : Taniguchi Y., Yamazaki S., Nakayama S.F., Sekiyama M., Michikawa T, Isobe T., Iwai M., Kobayashi Y., Takagi M., Kamijima M
Title : , Int. J. Environ. Res. Public Health, 19(6):3277 (2022)
Optimal method for determining the intraclass correlation coefficients of urinary biomarkers such as dialkylphosphates from imputed data

Presenter : Nishihama Y., LAI Y., Isobe T., Nakayama S.F.
Title : , Environment International, 170:107553 (2022)
Highly Sensitive Simultaneous Measurement of Steroid Hormone in Human Serum by Liquid Chromatography-electrospray Ionization Tandem Mass Spectrometry

Presenter : Khanh N.V., Hai N.T., Thuy N.T.D., Kido T., Nakayama S.F., Isobe T., Okuyama M., Honma S.
Title : , VNU Journal of Science: Medical and Pharmaceutical Sciences, 38(1):54-64 (2022)
Health risk assessment based on exposure to chemicals in air

Presenter : Sakamoto H., Uchiyama S., Sato A., Isobe T., Kunugita N., Ogura H., Nakayama S.F.
Title : , International Journal of Environmental Research and Public Health, 19(23):15813 (2022)
Maternal Metals Exposure and Infant Weight Trajectory: The Japan Environment and Children’s Study (JECS)

Presenter : Taniguchi Y., Yamazaki S., Nakayama S.F., Sekiyama M., Michikawa T., Isobe T., Iwai M., Kobayashi Y., Nitta H.
Title : , Environmental Health Perspectives, 130(12): (2022)
Exposure to heavy metals modifies optimal gestational weight gain: A large nationally representative cohort of the Japan Environment and Children’s Study

Presenter : Jung C., Nakayama S.F., Isobe T., Iwai-Shimada M., Kobayashi Y., Nishihama Y., Michikawa T., Sekiyama M., Taniguchi Y., Nitta H., Yamazaki S.
Title : , Environment International, 146:106276 (2021)
Occurrence, distribution, and potential exposure risk of organophosphate flame retardants in house dust in South Korea

Presenter : Gwon H.-R., Oh H.-J., Chang K.-H., Isobe T., Lee S.-Y., Kim J.-H., You S.-J., Kim J.-G., Kim J.-W.
Title : , Science of the Total Environment, 770:144571 (2021)
Association of prenatal maternal blood lead levels with birth outcomes in the Japan Environment and Children’s Study (JECS): a nationwide birth cohort study

Presenter : Goto Y., Mandai M., Nakayama T., Yamazaki S., Nakayama S.F., Isobe T., Sato T., Nitta H.
Title : , International Journal of Epidemiology, 50(1):156-164 (2021)
Comparison of Simultaneous Quantitative Analysis of Methylmercury and Inorganic Mercury in Cord Blood Using LC-ICP-MS and LC-CVAFS: The Pilot Study of the Japan Environment and Children’s Study

Presenter : Iwai-Shimada M., Kobayashi Y., Isobe T., Nakayama S.F., Sekiyama M., Taniguchi Y., Yamazaki S., Michikawa T., Oda M., Mitsubuchi H., Sanefuji M., Ohga S., Mise N., Ikegami A., Suga R., Shimono M.
Title : , Toxics, 9(82): (2021)
Association of prenatal exposure to cadmium with neurodevelopment in children at 2 years of age: The Japan Environment and Children's Study

Presenter : Ma C., Iwai-Shimada M., Nakayama S.F., Isobe T., Kobayashi Y., Tatsuta N., Taniguchi Y., Sekiyama M., Michikawa T., Yamazaki S., Kamijima M.
Title : , Environment International, 156(106762): (2021)
Anthropogenic and natural organohalogen compounds in melon-headed whales (Peponocephala electra) stranded along the Japanese coastal waters: Temporal trend analysis using archived samples in the environmental specimen bank (es-BANK)

Presenter : Kunisue T., Goto A., Sunouchi T., Egashira K., Ochiai M., Isobe T., Tajima Y., Yamada T.K., Tanabe S.
Title : , Chemosphere, 269:129401 (2021)
Indoor air quality of 5,000 households and its determinants. Part B: Volatile organic compounds and inorganic gaseous pollutants in the Japan Environment and Children's study

Presenter : Jung C., Nishihama Y., Nakayama S.F., Tamura K., Isobe T., Michikawa T., Iwai-Shimada M. , Kobayashi Y., Sekiyama M., Taniguchi Y., Yamazaki S.
Title : , Environmental Research, 197:111135 (2021)
Indoor air quality of 5,000 households and its determinants. Part A: Particulate matter (PM2.5 and PM10-2.5) concentrations in the Japan Environment and Children's Study

Presenter : Nishihama Y., Jung C., Nakayama S.F., Tamura K., Isobe T., Michikawa T., Iwai-Shimada M., Kobayashi Y., Sekiyama M., Taniguchi Y., Yamazaki S.
Title : , Environmental Research, 198:111196 (2021)
Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children's Study (JECS)

Presenter : Nishihama Y., Nakayama S.F., Isobe T., Jung CR., Iwai-Shimada M., Kobayashi Y., Michikawa T., Sekiyama M., Taniguchi Y., Yamazaki S.
Title : , International Journal of Environmental Research and Public Health, 18(11):5929 (2021)
Exposure to Organophosphate and Neonicotinoid Insecticides and Its Association with Steroid Hormones among Male Reproductive-Age Farmworkers in Northern Thailand

Presenter : Suwannarin N., Prapamontol T., Isobe T., Nishihama Y., Hashimoto Y., Mangklabruks A., Pantasri T., Chantara S., Naksen W., Nakayama S.F.
Title : , International Journal of Environmental Research and Public Health, 18(11):5599 (2021)
Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand

Presenter : Suwannarin N., Prapamontol T., Isobe T., Nishihama Y., Mangklabruks A., Pantasri T., Chantara S., Naksen W., Nakayama S.F.
Title : , International Journal of Environmental Research and Public Health, 18:10849 (2021)
Spatial Variations of Indoor Air Chemicals in an Apartment Unit and Personal Exposure of Residents

Presenter : Sakamoto H., Uchiyama S., Isobe T., Kunugita N., Ogura H., Nakayama S.F.
Title : , International Journal of Environmental Research and Public Health, 18:11511 (2021)
Maternal dietary intake of vitamin A during pregnancy was inversely associated with congenital diaphragmatic hernia: the Japan Environment and Children’s Study

Presenter : Michikawa T., Yamazaki S., Sekiyama M., Kuroda T., Nakayama S.F., Isobe T., Kobayashi Y., Iwai M., Suda E., Kawamoto T., Nitta H.
Title : , British Journal of Nutrition, 122(11):1295-1302 (2020)
Estrogenic action by tris(2,6-dimethylphenyl) phosphate impairs the development of female reproductive functions

Presenter : Sano K., Matsukami H., Suzuki G., Htike N.T.T., Morishita M., Tin-Tin-Win-Shwe, Hashimoto S., Kawashima T., Isobe T., Nakayama S.F., Tsukahara S., Maekawa F.
Title : , Environment International, 138:105662 (2020)
Health Risk Assessment and Source Apportionment of Mercury, Lead, Cadmium, Selenium, and Manganese in Japanese Women: An Adjunct Study to the Japan Environment and Children’s Study

Presenter : MA C., Iwai M., Tatsuta N., Nakai K., Isobe T., Takagi M., Nishihama Y., Nakayama S.F.
Title : , International Journal of Environmental Research and Public Health, 17(7):2231 (2020)
Poly- and perfluoroalkyl substances in maternal serum: Method development and application in Pilot Study of the Japan Environment and Children's Study

Presenter : Nakayama S.F., Isobe T., Iwai-Shimada M., Kobayashi Y., Nishihama Y., Taniguchi Y., Sekiyama M., Michikawa T., Yamazaki S., Nitta H., Oda M., Mitsubuchi H., Sanefuji M., Ohga S., Mise N., Ikegami A., Suga R., Shimono M.
Title : , Journal of Chromatography A, 1618:460933 (2020)
Characteristics of Exposure of Reproductive-Age Farmworkers in Chiang Mai Province, Thailand, to Organophosphate and Neonicotinoid Insecticides: A Pilot Study

Presenter : Suwannarin N., Prapamontol T., Isobe T., Nishihama Y., Nakayama S.F.
Title : , International Journal of Environmental Research and Public Health, 17:7871 (2020)
Non-target and target screening of organohalogen compounds in mussels and sediments from Hiroshima Bay, Japan: Occurrence of novel bioaccumulative substances

Presenter : Goto A., Tue N.M., Isobe T., Takahashi S., Tanabe S., Kunisue T.
Title : , Environmental Science and Technology, 54(9):5480-5488 (2020)
Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS)

Presenter : Nishihama Y., Nakayama S.F., Tabuchi T., Isobe T., Jung C., Iwai-Shimada M., Kobayashi Y., Michikawa T., Sekiyama M., Taniguchi Y., Nitta H., Yamazaki S.
Title : , International Journal of Environmental Research and Public Health, 17(15):5537 (2020)
Population genetic diversity and historical dynamics of Fraser’s dolphins Lagenodelphis hosei

Presenter : Chen I., Nishida S., Chou L.S., Isobe T., Mignucci Giannoni A.A., Hoelzel A.R.
Title : , MARINE ECOLOGY PROGRESS SERIES, 643:183-195 (2020)
Maternal intake of one-carbon metabolism-related B vitamins and anorectal malformations in the Japan Environment and Children’s Study

Presenter : Michikawa T., Nitta H., Sekiyama M., Kuroda T., Nakayama S.F., Isobe T., Kobayashi Y., Iwai M., Suda E., Taniguchi Y., Kawamoto T., Yamazaki S.
Title : , British Journal of Nutrition, 124(8):865-873 (2020)
Association of blood cadmium levels in pregnant women with infant birth size and small for gestational age infants: The Japan Environment and Children's study

Presenter : Inadera H., Takamori A., Matsumura K., Tsuchida A., Cui Z.G., Hamazaki K., Tanaka T., Ito M., Kigawa M., Origasa G., Michikawa T., Nakayama S.F., Isobe T., Takeuchi A., Sato T., Nitta H., Yamazaki S.
Title : , Environmental Research, 191:110007 (2020)
Development of Artificial Urine Certified Reference Material for Quantification of Neonicotinoid Insecticides

Presenter : Otake T., Nakayama S.F., Isobe T., Hanari N.
Title : , Journal of AOAC INTERNATIONAL, 103(6):1469-1477 (2020)
Study Design and Participants’ Profile in the Sub-Cohort Study in the Japan Environment and Children’s Study (JECS)

Presenter : Sekiyama M., Yamazaki S., Michikawa T., Nakayama S.F., Nitta H., Taniguchi Y., Suda E., Isobe T., Kobayashi Y., Iwai M., Ono M., Tamura K., Yonemoto J., Kawamoto K., Kamijima M
Title : , Journal of Epidemiology (2020)
Evaluation of a data-processing method for target and non-target screening using comprehensive two-dimensional gas chromatography coupled with high-resolution time-of-flight mass spectrometry for environmental samples

Presenter : Ieda T., Hashimoto S., Isobe T., Kunisue T., Tanabe S.
Title : , Talanta, 194:461-468 (2019)
Dioxins levels in human blood after implementation of measures against dioxin exposure in Japan

Presenter : Muzembobasilua A., Iwai-Shimada M., Isobe T., Arisawa K., Shima M., Fukushima T., Nakayama S.F.
Title : , Environmental Health and Preventive Medicine, 24(6): (2019)
Intra-individual variations of organophosphate pesticide metabolite concentrations in repeatedly collected urine samples from pregnant women in Japan

Presenter : Hioki K., Ito Y., Oya N., Nakayama S.F., Isobe T., Ebara T., Shibata K., Nishikawa N., Nakai K., Kamida T., Ueyama J., Sugiura-Ogasawara M., Kamijima M.
Title : , Environmental Health and Preventive Medicine, 24(7): (2019)
Within-individual and interlaboratory variability analyses of urinary metabolites measurements of organophosphorus insecticides

Presenter : Ito Y., Ueyama J., Nakayama S.F., Isobe T., Oya N., Sato H., Ebara T., Yoshimasu K., Tsuno K., Tatsuta N., Nakai K., Kamijima M.
Title : , Journal of Exposure Science and Environmental Epidemiology, 30(4):721-729 (2019)
Association between blood manganese level during pregnancy and birth size: The Japan environment and children's study (JECS)

Presenter : Yamamoto M., Sakurai K., Eguchi A., Yamazaki S., Nakayama S.F., Isobe T., Takeuchi A., Sato T., Hata A., Mori C., Nitta H.
Title : , Environmental Research, 172:117-126 (2019)
Isoflavone Intake in Early Pregnancy and Hypospadias in the Japan Environment and Children's Study

Presenter : Michikawa T., Yamazaki S., Ono M., Kuroda T., Nakayama S.F., Suda E., Isobe T., Iwai M., Kobayashi Y., Yonemoto J., Tamura K., Kawamoto T., Nitta H.
Title : , Urology, 124:229-236 (2019)
Fish consumption in early pregnancy and congenital gastrointestinal tract atresia in the Japan Environment and Children’s Study

Presenter : Michikawa T., Yamazaki S., Ono M., Kuroda T., Nakayama S.F., Suda E., Isobe T., Iwai M., Kobayashi Y., Tamura K., Yonemoto J., Kawamoto T., Nitta H.
Title : , British Journal of Nutrition, 121(1):100-108 (2019)
Blood mercury, lead, cadmium, manganese and selenium levels in pregnant women and their determinants: the Japan Environment and Children's Study (JECS)

Presenter : Nakayama S.F., Iwai-Shimada M., Oguri T., Isobe T., Takeuchi A., Kobayashi Y., Michikawa T., Yamazaki S., Nitta H., Kawamoto T.
Title : , Journal of Exposure Science and Environmental Epidemiology, 29(5):633-647 (2019)
Occurrence of benzotriazole ultraviolet stabilizers (BUVSs) in human breast milk from three Asian countries

Presenter : Kim J.W., Chang K.H., Prudente M., Viet P.H., Takahashi S., Tanabe S., Kunisue T., Isobe T.
Title : , Science of the Total Environment, 655:1081-1088 (2019)
Association of blood mercury levels during pregnancy with infant birth size by blood selenium levels in the Japan Environment and Children's Study: A prospective birth cohort

Presenter : Kobayashi S., Kishi R., Saijo Y., Ito Y., Oba K., Araki A., Miyashita C., Itoh S., Minatoya M., Yamazaki K., Ait Bamai Y., Sato T., Yamazaki S., Nakayama S.F., Isobe T., Nitta H.
Title : , Environment International, 125:418-429 (2019)
Does overweight before pregnancy reduce the occurrence of gastroschisis?: the Japan Environment and Children’s Study

Presenter : Michikawa T., Yamazaki S., Suda M., Kuroda T., Nakayama S.F., Isobe T., Kobayashi Y., Sekiyama M., Kawamoto T., Nitta H.
Title : , BMC Research Notes, 13: (2019)
Concordance between genetic diversity and marine biogeography in a highly mobile marine mammal, the Rissos dolphin

Presenter : Chen I., Nishida S., Chou L.S., Tajima Y., Yang W.C., Isobe T., Yamada T.K., Hartman K., Hoelzel A.R.
Title : , Journal of Biogeography, 2018(00):1-12 (2018)
Questionnaire results on exposure characteristics of pregnant women participating in the Japan Environment and Children’s Study

Presenter : Iwai-Shimada M., Nakayama S.F., Isobe T., Michikawa T., Yamazaki S., Nitta H., Takeuchi A., Kobayashi Y., Tamura K., Suda E., Ono M., Yonemoto J., Kawamoto T.
Title : , Environmental Health and Preventive Medicine, 23(1):45 (2018)
Levels of TBT and other selected organotin compounds in duplicate diet samples

Presenter : Sousa A.C.A., Coelho S.D., Pastorinho M.R., Taborda-Barata L., Nogueira A.J.A., Isobe T., Kunisue T., Takahashi S., Tanabe S.
Title : , Science of the Total Environment, 574:19-23 (2017)
Genetic diversity of bottlenose dolphin (Tursiops sp.) populations in the western North Pacific and the conservation implications

Presenter : Chen I., Nishida S., Yang W.C., Isobe T., Tajima Y., Hoelzel A.R.
Title : , Marine Biology, 164(10):202-218 (2017)
Spatio-temporal trends of polybrominated dibenzo-p-dioxins and dibenzofurans in archived sediments from Tokyo Bay, Japan

Presenter : Goto A., Tue N.M., Someya M., Isobe T., Takahashi S., Tanabe S., Kunisue T.
Title : , Science of The Total Environment, 599-600:340-347 (2017)
Polybrominated diphenyl ethers (PBDEs) and their hydroxylated and methoxylated analogues in the blood of harbor, Dalls and finless porpoises from the Japanese coastal waters

Presenter : Ochiai M., Nomiyama K., Isobe T., Yamada T.K., Tajima Y., Matsuda A., Shiozaki A., Matsuishi T., Amano M., Iwata H., Tanabe S.
Title : , Marine Environmental Research, 128:124-132 (2017)
Cadmium intake in women from the University of Aveiro, Portugal - A duplicate diet study

Presenter : Coelho S.D., Maricoto T., Pastorinho M.R., Itai T., Isobe T., Kunisue T., Tanabe S., Sousa A.C.A., Nogueira A.J.A.
Title : , Journal of Geochemical Exploration, 183:187-190 (2017)
Occurrence of Natural Mixed Halogenated Dibenzo-p-Dioxins: Specific Distribution and Profiles in Mussels from Seto Inland Sea, Japan

Presenter : Goto A., Tue N.M., Someya M., Isobe T., Takahashi S., Tanabe S., Kunisue T.
Title : , Environmental Science and Technology, 51(20):11771-11779 (2017)
In utero and Lactational Exposure to Acetamiprid Induces Abnormalities in Socio-Sexual and Anxiety-Related Behaviors of Male Mice

Presenter : Sano K., Isobe T., Yang J., Tin-Tin-Win-Shwe, Yoshikane M., Nakayama S., Kawashima T., Suzuki G., Hashimoto S., Nohara K., Tohyama C., Maekawa F.
Title : , Frontiers in Neuroscience, 10(228): (2016)
Brominated, chlorinated and phosphate organic contaminants in house dust from Portugal

Presenter : Coelho S.D., Sousa A.C.A., Isobe T., Kim J.W., Kunisue T., Nogueira A.J.A., Tanabe S.
Title : , Science of the Total Environment, 569-570:442-449 (2016)
Brominated flame retardants and organochlorine compounds in duplicate diet samples from a Portuguese academic community

Presenter : Coelho S.D., Sousa A.C.A., Isobe T., Kunisue T., Nogueira A.J.A., Tanabe S.
Title : , Chemosphere, 160:89-94 (2016)
Lead in duplicate diet samples from an academic community

Presenter : Coelho S.D., Pastorinho M.R., Itai T., Isobe T., Kunisue T., Nogueira A.J.A., Tanabe S., Sousa A.C.A.
Title : , Science of The Total Environment, 573:603-607 (2016)
Detection of glucocorticoid receptor agonists in effluents from sewage treatment plants in Japan

Presenter : Suzuki G., Sato K., Isobe T., Takigami H., Brouwer A., Nakayama K.
Title : , Science of the Total Environment, 527-528:328-334 (2015)
Toxic identification and evaluation of androgen receptor antagonistic activities in acid-treated liver extracts of high-trophic level wild animals from Japan

Presenter : Misaki K., Suzuki G., Tue N.M., Takahashi S., Someya M., Takigami H., Tajima Y., Yamada T.K., Amano M., Isobe T., Tanabe S.
Title : , Environmental Science and Technology, 49:11840-11848 (2015)
Determination of natural and synthetic glucocorticoids in effluent of sewage treatment plants using ultrahigh performance liquid chromatography-tandem mass spectrometry

Presenter : Isobe T., Sato K., Kim J.-W., Tanabe S., Suzuki G., Nakayama K.
Title : , Environmental Science and Pollution Research, 22:14127-14135 (2015)
Uptake and biological effects of synthetic glucocorticoids in common carp (Cyprinus carpio)

Presenter : Nakayama K., Inoue Y., Ikeda N., Hashizume N., Murakami H., Ishibashi T., Ikeda H., Isobe T., Kitamura S., Suzuki G.
Title : , Marine Pollution Bulletin, 85(2):370-375 (2014)

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Worldwide trends in tracing poly- and perfluoroalkyl substances (PFAS) in the environment

Presenter : Nakayama S.F., Yoshikane M., Onoda Y., Nishihama Y., Iwai-Shimada M., Takagi M., Kobayashi Y., Isobe T.
Title : , TrAC Trends in Analytical Chemistry, 121(115410): (2019)
Obesogens in the XXI century: emerging health challenges volume II

Presenter : Sousa A.C.A., Malarvannan G., Isobe T., Rato L.
Title : , Frontiers in Endocrinology, 14:1292334 (2023)
Obesogens in the XXI century: Emerging health challenges

Presenter : Sousa A.C.A., Malarvannan G., Isobe T., Rato L.
Title : , Frontiers in Endocrinology, 13:999908 (2022)

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Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective

Presenter : Zhang P., Carlsten C., Chaleckis R., Hanhineva K., Huang M., Isobe T., Koistinen V.M., Meister I., Papazian S., Sdougkou K., Xie H., Martin J.W., Rappaport S.M., Tsugawa H., Walker D.I., Woodruff T.J., Wright R.O., Wheelock C.E.
Title : , Environmental Science & Technology Letters, 8(10):839-852 (2021)
Baseline Profile of Participants in the Japan Environment and Children

Presenter : Michikawa T., Nitta H., Nakayama S., Yamazaki S., Isobe T., Tamura K., Suda E., Ono M., Yonemoto J., Iwai M., Kobayashi Y., Suzuki G., Kawamoto T.
Title : , Journal of Epidemiology (2017)
Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium

Presenter : Zhang P., Arora M., Chaleckis R., Isobe T., Jain M., Meister I., Melen E., Perzanowski M., Torta F., Wenk M.R., Wheelock C.E.
Title : , Metabolites, 9(6):106 (2019)

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Research Result (Presentation)

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Research Presentation
Research Lecture

Research Presentation
Exposure factor questionnaire development for personal care product usage among children

Presenter : Takagi M., Isobe T., Iwai M., Kobayashi Y., Nakayama S.F.
Name of Society : ISES-ISEE2025 (2025)
Name of Proceedings : Abstracts
Research Presentation
The National Human Biomonitoring Programme in Japan

Presenter : Nakayama S.F., Isobe T., Iwai-Shimada M., Takagi M., Kobayashi Y.
Name of Society : ISES-ISEE 2025 (2025)
Name of Proceedings : -
Research Presentation
Determinants of plasma poly- and perfluoroalkyl substances during pregnancy: the Japan Environment and Children’s Study

Presenter : Lai Y., Nakayama S.F., Nishihama Y., Isobe T.
Name of Society : ISES-ISEE 2025 (2025)
Name of Proceedings : -
Research Presentation
Association between essential and toxic elements in semen and sperm quality in Japanese men

Presenter : Iwai-Shimada M., Iwai K., Tatsuta N., Isobe T., Takagi M., Kobayashi Y., Nakayama S.F., Kumazawa Y., Takahashi K., Tanaka T., Terada Y., Nomura K., Okada H., Tamakoshi A., Maeda E.
Name of Society : Joint Annual Meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology 2025 (2025)
Name of Proceedings : Abstracts
Research Presentation
Semi-automated sample preparation and high-throughput determination of PFAS in plasma

Presenter : Isobe T., Iwai K., Yamaji T., Ono A., Iwasaki M., Inoue M., Tsugane S., Sawada N., Nguyen T., Nakayama S.F.
Name of Society : ISES-ISEE2025 (2025)
Name of Proceedings : Abstracts
Research Presentation
Machine learning approach for exposure determinant analysis

Presenter : Nakayama S.F., Lai Y., Nishihama Y., Isobe T.
Name of Society : The International Chemical Congress of Pacific Basin Societies 2025 (2025)
Name of Proceedings : -
Research Presentation
A simultaneous, high-throughput and sensitive method for analysing 13 neonicotinoids and metabolites in urine using a liquid chromatography-tandem mass spectrometry

Presenter : Nishihama Y., Nakayama S.F., Isobe T.
Name of Society : The International Chemical Congress of Pacific Basin Societies 2025 (2025)
Name of Proceedings : -
Research Presentation
Intervention Trial for Pharmacokinetic Study of Chemicals in Daily Use Products

Presenter : Isobe T., Ueyama J., Iwai M., Takagi M., Oguri T., Shinohara N., Kunisue T., Nakayama K., Tanoue R., Nakayama S.f.
Name of Society : 21st International Symposium on Toxicity Assessment (2024)
Name of Proceedings : Abstracts
Research Presentation
Exposure Assessment in Japan Environment and Children’s Study (JECS)

Presenter : Isobe T., Nakayama S.f., Iwai M., Kobayashi Y., Takagi M.
Name of Society : 2024 National PFAS Conference (2024)
Name of Proceedings : -
Research Presentation
DIETARY INTERVENTION TRIAL FOR PHARMACOKINETICS OF SELENONEINE IN HUMANS

Presenter : Kobayashi Y., Iwai M., Isobe T., Takagi M., Yamashita M, Nakayama S.f.
Name of Society : 9th International Symposium on Metallomics (2024)
Name of Proceedings : Abstracts, 123
Research Presentation
Survey of personal care products usage of Japanese children

Presenter : Takagi M., Isobe T., Iwai M., Kobayashi Y., Nakayama S.f.
Name of Society : ISES 2024 Annual Meeting (2024)
Name of Proceedings : Abstracts
Research Presentation
Study design of less-invasive intervention trial for investigation of pharmacokinetics

Presenter : Isobe T., Ueyama J., Iwai M., Takagi M., Oguri T., Shinohara N., Kunisue T., Nakayama K., Tanoue R., Nakayama S.f.
Name of Society : ISES 2024 Annual Meeting (2024)
Name of Proceedings : -
Research Presentation
Project HERO: Impact of Artificial Habitats and Environmental contaminants on Chronic Respiratory Diseases

Presenter : Sousa A.C.A., Namorado S., Jacinto H., Ramalhosa R., Assis D., Bonito R., Penha A., Morais M., Bravo J., Isobe T., Taborda-Barata L., Pastorinho M.R.
Name of Society : 4th Comprehensive Health Research Centre Annual Summit (2023)
Name of Proceedings : Abstracts
Research Presentation
Determination of exposure factors including use of personal care products via web-based questionnaire

Presenter : Takagi M., Isobe T., Iwai M., Kobayashi Y., Nakayama S.F.
Name of Society : ISES2022 (2022)
Name of Proceedings : Abstracts
Research Presentation
Exposure estimation from HBM data

Presenter : Isobe T.
Name of Society : ISES 2022 Annual Meeting (2022)
Name of Proceedings : -
Research Presentation
Link the Results of the Birth Cohort Study to Chemical Regulation

Presenter : Isobe T., Ueyama J., Iwai M., Takagi M., Oguri T., Shinohara N., Kunisue T., Nakayama K., Tanoue R., Nakayama S.F.
Name of Society : Impacts of early life exposure to environmental contaminants:children’s health in the Anthropocene (2022)
Name of Proceedings : Abstracts
Research Presentation
High-sensitive determination method of insect repellents and its metabolites in human urine by solid-phase extraction and high-performance liquid chromatography-tandem mass spectrometry

Presenter : Nishihara N., Isobe T., Takagi M., Nakayama S.F., Iwai M., Kunisue T., Oguri T., Saito I., Ueyama J.
Name of Society : Impacts of early life exposure to environmental contaminants:children’s health in the Anthropocene (2022)
Name of Proceedings : Abstracts
Research Presentation
Developing a Japanese Exposure Factors Database

Presenter : Takagi M., Isobe T., Iwai M., Kobayashi Y., Nakayama S.F.
Name of Society : Impacts of early life exposure to environmental contaminants:children’s health in the Anthropocene (2022)
Name of Proceedings : Abstracts
Research Presentation
Distinguishing heat-not-burn tobacco smokers from cigarette smokers using novel biomarkers and machine learning model

Presenter : Nishihama Y., Nakayama S.F., Isobe T.
Name of Society : ISES 2022 Annual Meeting (2022)
Name of Proceedings : -
Research Presentation
Environmental measurements in the Sub-Cohort Study of the Japan Environment and Children’s Study (JECS)

Presenter : Nishihama Y., Nakayama S.F., Isobe T.
Name of Society : Impacts of early life exposure to environmental contaminants: children’s health in the Anthropocene (2022)
Name of Proceedings : Impacts of early life exposure to environmental contaminants: children’s health in the Anthropocene Abstracts Book
Research Presentation
Elemental analysis of biological samples in large-scale birth cohort study

Presenter : Kobayashi Y., Isobe T., Iwai M., Takagi M., Nakayama S.F.
Name of Society : The 8th International Symposium on Metallomics (2022)
Name of Proceedings : Abstracts, 58
Research Presentation
Assessment on exposure and elimination half-life of Neonicotinoids (NEOs) in human urine in Japan

Presenter : NGUYEN T., Isobe T., Iwai M., Takagi M., Ueyama J., Nakayama S.F.
Name of Society : Joint Conference on Environmental Chemicals（第30回環境化学討論会） (2022)
Name of Proceedings : 同要旨集, 165-166
Research Presentation
A recommended practice for determining the intraclass correlation coefficient of a urinary biomarker: in case of organophosphate metabolites in pre-school children

Presenter : Nishihama Y., Isobe T., Nakayama S.F.
Name of Society : ISES2021 Virtual conference (2021)
Name of Proceedings : -
Research Presentation
Poly- and perfluoroalkyl substances in maternal serum: method development and application in Pilot Study of the Japan Environment and Children’s Study

Presenter : Nakayama S.F., Isobe T., Iwai-Shimada M., Kobayashi Y., Nishihama Y., Taniguchi Y., Sekiyama M., Michikawa T., Yamazaki S., Nitta H., Oda M., Mitsubuchi H., Sanefuji M., Ohga S., Mise N., Ikegami A., Suga R., Shimono M.
Name of Society : The 2020 International Chemical Congress of Pacific Basin Societies (Pacifichem 2020) (2021)
Name of Proceedings : -
Research Presentation
Method optimisation of the measurement of airborne particulate matters for a large-scale cohort study

Presenter : Nishihama Y., Tamura K., Isobe T., Nakayama S.F.
Name of Society : The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021) (2021)
Name of Proceedings : -
Research Lecture
Japan Environment and Children’s Study: Its Progress and Future

Presenter : Isobe T., Nakayama S.F.
Name of Society : the International Symposium on Children’s Environmental Health Birth Cohort (2021)
Name of Proceedings : -
Research Presentation
Simultaneous determination of urinary cotinine and 8-OHdG in a Japanese national birth cohort study

Presenter : Nishihama Y., Isobe T., SUN X. L., Nakayama S.F.
Name of Society : ISES2020 Virtual Meeting (2020)
Name of Proceedings : -, 21
Research Presentation
Development and application of online questionnaire for the assessment of personal care product use

Presenter : Nakayama S.F., Takagi M., Nishihama Y., Isobe T., Yoshinaga J.
Name of Society : 30th Annual Meeting of International Society of Exposure Science (2020)
Name of Proceedings : Abstracts, S-59
Research Presentation
Defining co-exposures of blood heavy metals in Japanese pregnant women

Presenter : JUNG C., Isobe T., Iwai M., Kobayashi Y., Nishihama Y., MA C., Nakayama S.F.
Name of Society : NYC Exposome Symposium (2020)
Name of Proceedings : -
Research Presentation
Environmental measurements in the Sub-Cohort Study of the Japan Environment and Children’s Study (JECS)

Presenter : Nishihama Y., Isobe T., Tamura K., Iwai M., Michikawa T., Yamazaki S., Nitta H., Takeuchi A., Kobayashi Y., Suda E., Sekiyama M., Ono M., Yonemoto J., Kawamoto T., Nakayama S.F.
Name of Society : ISES ISIAQ 2019 (2019)
Name of Proceedings : Abstracts, 301
Research Presentation
Determination of neonicotinoid insecticides in urine using semi-automated solid phase extraction coupled to UHPLC-MS/MS

Presenter : Isobe T., Iwai M., Kobayashi Y., Takagi M., Nakayama S.F.
Name of Society : 39th International Symposium on Halogenated Persistent Organic Pollutants (2019)
Name of Proceedings : Abstracts, 531
Research Presentation
Levels and profiles of endocrine disrupting chemicals in human urine from India, Indonesia, and Vietnam

Presenter : Kunisue T., Uchikawa A., Tanoue R., Nguyen T. M., Isobe T., Subramanian A., Sudaryanto A., Viet P.H., Tanabe S.
Name of Society : 39th International Symposium on Halogenated Persistent Organic Pollutants (2019)
Name of Proceedings : Abstracts, 761
Research Presentation
Integrated use of ChemTHEATRE and AIST-MeRAM for rapid and cost-effective risk assessment of environmental contaminants

Presenter : Nakayama K., Lin B.L., Isobe T., Uno S., Handoh I.C., Ohno N., Kunisue T.
Name of Society : 9th International Conferences on Marine Pollution and Ecotoxicology (2019)
Name of Proceedings : Abstracts
Research Presentation
Quantifying the relative importance of chemical versus noise pollution to marine mammal stranding/mortality events

Presenter : Handoh I.C., Sakai R., Kawai T., Isobe T., Ohno N., Nakayama K.
Name of Society : 9th International Conferences on Marine Pollution and Ecotoxicology (2019)
Name of Proceedings : Abstracts
Research Presentation
JECS (Japan Environment and Children’s Study): Progress during FY2018-19

Presenter : Isobe T., Mezawa H.
Name of Society : I4C Annual Meeting 2019 (2019)
Name of Proceedings : -
Research Presentation
Lessons from legacy approach of biological passive sampling - POP chemicals in mussels from asian coastal waters -

Presenter : Isobe T., Tanabe S., Kunisue T.
Name of Society : Society of Environmental Toxicology and Chemistry Asia-Pacific 2018 Conference (2018)
Name of Proceedings : Abstracts, 58-59
Research Presentation
Chemtheatre: opendata platform for environmental monitoring of pops and other contaminants

Presenter : Isobe T., Nakayama K., Uno S., Handoh I.C., Ohno N., Kunisue T.
Name of Society : Society of Environmental Toxicology and Chemistry Asia-Pacific 2018 Conference (2018)
Name of Proceedings : Abstracts, 82
Research Presentation
Disaster Response Research Development in Japan

Presenter : Nakayama SF., Takagi M., Nakajima D., Isobe T., Iwai-Shimada M., Kobayashi Y.
Name of Society : ISES-ISEE 2018 Joint Annual Meeting (2018)
Name of Proceedings : Abstracts, 655
Research Presentation
Daily Intakes of Phthalates among Japanese Children

Presenter : Takagi M., Isobe T., Iwai-Shimada M., Nakayama SF.
Name of Society : ISES-ISEE 2018 Joint Annual Meeting (2018)
Name of Proceedings : Abstracts, 1539
Research Lecture
How to Work Exposure Assessment-Large Scale Birth Cohort and Exposomics-

Presenter : Isobe T., Iwai M., Nakayama S.F.
Name of Society : The International Conference on Occupational and Environmental Diseases: ICOED (2018)
Name of Proceedings : -
Research Lecture
Japan Environment and Children’s Study (JECS) : Current Status (2018)

Presenter : Isobe T., Iwai M., Nakayama S.F., Mezawa H., Terashima K.
Name of Society : International Childhood Cancer Cohort Consortium (I4C) Childhood Leukemia International Consortium (CLIC) Joint Activities and Annual Meeting 2018 (2018)
Name of Proceedings : -
Research Presentation
Japan Environment and Children’s Study (JECS): Baseline characteristics of mothers, fathers, and their children

Presenter : Michikawa T., Nitta H., Nakayama S., Yamazaki S., Isobe T., Tamura K., Suda E., Ono M., Yonemoto J., Iwai M., Kobayashi Y., Suzuki G., Kawamoto T.
Name of Society : The 21st international Epidemiological Association, World Congress of Epidemiology (2017)
Name of Proceedings : Abstracts, 116
Research Presentation
Temporal trends of brominated flame retardants and organochlorines in melon-headed whales stranded along the Japanese coastal waters: utilization of samples and data stored in es-BANK and ChemTHEATRE

Presenter : Kunisue T., Egashira K., Isobe T., Nakayama K., Tajima Y., Yamada T.K., Tanabe S.
Name of Society : 37th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - DIOXIN 2017 (2017)
Name of Proceedings : Abstracts
Research Presentation
Occurrence and potential sources of brominated/chlorinated dibenzo-p-dioxins in mussels from the Seto Inland Sea, Japan

Presenter : Goto A., Tue N.M., Someya M., Isobe T., Takahashi S., Tanabe S., Kunisue T.
Name of Society : 37th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - DIOXIN 2017 (2017)
Name of Proceedings : Abstracts
Research Presentation
Biomonitoring of dioxins and other chemicals in Japan - Summary of nation-wide survey during 2011-2016

Presenter : Isobe T., Iwai M., Shibuya H., Tsukahara S., Kasamatsu J., Arisawa K., Nakayama S.
Name of Society : 37th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - DIOXIN 2017 (2017)
Name of Proceedings : Abstracts
Research Presentation
Developmental exposure to tetrabromobisphenol A (TBBPA) on late onset behavior and neurological biomarkers in adult mice

Presenter : Tin-Tin-Win-Shwe, Sano K., Isobe T., Kawashima T., Suzuki G., Hashimoto S., Nakayama S., Maekawa F.
Name of Society : The 40th Annual Meeting of the Japan Neuroscience Society (2017)
Name of Proceedings : Abstract, 218
Research Presentation
Exposome: Importance of life-course total exposure assessment and current status in a large-scale cohort study

Presenter : Isobe T., Nakayama S.
Name of Society : ICCA-LRI Workshop 2017:Fit-For-Purpose Exposure Assessments for Risk-Based Decision Making (2017)
Name of Proceedings : -
Research Lecture
Japan Environment and Children’s Study (JECS): Current Status (2017)

Presenter : Isobe T., Nakayama S., Mezawa H., Terashima K.
Name of Society : 2017 International Childhood Cancer Cohort Consortium Workshop (I4C) (2017)
Name of Proceedings : -
Research Presentation
Indoor dust ingestion rate for Japanese children

Presenter : Takagi M., Isobe T., Iwai M., Nakayama S.
Name of Society : International Society of Exposure Science (ISES) 27th Annual Meeting (2017)
Name of Proceedings : Abstracts, 314-315
Research Presentation
Effects of perinatal exposure to a phosphate ester flame retardant on novel object recognition ability and memory function-related gene expression in adult mice

Presenter : Tin-Tin-Win-Shwe, Sano K., Isobe T., Kawashima T., Suzuki G., Hashimoto S., Nakayama S., Maekawa F.
Name of Society : 45th Myanmar Health Research Congress (2017)
Name of Proceedings : Abstract, 120
Research Presentation
Comprehensive analysis of house dust using GC×GC-HRTOFMS and in-house software

Presenter : Ieda T., Hashimoto S., Takazawa Y., Tanabe K., Zushi Y., Shibata Y., Maekawa F., Sano K., Suzuki G., Nakayama S., Isobe T., Tin-Tin-Win-Shwe, Kawashima T.
Name of Society : DIOXIN2016 (2016)
Name of Proceedings : Abstracts
Research Presentation
Evaluation of Bioaccessibility of PCBs, PBDEs and HBCDs in Indoor Dust: The Japan Environment and Children

Presenter : Isobe T., Takagi M., Suzuki G., Ikegami A., Kayama F., Tsuji M., Senju A., Morokuma S., Sanefuji M., Oda M., Mitsubuchi H., Kato T., Nakayama S.
Name of Society : The 36th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2016) (2016)
Name of Proceedings : Abstracts
Research Presentation
Perinatal exposure to a phosphate ester flame retardant affects memory function and related gene expression in adult mice

Presenter : Tin-Tin-Win-Shwe, Sano K., Isobe T., Kawashima T., Suzuki G., Hashimoto S., Nakayama S., Maekawa F.
Name of Society : The 5th Annual Meeting of The Japan Society for Developmental Origins of Health and Disease (DOHaD-Japan) (2016)
Name of Proceedings : Abstract(P-07), 40
Research Presentation
Evaluation of potentially developmentally neurotoxic chemicals using behavioral testing and neuroendocrinological analysis

Presenter : Maekawa F., Sano K., Suzuki G., Nakayama S., Isobe T., Tin-Tin-Win-Shwe, Hashimoto S., Kawashima T.
Name of Society : The 93rd Annual Meeting of the Physiological Society of Japan (2016)
Name of Proceedings : Proceedings of The 93rd Annual Meeting of the Physiological Society of Japan, 66(supplement1):S73
Research Presentation
Management of the environmental monitoring data by ChemTHEATRE, a database for environmental contaminants

Presenter : Isobe T., Nakayama K., Uno S., Ohno N., Hando I., Kunisue T.
Name of Society : The 19th Annual Meeting of Japan Society Endocrine Disruptors Research (2016)
Name of Proceedings : Program and Abstracts, 88
Research Presentation
Levels of the obesogen tributyltin and other selected organotin compounds in house dust and duplicate diet samples from Portugal

Presenter : Sousa A.C.A., Isobe T., Coelho S., Pastorinho R.M., Taborda-Barata L., Nogueira A.J.A., Kunisue T., Takahashi S., Tanabe S.
Name of Society : 5th Conference on Prenatal Programming and Toxicity (pptoxV) (2016)
Name of Proceedings : Abstracts
Research Lecture
In vivo evaluation of a flame retardant having estrogenic activity using mouse model

Presenter : Sano K., Suzuki G., Htike N.T.T., Morishita M., Tin-Tin-Win-Shwe, Hashimoto S., Kawashima T., Isobe T., Nakayama S., Tsukahara S., Maekawa F.
Name of Society : Application of Recent Advances in Neuroscience to Environmental Health Research (2016)
Name of Proceedings : abstract, 1-4
Research Lecture
Japan Environment and Children’s Study (JECS): Current Status (2016)

Presenter : Isobe T., Nakayama S.
Name of Society : Ninth International Childhood Cancer Cohort Consortium Workshop (I4C) (2016)
Name of Proceedings : -
Research Presentation
Preliminary biomonitoring data from the Japan Environment and Children’s Study

Presenter : Nakayama S.F., Isobe T., Takeuchi A., Kamijima M., Nitta H., Kawamoto T.
Name of Society : ISES 2015 (2015)
Name of Proceedings : Abstracts, 189
Research Presentation
Glucocorticoid receptor (GR) agonist profiling in the effluents from sewage treatment plants in Japan

Presenter : Suzuki G., Sato K., Isobe T., Brouwer A., Nakayama K.
Name of Society : SETAC North America 35th Annual Meeting (2014)
Name of Proceedings : Abstracts, 261
Research Presentation
Risk evaluation of glucocorticoids discharged from sewage treatment plants in Japan: Effects on the response to bacterial infection in fish

Presenter : Nakayama K., Sato K., Ikeda H., Imajuku D., Kitamura S., Isobe T., Suzuki G.
Name of Society : SETAC North America 35th Annual Meeting (2014)
Name of Proceedings : Abstarcts of SETAC North America 35th Annual Meeting, 284-285
Research Presentation
Exposomics: A key approach for next generation children’s environmental health studies

Presenter : Nakayama S.F., Isobe T., Suzuki Y., Takagi M.
Name of Society : SETAC North America 35th Annual Meeting (2014)
Name of Proceedings : -
Research Presentation
Spatial distribution, partitioning, and time trends of perfluorooctane sulfonate(PFOS) and perfluorooctanoate(PFOA) in Tokyo Bay, Japan, 2004-2006

Presenter : Sakurai T., Serizawa S., Isobe T., Kobayashi J., Kodama K., Kume G., Lee J-H., Maki H., Imaizumi Y., Suzuki N., Horiguchi T., Morita M., Shiraishi H.
Name of Society : SETAC North Am.31st Annu.Meet. (2010)
Name of Proceedings : Abstracts, 128
Research Presentation
Evaluation estrogenic activity of river water discharged into Tokyo Bay using yeast two-hybrid assays incorporating human ERα or medaka ERα and using enzyme immunoassay

Presenter : Shiraishi F., Isobe T., Kim D.M., Nishikawa T., Maruo N.(*1), Furuta Y.(*1), Shiraishi H., Morita M.
Name of Society : China-Jpn.Jt.Symp.Environ.Chem.2004 (2004)
Name of Proceedings : Proceedings

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Machine learning approach for exposure determinant analysis

Presenter : Nakayama S.F., Lai Y., Nishihama Y., Isobe T.
Name of Society : The International Chemical Congress of Pacific Basin Societies 2025 (2025)
Name of Proceedings : -
A simultaneous, high-throughput and sensitive method for analysing 13 neonicotinoids and metabolites in urine using a liquid chromatography-tandem mass spectrometry

Presenter : Nishihama Y., Nakayama S.F., Isobe T.
Name of Society : The International Chemical Congress of Pacific Basin Societies 2025 (2025)
Name of Proceedings : -
Exposure estimation from HBM data

Presenter : Isobe T.
Name of Society : ISES 2022 Annual Meeting (2022)
Name of Proceedings : -
Distinguishing heat-not-burn tobacco smokers from cigarette smokers using novel biomarkers and machine learning model

Presenter : Nishihama Y., Nakayama S.F., Isobe T.
Name of Society : ISES 2022 Annual Meeting (2022)
Name of Proceedings : -
Elemental analysis of biological samples in large-scale birth cohort study

Presenter : Kobayashi Y., Isobe T., Iwai M., Takagi M., Nakayama S.F.
Name of Society : The 8th International Symposium on Metallomics (2022)
Name of Proceedings : Abstracts, 58
Assessment on exposure and elimination half-life of Neonicotinoids (NEOs) in human urine in Japan

Presenter : NGUYEN T., Isobe T., Iwai M., Takagi M., Ueyama J., Nakayama S.F.
Name of Society : Joint Conference on Environmental Chemicals（第30回環境化学討論会） (2022)
Name of Proceedings : 同要旨集, 165-166
Poly- and perfluoroalkyl substances in maternal serum: method development and application in Pilot Study of the Japan Environment and Children’s Study

Presenter : Nakayama S.F., Isobe T., Iwai-Shimada M., Kobayashi Y., Nishihama Y., Taniguchi Y., Sekiyama M., Michikawa T., Yamazaki S., Nitta H., Oda M., Mitsubuchi H., Sanefuji M., Ohga S., Mise N., Ikegami A., Suga R., Shimono M.
Name of Society : The 2020 International Chemical Congress of Pacific Basin Societies (Pacifichem 2020) (2021)
Name of Proceedings : -
Simultaneous determination of urinary cotinine and 8-OHdG in a Japanese national birth cohort study

Presenter : Nishihama Y., Isobe T., SUN X. L., Nakayama S.F.
Name of Society : ISES2020 Virtual Meeting (2020)
Name of Proceedings : -, 21
Development and application of online questionnaire for the assessment of personal care product use

Presenter : Nakayama S.F., Takagi M., Nishihama Y., Isobe T., Yoshinaga J.
Name of Society : 30th Annual Meeting of International Society of Exposure Science (2020)
Name of Proceedings : Abstracts, S-59
Determination of neonicotinoid insecticides in urine using semi-automated solid phase extraction coupled to UHPLC-MS/MS

Presenter : Isobe T., Iwai M., Kobayashi Y., Takagi M., Nakayama S.F.
Name of Society : 39th International Symposium on Halogenated Persistent Organic Pollutants (2019)
Name of Proceedings : Abstracts, 531
Integrated use of ChemTHEATRE and AIST-MeRAM for rapid and cost-effective risk assessment of environmental contaminants

Presenter : Nakayama K., Lin B.L., Isobe T., Uno S., Handoh I.C., Ohno N., Kunisue T.
Name of Society : 9th International Conferences on Marine Pollution and Ecotoxicology (2019)
Name of Proceedings : Abstracts
Quantifying the relative importance of chemical versus noise pollution to marine mammal stranding/mortality events

Presenter : Handoh I.C., Sakai R., Kawai T., Isobe T., Ohno N., Nakayama K.
Name of Society : 9th International Conferences on Marine Pollution and Ecotoxicology (2019)
Name of Proceedings : Abstracts
JECS (Japan Environment and Children’s Study): Progress during FY2018-19

Presenter : Isobe T., Mezawa H.
Name of Society : I4C Annual Meeting 2019 (2019)
Name of Proceedings : -
Lessons from legacy approach of biological passive sampling - POP chemicals in mussels from asian coastal waters -

Presenter : Isobe T., Tanabe S., Kunisue T.
Name of Society : Society of Environmental Toxicology and Chemistry Asia-Pacific 2018 Conference (2018)
Name of Proceedings : Abstracts, 58-59
Disaster Response Research Development in Japan

Presenter : Nakayama SF., Takagi M., Nakajima D., Isobe T., Iwai-Shimada M., Kobayashi Y.
Name of Society : ISES-ISEE 2018 Joint Annual Meeting (2018)
Name of Proceedings : Abstracts, 655
Biomonitoring of dioxins and other chemicals in Japan - Summary of nation-wide survey during 2011-2016

Presenter : Isobe T., Iwai M., Shibuya H., Tsukahara S., Kasamatsu J., Arisawa K., Nakayama S.
Name of Society : 37th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - DIOXIN 2017 (2017)
Name of Proceedings : Abstracts
Exposome: Importance of life-course total exposure assessment and current status in a large-scale cohort study

Presenter : Isobe T., Nakayama S.
Name of Society : ICCA-LRI Workshop 2017:Fit-For-Purpose Exposure Assessments for Risk-Based Decision Making (2017)
Name of Proceedings : -
Evaluation of potentially developmentally neurotoxic chemicals using behavioral testing and neuroendocrinological analysis

Presenter : Maekawa F., Sano K., Suzuki G., Nakayama S., Isobe T., Tin-Tin-Win-Shwe, Hashimoto S., Kawashima T.
Name of Society : The 93rd Annual Meeting of the Physiological Society of Japan (2016)
Name of Proceedings : Proceedings of The 93rd Annual Meeting of the Physiological Society of Japan, 66(supplement1):S73
Preliminary biomonitoring data from the Japan Environment and Children’s Study

Presenter : Nakayama S.F., Isobe T., Takeuchi A., Kamijima M., Nitta H., Kawamoto T.
Name of Society : ISES 2015 (2015)
Name of Proceedings : Abstracts, 189
Spatial distribution, partitioning, and time trends of perfluorooctane sulfonate(PFOS) and perfluorooctanoate(PFOA) in Tokyo Bay, Japan, 2004-2006

Presenter : Sakurai T., Serizawa S., Isobe T., Kobayashi J., Kodama K., Kume G., Lee J-H., Maki H., Imaizumi Y., Suzuki N., Horiguchi T., Morita M., Shiraishi H.
Name of Society : SETAC North Am.31st Annu.Meet. (2010)
Name of Proceedings : Abstracts, 128
Evaluation estrogenic activity of river water discharged into Tokyo Bay using yeast two-hybrid assays incorporating human ERα or medaka ERα and using enzyme immunoassay

Presenter : Shiraishi F., Isobe T., Kim D.M., Nishikawa T., Maruo N.(*1), Furuta Y.(*1), Shiraishi H., Morita M.
Name of Society : China-Jpn.Jt.Symp.Environ.Chem.2004 (2004)
Name of Proceedings : Proceedings
Exposure factor questionnaire development for personal care product usage among children

Presenter : Takagi M., Isobe T., Iwai M., Kobayashi Y., Nakayama S.F.
Name of Society : ISES-ISEE2025 (2025)
Name of Proceedings : Abstracts
The National Human Biomonitoring Programme in Japan

Presenter : Nakayama S.F., Isobe T., Iwai-Shimada M., Takagi M., Kobayashi Y.
Name of Society : ISES-ISEE 2025 (2025)
Name of Proceedings : -
Determinants of plasma poly- and perfluoroalkyl substances during pregnancy: the Japan Environment and Children’s Study

Presenter : Lai Y., Nakayama S.F., Nishihama Y., Isobe T.
Name of Society : ISES-ISEE 2025 (2025)
Name of Proceedings : -
Association between essential and toxic elements in semen and sperm quality in Japanese men

Presenter : Iwai-Shimada M., Iwai K., Tatsuta N., Isobe T., Takagi M., Kobayashi Y., Nakayama S.F., Kumazawa Y., Takahashi K., Tanaka T., Terada Y., Nomura K., Okada H., Tamakoshi A., Maeda E.
Name of Society : Joint Annual Meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology 2025 (2025)
Name of Proceedings : Abstracts
Semi-automated sample preparation and high-throughput determination of PFAS in plasma

Presenter : Isobe T., Iwai K., Yamaji T., Ono A., Iwasaki M., Inoue M., Tsugane S., Sawada N., Nguyen T., Nakayama S.F.
Name of Society : ISES-ISEE2025 (2025)
Name of Proceedings : Abstracts
Intervention Trial for Pharmacokinetic Study of Chemicals in Daily Use Products

Presenter : Isobe T., Ueyama J., Iwai M., Takagi M., Oguri T., Shinohara N., Kunisue T., Nakayama K., Tanoue R., Nakayama S.f.
Name of Society : 21st International Symposium on Toxicity Assessment (2024)
Name of Proceedings : Abstracts
Exposure Assessment in Japan Environment and Children’s Study (JECS)

Presenter : Isobe T., Nakayama S.f., Iwai M., Kobayashi Y., Takagi M.
Name of Society : 2024 National PFAS Conference (2024)
Name of Proceedings : -
DIETARY INTERVENTION TRIAL FOR PHARMACOKINETICS OF SELENONEINE IN HUMANS

Presenter : Kobayashi Y., Iwai M., Isobe T., Takagi M., Yamashita M, Nakayama S.f.
Name of Society : 9th International Symposium on Metallomics (2024)
Name of Proceedings : Abstracts, 123
Survey of personal care products usage of Japanese children

Presenter : Takagi M., Isobe T., Iwai M., Kobayashi Y., Nakayama S.f.
Name of Society : ISES 2024 Annual Meeting (2024)
Name of Proceedings : Abstracts
Study design of less-invasive intervention trial for investigation of pharmacokinetics

Presenter : Isobe T., Ueyama J., Iwai M., Takagi M., Oguri T., Shinohara N., Kunisue T., Nakayama K., Tanoue R., Nakayama S.f.
Name of Society : ISES 2024 Annual Meeting (2024)
Name of Proceedings : -
Project HERO: Impact of Artificial Habitats and Environmental contaminants on Chronic Respiratory Diseases

Presenter : Sousa A.C.A., Namorado S., Jacinto H., Ramalhosa R., Assis D., Bonito R., Penha A., Morais M., Bravo J., Isobe T., Taborda-Barata L., Pastorinho M.R.
Name of Society : 4th Comprehensive Health Research Centre Annual Summit (2023)
Name of Proceedings : Abstracts
Determination of exposure factors including use of personal care products via web-based questionnaire

Presenter : Takagi M., Isobe T., Iwai M., Kobayashi Y., Nakayama S.F.
Name of Society : ISES2022 (2022)
Name of Proceedings : Abstracts
Link the Results of the Birth Cohort Study to Chemical Regulation

Presenter : Isobe T., Ueyama J., Iwai M., Takagi M., Oguri T., Shinohara N., Kunisue T., Nakayama K., Tanoue R., Nakayama S.F.
Name of Society : Impacts of early life exposure to environmental contaminants:children’s health in the Anthropocene (2022)
Name of Proceedings : Abstracts
High-sensitive determination method of insect repellents and its metabolites in human urine by solid-phase extraction and high-performance liquid chromatography-tandem mass spectrometry

Presenter : Nishihara N., Isobe T., Takagi M., Nakayama S.F., Iwai M., Kunisue T., Oguri T., Saito I., Ueyama J.
Name of Society : Impacts of early life exposure to environmental contaminants:children’s health in the Anthropocene (2022)
Name of Proceedings : Abstracts
Developing a Japanese Exposure Factors Database

Presenter : Takagi M., Isobe T., Iwai M., Kobayashi Y., Nakayama S.F.
Name of Society : Impacts of early life exposure to environmental contaminants:children’s health in the Anthropocene (2022)
Name of Proceedings : Abstracts
Environmental measurements in the Sub-Cohort Study of the Japan Environment and Children’s Study (JECS)

Presenter : Nishihama Y., Nakayama S.F., Isobe T.
Name of Society : Impacts of early life exposure to environmental contaminants: children’s health in the Anthropocene (2022)
Name of Proceedings : Impacts of early life exposure to environmental contaminants: children’s health in the Anthropocene Abstracts Book
A recommended practice for determining the intraclass correlation coefficient of a urinary biomarker: in case of organophosphate metabolites in pre-school children

Presenter : Nishihama Y., Isobe T., Nakayama S.F.
Name of Society : ISES2021 Virtual conference (2021)
Name of Proceedings : -
Method optimisation of the measurement of airborne particulate matters for a large-scale cohort study

Presenter : Nishihama Y., Tamura K., Isobe T., Nakayama S.F.
Name of Society : The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021) (2021)
Name of Proceedings : -
Defining co-exposures of blood heavy metals in Japanese pregnant women

Presenter : JUNG C., Isobe T., Iwai M., Kobayashi Y., Nishihama Y., MA C., Nakayama S.F.
Name of Society : NYC Exposome Symposium (2020)
Name of Proceedings : -
Environmental measurements in the Sub-Cohort Study of the Japan Environment and Children’s Study (JECS)

Presenter : Nishihama Y., Isobe T., Tamura K., Iwai M., Michikawa T., Yamazaki S., Nitta H., Takeuchi A., Kobayashi Y., Suda E., Sekiyama M., Ono M., Yonemoto J., Kawamoto T., Nakayama S.F.
Name of Society : ISES ISIAQ 2019 (2019)
Name of Proceedings : Abstracts, 301
Levels and profiles of endocrine disrupting chemicals in human urine from India, Indonesia, and Vietnam

Presenter : Kunisue T., Uchikawa A., Tanoue R., Nguyen T. M., Isobe T., Subramanian A., Sudaryanto A., Viet P.H., Tanabe S.
Name of Society : 39th International Symposium on Halogenated Persistent Organic Pollutants (2019)
Name of Proceedings : Abstracts, 761
Chemtheatre: opendata platform for environmental monitoring of pops and other contaminants

Presenter : Isobe T., Nakayama K., Uno S., Handoh I.C., Ohno N., Kunisue T.
Name of Society : Society of Environmental Toxicology and Chemistry Asia-Pacific 2018 Conference (2018)
Name of Proceedings : Abstracts, 82
Daily Intakes of Phthalates among Japanese Children

Presenter : Takagi M., Isobe T., Iwai-Shimada M., Nakayama SF.
Name of Society : ISES-ISEE 2018 Joint Annual Meeting (2018)
Name of Proceedings : Abstracts, 1539
Japan Environment and Children’s Study (JECS): Baseline characteristics of mothers, fathers, and their children

Presenter : Michikawa T., Nitta H., Nakayama S., Yamazaki S., Isobe T., Tamura K., Suda E., Ono M., Yonemoto J., Iwai M., Kobayashi Y., Suzuki G., Kawamoto T.
Name of Society : The 21st international Epidemiological Association, World Congress of Epidemiology (2017)
Name of Proceedings : Abstracts, 116
Temporal trends of brominated flame retardants and organochlorines in melon-headed whales stranded along the Japanese coastal waters: utilization of samples and data stored in es-BANK and ChemTHEATRE

Presenter : Kunisue T., Egashira K., Isobe T., Nakayama K., Tajima Y., Yamada T.K., Tanabe S.
Name of Society : 37th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - DIOXIN 2017 (2017)
Name of Proceedings : Abstracts
Occurrence and potential sources of brominated/chlorinated dibenzo-p-dioxins in mussels from the Seto Inland Sea, Japan

Presenter : Goto A., Tue N.M., Someya M., Isobe T., Takahashi S., Tanabe S., Kunisue T.
Name of Society : 37th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - DIOXIN 2017 (2017)
Name of Proceedings : Abstracts
Developmental exposure to tetrabromobisphenol A (TBBPA) on late onset behavior and neurological biomarkers in adult mice

Presenter : Tin-Tin-Win-Shwe, Sano K., Isobe T., Kawashima T., Suzuki G., Hashimoto S., Nakayama S., Maekawa F.
Name of Society : The 40th Annual Meeting of the Japan Neuroscience Society (2017)
Name of Proceedings : Abstract, 218
Indoor dust ingestion rate for Japanese children

Presenter : Takagi M., Isobe T., Iwai M., Nakayama S.
Name of Society : International Society of Exposure Science (ISES) 27th Annual Meeting (2017)
Name of Proceedings : Abstracts, 314-315
Effects of perinatal exposure to a phosphate ester flame retardant on novel object recognition ability and memory function-related gene expression in adult mice

Presenter : Tin-Tin-Win-Shwe, Sano K., Isobe T., Kawashima T., Suzuki G., Hashimoto S., Nakayama S., Maekawa F.
Name of Society : 45th Myanmar Health Research Congress (2017)
Name of Proceedings : Abstract, 120
Comprehensive analysis of house dust using GC×GC-HRTOFMS and in-house software

Presenter : Ieda T., Hashimoto S., Takazawa Y., Tanabe K., Zushi Y., Shibata Y., Maekawa F., Sano K., Suzuki G., Nakayama S., Isobe T., Tin-Tin-Win-Shwe, Kawashima T.
Name of Society : DIOXIN2016 (2016)
Name of Proceedings : Abstracts
Evaluation of Bioaccessibility of PCBs, PBDEs and HBCDs in Indoor Dust: The Japan Environment and Children

Presenter : Isobe T., Takagi M., Suzuki G., Ikegami A., Kayama F., Tsuji M., Senju A., Morokuma S., Sanefuji M., Oda M., Mitsubuchi H., Kato T., Nakayama S.
Name of Society : The 36th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2016) (2016)
Name of Proceedings : Abstracts
Perinatal exposure to a phosphate ester flame retardant affects memory function and related gene expression in adult mice

Presenter : Tin-Tin-Win-Shwe, Sano K., Isobe T., Kawashima T., Suzuki G., Hashimoto S., Nakayama S., Maekawa F.
Name of Society : The 5th Annual Meeting of The Japan Society for Developmental Origins of Health and Disease (DOHaD-Japan) (2016)
Name of Proceedings : Abstract(P-07), 40
Management of the environmental monitoring data by ChemTHEATRE, a database for environmental contaminants

Presenter : Isobe T., Nakayama K., Uno S., Ohno N., Hando I., Kunisue T.
Name of Society : The 19th Annual Meeting of Japan Society Endocrine Disruptors Research (2016)
Name of Proceedings : Program and Abstracts, 88
Levels of the obesogen tributyltin and other selected organotin compounds in house dust and duplicate diet samples from Portugal

Presenter : Sousa A.C.A., Isobe T., Coelho S., Pastorinho R.M., Taborda-Barata L., Nogueira A.J.A., Kunisue T., Takahashi S., Tanabe S.
Name of Society : 5th Conference on Prenatal Programming and Toxicity (pptoxV) (2016)
Name of Proceedings : Abstracts
Glucocorticoid receptor (GR) agonist profiling in the effluents from sewage treatment plants in Japan

Presenter : Suzuki G., Sato K., Isobe T., Brouwer A., Nakayama K.
Name of Society : SETAC North America 35th Annual Meeting (2014)
Name of Proceedings : Abstracts, 261
Risk evaluation of glucocorticoids discharged from sewage treatment plants in Japan: Effects on the response to bacterial infection in fish

Presenter : Nakayama K., Sato K., Ikeda H., Imajuku D., Kitamura S., Isobe T., Suzuki G.
Name of Society : SETAC North America 35th Annual Meeting (2014)
Name of Proceedings : Abstarcts of SETAC North America 35th Annual Meeting, 284-285
Exposomics: A key approach for next generation children’s environmental health studies

Presenter : Nakayama S.F., Isobe T., Suzuki Y., Takagi M.
Name of Society : SETAC North America 35th Annual Meeting (2014)
Name of Proceedings : -

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Japan Environment and Children’s Study: Its Progress and Future

Presenter : Isobe T., Nakayama S.F.
Name of Society : the International Symposium on Children’s Environmental Health Birth Cohort (2021)
Name of Proceedings : -
How to Work Exposure Assessment-Large Scale Birth Cohort and Exposomics-

Presenter : Isobe T., Iwai M., Nakayama S.F.
Name of Society : The International Conference on Occupational and Environmental Diseases: ICOED (2018)
Name of Proceedings : -
Japan Environment and Children’s Study (JECS): Current Status (2017)

Presenter : Isobe T., Nakayama S., Mezawa H., Terashima K.
Name of Society : 2017 International Childhood Cancer Cohort Consortium Workshop (I4C) (2017)
Name of Proceedings : -
Japan Environment and Children’s Study (JECS): Current Status (2016)

Presenter : Isobe T., Nakayama S.
Name of Society : Ninth International Childhood Cancer Cohort Consortium Workshop (I4C) (2016)
Name of Proceedings : -
Japan Environment and Children’s Study (JECS) : Current Status (2018)

Presenter : Isobe T., Iwai M., Nakayama S.F., Mezawa H., Terashima K.
Name of Society : International Childhood Cancer Cohort Consortium (I4C) Childhood Leukemia International Consortium (CLIC) Joint Activities and Annual Meeting 2018 (2018)
Name of Proceedings : -
In vivo evaluation of a flame retardant having estrogenic activity using mouse model

Presenter : Sano K., Suzuki G., Htike N.T.T., Morishita M., Tin-Tin-Win-Shwe, Hashimoto S., Kawashima T., Isobe T., Nakayama S., Tsukahara S., Maekawa F.
Name of Society : Application of Recent Advances in Neuroscience to Environmental Health Research (2016)
Name of Proceedings : abstract, 1-4

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ISOBE Tomohiko

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