Latest Update：2026/03/24 10:41:41

Miyuki Iwai-Shimada

Researcher Name: Miyuki Iwai-Shimada

Div (Section) name/title: Health and Environmental Risk Division（Exposure Dynamics Research Section）／Senior Researcher

Research Subject: Environmental Health Sciences, Toxicology

Degree(s): Ph.D.

Professional Qualification(s): Pharmacy,Medicine,Biochemistry

Environmental Speciality Field: Environmental Health Sciences,Toxicology,Exposure Science

Keyword(s): Methylmercury,Toxic metals,Environmental pollutants,Human Biomonitoring,Deciduous teeth

Membership of Academic Society: The Japanese Society for Hygiene,The pharmaceutical society of japan,The Japanese Society of Toxicology,Japan Epidemiological Association,Japanese Society of Public Health,International Society of Exposure Science

Research Subject

Fiscal Year: 2025
- 27218 : Research project on comprehensive analysis of all substances of concern
- 27254 : Japan Environment and Children
- 27420 : Exposure Dynamics Research
- 27472 : Management expenses for mercury research
- 27549 : Research contributing to the advancement of nutritional science for the development of Dietary Reference Intakes for Japanese
- 27550 : Development of health maintenance/disease risk management system in space based on trace element profile
Fiscal Year: 2024
- 26832 : Research project on comprehensive analysis of all substances of concern
- 26877 : Japan Environment and Children
- 27036 : Management expenses for mercury research
- 27116 : Exposure Dynamics Research
- 27117 : JST COI-NEXT: Establishing A Research Hub for Environmental Health/Medicine of Future Generations Utilising Digital Bio-Information and Artificial Intelligence
- 27177 : Research contributing to the advancement of nutritional science for the development of Dietary Reference Intakes for Japanese
- 27178 : Development of health maintenance/disease risk management system in space based on trace element profile
Fiscal Year: 2023
- 26422 : Research project on comprehensive analysis of all substances of concern
- 26460 : Japan Environment and Children
- 26522 : Exposure Dynamics Research
- 26523 : JST COI-NEXT: Establishing A Research Hub for Environmental Health/Medicine of Future Generations Utilising Digital Bio-Information and Artificial Intelligence
- 26524 : The actual state of lead exposure in Japan and its impact on pediatric neurodevelopment
- 26525 : Trajectories of chemical exposure from fetal to infancy: Development of a deciduous tooth analysis method.
- 26609 : Management expenses for mercury research
Fiscal Year: 2022
- 25975 : Research project on comprehensive analysis of all substances of concern
- 26024 : Japan Environment and Children
- 26058 : Exposure Dynamics Research
- 26059 : Systematic Development of Pharmacokinetic and Exposure Reconstruction Models for Chemicals of Personal Use
- 26152 : Management expenses for mercury research
- 26196 : JST COI-NEXT: Establishing A Research Hub for Environmental Health/Medicine of Future Generations Utilising Digital Bio-Information and Artificial Intelligence
- 26271 : Methylmercury exposure assessment after birth
- 26274 : The actual state of lead exposure in Japan and its impact on pediatric neurodevelopment
- 26395 : Trajectories of chemical exposure from fetal to infancy: Development of a deciduous tooth analysis method.
Fiscal Year: 2021
- 25519 : Research project on comprehensive analysis of all substances of concern
- 25557 : Japan Environment and Children
- 25598 : Systematic Development of Pharmacokinetic and Exposure Reconstruction Models for Chemicals of Personal Use
- 25639 : Exposure Dynamics Research
- 25643 : Methylmercury exposure assessment after birth
- 25808 : Management expenses for mercury research
Fiscal Year: 2020
- 25099 : Research Program on Health and Environmental Safety
- 25123 : Japan Environment and Children
- 25141 : Research Project on Health Impacts of Chemicals on Children and Future Generations
- 25142 : Project to Develop Integrated Approaches to Detecting and Assessment of Multiple and Unknown Chemicals, and Building Environmental Monitoring Networks
- 25206 : Systematic Development of Pharmacokinetic and Exposure Reconstruction Models for Chemicals of Personal Use
- 25216 : Exposure Dynamics Research
- 25348 : Determination of prenatal and postnatal exposure to toxic and trace elements using deciduous teeth and the identification of critical windows of their effects
- 25349 : Mehtylmercury exposure assessment for neonate to infant
- 25353 : Study on Global Mercury Dynamics and Risk Management of Mercury
Fiscal Year: 2019
- 24696 : Research Program on Health and Environmental Safety
- 24721 : Research Project on Health Impacts of Chemicals on Children and Future Generations
- 24722 : Project to Develop Integrated Approaches to Detecting and Assessment of Multiple and Unknown Chemicals, and Building Environmental Monitoring Networks
- 24755 : Japan Environment and Children's Study
- 24760 : Exposure Dynamics Research
- 24937 : Determination of prenatal and postnatal exposure to toxic and trace elements using deciduous teeth and the identification of critical windows of their effects
- 24978 : Study on Global Mercury Dynamics and Risk Management of Mercury
Fiscal Year: 2018
- 24304 : Research project on health impacts of chemicals on children and future generations
- 24305 : Project to develop integrated approaches to detecting and assessment of multiple and unknown chemicals, and building environmental monitoring networks
- 24338 : Japan Environment and Children
- 24355 : Research program on health and environmental safety
- 24499 : Exposure dynamics research
- 24556 : Study on global mercury dynamics and risk management of mercury
Fiscal Year: 2017
- 23823 : Project to develop integrated approaches to detecting and assessment of multiple and unknown chemicals, and building environmental monitoring networks
- 23824 : Research project on health impacts of chemicals on children and future generations
- 23847 : Research program on health and environmental safety
- 23859 : Japan Environment and Children
- 24147 : Exposure dynamics research
Fiscal Year: 2016
- 23414 : Research program on health and environmental safety
- 23415 : Research project on health impacts of chemicals on children and future generations
- 23416 : Project to develop integrated approaches to detecting and assessment of multiple and unknown chemicals, and building environmental monitoring networks
- 23441 : Japan Environment and Children's Study
- 23551 : The Role of cholesterol hydroxylase against methylmercury-induced neurotoxic effect
- 23612 : Exposure dynamics research

View all

Research Result (Publication)

all
Original Paper
Review
Other Publications

Original Paper
Serum mercury, lead, cadmium, and arsenic and incidence of type 2 diabetes among adults: A nested case–control study

Presenter : Ito A., Yamamoto S., Iwai M., Kobayashi Y., Isobe T., Iwai K., Nakayama S.F., Konishi M., Yamamoto S., Nakagawa T., Yamazaki S., Mizoue T.
Title : , Clinical Nutrition, 57:106563 (2026)
Original Paper
High-throughput mercury speciation analysis of breast milk using HPLC-ICP-MS

Presenter : Iwai K., Iwai-Shimada M., Tatsuta N., Kobayashi Y., Asato K., Nishimoto M., Nakai K., Nakayama S.f.
Title : , Microchemical Journal, 211(113142): (2025)
Original Paper
Direct and indirect effects of smoking during pregnancy on child development: The Japan Environment and Children’s Study

Presenter : Tatsuta N., Nakai K., Sekiyama M., Taniguchi Y., Iwai M., Takagi M., Kobayashi Y., Isobe T., Nakayama S.F., Yamazaki S.
Title : , Scientific Reports, 15(18053): (2025)
Original Paper
Human hair certified reference material for total mercury, methylmercury, and trace element analyses

Presenter : Yamakawa A., Nagano K., Onishi K., Ukachi M., Ieda T., Kobayashi M., Sano T., Iwai M., Iwai K., Amouroux D., Tessier E., Horvat M., Alilovic A., Klemencic P., Begu E., Hudobivnik M.J., Matthew R., Haraguchi K., Li P., Rodriguez-Gonzalez P., Suarez-Criado L., Hu L., Takeda N., Li Y.-F., Uchida K.
Title : , Accreditation and Quality Assurance, 30:277-290 (2025)
Original Paper
Intra-day and inter-day variations of methylmercury and inorganic mercury concentrations in breast milk

Presenter : Tatsuta N., Iwai M., Asato K., Iwai K., Nakai K.
Title : , Environmental Research, 285(122736): (2025)
Original Paper
Nutritional Status and Associated Factors Among Women in the Third Trimester of Pregnancy

Presenter : Uchida S., Tatsuta N., Asato K., Hara Y., Iwai M., Nakai K., Omori J.
Title : , Reproductive, Female and Child Health, 4(e70036): (2025)
Original Paper
Association between exposure to perfluoroalkyl compounds during early pregnancy and risk of late miscarriage: The Japan Environment and Children’s Study

Presenter : Tatsuta N., Iwai M., Isobe T., Nakayama S.F., Sekiyama M., Takagi M., Kobayashi Y., Taniguchi Y., Yamazaki S.
Title : , International Journal of Hygiene and Environmental Health, 270(114673): (2025)
Original Paper
Determination of skin-insect repellent icaridin and DEET in human urine using solid-phase extraction and liquid chromatography with tandem mass spectrometry and its application to a sample of Japanese adults

Presenter : Nishihara N., Isobe T., Takagi M., Tajima T., Kitahara Y., Hayashi M., Saito I., Watanabe S., Iwai M., Ueyama J.
Title : , Environmental Health and Preventive Medicine, 30:18 (2025)
Original Paper
Urinary concentrations and elimination half-lives of parabens, benzophenones, bisphenol and triclosan in Japanese young adults

Presenter : Nguyen T., Isobe T., Iwai M., Takagi M., Ueyama J., Oura K., Tanoue R., Kunisue T., Nakayama S.f.
Title : , Chemosphere, 349:140920 (2024)
Original Paper
Dietary intake of methylmercury by 0-5 years children using the duplicate diet method in Japan

Presenter : Tatsuta N., Asato K., Iwai M., Iwai K., Nakayama S.f., Yamazaki S., Nakai K.
Title : , Environmental Health and Preventive Medicine, 29(27): (2024)
Original Paper
Association between prenatal mercury exposure and pediatric neurodevelopment: The Japan environment and children's study

Presenter : Kuraoka S., Oda M., Ohba T., Mitsubuchi H., Iwai-Shimada M., Tatsuta N., Kamijima M., Nakamura K., Katoh T.
Title : , Science of the Total Environment, 957(177489): (2024)
Original Paper
Prenatal mercury exposure and the secondary sex ratio: The Japan Environment and Children’s Study

Presenter : Hasegawa K., Inaba Y., Toubou H., Shibazaki T., Iwai-Shimada M., Yamazaki S., Kamijima M., Tsukahara T., Nomiyama T.
Title : , Reproductive Toxicology, 130(108685): (2024)
Original Paper
Baseline Complete Blood Count and Chemistry Panel Profile from the Japan Environment and Children’s Study (JECS)

Presenter : Taniguchi Y., Yamazaki S., Nakayama S.F., Sekiyama M., Michikawa T, Isobe T., Iwai M., Kobayashi Y., Takagi M., Kamijima M
Title : , Int. J. Environ. Res. Public Health, 19(6):3277 (2022)
Original Paper
Intra- and Inter-Day Element Variability in Human Breast Milk: Pilot Study

Presenter : Iwai K., Iwai M., Kobayashi Y., Nakayama S.F., Asato K., Nakai K., Tatsuta N.
Title : , Toxics, 10(3):109 (2022)
Original Paper
Global DNA Methylation in Cord Blood as a Biomarker for Prenatal Lead and Antimony Exposures

Presenter : Okamoto Y., Iwai-Shimada M., Nakai K., Tatsuta N., Mori Y., Aoki A., Kojima N., Takada T., Satoh H., Jinno H.
Title : , Toxics, 10(157): (2022)
Original Paper
Association between whole blood metallic elements concentrations and gestational diabetes mellitus in Japanese women: The Japan environment and Children's Study

Presenter : Tatsuta N., Iwai-Shimada N., Nakayama S.F., Iwama N., Metoki H., Arima T., Sakurai K., Anai A., Asato K., Kuriyama S., Sugawara J., Suzuki K., Yaegashi N., Kamijima M., Nakai K.
Title : , Environmental Research, 212:113231 (2022)
Original Paper
Elemental Dynamics in Hair Accurately Predict Future Autism Spectrum Disorder Diagnosis: An International Multi‐Center Study

Presenter : Austin C., Curtin P., Arora M., Reichenberg A., Curtin A., Iwai-Shimada M., Wright R.O., Wright R.J., Remnelius K.L., Isaksson J., Bolte S., Nakayama S.F.
Title : , Journal of Clinical Medicine, 11:7154 (2022)
Original Paper
Maternal Metals Exposure and Infant Weight Trajectory: The Japan Environment and Children’s Study (JECS)

Presenter : Taniguchi Y., Yamazaki S., Nakayama S.F., Sekiyama M., Michikawa T., Isobe T., Iwai M., Kobayashi Y., Nitta H.
Title : , Environmental Health Perspectives, 130(12): (2022)
Original Paper
Exposure to heavy metals modifies optimal gestational weight gain: A large nationally representative cohort of the Japan Environment and Children’s Study

Presenter : Jung C., Nakayama S.F., Isobe T., Iwai-Shimada M., Kobayashi Y., Nishihama Y., Michikawa T., Sekiyama M., Taniguchi Y., Nitta H., Yamazaki S.
Title : , Environment International, 146:106276 (2021)
Original Paper
Comparison of Simultaneous Quantitative Analysis of Methylmercury and Inorganic Mercury in Cord Blood Using LC-ICP-MS and LC-CVAFS: The Pilot Study of the Japan Environment and Children’s Study

Presenter : Iwai-Shimada M., Kobayashi Y., Isobe T., Nakayama S.F., Sekiyama M., Taniguchi Y., Yamazaki S., Michikawa T., Oda M., Mitsubuchi H., Sanefuji M., Ohga S., Mise N., Ikegami A., Suga R., Shimono M.
Title : , Toxics, 9(82): (2021)
Original Paper
Cold Spells and Cause-Specific Mortality in 47 Japanese Prefectures: A Systematic Evaluation

Presenter : Ma C., Yang J., Nakayama S.F., Iwai-Shimada M., Jung C., SUN X. L., Honda Y.
Title : , Environmental Health Perspectives, 129(6):067001-1-067001-10 (2021)
Original Paper
Association of prenatal exposure to cadmium with neurodevelopment in children at 2 years of age: The Japan Environment and Children's Study

Presenter : Ma C., Iwai-Shimada M., Nakayama S.F., Isobe T., Kobayashi Y., Tatsuta N., Taniguchi Y., Sekiyama M., Michikawa T., Yamazaki S., Kamijima M.
Title : , Environment International, 156(106762): (2021)
Original Paper
Indoor air quality of 5,000 households and its determinants. Part B: Volatile organic compounds and inorganic gaseous pollutants in the Japan Environment and Children's study

Presenter : Jung C., Nishihama Y., Nakayama S.F., Tamura K., Isobe T., Michikawa T., Iwai-Shimada M. , Kobayashi Y., Sekiyama M., Taniguchi Y., Yamazaki S.
Title : , Environmental Research, 197:111135 (2021)
Original Paper
Indoor air quality of 5,000 households and its determinants. Part A: Particulate matter (PM2.5 and PM10-2.5) concentrations in the Japan Environment and Children's Study

Presenter : Nishihama Y., Jung C., Nakayama S.F., Tamura K., Isobe T., Michikawa T., Iwai-Shimada M., Kobayashi Y., Sekiyama M., Taniguchi Y., Yamazaki S.
Title : , Environmental Research, 198:111196 (2021)
Original Paper
Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children's Study (JECS)

Presenter : Nishihama Y., Nakayama S.F., Isobe T., Jung CR., Iwai-Shimada M., Kobayashi Y., Michikawa T., Sekiyama M., Taniguchi Y., Yamazaki S.
Title : , International Journal of Environmental Research and Public Health, 18(11):5929 (2021)
Original Paper
The association between gestational use of personal care products and neonatal urological abnormality at birth: The Japan Environment and Children's Study

Presenter : Nishihama Y., Tatsuta N., Iwai-Shimada M., Nakai K., Arima T., Fujiwara I., Yaegashi N., Takeuchi A., Nakayama S.F.
Title : , Reproductive Toxicology, 93:83-88 (2020)
Original Paper
Health Risk Assessment and Source Apportionment of Mercury, Lead, Cadmium, Selenium, and Manganese in Japanese Women: An Adjunct Study to the Japan Environment and Children’s Study

Presenter : MA C., Iwai M., Tatsuta N., Nakai K., Isobe T., Takagi M., Nishihama Y., Nakayama S.F.
Title : , International Journal of Environmental Research and Public Health, 17(7):2231 (2020)
Original Paper
Maternal dietary intake of vitamin A during pregnancy was inversely associated with congenital diaphragmatic hernia: the Japan Environment and Children’s Study

Presenter : Michikawa T., Yamazaki S., Sekiyama M., Kuroda T., Nakayama S.F., Isobe T., Kobayashi Y., Iwai M., Suda E., Kawamoto T., Nitta H.
Title : , British Journal of Nutrition, 122(11):1295-1302 (2020)
Original Paper
Poly- and perfluoroalkyl substances in maternal serum: Method development and application in Pilot Study of the Japan Environment and Children's Study

Presenter : Nakayama S.F., Isobe T., Iwai-Shimada M., Kobayashi Y., Nishihama Y., Taniguchi Y., Sekiyama M., Michikawa T., Yamazaki S., Nitta H., Oda M., Mitsubuchi H., Sanefuji M., Ohga S., Mise N., Ikegami A., Suga R., Shimono M.
Title : , Journal of Chromatography A, 1618:460933 (2020)
Original Paper
Estimated postnatal p,p'-DDT and p,p'-DDE levels and body mass index at 42 months of age in a longitudinal study of Japanese children

Presenter : Plouffe L., Bosson-Rieutort D., Madaniyazi L., Iwai-Shimada M., Nakai K., Tatsuta N., Nakayama S.F., Verner M.A.
Title : , Environmental Health, 19(1):49 (2020)
Original Paper
Prenatal and postnatal lead exposures and intellectual development among 12-year-old Japanese children

Presenter : Tatsuta N., Nakai K., Kasanuma Y., Iwai-Shimada M., Sakamoto M., Murata K., Satoh H.
Title : , Environmental Research, 189(109844): (2020)
Original Paper
Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS)

Presenter : Nishihama Y., Nakayama S.F., Tabuchi T., Isobe T., Jung C., Iwai-Shimada M., Kobayashi Y., Michikawa T., Sekiyama M., Taniguchi Y., Nitta H., Yamazaki S.
Title : , International Journal of Environmental Research and Public Health, 17(15):5537 (2020)
Original Paper
Maternal intake of one-carbon metabolism-related B vitamins and anorectal malformations in the Japan Environment and Children’s Study

Presenter : Michikawa T., Nitta H., Sekiyama M., Kuroda T., Nakayama S.F., Isobe T., Kobayashi Y., Iwai M., Suda E., Taniguchi Y., Kawamoto T., Yamazaki S.
Title : , British Journal of Nutrition, 124(8):865-873 (2020)
Original Paper
Study Design and Participants’ Profile in the Sub-Cohort Study in the Japan Environment and Children’s Study (JECS)

Presenter : Sekiyama M., Yamazaki S., Michikawa T., Nakayama S.F., Nitta H., Taniguchi Y., Suda E., Isobe T., Kobayashi Y., Iwai M., Ono M., Tamura K., Yonemoto J., Kawamoto K., Kamijima M
Title : , Journal of Epidemiology (2020)
Original Paper
Dioxins levels in human blood after implementation of measures against dioxin exposure in Japan

Presenter : Muzembobasilua A., Iwai-Shimada M., Isobe T., Arisawa K., Shima M., Fukushima T., Nakayama S.F.
Title : , Environmental Health and Preventive Medicine, 24(6): (2019)
Original Paper
Isoflavone Intake in Early Pregnancy and Hypospadias in the Japan Environment and Children's Study

Presenter : Michikawa T., Yamazaki S., Ono M., Kuroda T., Nakayama S.F., Suda E., Isobe T., Iwai M., Kobayashi Y., Yonemoto J., Tamura K., Kawamoto T., Nitta H.
Title : , Urology, 124:229-236 (2019)
Original Paper
Fish consumption in early pregnancy and congenital gastrointestinal tract atresia in the Japan Environment and Children’s Study

Presenter : Michikawa T., Yamazaki S., Ono M., Kuroda T., Nakayama S.F., Suda E., Isobe T., Iwai M., Kobayashi Y., Tamura K., Yonemoto J., Kawamoto T., Nitta H.
Title : , British Journal of Nutrition, 121(1):100-108 (2019)
Original Paper
For making a declaration of countermeasures against the falling birth rate from the Japanese Society for Hygiene: summary of discussion in the working group on academic research strategy against an aging society with low birth rate

Presenter : Nomura K., Karita K., Araki A., Nishioka E., Muto G., Iwai-Shimada M., NIshikitani M., Inoue M., Tsurugano S., Kitano N., Tsuji M., Iijima S., Ueda K., Kamijima M., Yamagata Z., Sakata K., Iki M., Yanagisawa H., Kato M., Inadera H., Kokubo Y., Yokoyama K., Koizumi A., Otsuki T.
Title : , Environmental Health and Preventive Medicine, 24(14): (2019)
Review
Worldwide trends in tracing poly- and perfluoroalkyl substances (PFAS) in the environment

Presenter : Nakayama S.F., Yoshikane M., Onoda Y., Nishihama Y., Iwai-Shimada M., Takagi M., Kobayashi Y., Isobe T.
Title : , TrAC Trends in Analytical Chemistry, 121(115410): (2019)
Original Paper
Exposure profile of mercury, lead, cadmium, arsenic, antimony, copper, selenium and zinc in maternal blood, cord blood and placenta: the Tohoku Study of Child Development in Japan

Presenter : Iwai-Shimada M., Kameo S., Nakai K., Yaginuma-Sakurai K., Tatsuta N., Kurokawa N., Nakayama S.F., Satoh H.
Title : , Environmental Health and Preventive Medicine, 24(35): (2019)
Original Paper
Induction of chemokine CCL3 by NF-κB reduces methylmercury toxicity in C17.2 mouse neural stem cells

Presenter : Takahashi T., Kim MS., Iwai-Shimada M., Hoshi T., Fujiwara M., Toyama T., Fujiwara Y., Naganuma A., Hwang GW.
Title : , Environmental Toxicology and Pharmacology, 71(103216): (2019)
Original Paper
Blood mercury, lead, cadmium, manganese and selenium levels in pregnant women and their determinants: the Japan Environment and Children's Study (JECS)

Presenter : Nakayama S.F., Iwai-Shimada M., Oguri T., Isobe T., Takeuchi A., Kobayashi Y., Michikawa T., Yamazaki S., Nitta H., Kawamoto T.
Title : , Journal of Exposure Science and Environmental Epidemiology, 29(5):633-647 (2019)
Original Paper
Benefits of cooperation among large-scale cohort studies and human biomonitoring projects in environmental health research: An exercise in blood lead analysis of the Environment and Child Health International Birth Cohort Group

Presenter : Nakayama S.F., Espina C., Kamijima M., Magnus P., Charles MA., Zhang J., Wolz B., Conrad A., Murawski A., Iwai-Shimada M., Zaroz C., Caspersen I.H., Kolossa-Gehring M., Meltzer H.M., Olsen S.F., Etzel R.A., Schuz J.
Title : , International Journal of Hygiene and Environmental Health, 222(8):1059-1067 (2019)
Original Paper
Variability and reliability of POP concentrations in multiple breast milk samples collected from the same mothers

Presenter : Kakimoto R., Ichiba M., Matsumoto A., Nakai K., Tatsuta N., Iwai M., Ishiyama M., Ryuda N., Someya T., Tokumoto I., Ueno D.
Title : , Environmental Science and Pollution Research, 1-7 (2018)
Original Paper
Chemokine CCL4 Induced in Mouse Brain Has a Protective Role against Methylmercury Toxicity

Presenter : Takahashi T., Kim M.S., Iwai M., Fujimura M., Toyama T., Naganuma A., Hwang G.W.
Title : , Toxics, 6(36):2-9 (2018)
Original Paper
Questionnaire results on exposure characteristics of pregnant women participating in the Japan Environment and Children’s Study

Presenter : Iwai-Shimada M., Nakayama S.F., Isobe T., Michikawa T., Yamazaki S., Nitta H., Takeuchi A., Kobayashi Y., Tamura K., Suda E., Ono M., Yonemoto J., Kawamoto T.
Title : , Environmental Health and Preventive Medicine, 23(1):45 (2018)
Original Paper
Total mercury levels in hair of children aged 7 years before and after the Great East Japan Earthquake

Presenter : Tatsuta N., Nakai K., Iwai-Shimada M., Suzuki T., Satoh H., Murata K.
Title : , Science of the Total Environment, 596-597:207-211 (2017)
Original Paper
Effects of intrauterine exposures to polychlorinated biphenyls, methylmercury,and lead on birth weight in Japanese male and female newborns

Presenter : Tatsuta N., Kurokawa N., Nakai K., Suzuki K., Iwai-Shimada M., Murata K., Satoh H.
Title : , Environmental Health and Preventive Medicine, 22(39):1-8 (2017)
Original Paper
Psychomotor Ability in Children Prenatally Exposed to Methylmercury: The 18-Month Follow-Up of Tohoku Study of Child Development

Presenter : Tatsuta N., Murata K., Iwai-Shimada M., Yaginuma-Sakurai K., Satoh H., Nakai K.
Title : , The Tohoku Journal of Experimental Medicine, 242:1-8 (2017)
Other Publications
Baseline Profile of Participants in the Japan Environment and Children

Presenter : Michikawa T., Nitta H., Nakayama S., Yamazaki S., Isobe T., Tamura K., Suda E., Ono M., Yonemoto J., Iwai M., Kobayashi Y., Suzuki G., Kawamoto T.
Title : , Journal of Epidemiology (2017)
Original Paper
A methodological consideration for blood lead concentrations obtained from the earlobe in Japanese adults occupationally unexposed to lead

Presenter : Tatsuta N, Nakai K, Iwai-Shimada M., Mizutani F, Murata K., Chisaki Y., Satoh H.
Title : , Environmental Health and Preventive Medicine, 22(78):1-5 (2017)
Original Paper
Methylmercury induces the expression of TNF-α selectively in the brain of mice

Presenter : Iwai-Shimada M., Takahashi T., Kim M.S., Fujimura M., Ito H., Toyama T., Naganuma A., Hwang G.W.
Title : , Scientific Reports, 6(38294): (2016)

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Serum mercury, lead, cadmium, and arsenic and incidence of type 2 diabetes among adults: A nested case–control study

Presenter : Ito A., Yamamoto S., Iwai M., Kobayashi Y., Isobe T., Iwai K., Nakayama S.F., Konishi M., Yamamoto S., Nakagawa T., Yamazaki S., Mizoue T.
Title : , Clinical Nutrition, 57:106563 (2026)
High-throughput mercury speciation analysis of breast milk using HPLC-ICP-MS

Presenter : Iwai K., Iwai-Shimada M., Tatsuta N., Kobayashi Y., Asato K., Nishimoto M., Nakai K., Nakayama S.f.
Title : , Microchemical Journal, 211(113142): (2025)
Direct and indirect effects of smoking during pregnancy on child development: The Japan Environment and Children’s Study

Presenter : Tatsuta N., Nakai K., Sekiyama M., Taniguchi Y., Iwai M., Takagi M., Kobayashi Y., Isobe T., Nakayama S.F., Yamazaki S.
Title : , Scientific Reports, 15(18053): (2025)
Human hair certified reference material for total mercury, methylmercury, and trace element analyses

Presenter : Yamakawa A., Nagano K., Onishi K., Ukachi M., Ieda T., Kobayashi M., Sano T., Iwai M., Iwai K., Amouroux D., Tessier E., Horvat M., Alilovic A., Klemencic P., Begu E., Hudobivnik M.J., Matthew R., Haraguchi K., Li P., Rodriguez-Gonzalez P., Suarez-Criado L., Hu L., Takeda N., Li Y.-F., Uchida K.
Title : , Accreditation and Quality Assurance, 30:277-290 (2025)
Intra-day and inter-day variations of methylmercury and inorganic mercury concentrations in breast milk

Presenter : Tatsuta N., Iwai M., Asato K., Iwai K., Nakai K.
Title : , Environmental Research, 285(122736): (2025)
Nutritional Status and Associated Factors Among Women in the Third Trimester of Pregnancy

Presenter : Uchida S., Tatsuta N., Asato K., Hara Y., Iwai M., Nakai K., Omori J.
Title : , Reproductive, Female and Child Health, 4(e70036): (2025)
Association between exposure to perfluoroalkyl compounds during early pregnancy and risk of late miscarriage: The Japan Environment and Children’s Study

Presenter : Tatsuta N., Iwai M., Isobe T., Nakayama S.F., Sekiyama M., Takagi M., Kobayashi Y., Taniguchi Y., Yamazaki S.
Title : , International Journal of Hygiene and Environmental Health, 270(114673): (2025)
Determination of skin-insect repellent icaridin and DEET in human urine using solid-phase extraction and liquid chromatography with tandem mass spectrometry and its application to a sample of Japanese adults

Presenter : Nishihara N., Isobe T., Takagi M., Tajima T., Kitahara Y., Hayashi M., Saito I., Watanabe S., Iwai M., Ueyama J.
Title : , Environmental Health and Preventive Medicine, 30:18 (2025)
Urinary concentrations and elimination half-lives of parabens, benzophenones, bisphenol and triclosan in Japanese young adults

Presenter : Nguyen T., Isobe T., Iwai M., Takagi M., Ueyama J., Oura K., Tanoue R., Kunisue T., Nakayama S.f.
Title : , Chemosphere, 349:140920 (2024)
Dietary intake of methylmercury by 0-5 years children using the duplicate diet method in Japan

Presenter : Tatsuta N., Asato K., Iwai M., Iwai K., Nakayama S.f., Yamazaki S., Nakai K.
Title : , Environmental Health and Preventive Medicine, 29(27): (2024)
Association between prenatal mercury exposure and pediatric neurodevelopment: The Japan environment and children's study

Presenter : Kuraoka S., Oda M., Ohba T., Mitsubuchi H., Iwai-Shimada M., Tatsuta N., Kamijima M., Nakamura K., Katoh T.
Title : , Science of the Total Environment, 957(177489): (2024)
Prenatal mercury exposure and the secondary sex ratio: The Japan Environment and Children’s Study

Presenter : Hasegawa K., Inaba Y., Toubou H., Shibazaki T., Iwai-Shimada M., Yamazaki S., Kamijima M., Tsukahara T., Nomiyama T.
Title : , Reproductive Toxicology, 130(108685): (2024)
Baseline Complete Blood Count and Chemistry Panel Profile from the Japan Environment and Children’s Study (JECS)

Presenter : Taniguchi Y., Yamazaki S., Nakayama S.F., Sekiyama M., Michikawa T, Isobe T., Iwai M., Kobayashi Y., Takagi M., Kamijima M
Title : , Int. J. Environ. Res. Public Health, 19(6):3277 (2022)
Intra- and Inter-Day Element Variability in Human Breast Milk: Pilot Study

Presenter : Iwai K., Iwai M., Kobayashi Y., Nakayama S.F., Asato K., Nakai K., Tatsuta N.
Title : , Toxics, 10(3):109 (2022)
Global DNA Methylation in Cord Blood as a Biomarker for Prenatal Lead and Antimony Exposures

Presenter : Okamoto Y., Iwai-Shimada M., Nakai K., Tatsuta N., Mori Y., Aoki A., Kojima N., Takada T., Satoh H., Jinno H.
Title : , Toxics, 10(157): (2022)
Association between whole blood metallic elements concentrations and gestational diabetes mellitus in Japanese women: The Japan environment and Children's Study

Presenter : Tatsuta N., Iwai-Shimada N., Nakayama S.F., Iwama N., Metoki H., Arima T., Sakurai K., Anai A., Asato K., Kuriyama S., Sugawara J., Suzuki K., Yaegashi N., Kamijima M., Nakai K.
Title : , Environmental Research, 212:113231 (2022)
Elemental Dynamics in Hair Accurately Predict Future Autism Spectrum Disorder Diagnosis: An International Multi‐Center Study

Presenter : Austin C., Curtin P., Arora M., Reichenberg A., Curtin A., Iwai-Shimada M., Wright R.O., Wright R.J., Remnelius K.L., Isaksson J., Bolte S., Nakayama S.F.
Title : , Journal of Clinical Medicine, 11:7154 (2022)
Maternal Metals Exposure and Infant Weight Trajectory: The Japan Environment and Children’s Study (JECS)

Presenter : Taniguchi Y., Yamazaki S., Nakayama S.F., Sekiyama M., Michikawa T., Isobe T., Iwai M., Kobayashi Y., Nitta H.
Title : , Environmental Health Perspectives, 130(12): (2022)
Exposure to heavy metals modifies optimal gestational weight gain: A large nationally representative cohort of the Japan Environment and Children’s Study

Presenter : Jung C., Nakayama S.F., Isobe T., Iwai-Shimada M., Kobayashi Y., Nishihama Y., Michikawa T., Sekiyama M., Taniguchi Y., Nitta H., Yamazaki S.
Title : , Environment International, 146:106276 (2021)
Comparison of Simultaneous Quantitative Analysis of Methylmercury and Inorganic Mercury in Cord Blood Using LC-ICP-MS and LC-CVAFS: The Pilot Study of the Japan Environment and Children’s Study

Presenter : Iwai-Shimada M., Kobayashi Y., Isobe T., Nakayama S.F., Sekiyama M., Taniguchi Y., Yamazaki S., Michikawa T., Oda M., Mitsubuchi H., Sanefuji M., Ohga S., Mise N., Ikegami A., Suga R., Shimono M.
Title : , Toxics, 9(82): (2021)
Cold Spells and Cause-Specific Mortality in 47 Japanese Prefectures: A Systematic Evaluation

Presenter : Ma C., Yang J., Nakayama S.F., Iwai-Shimada M., Jung C., SUN X. L., Honda Y.
Title : , Environmental Health Perspectives, 129(6):067001-1-067001-10 (2021)
Association of prenatal exposure to cadmium with neurodevelopment in children at 2 years of age: The Japan Environment and Children's Study

Presenter : Ma C., Iwai-Shimada M., Nakayama S.F., Isobe T., Kobayashi Y., Tatsuta N., Taniguchi Y., Sekiyama M., Michikawa T., Yamazaki S., Kamijima M.
Title : , Environment International, 156(106762): (2021)
Indoor air quality of 5,000 households and its determinants. Part B: Volatile organic compounds and inorganic gaseous pollutants in the Japan Environment and Children's study

Presenter : Jung C., Nishihama Y., Nakayama S.F., Tamura K., Isobe T., Michikawa T., Iwai-Shimada M. , Kobayashi Y., Sekiyama M., Taniguchi Y., Yamazaki S.
Title : , Environmental Research, 197:111135 (2021)
Indoor air quality of 5,000 households and its determinants. Part A: Particulate matter (PM2.5 and PM10-2.5) concentrations in the Japan Environment and Children's Study

Presenter : Nishihama Y., Jung C., Nakayama S.F., Tamura K., Isobe T., Michikawa T., Iwai-Shimada M., Kobayashi Y., Sekiyama M., Taniguchi Y., Yamazaki S.
Title : , Environmental Research, 198:111196 (2021)
Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children's Study (JECS)

Presenter : Nishihama Y., Nakayama S.F., Isobe T., Jung CR., Iwai-Shimada M., Kobayashi Y., Michikawa T., Sekiyama M., Taniguchi Y., Yamazaki S.
Title : , International Journal of Environmental Research and Public Health, 18(11):5929 (2021)
The association between gestational use of personal care products and neonatal urological abnormality at birth: The Japan Environment and Children's Study

Presenter : Nishihama Y., Tatsuta N., Iwai-Shimada M., Nakai K., Arima T., Fujiwara I., Yaegashi N., Takeuchi A., Nakayama S.F.
Title : , Reproductive Toxicology, 93:83-88 (2020)
Health Risk Assessment and Source Apportionment of Mercury, Lead, Cadmium, Selenium, and Manganese in Japanese Women: An Adjunct Study to the Japan Environment and Children’s Study

Presenter : MA C., Iwai M., Tatsuta N., Nakai K., Isobe T., Takagi M., Nishihama Y., Nakayama S.F.
Title : , International Journal of Environmental Research and Public Health, 17(7):2231 (2020)
Maternal dietary intake of vitamin A during pregnancy was inversely associated with congenital diaphragmatic hernia: the Japan Environment and Children’s Study

Presenter : Michikawa T., Yamazaki S., Sekiyama M., Kuroda T., Nakayama S.F., Isobe T., Kobayashi Y., Iwai M., Suda E., Kawamoto T., Nitta H.
Title : , British Journal of Nutrition, 122(11):1295-1302 (2020)
Poly- and perfluoroalkyl substances in maternal serum: Method development and application in Pilot Study of the Japan Environment and Children's Study

Presenter : Nakayama S.F., Isobe T., Iwai-Shimada M., Kobayashi Y., Nishihama Y., Taniguchi Y., Sekiyama M., Michikawa T., Yamazaki S., Nitta H., Oda M., Mitsubuchi H., Sanefuji M., Ohga S., Mise N., Ikegami A., Suga R., Shimono M.
Title : , Journal of Chromatography A, 1618:460933 (2020)
Estimated postnatal p,p'-DDT and p,p'-DDE levels and body mass index at 42 months of age in a longitudinal study of Japanese children

Presenter : Plouffe L., Bosson-Rieutort D., Madaniyazi L., Iwai-Shimada M., Nakai K., Tatsuta N., Nakayama S.F., Verner M.A.
Title : , Environmental Health, 19(1):49 (2020)
Prenatal and postnatal lead exposures and intellectual development among 12-year-old Japanese children

Presenter : Tatsuta N., Nakai K., Kasanuma Y., Iwai-Shimada M., Sakamoto M., Murata K., Satoh H.
Title : , Environmental Research, 189(109844): (2020)
Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS)

Presenter : Nishihama Y., Nakayama S.F., Tabuchi T., Isobe T., Jung C., Iwai-Shimada M., Kobayashi Y., Michikawa T., Sekiyama M., Taniguchi Y., Nitta H., Yamazaki S.
Title : , International Journal of Environmental Research and Public Health, 17(15):5537 (2020)
Maternal intake of one-carbon metabolism-related B vitamins and anorectal malformations in the Japan Environment and Children’s Study

Presenter : Michikawa T., Nitta H., Sekiyama M., Kuroda T., Nakayama S.F., Isobe T., Kobayashi Y., Iwai M., Suda E., Taniguchi Y., Kawamoto T., Yamazaki S.
Title : , British Journal of Nutrition, 124(8):865-873 (2020)
Study Design and Participants’ Profile in the Sub-Cohort Study in the Japan Environment and Children’s Study (JECS)

Presenter : Sekiyama M., Yamazaki S., Michikawa T., Nakayama S.F., Nitta H., Taniguchi Y., Suda E., Isobe T., Kobayashi Y., Iwai M., Ono M., Tamura K., Yonemoto J., Kawamoto K., Kamijima M
Title : , Journal of Epidemiology (2020)
Dioxins levels in human blood after implementation of measures against dioxin exposure in Japan

Presenter : Muzembobasilua A., Iwai-Shimada M., Isobe T., Arisawa K., Shima M., Fukushima T., Nakayama S.F.
Title : , Environmental Health and Preventive Medicine, 24(6): (2019)
Isoflavone Intake in Early Pregnancy and Hypospadias in the Japan Environment and Children's Study

Presenter : Michikawa T., Yamazaki S., Ono M., Kuroda T., Nakayama S.F., Suda E., Isobe T., Iwai M., Kobayashi Y., Yonemoto J., Tamura K., Kawamoto T., Nitta H.
Title : , Urology, 124:229-236 (2019)
Fish consumption in early pregnancy and congenital gastrointestinal tract atresia in the Japan Environment and Children’s Study

Presenter : Michikawa T., Yamazaki S., Ono M., Kuroda T., Nakayama S.F., Suda E., Isobe T., Iwai M., Kobayashi Y., Tamura K., Yonemoto J., Kawamoto T., Nitta H.
Title : , British Journal of Nutrition, 121(1):100-108 (2019)
For making a declaration of countermeasures against the falling birth rate from the Japanese Society for Hygiene: summary of discussion in the working group on academic research strategy against an aging society with low birth rate

Presenter : Nomura K., Karita K., Araki A., Nishioka E., Muto G., Iwai-Shimada M., NIshikitani M., Inoue M., Tsurugano S., Kitano N., Tsuji M., Iijima S., Ueda K., Kamijima M., Yamagata Z., Sakata K., Iki M., Yanagisawa H., Kato M., Inadera H., Kokubo Y., Yokoyama K., Koizumi A., Otsuki T.
Title : , Environmental Health and Preventive Medicine, 24(14): (2019)
Exposure profile of mercury, lead, cadmium, arsenic, antimony, copper, selenium and zinc in maternal blood, cord blood and placenta: the Tohoku Study of Child Development in Japan

Presenter : Iwai-Shimada M., Kameo S., Nakai K., Yaginuma-Sakurai K., Tatsuta N., Kurokawa N., Nakayama S.F., Satoh H.
Title : , Environmental Health and Preventive Medicine, 24(35): (2019)
Induction of chemokine CCL3 by NF-κB reduces methylmercury toxicity in C17.2 mouse neural stem cells

Presenter : Takahashi T., Kim MS., Iwai-Shimada M., Hoshi T., Fujiwara M., Toyama T., Fujiwara Y., Naganuma A., Hwang GW.
Title : , Environmental Toxicology and Pharmacology, 71(103216): (2019)
Blood mercury, lead, cadmium, manganese and selenium levels in pregnant women and their determinants: the Japan Environment and Children's Study (JECS)

Presenter : Nakayama S.F., Iwai-Shimada M., Oguri T., Isobe T., Takeuchi A., Kobayashi Y., Michikawa T., Yamazaki S., Nitta H., Kawamoto T.
Title : , Journal of Exposure Science and Environmental Epidemiology, 29(5):633-647 (2019)
Benefits of cooperation among large-scale cohort studies and human biomonitoring projects in environmental health research: An exercise in blood lead analysis of the Environment and Child Health International Birth Cohort Group

Presenter : Nakayama S.F., Espina C., Kamijima M., Magnus P., Charles MA., Zhang J., Wolz B., Conrad A., Murawski A., Iwai-Shimada M., Zaroz C., Caspersen I.H., Kolossa-Gehring M., Meltzer H.M., Olsen S.F., Etzel R.A., Schuz J.
Title : , International Journal of Hygiene and Environmental Health, 222(8):1059-1067 (2019)
Variability and reliability of POP concentrations in multiple breast milk samples collected from the same mothers

Presenter : Kakimoto R., Ichiba M., Matsumoto A., Nakai K., Tatsuta N., Iwai M., Ishiyama M., Ryuda N., Someya T., Tokumoto I., Ueno D.
Title : , Environmental Science and Pollution Research, 1-7 (2018)
Chemokine CCL4 Induced in Mouse Brain Has a Protective Role against Methylmercury Toxicity

Presenter : Takahashi T., Kim M.S., Iwai M., Fujimura M., Toyama T., Naganuma A., Hwang G.W.
Title : , Toxics, 6(36):2-9 (2018)
Questionnaire results on exposure characteristics of pregnant women participating in the Japan Environment and Children’s Study

Presenter : Iwai-Shimada M., Nakayama S.F., Isobe T., Michikawa T., Yamazaki S., Nitta H., Takeuchi A., Kobayashi Y., Tamura K., Suda E., Ono M., Yonemoto J., Kawamoto T.
Title : , Environmental Health and Preventive Medicine, 23(1):45 (2018)
Total mercury levels in hair of children aged 7 years before and after the Great East Japan Earthquake

Presenter : Tatsuta N., Nakai K., Iwai-Shimada M., Suzuki T., Satoh H., Murata K.
Title : , Science of the Total Environment, 596-597:207-211 (2017)
Effects of intrauterine exposures to polychlorinated biphenyls, methylmercury,and lead on birth weight in Japanese male and female newborns

Presenter : Tatsuta N., Kurokawa N., Nakai K., Suzuki K., Iwai-Shimada M., Murata K., Satoh H.
Title : , Environmental Health and Preventive Medicine, 22(39):1-8 (2017)
Psychomotor Ability in Children Prenatally Exposed to Methylmercury: The 18-Month Follow-Up of Tohoku Study of Child Development

Presenter : Tatsuta N., Murata K., Iwai-Shimada M., Yaginuma-Sakurai K., Satoh H., Nakai K.
Title : , The Tohoku Journal of Experimental Medicine, 242:1-8 (2017)
A methodological consideration for blood lead concentrations obtained from the earlobe in Japanese adults occupationally unexposed to lead

Presenter : Tatsuta N, Nakai K, Iwai-Shimada M., Mizutani F, Murata K., Chisaki Y., Satoh H.
Title : , Environmental Health and Preventive Medicine, 22(78):1-5 (2017)
Methylmercury induces the expression of TNF-α selectively in the brain of mice

Presenter : Iwai-Shimada M., Takahashi T., Kim M.S., Fujimura M., Ito H., Toyama T., Naganuma A., Hwang G.W.
Title : , Scientific Reports, 6(38294): (2016)

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Worldwide trends in tracing poly- and perfluoroalkyl substances (PFAS) in the environment

Presenter : Nakayama S.F., Yoshikane M., Onoda Y., Nishihama Y., Iwai-Shimada M., Takagi M., Kobayashi Y., Isobe T.
Title : , TrAC Trends in Analytical Chemistry, 121(115410): (2019)

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Baseline Profile of Participants in the Japan Environment and Children

Presenter : Michikawa T., Nitta H., Nakayama S., Yamazaki S., Isobe T., Tamura K., Suda E., Ono M., Yonemoto J., Iwai M., Kobayashi Y., Suzuki G., Kawamoto T.
Title : , Journal of Epidemiology (2017)

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Research Result (Presentation)

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Research Presentation
Research Lecture

Research Presentation
Exposure factor questionnaire development for personal care product usage among children

Presenter : Takagi M., Isobe T., Iwai M., Kobayashi Y., Nakayama S.F.
Name of Society : ISES-ISEE2025 (2025)
Name of Proceedings : Abstracts
Research Presentation
The National Human Biomonitoring Programme in Japan

Presenter : Nakayama S.F., Isobe T., Iwai-Shimada M., Takagi M., Kobayashi Y.
Name of Society : ISES-ISEE 2025 (2025)
Name of Proceedings : -
Research Presentation
Association between prenatal lead exposure and secondary sex ratio: Japan Environment and Children's Study

Presenter : Tatsuta N., Iwai M., Nakayama S.F., Nakai K.
Name of Society : ISES-ISEE 2025 (2025)
Name of Proceedings : Abstracts
Research Presentation
Intervention Trial for Pharmacokinetic Study of Chemicals in Daily Use Products

Presenter : Isobe T., Ueyama J., Iwai M., Takagi M., Oguri T., Shinohara N., Kunisue T., Nakayama K., Tanoue R., Nakayama S.f.
Name of Society : 21st International Symposium on Toxicity Assessment (2024)
Name of Proceedings : Abstracts
Research Presentation
Exposure Assessment in Japan Environment and Children’s Study (JECS)

Presenter : Isobe T., Nakayama S.f., Iwai M., Kobayashi Y., Takagi M.
Name of Society : 2024 National PFAS Conference (2024)
Name of Proceedings : -
Research Presentation
DIETARY INTERVENTION TRIAL FOR PHARMACOKINETICS OF SELENONEINE IN HUMANS

Presenter : Kobayashi Y., Iwai M., Isobe T., Takagi M., Yamashita M, Nakayama S.f.
Name of Society : 9th International Symposium on Metallomics (2024)
Name of Proceedings : Abstracts, 123
Research Presentation
Evaluation of estimated daily intake of essential trace elements and toxic metals in newborns via breast milk or infant formula

Presenter : Iwai-Shimada M., Iwai K., Asato K., Nakai K., Kobayashi Y., Nakayama S.f., Tatsuta N.
Name of Society : 2024 Sapporo Exposome Symposium (2024)
Name of Proceedings : -
Research Presentation
Survey of personal care products usage of Japanese children

Presenter : Takagi M., Isobe T., Iwai M., Kobayashi Y., Nakayama S.f.
Name of Society : ISES 2024 Annual Meeting (2024)
Name of Proceedings : Abstracts
Research Presentation
Study design of less-invasive intervention trial for investigation of pharmacokinetics

Presenter : Isobe T., Ueyama J., Iwai M., Takagi M., Oguri T., Shinohara N., Kunisue T., Nakayama K., Tanoue R., Nakayama S.f.
Name of Society : ISES 2024 Annual Meeting (2024)
Name of Proceedings : -
Research Presentation
Determination of exposure factors including use of personal care products via web-based questionnaire

Presenter : Takagi M., Isobe T., Iwai M., Kobayashi Y., Nakayama S.F.
Name of Society : ISES2022 (2022)
Name of Proceedings : Abstracts
Research Presentation
Link the Results of the Birth Cohort Study to Chemical Regulation

Presenter : Isobe T., Ueyama J., Iwai M., Takagi M., Oguri T., Shinohara N., Kunisue T., Nakayama K., Tanoue R., Nakayama S.F.
Name of Society : Impacts of early life exposure to environmental contaminants:children’s health in the Anthropocene (2022)
Name of Proceedings : Abstracts
Research Presentation
High-sensitive determination method of insect repellents and its metabolites in human urine by solid-phase extraction and high-performance liquid chromatography-tandem mass spectrometry

Presenter : Nishihara N., Isobe T., Takagi M., Nakayama S.F., Iwai M., Kunisue T., Oguri T., Saito I., Ueyama J.
Name of Society : Impacts of early life exposure to environmental contaminants:children’s health in the Anthropocene (2022)
Name of Proceedings : Abstracts
Research Presentation
Developing a Japanese Exposure Factors Database

Presenter : Takagi M., Isobe T., Iwai M., Kobayashi Y., Nakayama S.F.
Name of Society : Impacts of early life exposure to environmental contaminants:children’s health in the Anthropocene (2022)
Name of Proceedings : Abstracts
Research Lecture
Challenge to elucidate critical windows of susceptibility: Temporal trends in elemental exposure of each individual

Presenter : Iwai-Shimada M., Nakayama S.F.
Name of Society : フォーラム2022：衛生薬学・環境トキシコロジー (2022)
Name of Proceedings : BPB Reports, 5:124
Research Presentation
Estimation of exposure to various elements in infancy via breast milk and formula milk

Presenter : Iwai-Shimada M., Tatsuta N., Iwai K., Asato K., Nakai K., Kobayashi Y., Takagi M., Nakayama S.F.
Name of Society : The 8th International Symposium on METALLOMICS (2022)
Name of Proceedings : Abstracts, 121-121
Research Presentation
Elemental analysis of biological samples in large-scale birth cohort study

Presenter : Kobayashi Y., Isobe T., Iwai M., Takagi M., Nakayama S.F.
Name of Society : The 8th International Symposium on Metallomics (2022)
Name of Proceedings : Abstracts, 58
Research Presentation
Assessment on exposure and elimination half-life of Neonicotinoids (NEOs) in human urine in Japan

Presenter : NGUYEN T., Isobe T., Iwai M., Takagi M., Ueyama J., Nakayama S.F.
Name of Society : Joint Conference on Environmental Chemicals（第30回環境化学討論会） (2022)
Name of Proceedings : 同要旨集, 165-166
Research Presentation
Poly- and perfluoroalkyl substances in maternal serum: method development and application in Pilot Study of the Japan Environment and Children’s Study

Presenter : Nakayama S.F., Isobe T., Iwai-Shimada M., Kobayashi Y., Nishihama Y., Taniguchi Y., Sekiyama M., Michikawa T., Yamazaki S., Nitta H., Oda M., Mitsubuchi H., Sanefuji M., Ohga S., Mise N., Ikegami A., Suga R., Shimono M.
Name of Society : The 2020 International Chemical Congress of Pacific Basin Societies (Pacifichem 2020) (2021)
Name of Proceedings : -
Research Presentation
A Population Toxicokinetic Modelling of Mercury and Methylmercury in Human

Presenter : Iwai-Shimada M., Yaginuma-Sakurai K., Tatsuta N., Nakai K., Nakayama S.F.
Name of Society : the SOT 59th Annual Meeting and ToxExpo (2020)
Name of Proceedings : SOT 2020, The Toxicologist, Supplement to Toxicological Sciences, 369
Research Presentation
Defining co-exposures of blood heavy metals in Japanese pregnant women

Presenter : JUNG C., Isobe T., Iwai M., Kobayashi Y., Nishihama Y., MA C., Nakayama S.F.
Name of Society : NYC Exposome Symposium (2020)
Name of Proceedings : -
Research Presentation
Environmental measurements in the Sub-Cohort Study of the Japan Environment and Children’s Study (JECS)

Presenter : Nishihama Y., Isobe T., Tamura K., Iwai M., Michikawa T., Yamazaki S., Nitta H., Takeuchi A., Kobayashi Y., Suda E., Sekiyama M., Ono M., Yonemoto J., Kawamoto T., Nakayama S.F.
Name of Society : ISES ISIAQ 2019 (2019)
Name of Proceedings : Abstracts, 301
Research Presentation
Determination of neonicotinoid insecticides in urine using semi-automated solid phase extraction coupled to UHPLC-MS/MS

Presenter : Isobe T., Iwai M., Kobayashi Y., Takagi M., Nakayama S.F.
Name of Society : 39th International Symposium on Halogenated Persistent Organic Pollutants (2019)
Name of Proceedings : Abstracts, 531
Research Presentation
Disaster Response Research Development in Japan

Presenter : Nakayama SF., Takagi M., Nakajima D., Isobe T., Iwai-Shimada M., Kobayashi Y.
Name of Society : ISES-ISEE 2018 Joint Annual Meeting (2018)
Name of Proceedings : Abstracts, 655
Research Presentation
Daily Intakes of Phthalates among Japanese Children

Presenter : Takagi M., Isobe T., Iwai-Shimada M., Nakayama SF.
Name of Society : ISES-ISEE 2018 Joint Annual Meeting (2018)
Name of Proceedings : Abstracts, 1539
Research Presentation
Prenatal Exposure to Polychlorinated Biphenyls and Mercury Are Associated with Insulin-Like Growth Factor 1 and Thyroid-Stimulating Hormone in Cord Plasma

Presenter : Iwai-Shimada M., Tatsuta N., Nakayama S., Nakai K., Satoh H.
Name of Society : Joint Annual Meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology (ISES-ISEE 2018) (2018)
Name of Proceedings : Abstracts book, 623
Research Presentation
Estimating Children’s Postnatal Exposure to DDT and DDE Using a Physiologically-Based Pharmacokinetic (PBPK) Model

Presenter : Plouffe L., Iwai M., Nakayama S., Nakai K., Verner M.A.
Name of Society : Society of Toxicology 57th Annual Meeting (2018)
Name of Proceedings : -, 238
Research Lecture
How to Work Exposure Assessment-Large Scale Birth Cohort and Exposomics-

Presenter : Isobe T., Iwai M., Nakayama S.F.
Name of Society : The International Conference on Occupational and Environmental Diseases: ICOED (2018)
Name of Proceedings : -
Research Lecture
Japan Environment and Children’s Study (JECS) : Current Status (2018)

Presenter : Isobe T., Iwai M., Nakayama S.F., Mezawa H., Terashima K.
Name of Society : International Childhood Cancer Cohort Consortium (I4C) Childhood Leukemia International Consortium (CLIC) Joint Activities and Annual Meeting 2018 (2018)
Name of Proceedings : -
Research Presentation
Japan Environment and Children’s Study (JECS): Baseline characteristics of mothers, fathers, and their children

Presenter : Michikawa T., Nitta H., Nakayama S., Yamazaki S., Isobe T., Tamura K., Suda E., Ono M., Yonemoto J., Iwai M., Kobayashi Y., Suzuki G., Kawamoto T.
Name of Society : The 21st international Epidemiological Association, World Congress of Epidemiology (2017)
Name of Proceedings : Abstracts, 116
Research Presentation
Biomonitoring of dioxins and other chemicals in Japan - Summary of nation-wide survey during 2011-2016

Presenter : Isobe T., Iwai M., Shibuya H., Tsukahara S., Kasamatsu J., Arisawa K., Nakayama S.
Name of Society : 37th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - DIOXIN 2017 (2017)
Name of Proceedings : Abstracts
Research Presentation
Indoor dust ingestion rate for Japanese children

Presenter : Takagi M., Isobe T., Iwai M., Nakayama S.
Name of Society : International Society of Exposure Science (ISES) 27th Annual Meeting (2017)
Name of Proceedings : Abstracts, 314-315
Research Lecture
Birth weight of male infants is susceptible to prenatal exposure to methylmercury-Tohoku Study of Child Development

Presenter : Tatsuta N., Kurokawa N, Nakai K., Suzuki K, Iwai-Shimada M., Sakamoto M., Murata K., Satoh H.
Name of Society : Prenatal Programming and Toxicity V (PPTox V) (2016)
Name of Proceedings : Abstracts
Research Presentation
Distribution differences of toxic and essential elements between cord blood and maternal blood

Presenter : Iwai-Shimada M., Kameo S., Nakai K., Tatsuta N., Satoh H.
Name of Society : Prenatal Programming and Toxicity V (PPTox V) (2016)
Name of Proceedings : Abstract

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Elemental analysis of biological samples in large-scale birth cohort study

Presenter : Kobayashi Y., Isobe T., Iwai M., Takagi M., Nakayama S.F.
Name of Society : The 8th International Symposium on Metallomics (2022)
Name of Proceedings : Abstracts, 58
Assessment on exposure and elimination half-life of Neonicotinoids (NEOs) in human urine in Japan

Presenter : NGUYEN T., Isobe T., Iwai M., Takagi M., Ueyama J., Nakayama S.F.
Name of Society : Joint Conference on Environmental Chemicals（第30回環境化学討論会） (2022)
Name of Proceedings : 同要旨集, 165-166
Poly- and perfluoroalkyl substances in maternal serum: method development and application in Pilot Study of the Japan Environment and Children’s Study

Presenter : Nakayama S.F., Isobe T., Iwai-Shimada M., Kobayashi Y., Nishihama Y., Taniguchi Y., Sekiyama M., Michikawa T., Yamazaki S., Nitta H., Oda M., Mitsubuchi H., Sanefuji M., Ohga S., Mise N., Ikegami A., Suga R., Shimono M.
Name of Society : The 2020 International Chemical Congress of Pacific Basin Societies (Pacifichem 2020) (2021)
Name of Proceedings : -
Determination of neonicotinoid insecticides in urine using semi-automated solid phase extraction coupled to UHPLC-MS/MS

Presenter : Isobe T., Iwai M., Kobayashi Y., Takagi M., Nakayama S.F.
Name of Society : 39th International Symposium on Halogenated Persistent Organic Pollutants (2019)
Name of Proceedings : Abstracts, 531
Disaster Response Research Development in Japan

Presenter : Nakayama SF., Takagi M., Nakajima D., Isobe T., Iwai-Shimada M., Kobayashi Y.
Name of Society : ISES-ISEE 2018 Joint Annual Meeting (2018)
Name of Proceedings : Abstracts, 655
Prenatal Exposure to Polychlorinated Biphenyls and Mercury Are Associated with Insulin-Like Growth Factor 1 and Thyroid-Stimulating Hormone in Cord Plasma

Presenter : Iwai-Shimada M., Tatsuta N., Nakayama S., Nakai K., Satoh H.
Name of Society : Joint Annual Meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology (ISES-ISEE 2018) (2018)
Name of Proceedings : Abstracts book, 623
Biomonitoring of dioxins and other chemicals in Japan - Summary of nation-wide survey during 2011-2016

Presenter : Isobe T., Iwai M., Shibuya H., Tsukahara S., Kasamatsu J., Arisawa K., Nakayama S.
Name of Society : 37th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - DIOXIN 2017 (2017)
Name of Proceedings : Abstracts
Exposure factor questionnaire development for personal care product usage among children

Presenter : Takagi M., Isobe T., Iwai M., Kobayashi Y., Nakayama S.F.
Name of Society : ISES-ISEE2025 (2025)
Name of Proceedings : Abstracts
The National Human Biomonitoring Programme in Japan

Presenter : Nakayama S.F., Isobe T., Iwai-Shimada M., Takagi M., Kobayashi Y.
Name of Society : ISES-ISEE 2025 (2025)
Name of Proceedings : -
Association between prenatal lead exposure and secondary sex ratio: Japan Environment and Children's Study

Presenter : Tatsuta N., Iwai M., Nakayama S.F., Nakai K.
Name of Society : ISES-ISEE 2025 (2025)
Name of Proceedings : Abstracts
Intervention Trial for Pharmacokinetic Study of Chemicals in Daily Use Products

Presenter : Isobe T., Ueyama J., Iwai M., Takagi M., Oguri T., Shinohara N., Kunisue T., Nakayama K., Tanoue R., Nakayama S.f.
Name of Society : 21st International Symposium on Toxicity Assessment (2024)
Name of Proceedings : Abstracts
Exposure Assessment in Japan Environment and Children’s Study (JECS)

Presenter : Isobe T., Nakayama S.f., Iwai M., Kobayashi Y., Takagi M.
Name of Society : 2024 National PFAS Conference (2024)
Name of Proceedings : -
DIETARY INTERVENTION TRIAL FOR PHARMACOKINETICS OF SELENONEINE IN HUMANS

Presenter : Kobayashi Y., Iwai M., Isobe T., Takagi M., Yamashita M, Nakayama S.f.
Name of Society : 9th International Symposium on Metallomics (2024)
Name of Proceedings : Abstracts, 123
Evaluation of estimated daily intake of essential trace elements and toxic metals in newborns via breast milk or infant formula

Presenter : Iwai-Shimada M., Iwai K., Asato K., Nakai K., Kobayashi Y., Nakayama S.f., Tatsuta N.
Name of Society : 2024 Sapporo Exposome Symposium (2024)
Name of Proceedings : -
Survey of personal care products usage of Japanese children

Presenter : Takagi M., Isobe T., Iwai M., Kobayashi Y., Nakayama S.f.
Name of Society : ISES 2024 Annual Meeting (2024)
Name of Proceedings : Abstracts
Study design of less-invasive intervention trial for investigation of pharmacokinetics

Presenter : Isobe T., Ueyama J., Iwai M., Takagi M., Oguri T., Shinohara N., Kunisue T., Nakayama K., Tanoue R., Nakayama S.f.
Name of Society : ISES 2024 Annual Meeting (2024)
Name of Proceedings : -
Determination of exposure factors including use of personal care products via web-based questionnaire

Presenter : Takagi M., Isobe T., Iwai M., Kobayashi Y., Nakayama S.F.
Name of Society : ISES2022 (2022)
Name of Proceedings : Abstracts
Link the Results of the Birth Cohort Study to Chemical Regulation

Presenter : Isobe T., Ueyama J., Iwai M., Takagi M., Oguri T., Shinohara N., Kunisue T., Nakayama K., Tanoue R., Nakayama S.F.
Name of Society : Impacts of early life exposure to environmental contaminants:children’s health in the Anthropocene (2022)
Name of Proceedings : Abstracts
High-sensitive determination method of insect repellents and its metabolites in human urine by solid-phase extraction and high-performance liquid chromatography-tandem mass spectrometry

Presenter : Nishihara N., Isobe T., Takagi M., Nakayama S.F., Iwai M., Kunisue T., Oguri T., Saito I., Ueyama J.
Name of Society : Impacts of early life exposure to environmental contaminants:children’s health in the Anthropocene (2022)
Name of Proceedings : Abstracts
Developing a Japanese Exposure Factors Database

Presenter : Takagi M., Isobe T., Iwai M., Kobayashi Y., Nakayama S.F.
Name of Society : Impacts of early life exposure to environmental contaminants:children’s health in the Anthropocene (2022)
Name of Proceedings : Abstracts
Estimation of exposure to various elements in infancy via breast milk and formula milk

Presenter : Iwai-Shimada M., Tatsuta N., Iwai K., Asato K., Nakai K., Kobayashi Y., Takagi M., Nakayama S.F.
Name of Society : The 8th International Symposium on METALLOMICS (2022)
Name of Proceedings : Abstracts, 121-121
A Population Toxicokinetic Modelling of Mercury and Methylmercury in Human

Presenter : Iwai-Shimada M., Yaginuma-Sakurai K., Tatsuta N., Nakai K., Nakayama S.F.
Name of Society : the SOT 59th Annual Meeting and ToxExpo (2020)
Name of Proceedings : SOT 2020, The Toxicologist, Supplement to Toxicological Sciences, 369
Defining co-exposures of blood heavy metals in Japanese pregnant women

Presenter : JUNG C., Isobe T., Iwai M., Kobayashi Y., Nishihama Y., MA C., Nakayama S.F.
Name of Society : NYC Exposome Symposium (2020)
Name of Proceedings : -
Environmental measurements in the Sub-Cohort Study of the Japan Environment and Children’s Study (JECS)

Presenter : Nishihama Y., Isobe T., Tamura K., Iwai M., Michikawa T., Yamazaki S., Nitta H., Takeuchi A., Kobayashi Y., Suda E., Sekiyama M., Ono M., Yonemoto J., Kawamoto T., Nakayama S.F.
Name of Society : ISES ISIAQ 2019 (2019)
Name of Proceedings : Abstracts, 301
Daily Intakes of Phthalates among Japanese Children

Presenter : Takagi M., Isobe T., Iwai-Shimada M., Nakayama SF.
Name of Society : ISES-ISEE 2018 Joint Annual Meeting (2018)
Name of Proceedings : Abstracts, 1539
Estimating Children’s Postnatal Exposure to DDT and DDE Using a Physiologically-Based Pharmacokinetic (PBPK) Model

Presenter : Plouffe L., Iwai M., Nakayama S., Nakai K., Verner M.A.
Name of Society : Society of Toxicology 57th Annual Meeting (2018)
Name of Proceedings : -, 238
Japan Environment and Children’s Study (JECS): Baseline characteristics of mothers, fathers, and their children

Presenter : Michikawa T., Nitta H., Nakayama S., Yamazaki S., Isobe T., Tamura K., Suda E., Ono M., Yonemoto J., Iwai M., Kobayashi Y., Suzuki G., Kawamoto T.
Name of Society : The 21st international Epidemiological Association, World Congress of Epidemiology (2017)
Name of Proceedings : Abstracts, 116
Indoor dust ingestion rate for Japanese children

Presenter : Takagi M., Isobe T., Iwai M., Nakayama S.
Name of Society : International Society of Exposure Science (ISES) 27th Annual Meeting (2017)
Name of Proceedings : Abstracts, 314-315
Distribution differences of toxic and essential elements between cord blood and maternal blood

Presenter : Iwai-Shimada M., Kameo S., Nakai K., Tatsuta N., Satoh H.
Name of Society : Prenatal Programming and Toxicity V (PPTox V) (2016)
Name of Proceedings : Abstract

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Challenge to elucidate critical windows of susceptibility: Temporal trends in elemental exposure of each individual

Presenter : Iwai-Shimada M., Nakayama S.F.
Name of Society : フォーラム2022：衛生薬学・環境トキシコロジー (2022)
Name of Proceedings : BPB Reports, 5:124
How to Work Exposure Assessment-Large Scale Birth Cohort and Exposomics-

Presenter : Isobe T., Iwai M., Nakayama S.F.
Name of Society : The International Conference on Occupational and Environmental Diseases: ICOED (2018)
Name of Proceedings : -
Japan Environment and Children’s Study (JECS) : Current Status (2018)

Presenter : Isobe T., Iwai M., Nakayama S.F., Mezawa H., Terashima K.
Name of Society : International Childhood Cancer Cohort Consortium (I4C) Childhood Leukemia International Consortium (CLIC) Joint Activities and Annual Meeting 2018 (2018)
Name of Proceedings : -
Birth weight of male infants is susceptible to prenatal exposure to methylmercury-Tohoku Study of Child Development

Presenter : Tatsuta N., Kurokawa N, Nakai K., Suzuki K, Iwai-Shimada M., Sakamoto M., Murata K., Satoh H.
Name of Society : Prenatal Programming and Toxicity V (PPTox V) (2016)
Name of Proceedings : Abstracts

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Miyuki Iwai-Shimada

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