Latest Update：2026/03/24 10:41:05

MAEKAWA Fumihiko

Researcher Name: MAEKAWA Fumihiko

Div (Section) name/title: Health and Environmental Risk Division（Health Effect Assessment Section）／Prime Senior Researcher

Research Subject

Fiscal Year: 2025
- 27216 : Research project on the health hazard assessment considering the real-life environment and vulnerability
- 27364 : Comprehensive Study of the Developmental Neurotoxic Effects of Nanoplastics
- 27366 : A novel developmental neurotoxicity assessment using a primate model
- 27381 : A fundamental study for evaluating health impact of environmental factors
- 27393 : Nanoplastic particles: Preparation of standard materials and their potential health hazards
- 27437 : Libraries of standard samples micro- and nanoplastic in the environment and exploring the safety information
Fiscal Year: 2024
- 26829 : Research project on the health hazard assessment considering the real-life environment and vulnerability
- 26926 : Comprehensive Study of the Developmental Neurotoxic Effects of Nanoplastics
- 26932 : A novel developmental neurotoxicity assessment using a primate model
- 26947 : A fundamental study for evaluating health impact of environmental factors
- 26952 : Libraries of standard samples micro- and nanoplastic in the environment and exploring the safety information
- 26999 : Longitudinal Tracking of Behavioral Effects of Developmental Methylmercury Exposure in Mice
- 27059 : Nanoplastic particles: Preparation of standard materials and their potential health hazards
Fiscal Year: 2023
- 26420 : Research project on the health hazard assessment considering the real-life environment and vulnerability
- 26502 : Longitudinal Tracking of Behavioral Effects of Developmental Methylmercury Exposure in Mice
- 26709 : A fundamental study for evaluating health impact of environmental factors
- 26710 : A novel developmental neurotoxicity assessment using a primate model
Fiscal Year: 2022
- 25973 : Research project on the health hazard assessment considering the real-life environment and vulnerability
- 26159 : A fundamental study for evaluating health impact of environmental factors
- 26312 : Longitudinal Tracking of Behavioral Effects of Developmental Methylmercury Exposure in Mice
Fiscal Year: 2021
- 25517 : Research on the health hazard assessment considering the real-life environment and vulnerability
- 25625 : A fundamental study for evaluating health impact of environmental factors
- 25686 : The influence of the exposure to metals on mice brain and behavior
- 25687 : Elucidation of the molecular mechanism of acute encephalopathy by Sugihiratake and the application development
- 25688 : Elucidation of the relationship between developmental dioxin exposure and cognitive decline in advanced age
Fiscal Year: 2020
- 25099 : Research Program on Health and Environmental Safety
- 25141 : Research Project on Health Impacts of Chemicals on Children and Future Generations
- 25212 : To what degree is the neural circuit controlling aggression affected by environment?: Searching for the intersection of gene and environment.
- 25213 : The influence of the exposure to metals on mice brain and behavior
- 25214 : Elucidation of the molecular mechanism of acute encephalopathy by Sugihiratake and the application development
- 25215 : Elucidation of the relationship between developmental dioxin exposure and cognitive decline in advanced age
- 25236 : A Fundamental Study for Evaluating Health Impact of Environmental Factors
Fiscal Year: 2019
- 24696 : Research Program on Health and Environmental Safety
- 24721 : Research Project on Health Impacts of Chemicals on Children and Future Generations
- 24817 : A comprehensive risk management and presentation of toxicity equivalency factors for unintentional brominated dioxin-like compounds
- 24926 : A Fundamental Study for Evaluating Health Impact of Environmental Factors
- 24928 : To what degree is the neural circuit controlling aggression affected by environment?: Searching for the intersection of gene and environment.
- 24931 : The influence of the exposure to metals on mice brain and behavior
- 24933 : Elucidation of the molecular mechanism of acute encephalopathy by Sugihiratake and the application development
- 24934 : Elucidation of the relationship between developmental dioxin exposure and cognitive decline in advanced age
Fiscal Year: 2018
- 24304 : Research project on health impacts of chemicals on children and future generations
- 24355 : Research program on health and environmental safety
- 24421 : A comprehensive risk management and presentation of toxicity equivalency factors for unintentional brominated dioxin-like compounds
- 24450 : To what degree is the neural circuit controlling aggression affected by environment?: Searching for the intersection of gene and environment.
- 24531 : A fundamental study for evaluating health impact of environmental factors
Fiscal Year: 2017
- 23824 : Research project on health impacts of chemicals on children and future generations
- 23847 : Research program on health and environmental safety
- 23938 : Is sex chromosome-dependent brain sexual differentiation affected by environmental factors?
- 23975 : A fundamental study for evaluating health impact of environmental factors
- 24000 : A comprehensive risk management and presentation of toxicity equivalency factors for unintentional brominated dioxin-like compounds
Fiscal Year: 2016
- 23414 : Research program on health and environmental safety
- 23415 : Research project on health impacts of chemicals on children and future generations
- 23579 : Establishment of multidisciplinary strategy toward comprehensive understanding of developmental neurotoxicity induced by environmental chemicals in house dust
- 23580 : Is sex chromosome-dependent brain sexual differentiation affected by environmental factors?
- 23659 : A fundamental study for evaluating health impact of environmental factors
- 23727 : A phylogenetic approach to brain focusing on sexual dimorphic nucleus
Fiscal Year: 2015
- 23018 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 23116 : Establishment of multidisciplinary strategy toward comprehensive understanding of developmental neurotoxicity induced by environmental chemicals in house dust
- 23118 : Is sex chromosome-dependent brain sexual differentiation affected by environmental factors?
- 23173 : Analysis of vasopressin receptor functions to establish pharmacological approaches to developmental disorders
Fiscal Year: 2014
- 22606 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 22796 : The sex difference of retrotransposon expression in the brain and the relation to reproductive function.
- 22802 : Establishment of multidisciplinary strategy toward comprehensive understanding of developmental neurotoxicity induced by environmental chemicals in house dust
Fiscal Year: 2013
- 22190 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 22306 : The sex difference of retrotransposon expression in the brain and the relation to reproductive function.
- 22307 : Feasibility study for establishment of method to assess developmental neurotoxicity in birds
- 22475 : Exploration of molecular epidemiological indexes to health effects of environmental factors focusing on genetic and epigenetic mutation
- 22496 : Establishment of Japanese quail standard inbred strains for toxicity testing of chemicals
- 22544 : Establishment of an international cooperation for promoting arsenic research
Fiscal Year: 2012
- 21761 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 21986 : Studies of factors contributing to the regulation of epigenetics
- 21987 : The sex difference of retrotransposon expression in the brain and the relation to reproductive function.
Fiscal Year: 2011
- 21319 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 21480 : Studies of factors contributing to the regulation of epigenetics
- 21481 : Studies on the mechanism of transcription factor dependent effects of environmental chemicals
- 21484 : Development of new methods for detecting social impairments caused by environmental factors
Fiscal Year: 2010
- 21051 : Studies to evaluate toxicityies of environmental chemicals focusing on their epigenetic effects
- 21053 : Studies of factors contributing to the regulation of epigenetics
- 21055 : Studies on the mechanism of transcription factor dependent effects of environmental chemicals
- 21249 : Development of new methods for detecting social impairments caused by environmental factors

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Research Result (Publication)

Original Paper

Intestinal butyric acid-mediated disruption of gut hormone secretion and lipid metabolism in vasopressin receptor-deficient mice

Presenter : HARADA K., Wada E., Osuga Y., Shimizu K., Uenoyama R., Hirai YM., Maekawa F., Miyazaki M., Hayashi KY., Nakamura K., Tsuboi T.
Title : , Molecular Metabolism, 91:102072 (2025)
Original Paper

Human neurons are susceptible to the internalization of small-sized nanoplastics

Presenter : Ito T., Ikuno Y., Udagawa O., Tanaka K., Kurokawa Y., Kakeyama M., Maekawa F.
Title : , Environmental Toxicology and Pharmacology, 118:104776 (2025)
Review

Editorial: The roles of micro-RNAs in neuroendocrine systems

Presenter : Mounien L., Nakamura K., Chigr F., Maekawa F.
Title : , Frontiers in Endocrinology, 15:1349804 (2024)
Original Paper

Uptake, Elimination and Metabolism of Brominated Dibenzofurans in Mice

Presenter : Tue N.M., Kimura E., Maekawa F., Goto A., Uramaru N., Kunisue T., Suzuki G.
Title : , Toxics, 12(656): (2024)
Original Paper

Possible molecular mechanism for acute encephalopathy by angel-wing mushroom ingestion -Involvement of three constituents in onset-

Presenter : Suzuki T., Asakawa T., Maekawa F., Kimura E., Tezuka Y., Nakamura L., Sato T., Arai Y., Choi J-H., Suzuki M., Dohra H., Hirai H., Kawagishi H.
Title : , Toxicon, 221:106958 (2023)
Original Paper

Presence of sibling during the learning phase of imprinting affects escape behavior from a new object in chicks

Presenter : Chiba Y., Tsuchida K., Maekawa F., Nakamori T., Inaoka H., Ohki-Hamazaki H.
Title : , Neuroscience Research, 190:60-66 (2023)
Original Paper

2-Chloro-3,7,8-tribromodibenzofuran as a new environmental pollutant inducing atypical ultrasonic vocalization in infant mice

Presenter : Kimura E., Suzuki G., Uramaru N., Kakeyama M., Maekawa F.
Title : , Toxicology Research, tfad069: (2023)
Original Paper

Neurons expressing the aryl hydrocarbon receptor in the locus coeruleus and island of Calleja major are novel targets of dioxin in the mouse brain

Presenter : Kimura E., Koda M., Maekawa F., Fujii-Kuriyama Y,, Tohyama C.
Title : , Histochemistry and Cell Biology, 156(2):147-163 (2021)
Original Paper

Liver-specific decrease in Tff3 gene expression in infant mice perinatally exposed to 2,3,7,8-tetrabromodibenzofuran or 2,3,7,8-tetrachlorodibenzo-p-dioxin

Presenter : Kimura E., Suzuki G., Uramaru N., Kakeyama M., Maekawa F.
Title : , Journal of Applied Toxicology, 1-13 (2021)
Original Paper

Estrogenic action by tris(2,6-dimethylphenyl) phosphate impairs the development of female reproductive functions

Presenter : Sano K., Matsukami H., Suzuki G., Htike N.T.T., Morishita M., Tin-Tin-Win-Shwe, Hashimoto S., Kawashima T., Isobe T., Nakayama S.F., Tsukahara S., Maekawa F.
Title : , Environment International, 138:105662 (2020)
Original Paper

Behavioral impairments in infant and adult mouse offspring exposed to 2,3,7,8-tetrabromodibenzofuran in utero and via lactation

Presenter : Kimura E., Suzuki G., Uramaru N., Endo T., Maekawa F.
Title : , Environment International, 142:105833 (2020)
Original Paper

Strain differences in intermale aggression and possible factors regulating increased aggression in Japanese quail

Presenter : Maekawa F., Nagino K., Yang J., Htike N.T.T., Tsukahara S., Ubuka T., Tsutsui K., Kawashima T.
Title : , General and Comparative Endocrinology, 256:63-70 (2018)
Original Paper

Analyzing the effects of co-expression of chick (Gallus gallus) melanocortin receptors with either chick MRAP1 or MRAP2 in CHO cells on sensitivity to ACTH(1-24) or ACTH(1-13)NH2: Implications for the avian HPA axis and avian melanocortin circuits in the hypothalamus

Presenter : Thomas A.L., Maekawa F., Kawashima T., Sakamoto H., Sakamoto T., Davis P., Dores R.M.
Title : , General and Comparative Endocrinology, 256:50-56 (2018)
Original Paper

Weaning stage hyperglycemia induces glucose-insensitivity in arcuate POMC neurons and hyperphagia in type 2 diabetic GK rats

Presenter : Ando A., Gantulga D., Nakata M., Maekawa F., Dezaki K., Ishibashi S., Yada T.
Title : , Neuropeptides, 68:49-56 (2018)
Review

Editorial: Chemicals in the Environment and Brain Development: Importance of Neuroendocrinological Approaches

Presenter : Maekawa F., Nakamura K., Nakayama SF.
Title : , Frontiers in Neuroscience, 11(133): (2017)
Book

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Presenter : Maekawa F., Nakamura K., Nakayama S.
Title : , CHEMICALS IN THE ENVIRONMENT AND BRAIN DEVELOPMENT: IMPORTANCE OF NEUROENDOCRINOLOGICAL APPROACHES (2017)
Original Paper

Prenatal Exposure to Arsenic Impairs Behavioral Flexibility and Cortical Structure in Mice

Presenter : Aung K.H., Kyi-Tha-ThuC, Sano K., Nakamura K., Tanoue A., Nohara K., Kakeyama M., Tohyama C., Tsukahara S., Maekawa F.
Title : , Frontiers in Neuroscience, 10(137): (2016)
Original Paper

Arsenic Exposure Induces Unscheduled Mitotic S Phase Entry Coupled with Cell Death in Mouse Cortical Astrocytes

Presenter : Htike N.T.T., Maekawa F., Soutome H., Sano K., Maejima S., Aung K.H., Tokuda M., Tsukahara S.
Title : , Frontiers in Neuroscience, 10(297): (2016)
Original Paper

Glucose level determines excitatory or inhibitory effects of adiponectin on arcuate POMC neuron activity and feeding

Presenter : Suyama S., Maekawa F., Maejima Y., Kubota N., Kadowaki T., Yada T.
Title : , Scientific Reports, 6(30796): (2016)
Other Publications

A comparative study of sex difference in calbindin neurons among mice, musk shrews, and Japanese quails

Presenter : Moe Y., Tanaka T., Morishita M., Ohta R., Nakahara C., Kawashima T., Maekawa F., Sakata I., Sakai T., Tsukahara S.
Title : , Neuroscience Letters, 631:63-69 (2016)
Original Paper

In utero and Lactational Exposure to Acetamiprid Induces Abnormalities in Socio-Sexual and Anxiety-Related Behaviors of Male Mice

Presenter : Sano K., Isobe T., Yang J., Tin-Tin-Win-Shwe, Yoshikane M., Nakayama S., Kawashima T., Suzuki G., Hashimoto S., Nohara K., Tohyama C., Maekawa F.
Title : , Frontiers in Neuroscience, 10(228): (2016)
Original Paper

Nano-Sized Secondary Organic Aerosol of Diesel Engine Exhaust Origin Impairs Olfactory-Based Spatial Learning Performance in Preweaning Mice

Presenter : Tin-Tin-Win-Shwe, Chaw Kyi Tha thu, Yadanar Moe, Maekawa F., Yanagisawa R., Furuyama A., Tsukahara, Fujitani Y., Hirano S.
Title : , Nanomaterials, 2015(5):1147-1162 (2015)
Review

Role of Environmental Chemical Insult in Neuronal Cell Death and Cytoskeleton Damage

Presenter : Aung KH., Tsukahara S., Maekawa F., Nohara K., Nakamura K., Tanoue A.
Title : , Biological and Pharmaceutical Bulletin, 38(8):1109-1112 (2015)
Original Paper

Unilateral Lesion Increases Oestrogen Receptor α Expression in the Intact Side of the Ventromedial Hypothalamic Nucleus in Ovariectomised Rats

Presenter : Shimogawa Y., Maekawa F., Yamanouchi K.
Title : , Journal of Neuroendocrinology, 26(4):258-266 (2014)
Review

The mechanisms underlying sexual differentiation of behavior and physiology in mammals and birds: relative contributions of sex steroids and sex chromosomes

Presenter : Maekawa F., Tsukahara S., Kawashima T., Nohara K., Ohki-Hamazaki H.
Title : , Frontiers in Neuroscience, 8(242): (2014)
Original Paper

Neural basis of imprinting behavior in chicks

Presenter : Nakamori T., Maekawa F., Sato K., Tanaka K., Ohki-Hamazaki H.
Title : , Development, Growth & Differentiation, 55:198-206 (2013)
Original Paper

Inhibition of neurite outgrowth and alteration of cytoskeletal gene expression by sodium arsenite

Presenter : Aung K.H., Kurihara R., Nakashima S., Maekawa F., Nohara K., Kobayashi T., Tsukahara S.
Title : , Neuro Toxicology, 34:226-235 (2013)
Original Paper

A genetically female brain is required for a regular reproductive cycle in chicken brain chimeras

Presenter : Maekawa F., Sakurai M., Yamashita Y., Tanaka K., Haraguchi S., Yamamoto K., Tsutsui K., Yoshioka H., Murakami S., Tadano R., Goto T., Shiraishi J., Tomonari K., Oka T., Ohara K., Maeda T., Bungo T., Tsudzuki M., Ohki-Hamazaki H.
Title : , Nature Communications, 4(Article number1372): (2013)
Original Paper

Effects of sodium arsenite on neurite outgrowth and glutamate AMPA receptor expression in mouse cortical neurons.

Presenter : Maekawa F., Tsuboi T., Oya M., Aung K.H., Tsukahara S., Pellerin L., Nohara K.
Title : , NeuroToxicology, 37:197-206 (2013)
Original Paper

Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto-Kakizaki rats.

Presenter : Maekawa F., Fujiwara K., Toriya M., Maejima Y., Nishio T., Toyoda Y., Nohara K., Yashiro T., Yada T.
Title : , Frontiers in Synaptic Neuroscience, 5(7): (2013)
Original Paper

Diurnal expression of Dnmt3b mRNA in mouse liver is regulated by feeding and hepatic clockwork

Presenter : Maekawa F., Shimba S., Takumi S., Sano T., Suzuki T., Bao J., Ohwada M., Ehara T., Ogawa Y., Nohara K.
Title : , Epigenetics, 1046-1056 (2012)
Original Paper

Late-onset Increases in Oxidative Stress and Other Tumorigenic Activities and Tumors With a Ha-ras Mutation in the Liver of Adult Male C3H Mice Gestationally Exposed to Arsenic

Presenter : Nohara K., Tateishi Y., Suzuki T., Okamura K., Murai H., Takumi S., Maekawa F., Nishimura N., Kobori M., Ito T.
Title : , Toxicological Sciences, 129:293-304 (2012)
Original Paper

Elevated expression of brain-derived neurotrophic factor facilitates visual imprinting in chicks

Presenter : Suzuki K., Maekawa F., Suzuki S., Nakamori T., Sugiyama H., Kanamatsu T., Tanaka K., Ohki-Hamazaki H.
Title : , Journal of Neurochemistry, 123:800-810 (2012)
Other Publications

Involvement of postnatal apoptosis on sex difference in number of cells generated during late fetal period in the sexually dimorphic nucleus of the preoptic area in rats.

Presenter : Kato Y., Nakashima S., Maekawa F., Tsukahara S.
Title : , Neuroscience letters, 516(2):290-295 (2012)
Review

Neurohormones, Rikkunshito and Hypothalamic Neurons Interactively Control Appetite and Anorexia

Presenter : Yada T., Kohno D., Maejima M., Sedbazar U., Arai T., Toriya M., Maekawa F., Kurita H., Niijima A. , Yakabi K.
Title : , Current Pharmaceutical Design, 18(31):4854-64 (2012)
Original Paper

Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage

Presenter : Endo T., Maekawa F., Voikar V., Haijima A., Uemura Y., Zhang Y., Miyazaki W., Suyama S., Shimazaki K., Wolfer D.P., Yada T., Tohyama C., Lipp H.P., Kakeyama M.
Title : , Behavioural Brain Research, 221:172-181 (2011)
Original Paper

Long-term Infusion of Brain-Derived Neurotrophic Factor Reduces Food Intake and Body Weight via a Corticotrophin-Releasing Hormone Pathway in the Paraventricular Nucleus of the Hypothalamus

Presenter : Toriya M., Maekawa F., Maejima Y., Onaka T., Fujiwara K., Nakagawa T., Nakata M., Yada O.
Title : , Journal of Neuroendocrinology, 22:1-9 (2010)

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Intestinal butyric acid-mediated disruption of gut hormone secretion and lipid metabolism in vasopressin receptor-deficient mice

Presenter : HARADA K., Wada E., Osuga Y., Shimizu K., Uenoyama R., Hirai YM., Maekawa F., Miyazaki M., Hayashi KY., Nakamura K., Tsuboi T.
Title : , Molecular Metabolism, 91:102072 (2025)
Human neurons are susceptible to the internalization of small-sized nanoplastics

Presenter : Ito T., Ikuno Y., Udagawa O., Tanaka K., Kurokawa Y., Kakeyama M., Maekawa F.
Title : , Environmental Toxicology and Pharmacology, 118:104776 (2025)
Uptake, Elimination and Metabolism of Brominated Dibenzofurans in Mice

Presenter : Tue N.M., Kimura E., Maekawa F., Goto A., Uramaru N., Kunisue T., Suzuki G.
Title : , Toxics, 12(656): (2024)
Possible molecular mechanism for acute encephalopathy by angel-wing mushroom ingestion -Involvement of three constituents in onset-

Presenter : Suzuki T., Asakawa T., Maekawa F., Kimura E., Tezuka Y., Nakamura L., Sato T., Arai Y., Choi J-H., Suzuki M., Dohra H., Hirai H., Kawagishi H.
Title : , Toxicon, 221:106958 (2023)
Presence of sibling during the learning phase of imprinting affects escape behavior from a new object in chicks

Presenter : Chiba Y., Tsuchida K., Maekawa F., Nakamori T., Inaoka H., Ohki-Hamazaki H.
Title : , Neuroscience Research, 190:60-66 (2023)
2-Chloro-3,7,8-tribromodibenzofuran as a new environmental pollutant inducing atypical ultrasonic vocalization in infant mice

Presenter : Kimura E., Suzuki G., Uramaru N., Kakeyama M., Maekawa F.
Title : , Toxicology Research, tfad069: (2023)
Neurons expressing the aryl hydrocarbon receptor in the locus coeruleus and island of Calleja major are novel targets of dioxin in the mouse brain

Presenter : Kimura E., Koda M., Maekawa F., Fujii-Kuriyama Y,, Tohyama C.
Title : , Histochemistry and Cell Biology, 156(2):147-163 (2021)
Liver-specific decrease in Tff3 gene expression in infant mice perinatally exposed to 2,3,7,8-tetrabromodibenzofuran or 2,3,7,8-tetrachlorodibenzo-p-dioxin

Presenter : Kimura E., Suzuki G., Uramaru N., Kakeyama M., Maekawa F.
Title : , Journal of Applied Toxicology, 1-13 (2021)
Estrogenic action by tris(2,6-dimethylphenyl) phosphate impairs the development of female reproductive functions

Presenter : Sano K., Matsukami H., Suzuki G., Htike N.T.T., Morishita M., Tin-Tin-Win-Shwe, Hashimoto S., Kawashima T., Isobe T., Nakayama S.F., Tsukahara S., Maekawa F.
Title : , Environment International, 138:105662 (2020)
Behavioral impairments in infant and adult mouse offspring exposed to 2,3,7,8-tetrabromodibenzofuran in utero and via lactation

Presenter : Kimura E., Suzuki G., Uramaru N., Endo T., Maekawa F.
Title : , Environment International, 142:105833 (2020)
Strain differences in intermale aggression and possible factors regulating increased aggression in Japanese quail

Presenter : Maekawa F., Nagino K., Yang J., Htike N.T.T., Tsukahara S., Ubuka T., Tsutsui K., Kawashima T.
Title : , General and Comparative Endocrinology, 256:63-70 (2018)
Analyzing the effects of co-expression of chick (Gallus gallus) melanocortin receptors with either chick MRAP1 or MRAP2 in CHO cells on sensitivity to ACTH(1-24) or ACTH(1-13)NH2: Implications for the avian HPA axis and avian melanocortin circuits in the hypothalamus

Presenter : Thomas A.L., Maekawa F., Kawashima T., Sakamoto H., Sakamoto T., Davis P., Dores R.M.
Title : , General and Comparative Endocrinology, 256:50-56 (2018)
Weaning stage hyperglycemia induces glucose-insensitivity in arcuate POMC neurons and hyperphagia in type 2 diabetic GK rats

Presenter : Ando A., Gantulga D., Nakata M., Maekawa F., Dezaki K., Ishibashi S., Yada T.
Title : , Neuropeptides, 68:49-56 (2018)
Prenatal Exposure to Arsenic Impairs Behavioral Flexibility and Cortical Structure in Mice

Presenter : Aung K.H., Kyi-Tha-ThuC, Sano K., Nakamura K., Tanoue A., Nohara K., Kakeyama M., Tohyama C., Tsukahara S., Maekawa F.
Title : , Frontiers in Neuroscience, 10(137): (2016)
Arsenic Exposure Induces Unscheduled Mitotic S Phase Entry Coupled with Cell Death in Mouse Cortical Astrocytes

Presenter : Htike N.T.T., Maekawa F., Soutome H., Sano K., Maejima S., Aung K.H., Tokuda M., Tsukahara S.
Title : , Frontiers in Neuroscience, 10(297): (2016)
Glucose level determines excitatory or inhibitory effects of adiponectin on arcuate POMC neuron activity and feeding

Presenter : Suyama S., Maekawa F., Maejima Y., Kubota N., Kadowaki T., Yada T.
Title : , Scientific Reports, 6(30796): (2016)
In utero and Lactational Exposure to Acetamiprid Induces Abnormalities in Socio-Sexual and Anxiety-Related Behaviors of Male Mice

Presenter : Sano K., Isobe T., Yang J., Tin-Tin-Win-Shwe, Yoshikane M., Nakayama S., Kawashima T., Suzuki G., Hashimoto S., Nohara K., Tohyama C., Maekawa F.
Title : , Frontiers in Neuroscience, 10(228): (2016)
Nano-Sized Secondary Organic Aerosol of Diesel Engine Exhaust Origin Impairs Olfactory-Based Spatial Learning Performance in Preweaning Mice

Presenter : Tin-Tin-Win-Shwe, Chaw Kyi Tha thu, Yadanar Moe, Maekawa F., Yanagisawa R., Furuyama A., Tsukahara, Fujitani Y., Hirano S.
Title : , Nanomaterials, 2015(5):1147-1162 (2015)
Unilateral Lesion Increases Oestrogen Receptor α Expression in the Intact Side of the Ventromedial Hypothalamic Nucleus in Ovariectomised Rats

Presenter : Shimogawa Y., Maekawa F., Yamanouchi K.
Title : , Journal of Neuroendocrinology, 26(4):258-266 (2014)
Neural basis of imprinting behavior in chicks

Presenter : Nakamori T., Maekawa F., Sato K., Tanaka K., Ohki-Hamazaki H.
Title : , Development, Growth & Differentiation, 55:198-206 (2013)
Inhibition of neurite outgrowth and alteration of cytoskeletal gene expression by sodium arsenite

Presenter : Aung K.H., Kurihara R., Nakashima S., Maekawa F., Nohara K., Kobayashi T., Tsukahara S.
Title : , Neuro Toxicology, 34:226-235 (2013)
A genetically female brain is required for a regular reproductive cycle in chicken brain chimeras

Presenter : Maekawa F., Sakurai M., Yamashita Y., Tanaka K., Haraguchi S., Yamamoto K., Tsutsui K., Yoshioka H., Murakami S., Tadano R., Goto T., Shiraishi J., Tomonari K., Oka T., Ohara K., Maeda T., Bungo T., Tsudzuki M., Ohki-Hamazaki H.
Title : , Nature Communications, 4(Article number1372): (2013)
Effects of sodium arsenite on neurite outgrowth and glutamate AMPA receptor expression in mouse cortical neurons.

Presenter : Maekawa F., Tsuboi T., Oya M., Aung K.H., Tsukahara S., Pellerin L., Nohara K.
Title : , NeuroToxicology, 37:197-206 (2013)
Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto-Kakizaki rats.

Presenter : Maekawa F., Fujiwara K., Toriya M., Maejima Y., Nishio T., Toyoda Y., Nohara K., Yashiro T., Yada T.
Title : , Frontiers in Synaptic Neuroscience, 5(7): (2013)
Diurnal expression of Dnmt3b mRNA in mouse liver is regulated by feeding and hepatic clockwork

Presenter : Maekawa F., Shimba S., Takumi S., Sano T., Suzuki T., Bao J., Ohwada M., Ehara T., Ogawa Y., Nohara K.
Title : , Epigenetics, 1046-1056 (2012)
Late-onset Increases in Oxidative Stress and Other Tumorigenic Activities and Tumors With a Ha-ras Mutation in the Liver of Adult Male C3H Mice Gestationally Exposed to Arsenic

Presenter : Nohara K., Tateishi Y., Suzuki T., Okamura K., Murai H., Takumi S., Maekawa F., Nishimura N., Kobori M., Ito T.
Title : , Toxicological Sciences, 129:293-304 (2012)
Elevated expression of brain-derived neurotrophic factor facilitates visual imprinting in chicks

Presenter : Suzuki K., Maekawa F., Suzuki S., Nakamori T., Sugiyama H., Kanamatsu T., Tanaka K., Ohki-Hamazaki H.
Title : , Journal of Neurochemistry, 123:800-810 (2012)
Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage

Presenter : Endo T., Maekawa F., Voikar V., Haijima A., Uemura Y., Zhang Y., Miyazaki W., Suyama S., Shimazaki K., Wolfer D.P., Yada T., Tohyama C., Lipp H.P., Kakeyama M.
Title : , Behavioural Brain Research, 221:172-181 (2011)
Long-term Infusion of Brain-Derived Neurotrophic Factor Reduces Food Intake and Body Weight via a Corticotrophin-Releasing Hormone Pathway in the Paraventricular Nucleus of the Hypothalamus

Presenter : Toriya M., Maekawa F., Maejima Y., Onaka T., Fujiwara K., Nakagawa T., Nakata M., Yada O.
Title : , Journal of Neuroendocrinology, 22:1-9 (2010)

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Role of Environmental Chemical Insult in Neuronal Cell Death and Cytoskeleton Damage

Presenter : Aung KH., Tsukahara S., Maekawa F., Nohara K., Nakamura K., Tanoue A.
Title : , Biological and Pharmaceutical Bulletin, 38(8):1109-1112 (2015)
The mechanisms underlying sexual differentiation of behavior and physiology in mammals and birds: relative contributions of sex steroids and sex chromosomes

Presenter : Maekawa F., Tsukahara S., Kawashima T., Nohara K., Ohki-Hamazaki H.
Title : , Frontiers in Neuroscience, 8(242): (2014)
Neurohormones, Rikkunshito and Hypothalamic Neurons Interactively Control Appetite and Anorexia

Presenter : Yada T., Kohno D., Maejima M., Sedbazar U., Arai T., Toriya M., Maekawa F., Kurita H., Niijima A. , Yakabi K.
Title : , Current Pharmaceutical Design, 18(31):4854-64 (2012)
Editorial: The roles of micro-RNAs in neuroendocrine systems

Presenter : Mounien L., Nakamura K., Chigr F., Maekawa F.
Title : , Frontiers in Endocrinology, 15:1349804 (2024)
Editorial: Chemicals in the Environment and Brain Development: Importance of Neuroendocrinological Approaches

Presenter : Maekawa F., Nakamura K., Nakayama SF.
Title : , Frontiers in Neuroscience, 11(133): (2017)

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Presenter : Maekawa F., Nakamura K., Nakayama S.
Title : , CHEMICALS IN THE ENVIRONMENT AND BRAIN DEVELOPMENT: IMPORTANCE OF NEUROENDOCRINOLOGICAL APPROACHES (2017)

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A comparative study of sex difference in calbindin neurons among mice, musk shrews, and Japanese quails

Presenter : Moe Y., Tanaka T., Morishita M., Ohta R., Nakahara C., Kawashima T., Maekawa F., Sakata I., Sakai T., Tsukahara S.
Title : , Neuroscience Letters, 631:63-69 (2016)
Involvement of postnatal apoptosis on sex difference in number of cells generated during late fetal period in the sexually dimorphic nucleus of the preoptic area in rats.

Presenter : Kato Y., Nakashima S., Maekawa F., Tsukahara S.
Title : , Neuroscience letters, 516(2):290-295 (2012)

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Research Result (Presentation)

Research Presentation

Neonatal Brain Exposure to Nanoplastics via Oral Route: Size-Dependent Uptake and Regional Localization

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : Microplastics Exposure and Human Health Conference (2026)
Name of Proceedings : Conference Prpgram, 52
Research Presentation

Investigation of hazardous effects by nanoplastic particles on intracellular signaling dynamics and respiratory functions

Presenter : HARADA K., Udagawa O., Ikuno Y., Tanaka K., Ito T., Maekawa F., Kitaguchi T., Tsuboi T., Fujitani Y.
Name of Society : Microplastics Exposure and Human Health Conference (2026)
Name of Proceedings : Abstracts, 118
Research Presentation

Accumulation of nanoplastics in the neonatal mouse brain visualized by imaging

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : The 96th Annual Meeting of the Zoological Society of Japan (2025)
Name of Proceedings : Abstracts, 27
Research Presentation

Nanoplastics in the Brain: Size-Dependent Biodistribution

Presenter : MI Y., Maekawa F.
Name of Society : The 39th Meeting Japanese Society for Behavioral Neuroendocrinology (2025)
Name of Proceedings : Abstracts, 28
Research Presentation

Oral Exposure to Fluorescent Polystyrene Nanoplastics: Size-Driven Accumulation in Neonatal Mice

Presenter : MI Y., Maekawa F.
Name of Society : 202e reunion Societe Franco-Japonaise de Biologie (2025)
Name of Proceedings : Abstracts, 8
Research Presentation

Accumulation of fluorescence-labeled polystyrene nanoplastics in neonatal mice following oral exposure

Presenter : MI Y., Maekawa F.
Name of Society : APPW2025 The 130th Annual Meeting of the Japanese Association of Anatomists (JAA) The 102nd Annual Meeting of the Physiological Society of Japan (PSJ) The 98th Annual Meeting of the Japanese Pharmacological Society (JPS) (2025)
Name of Proceedings : Young Investigator Award (YIA) Award-Nominated Abstract
Research Presentation

Nanoplastics and the Developing Brain: Early-Life Oral Exposure and Size- Dependent Accumulation

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : The 27th Research Presentation Meeting of the Japan Society of Endocrine Disruptors Research (2025)
Name of Proceedings : Abstracts
Research Presentation

Analysis of effects of nanoplastic particles on human neurons

Presenter : Ito T., Maekawa F.
Name of Society : ISTA21 (21st International Symposium on Toxicity Assessment) (2024)
Name of Proceedings : Abstracts, 66
Research Presentation

Dioxin target neurons in the mammalian brain

Presenter : Kimura E., Kouda M., Maekawa F., Hiraku Y., Tohyama C.
Name of Society : The 21th Internationl Symposium on Toxicity Assessment(ISTA21) (2024)
Name of Proceedings : Abstracts, 64
Research Presentation

BEHAVIORAL ANALYSIS OF GROWTH-RETARDED MICE WITH CONGENITAL HYPOTHYROIDISM USING INTELLICAGE

Presenter : Maekawa F., Nakamura K., Kobayashi K.
Name of Society : The Federation of European Neuroscience Societies (FENS) Forum 2024 (2024)
Name of Proceedings : -
Research Presentation

MOUSE CAN RECOGNIZE OTHER INDIVIDUALS: MATERNAL EXPOSURE TO DIOXIN DOES NOT AFFECT IDENTIFICATION BUT PERTURBS THE RECOGNITION ABILITY OF OTHER INDIVIDUALS

Presenter : Ichihara H., Maekawa F., Kakeyama M.
Name of Society : The Federation of European Neuroscience Societies (FENS) Forum 2024 (2024)
Name of Proceedings : -
Research Presentation

Behavioral Analysis of Mice with Congenital Hypothyroidism Using Automated Group-based Behavior Recording System

Presenter : Maekawa F., Nakamura K., Kobayashi K.
Name of Society : 第101回日本生理学会大会 (2024)
Name of Proceedings : Abstracts
Research Presentation

Sodium Arsenite Attenuates the Cytoskeletal Gene Expression and Alters Morphology of Primarily Cultured Mouse Cortical Astrocytes

Presenter : Htike NTT., Maekawa F., Kobayashi S., Maejima S., Tun ZH. , Tin-Tin-Win-Shwe, Tsukahara S.
Name of Society : EUROTOX2023 (2023)
Name of Proceedings : Toxicology Letters, 384(Supplement 1):S303-S304
Research Presentation

Effects of developmental exposure to polyhalogenated dibenzofuran on ultrasonic vocalization in newborn mouse

Presenter : Maekawa F., Kimura E., Suzuki G., Uramaru N., Kakeyama M.
Name of Society : The 100th Anniversary Annual Meeting of The Physiological Society of Japan (2023)
Name of Proceedings : -, 190
Research Presentation

Developmental exposure to 2-chloro-3,7,8-tribromodibenzofuran impaired neurobehavioral development in mice

Presenter : Maekawa F., Kimura E., Suzuki G., Uramaru N., Kakeyama M.
Name of Society : Neuroscience 2023 Society for Neuroscience (2023)
Name of Proceedings : -, PSTR202.05
Research Presentation

Immunocytochemistry: A Method for Purity Assessment of Primarily Cultured Cells

Presenter : Mohd J. N.A., Tin-Tin-Win-Shwe, Maekawa F., Fidous J., Muhamad N., Tsukahara S. , Htike N.T.T.
Name of Society : 5th International Conference on Tropical Medicine and Infectious Diseases (ICTMID 2022) (2022)
Name of Proceedings : Abstracts, 79
Research Presentation

Application of chick imprinting behavior to evaluate developmental neurotoxicity of chemicals: Effects of in ovo valproic acid exposure

Presenter : Maekawa F., Ohki-Hamazaki S.
Name of Society : International Symposium on Avian Endocrinology 2022 (2022)
Name of Proceedings : Abstracts, 118
Research Presentation

Search for reliable behavioral indicators capable of detecting abnormalities induced by developmental methylmercury exposure

Presenter : Maekawa F., Endo T., Kakeyama M.
Name of Society : The 99th Annual Meeting of the Physiological Society of Japan (2022)
Name of Proceedings : -
Research Presentation

Development of an automated cognitive behavioral testing method for juvenile mice in a group-housed environment and its application to developmental neurotoxicological study

Presenter : Endo T., Maekawa F., Tohyama C.
Name of Society : EUROTOX 2021 (2021)
Name of Proceedings : Abstracts, 473
Research Presentation

Locus coeruleus noradrenergic neurons are novel targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse brain

Presenter : Kimura E., Kouda M., Maekawa F., Tohyama C.
Name of Society : The Virtual 2021 SOT Annual Meeting (2021)
Name of Proceedings : -
Research Presentation

Detection of a behavioral endpoint related to developmental methylmercury exposure independent of experimental environment in mice

Presenter : Maekawa F., Endo T., Kakeyama M.
Name of Society : the 126th Annual Meeting of The Japanese Association of Anatomists/the 98th Annual Meeting of The Physiological Society of Japan (2021)
Name of Proceedings : -
Research Presentation

Uptake, clearance and metabolites of 2,3,7,8-tetrabrominateddibensofuran in mouse

Presenter : Tue N.M., Kimura E., Maekawa F., Goto A., Kunisue T., Suzuki G.
Name of Society : 39th International Symposium on Halogenated Persistent Organic Pollutants (2019)
Name of Proceedings : Abstract Book, 829
Research Presentation

Perinatal exposure to dioxins impacts on gene expression and infant behavior in the mouse

Presenter : Kimura E., Suzuki G., Uramaru N., Maekawa F.
Name of Society : NIPS international workshop “Sensing food/nutrient/environment toward integrative metabolic regulation” (2019)
Name of Proceedings : Abstracts, 29
Research Lecture

Early developmental exposure to environmental chemicals and energy metabolism

Presenter : Maekawa F.
Name of Society : NIPS international workshop “Sensing food/nutrient/environment toward integrative metabolic regulation” (2019)
Name of Proceedings : Abstracts, 24
Research Lecture

Estrogenic action by tris(2,6-dimethylphenyl) phosphate, an impurity in flame retardant formulations, impairs the development of female reproductive functions

Presenter : Maekawa F., Sano K., Suzuki G., Matsukami H., Tsukahara S.
Name of Society : The 3rd Sino-Japan Symposium on the frontier of Behavioral Neuroendocrinology (2019)
Name of Proceedings : Abstracts
Research Presentation

Common behavioral characteristics in the mice maternally exposed to different types of dioxins

Presenter : Maekawa F., Kimura E., Uramaru N., Suzuki G.
Name of Society : 9th Federation of the Asian and Oceanian Physiological Societies (FAOPS) Congress (2019)
Name of Proceedings : -
Research Presentation

Behavioral traits associated with neurodevelopmental disorders in the mice lacking both vasopressin 1a and 1b receptors

Presenter : Maekawa F., Kimura E., Sano K., Endo T., Nakamura K.
Name of Society : Neuroscience 2019 (2019)
Name of Proceedings : -
Research Presentation

Behavioral profile of mice genetically deficient in vasopressin 1a and/or 1b receptors in the IntelliCage

Presenter : Maekawa F., Sano K., Kimura E., Nakamura K.
Name of Society : 11th FENS Forum (2018)
Name of Proceedings : -, C154
Research Presentation

Investigation of gene expressions related to aggression in quail diencephalon

Presenter : Maekawa F., Nagino K., Yang J., Htike N.T.T., Tsukahara S., Ubuka T., Tsutsui K., Kawashima T.
Name of Society : The 95th Annual Meeting of the Physiological Society of Japan (2018)
Name of Proceedings : Proceedings of the 95th Annual Meeting of the Physiological Society of Japan, S151
Research Presentation

Developmental exposure to tetrabromobisphenol A (TBBPA) on late onset behavior and neurological biomarkers in adult mice

Presenter : Tin-Tin-Win-Shwe, Sano K., Isobe T., Kawashima T., Suzuki G., Hashimoto S., Nakayama S., Maekawa F.
Name of Society : The 40th Annual Meeting of the Japan Neuroscience Society (2017)
Name of Proceedings : Abstract, 218
Experimental approaches toward understanding the association between early-life exposure to environmental chemicals and developmental disorders

Presenter : Maekawa F.
Name of Society : INTERNATIONAL SYMPOSIUM ON AUTISM 2017: CELEBRATING BRIMS 10TH YEAR ANNIVERSARY (2017)
Name of Proceedings : Abstracts, 14-15
Research Presentation

Effects of perinatal exposure to a phosphate ester flame retardant on novel object recognition ability and memory function-related gene expression in adult mice

Presenter : Tin-Tin-Win-Shwe, Sano K., Isobe T., Kawashima T., Suzuki G., Hashimoto S., Nakayama S., Maekawa F.
Name of Society : 45th Myanmar Health Research Congress (2017)
Name of Proceedings : Abstract, 120
Research Presentation

Comprehensive analysis of house dust using GC×GC-HRTOFMS and in-house software

Presenter : Ieda T., Hashimoto S., Takazawa Y., Tanabe K., Zushi Y., Shibata Y., Maekawa F., Sano K., Suzuki G., Nakayama S., Isobe T., Tin-Tin-Win-Shwe, Kawashima T.
Name of Society : DIOXIN2016 (2016)
Name of Proceedings : Abstracts
Research Presentation

Developmental exposure to acetamiprid alters behavioral profile of male mice

Presenter : Sano K., Yang J., Tin-Tin-Win-Shwe, Maekawa F.
Name of Society : 10th FENS (the Federation of European Neuroscience Societies) Forum (2016)
Name of Proceedings : Abstracts, (C076)
Research Presentation

Perinatal exposure to a phosphate ester flame retardant affects memory function and related gene expression in adult mice

Presenter : Tin-Tin-Win-Shwe, Sano K., Isobe T., Kawashima T., Suzuki G., Hashimoto S., Nakayama S., Maekawa F.
Name of Society : The 5th Annual Meeting of The Japan Society for Developmental Origins of Health and Disease (DOHaD-Japan) (2016)
Name of Proceedings : Abstract(P-07), 40
Research Lecture

Developmental exposure to a neonicotinoid affects certain behavioral parameters of mice in adulthood: Requirement of evaluation of socio-sexual and emotional behaviors using animal models

Presenter : Maekawa F.
Name of Society : Symposium on Systemic Pesticides Post-Neonics -What Next? (2016)
Name of Proceedings : Abstracts
Research Presentation

Evaluation of potentially developmentally neurotoxic chemicals using behavioral testing and neuroendocrinological analysis

Presenter : Maekawa F., Sano K., Suzuki G., Nakayama S., Isobe T., Tin-Tin-Win-Shwe, Hashimoto S., Kawashima T.
Name of Society : The 93rd Annual Meeting of the Physiological Society of Japan (2016)
Name of Proceedings : Proceedings of The 93rd Annual Meeting of the Physiological Society of Japan, 66(supplement1):S73
Research Presentation

Male aggressive and reproductive behaviors in long-term breeding closed colony NIES-L of Japanese quail

Presenter : NAGINO K., Ubuka T., Tsutsui K., Maekawa F., Kawashima T.
Name of Society : Avian Model Systems 9: A New Integrative Platform (2016)
Name of Proceedings : Proceedings of Avian Model System 9: A New Integrative Platform, 115
Research Lecture

In vivo evaluation of a flame retardant having estrogenic activity using mouse model

Presenter : Sano K., Suzuki G., Htike N.T.T., Morishita M., Tin-Tin-Win-Shwe, Hashimoto S., Kawashima T., Isobe T., Nakayama S., Tsukahara S., Maekawa F.
Name of Society : Application of Recent Advances in Neuroscience to Environmental Health Research (2016)
Name of Proceedings : abstract, 1-4
Research Presentation

Analysis of aggressive behavior in two Japanese quail strains and their gene expressions possibly related to aggression in the hypothalamus

Presenter : Maekawa F., Nagino K., Yang J., Ubuka T., Tsutsui K., Kawashima T.
Name of Society : 11th International Symposium on Avian Endocrinology (2016)
Name of Proceedings : 11th International Symposium on Avian Endocrinology Abstracts, 68
Research Presentation

Melanocortin Receptors and MRAP expression in the chick adrenal gland: correlating mRNA expression levels and ligand sensitivity of chick melanocortin receptors expressed in CHO cell

Presenter : Dores R.M., Thomas A., Maekawa F., Kawashima T., Sakamoto H., Sukamoto T.
Name of Society : 11th International Symposium on Avian Endocrinology (2016)
Name of Proceedings : 11th International Symposium on Avian Endocrinology Abstracts, 60
Research Presentation

Novel approach to olfactory-based spatial learning ability for preweaning mice and the effects of early exposure to diesel exhaust origin secondary organic aerosol

Presenter : Tin-Tin-Win-Shwe, Chaw Kyi Tha Thu, Yadanar Moe, Fujitani Y., Shinji Tsukahara, Maekawa F., Hirano S.
Name of Society : 44th Myanmar Health Research Congress (2016)
Name of Proceedings : Abstract, 79
Research Presentation

PRENATAL ARSENIC EXPOSURE IMPAIRED BEHAVIORAL FLEXIBILITY AND MORPHOLOGY OF CORTEX IN MICE

Presenter : Maekawa F., KYAW HTET AUNG, CHAW KYI THA THU, Sano K., NAKAMURA S., Tanoue A., Kakeyama M., Tohyama C., Nohara K., Tsukahara S.
Name of Society : 9th World Congress International Brain Research Organization (2015)
Name of Proceedings : Abstracts, (301)
Research Presentation

Adipose tissue malfunction in prenatally arsenic-exposed mice

Presenter : Sano K., Maekawa F., Murai H., Nohara K.
Name of Society : The Joint Meeting of the 120th Annual Meeting of The Japanese Association of Anatomists, the 92nd Annual Meeting of The Physiological Society of Japan. (2015)
Name of Proceedings : The Journal of Physiological Sciences, 65(Supplement 1):S235
Research Presentation

Effect of developmental exposure to acetamiprid on behavioral profiles in mice

Presenter : Sano K., Yang J., Tin-Tin-Win-Shwe, Nohara K., Maekawa F.
Name of Society : The 8th congress of the federation of the asian and oceanian physiological societies (2015)
Name of Proceedings : Abstracts, 65(Supplemental 2):S-A179
Research Presentation

Effect of prenatal exposure to arsenic on cell number and morphology of neuron in prelimbic cortex of adult mice

Presenter : Kyaw Htet Aung, Maekawa F., Chaw Kyi Tha Thu, Sano K., Nakamura K, Tanoue A, Kakeyama M, Nohara K., Tsukahara S
Name of Society : 21st Japanese Society for Behavioral Neuroendocrinology (2014)
Name of Proceedings : Abstracts, 17
Research Presentation

Effects of developmental exposure to diesel engine exhaust origin secondary organic aerosol on social and learning behavior in adult mice

Presenter : Tin-Tin-Win-Shwe, Maekawa F., Chaw Kyi Tha Thu, Fujitani Y., Yanagisawa R., Furuyama A., Tsukahara S, Nohara K., Nitta H., Hirano S.
Name of Society : 37th Annual Meeting of the Japan Neuroscience Society (2014)
Name of Proceedings : Abstract, 131
Research Presentation

Live imaging analysis of sodium arsenite-induced inhibition of neurite outgrowth in Neuro-2a cells

Presenter : Aung K.H., Kurihara R., Nakashima S., Maekawa F., Nohara K., Kobayashi T., Tsukahara S.
Name of Society : 分子予防環境医学研究大会第12回 (2013)
Name of Proceedings : 同予稿集, 35
Research Presentation

The Effects of Gestational Inorganic Arsenic Exposure in the Offspring and Future Generations

Presenter : Nohara K., Suzuki T., Takumi S., Okamura K., Maekawa F.
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 15
Research Presentation

Effects of Perinatal Arsenic Exposure on the Development of Mice Brain

Presenter : Maekawa F., Tsukahara S., Nohara K.
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 21
Research Presentation

Evaluation of sodium arsenite-induced inhibition of neurite outgrowth by live cell imaging and alteration of cytoskeletal gene expression in Neuro-2a cells

Presenter : Aung K.H., Kurihara R., Nakashima S., Maekawa F., Nohara K., Kobayashi T., Tsukahara S.
Name of Society : 日本行動神経内分泌研究会第17回 (2012)
Name of Proceedings : 同予稿集, (5-1)
Research Presentation

Late increases in tumorigenic stress and tumors with a Ha-ras mutation in the liver of adult male C3H mice gestationally exposed to arsenic

Presenter : Nohara K., Suzuki T., Tateishi Y., Okamura K., Murai H., Takumi S., Maekawa F., Nishimura N., Ito T.
Name of Society : Prenatal Programming and Toxicity（PPTOX）? Meeting (2012)
Name of Proceedings : Abstracts
Research Presentation

Late-onset gene expression changes in the livers of male C3H mice maternally exposed to arsenic: Implications for an increase in hepatic tumor incidence

Presenter : Nohara K., Tateishi Y., Suzuki T., Murai H., Takumi S., Okamura K., Maekawa f. , Nishimura N., Ito T.
Name of Society : SOCIETY OF TOXICOLOGY 51st Annual Meeting (2012)
Name of Proceedings : Abstracts of SOCIETY OF TOXICOLOGY 51st Annual Meeting
Research Presentation

Impairment of glutamate AMPA receptor expression by sodium arsenite is related to the neurite suppression in mouse cortical neurons.

Presenter : Maekawa F., Tsuboi T., Tsukahara S., Nohara K.
Name of Society : NEUROSCIENCE 2012 42nd annual meeting (2012)
Name of Proceedings : -
Research Presentation

The effect of AMPA receptor overexpression on suppressed neurite outgrowth by sodium arsenite in mouse cortical neuron

Presenter : Maekawa f. , Tsuboi T, Nohara K.
Name of Society : The 34th Annual Meeting of the Japan Neuroscience Society (2011)
Name of Proceedings : Abstracts of The 34th Annual Meeting of the Japan Neuroscience Society, s19

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Neonatal Brain Exposure to Nanoplastics via Oral Route: Size-Dependent Uptake and Regional Localization

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : Microplastics Exposure and Human Health Conference (2026)
Name of Proceedings : Conference Prpgram, 52
Accumulation of nanoplastics in the neonatal mouse brain visualized by imaging

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : The 96th Annual Meeting of the Zoological Society of Japan (2025)
Name of Proceedings : Abstracts, 27
Nanoplastics in the Brain: Size-Dependent Biodistribution

Presenter : MI Y., Maekawa F.
Name of Society : The 39th Meeting Japanese Society for Behavioral Neuroendocrinology (2025)
Name of Proceedings : Abstracts, 28
Oral Exposure to Fluorescent Polystyrene Nanoplastics: Size-Driven Accumulation in Neonatal Mice

Presenter : MI Y., Maekawa F.
Name of Society : 202e reunion Societe Franco-Japonaise de Biologie (2025)
Name of Proceedings : Abstracts, 8
Accumulation of fluorescence-labeled polystyrene nanoplastics in neonatal mice following oral exposure

Presenter : MI Y., Maekawa F.
Name of Society : APPW2025 The 130th Annual Meeting of the Japanese Association of Anatomists (JAA) The 102nd Annual Meeting of the Physiological Society of Japan (PSJ) The 98th Annual Meeting of the Japanese Pharmacological Society (JPS) (2025)
Name of Proceedings : Young Investigator Award (YIA) Award-Nominated Abstract
Nanoplastics and the Developing Brain: Early-Life Oral Exposure and Size- Dependent Accumulation

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : The 27th Research Presentation Meeting of the Japan Society of Endocrine Disruptors Research (2025)
Name of Proceedings : Abstracts
Analysis of effects of nanoplastic particles on human neurons

Presenter : Ito T., Maekawa F.
Name of Society : ISTA21 (21st International Symposium on Toxicity Assessment) (2024)
Name of Proceedings : Abstracts, 66
Dioxin target neurons in the mammalian brain

Presenter : Kimura E., Kouda M., Maekawa F., Hiraku Y., Tohyama C.
Name of Society : The 21th Internationl Symposium on Toxicity Assessment(ISTA21) (2024)
Name of Proceedings : Abstracts, 64
Evaluation of potentially developmentally neurotoxic chemicals using behavioral testing and neuroendocrinological analysis

Presenter : Maekawa F., Sano K., Suzuki G., Nakayama S., Isobe T., Tin-Tin-Win-Shwe, Hashimoto S., Kawashima T.
Name of Society : The 93rd Annual Meeting of the Physiological Society of Japan (2016)
Name of Proceedings : Proceedings of The 93rd Annual Meeting of the Physiological Society of Japan, 66(supplement1):S73
Effect of prenatal exposure to arsenic on cell number and morphology of neuron in prelimbic cortex of adult mice

Presenter : Kyaw Htet Aung, Maekawa F., Chaw Kyi Tha Thu, Sano K., Nakamura K, Tanoue A, Kakeyama M, Nohara K., Tsukahara S
Name of Society : 21st Japanese Society for Behavioral Neuroendocrinology (2014)
Name of Proceedings : Abstracts, 17
Live imaging analysis of sodium arsenite-induced inhibition of neurite outgrowth in Neuro-2a cells

Presenter : Aung K.H., Kurihara R., Nakashima S., Maekawa F., Nohara K., Kobayashi T., Tsukahara S.
Name of Society : 分子予防環境医学研究大会第12回 (2013)
Name of Proceedings : 同予稿集, 35
The Effects of Gestational Inorganic Arsenic Exposure in the Offspring and Future Generations

Presenter : Nohara K., Suzuki T., Takumi S., Okamura K., Maekawa F.
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 15
Effects of Perinatal Arsenic Exposure on the Development of Mice Brain

Presenter : Maekawa F., Tsukahara S., Nohara K.
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 21
Evaluation of sodium arsenite-induced inhibition of neurite outgrowth by live cell imaging and alteration of cytoskeletal gene expression in Neuro-2a cells

Presenter : Aung K.H., Kurihara R., Nakashima S., Maekawa F., Nohara K., Kobayashi T., Tsukahara S.
Name of Society : 日本行動神経内分泌研究会第17回 (2012)
Name of Proceedings : 同予稿集, (5-1)
Investigation of hazardous effects by nanoplastic particles on intracellular signaling dynamics and respiratory functions

Presenter : HARADA K., Udagawa O., Ikuno Y., Tanaka K., Ito T., Maekawa F., Kitaguchi T., Tsuboi T., Fujitani Y.
Name of Society : Microplastics Exposure and Human Health Conference (2026)
Name of Proceedings : Abstracts, 118
BEHAVIORAL ANALYSIS OF GROWTH-RETARDED MICE WITH CONGENITAL HYPOTHYROIDISM USING INTELLICAGE

Presenter : Maekawa F., Nakamura K., Kobayashi K.
Name of Society : The Federation of European Neuroscience Societies (FENS) Forum 2024 (2024)
Name of Proceedings : -
MOUSE CAN RECOGNIZE OTHER INDIVIDUALS: MATERNAL EXPOSURE TO DIOXIN DOES NOT AFFECT IDENTIFICATION BUT PERTURBS THE RECOGNITION ABILITY OF OTHER INDIVIDUALS

Presenter : Ichihara H., Maekawa F., Kakeyama M.
Name of Society : The Federation of European Neuroscience Societies (FENS) Forum 2024 (2024)
Name of Proceedings : -
Behavioral Analysis of Mice with Congenital Hypothyroidism Using Automated Group-based Behavior Recording System

Presenter : Maekawa F., Nakamura K., Kobayashi K.
Name of Society : 第101回日本生理学会大会 (2024)
Name of Proceedings : Abstracts
Sodium Arsenite Attenuates the Cytoskeletal Gene Expression and Alters Morphology of Primarily Cultured Mouse Cortical Astrocytes

Presenter : Htike NTT., Maekawa F., Kobayashi S., Maejima S., Tun ZH. , Tin-Tin-Win-Shwe, Tsukahara S.
Name of Society : EUROTOX2023 (2023)
Name of Proceedings : Toxicology Letters, 384(Supplement 1):S303-S304
Effects of developmental exposure to polyhalogenated dibenzofuran on ultrasonic vocalization in newborn mouse

Presenter : Maekawa F., Kimura E., Suzuki G., Uramaru N., Kakeyama M.
Name of Society : The 100th Anniversary Annual Meeting of The Physiological Society of Japan (2023)
Name of Proceedings : -, 190
Developmental exposure to 2-chloro-3,7,8-tribromodibenzofuran impaired neurobehavioral development in mice

Presenter : Maekawa F., Kimura E., Suzuki G., Uramaru N., Kakeyama M.
Name of Society : Neuroscience 2023 Society for Neuroscience (2023)
Name of Proceedings : -, PSTR202.05
Immunocytochemistry: A Method for Purity Assessment of Primarily Cultured Cells

Presenter : Mohd J. N.A., Tin-Tin-Win-Shwe, Maekawa F., Fidous J., Muhamad N., Tsukahara S. , Htike N.T.T.
Name of Society : 5th International Conference on Tropical Medicine and Infectious Diseases (ICTMID 2022) (2022)
Name of Proceedings : Abstracts, 79
Application of chick imprinting behavior to evaluate developmental neurotoxicity of chemicals: Effects of in ovo valproic acid exposure

Presenter : Maekawa F., Ohki-Hamazaki S.
Name of Society : International Symposium on Avian Endocrinology 2022 (2022)
Name of Proceedings : Abstracts, 118
Search for reliable behavioral indicators capable of detecting abnormalities induced by developmental methylmercury exposure

Presenter : Maekawa F., Endo T., Kakeyama M.
Name of Society : The 99th Annual Meeting of the Physiological Society of Japan (2022)
Name of Proceedings : -
Development of an automated cognitive behavioral testing method for juvenile mice in a group-housed environment and its application to developmental neurotoxicological study

Presenter : Endo T., Maekawa F., Tohyama C.
Name of Society : EUROTOX 2021 (2021)
Name of Proceedings : Abstracts, 473
Locus coeruleus noradrenergic neurons are novel targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse brain

Presenter : Kimura E., Kouda M., Maekawa F., Tohyama C.
Name of Society : The Virtual 2021 SOT Annual Meeting (2021)
Name of Proceedings : -
Detection of a behavioral endpoint related to developmental methylmercury exposure independent of experimental environment in mice

Presenter : Maekawa F., Endo T., Kakeyama M.
Name of Society : the 126th Annual Meeting of The Japanese Association of Anatomists/the 98th Annual Meeting of The Physiological Society of Japan (2021)
Name of Proceedings : -
Uptake, clearance and metabolites of 2,3,7,8-tetrabrominateddibensofuran in mouse

Presenter : Tue N.M., Kimura E., Maekawa F., Goto A., Kunisue T., Suzuki G.
Name of Society : 39th International Symposium on Halogenated Persistent Organic Pollutants (2019)
Name of Proceedings : Abstract Book, 829
Perinatal exposure to dioxins impacts on gene expression and infant behavior in the mouse

Presenter : Kimura E., Suzuki G., Uramaru N., Maekawa F.
Name of Society : NIPS international workshop “Sensing food/nutrient/environment toward integrative metabolic regulation” (2019)
Name of Proceedings : Abstracts, 29
Common behavioral characteristics in the mice maternally exposed to different types of dioxins

Presenter : Maekawa F., Kimura E., Uramaru N., Suzuki G.
Name of Society : 9th Federation of the Asian and Oceanian Physiological Societies (FAOPS) Congress (2019)
Name of Proceedings : -
Behavioral traits associated with neurodevelopmental disorders in the mice lacking both vasopressin 1a and 1b receptors

Presenter : Maekawa F., Kimura E., Sano K., Endo T., Nakamura K.
Name of Society : Neuroscience 2019 (2019)
Name of Proceedings : -
Behavioral profile of mice genetically deficient in vasopressin 1a and/or 1b receptors in the IntelliCage

Presenter : Maekawa F., Sano K., Kimura E., Nakamura K.
Name of Society : 11th FENS Forum (2018)
Name of Proceedings : -, C154
Investigation of gene expressions related to aggression in quail diencephalon

Presenter : Maekawa F., Nagino K., Yang J., Htike N.T.T., Tsukahara S., Ubuka T., Tsutsui K., Kawashima T.
Name of Society : The 95th Annual Meeting of the Physiological Society of Japan (2018)
Name of Proceedings : Proceedings of the 95th Annual Meeting of the Physiological Society of Japan, S151
Developmental exposure to tetrabromobisphenol A (TBBPA) on late onset behavior and neurological biomarkers in adult mice

Presenter : Tin-Tin-Win-Shwe, Sano K., Isobe T., Kawashima T., Suzuki G., Hashimoto S., Nakayama S., Maekawa F.
Name of Society : The 40th Annual Meeting of the Japan Neuroscience Society (2017)
Name of Proceedings : Abstract, 218
Effects of perinatal exposure to a phosphate ester flame retardant on novel object recognition ability and memory function-related gene expression in adult mice

Presenter : Tin-Tin-Win-Shwe, Sano K., Isobe T., Kawashima T., Suzuki G., Hashimoto S., Nakayama S., Maekawa F.
Name of Society : 45th Myanmar Health Research Congress (2017)
Name of Proceedings : Abstract, 120
Comprehensive analysis of house dust using GC×GC-HRTOFMS and in-house software

Presenter : Ieda T., Hashimoto S., Takazawa Y., Tanabe K., Zushi Y., Shibata Y., Maekawa F., Sano K., Suzuki G., Nakayama S., Isobe T., Tin-Tin-Win-Shwe, Kawashima T.
Name of Society : DIOXIN2016 (2016)
Name of Proceedings : Abstracts
Developmental exposure to acetamiprid alters behavioral profile of male mice

Presenter : Sano K., Yang J., Tin-Tin-Win-Shwe, Maekawa F.
Name of Society : 10th FENS (the Federation of European Neuroscience Societies) Forum (2016)
Name of Proceedings : Abstracts, (C076)
Perinatal exposure to a phosphate ester flame retardant affects memory function and related gene expression in adult mice

Presenter : Tin-Tin-Win-Shwe, Sano K., Isobe T., Kawashima T., Suzuki G., Hashimoto S., Nakayama S., Maekawa F.
Name of Society : The 5th Annual Meeting of The Japan Society for Developmental Origins of Health and Disease (DOHaD-Japan) (2016)
Name of Proceedings : Abstract(P-07), 40
Male aggressive and reproductive behaviors in long-term breeding closed colony NIES-L of Japanese quail

Presenter : NAGINO K., Ubuka T., Tsutsui K., Maekawa F., Kawashima T.
Name of Society : Avian Model Systems 9: A New Integrative Platform (2016)
Name of Proceedings : Proceedings of Avian Model System 9: A New Integrative Platform, 115
Analysis of aggressive behavior in two Japanese quail strains and their gene expressions possibly related to aggression in the hypothalamus

Presenter : Maekawa F., Nagino K., Yang J., Ubuka T., Tsutsui K., Kawashima T.
Name of Society : 11th International Symposium on Avian Endocrinology (2016)
Name of Proceedings : 11th International Symposium on Avian Endocrinology Abstracts, 68
Melanocortin Receptors and MRAP expression in the chick adrenal gland: correlating mRNA expression levels and ligand sensitivity of chick melanocortin receptors expressed in CHO cell

Presenter : Dores R.M., Thomas A., Maekawa F., Kawashima T., Sakamoto H., Sukamoto T.
Name of Society : 11th International Symposium on Avian Endocrinology (2016)
Name of Proceedings : 11th International Symposium on Avian Endocrinology Abstracts, 60
Novel approach to olfactory-based spatial learning ability for preweaning mice and the effects of early exposure to diesel exhaust origin secondary organic aerosol

Presenter : Tin-Tin-Win-Shwe, Chaw Kyi Tha Thu, Yadanar Moe, Fujitani Y., Shinji Tsukahara, Maekawa F., Hirano S.
Name of Society : 44th Myanmar Health Research Congress (2016)
Name of Proceedings : Abstract, 79
PRENATAL ARSENIC EXPOSURE IMPAIRED BEHAVIORAL FLEXIBILITY AND MORPHOLOGY OF CORTEX IN MICE

Presenter : Maekawa F., KYAW HTET AUNG, CHAW KYI THA THU, Sano K., NAKAMURA S., Tanoue A., Kakeyama M., Tohyama C., Nohara K., Tsukahara S.
Name of Society : 9th World Congress International Brain Research Organization (2015)
Name of Proceedings : Abstracts, (301)
Adipose tissue malfunction in prenatally arsenic-exposed mice

Presenter : Sano K., Maekawa F., Murai H., Nohara K.
Name of Society : The Joint Meeting of the 120th Annual Meeting of The Japanese Association of Anatomists, the 92nd Annual Meeting of The Physiological Society of Japan. (2015)
Name of Proceedings : The Journal of Physiological Sciences, 65(Supplement 1):S235
Effect of developmental exposure to acetamiprid on behavioral profiles in mice

Presenter : Sano K., Yang J., Tin-Tin-Win-Shwe, Nohara K., Maekawa F.
Name of Society : The 8th congress of the federation of the asian and oceanian physiological societies (2015)
Name of Proceedings : Abstracts, 65(Supplemental 2):S-A179
Effects of developmental exposure to diesel engine exhaust origin secondary organic aerosol on social and learning behavior in adult mice

Presenter : Tin-Tin-Win-Shwe, Maekawa F., Chaw Kyi Tha Thu, Fujitani Y., Yanagisawa R., Furuyama A., Tsukahara S, Nohara K., Nitta H., Hirano S.
Name of Society : 37th Annual Meeting of the Japan Neuroscience Society (2014)
Name of Proceedings : Abstract, 131
Late increases in tumorigenic stress and tumors with a Ha-ras mutation in the liver of adult male C3H mice gestationally exposed to arsenic

Presenter : Nohara K., Suzuki T., Tateishi Y., Okamura K., Murai H., Takumi S., Maekawa F., Nishimura N., Ito T.
Name of Society : Prenatal Programming and Toxicity（PPTOX）? Meeting (2012)
Name of Proceedings : Abstracts
Late-onset gene expression changes in the livers of male C3H mice maternally exposed to arsenic: Implications for an increase in hepatic tumor incidence

Presenter : Nohara K., Tateishi Y., Suzuki T., Murai H., Takumi S., Okamura K., Maekawa f. , Nishimura N., Ito T.
Name of Society : SOCIETY OF TOXICOLOGY 51st Annual Meeting (2012)
Name of Proceedings : Abstracts of SOCIETY OF TOXICOLOGY 51st Annual Meeting
Impairment of glutamate AMPA receptor expression by sodium arsenite is related to the neurite suppression in mouse cortical neurons.

Presenter : Maekawa F., Tsuboi T., Tsukahara S., Nohara K.
Name of Society : NEUROSCIENCE 2012 42nd annual meeting (2012)
Name of Proceedings : -
The effect of AMPA receptor overexpression on suppressed neurite outgrowth by sodium arsenite in mouse cortical neuron

Presenter : Maekawa f. , Tsuboi T, Nohara K.
Name of Society : The 34th Annual Meeting of the Japan Neuroscience Society (2011)
Name of Proceedings : Abstracts of The 34th Annual Meeting of the Japan Neuroscience Society, s19

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Early developmental exposure to environmental chemicals and energy metabolism

Presenter : Maekawa F.
Name of Society : NIPS international workshop “Sensing food/nutrient/environment toward integrative metabolic regulation” (2019)
Name of Proceedings : Abstracts, 24
Estrogenic action by tris(2,6-dimethylphenyl) phosphate, an impurity in flame retardant formulations, impairs the development of female reproductive functions

Presenter : Maekawa F., Sano K., Suzuki G., Matsukami H., Tsukahara S.
Name of Society : The 3rd Sino-Japan Symposium on the frontier of Behavioral Neuroendocrinology (2019)
Name of Proceedings : Abstracts
Developmental exposure to a neonicotinoid affects certain behavioral parameters of mice in adulthood: Requirement of evaluation of socio-sexual and emotional behaviors using animal models

Presenter : Maekawa F.
Name of Society : Symposium on Systemic Pesticides Post-Neonics -What Next? (2016)
Name of Proceedings : Abstracts
In vivo evaluation of a flame retardant having estrogenic activity using mouse model

Presenter : Sano K., Suzuki G., Htike N.T.T., Morishita M., Tin-Tin-Win-Shwe, Hashimoto S., Kawashima T., Isobe T., Nakayama S., Tsukahara S., Maekawa F.
Name of Society : Application of Recent Advances in Neuroscience to Environmental Health Research (2016)
Name of Proceedings : abstract, 1-4

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MAEKAWA Fumihiko

Research Subject

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Research Result (Publication)

Research Result (Presentation)