ITO Tomohiro

Researcher Name
ITO Tomohiro
Div (Section) name/title
Health and Environmental Risk Division（Health Effect Assessment Section）／Senior Researcher
Research Subject
Studies on the effects of environmental chemicals on immune cells and their mechanisms
Degree(s)
Ph.D. (Environmental Science)
Professional Qualification(s)
Pharmacy,Biochemistry
Environmental Speciality Field
Environmental toxicology
Keyword(s)
Immunology,Dioxin,Cell culture,Gene recombination,Flow cytometry,Molecular biology,Microarray,RNA interference,Dendritic cells
Membership of Academic Society
Japan Society of Endocrine Disrupters Research (JSEDR),The Molecular Biology Society of Japan,The pharmaceutical society of japan

Research Subject

  • Fiscal Year: 2025

    • 27216 : Research project on the health hazard assessment considering the real-life environment and vulnerability
    • 27364 : Comprehensive Study of the Developmental Neurotoxic Effects of Nanoplastics
    • 27381 : A fundamental study for evaluating health impact of environmental factors
    • 27393 : Nanoplastic particles: Preparation of standard materials and their potential health hazards

  • Fiscal Year: 2024

    • 26829 : Research project on the health hazard assessment considering the real-life environment and vulnerability
    • 26926 : Comprehensive Study of the Developmental Neurotoxic Effects of Nanoplastics
    • 26947 : A fundamental study for evaluating health impact of environmental factors
    • 27059 : Nanoplastic particles: Preparation of standard materials and their potential health hazards

  • Fiscal Year: 2023

    • 26420 : Research project on the health hazard assessment considering the real-life environment and vulnerability
    • 26709 : A fundamental study for evaluating health impact of environmental factors

  • Fiscal Year: 2022

    • 25973 : Research project on the health hazard assessment considering the real-life environment and vulnerability
    • 26159 : A fundamental study for evaluating health impact of environmental factors
    • 26270 : Long-term analysis of greenhouse gases in the polar region with the Siberian tower network

  • Fiscal Year: 2021

    • 25517 : Research on the health hazard assessment considering the real-life environment and vulnerability
    • 25625 : A fundamental study for evaluating health impact of environmental factors

  • Fiscal Year: 2020

    • 25099 : Research Program on Health and Environmental Safety
    • 25141 : Research Project on Health Impacts of Chemicals on Children and Future Generations
    • 25142 : Project to Develop Integrated Approaches to Detecting and Assessment of Multiple and Unknown Chemicals, and Building Environmental Monitoring Networks
    • 25236 : A Fundamental Study for Evaluating Health Impact of Environmental Factors
    • 25324 : Development of neurotoxicity testing with multi-neurodevelopmental processes by using mouse ES cells

  • Fiscal Year: 2019

    • 24696 : Research Program on Health and Environmental Safety
    • 24721 : Research Project on Health Impacts of Chemicals on Children and Future Generations
    • 24722 : Project to Develop Integrated Approaches to Detecting and Assessment of Multiple and Unknown Chemicals, and Building Environmental Monitoring Networks
    • 24832 : Source apportionment of various toxicities by atmospheric organic aerosols
    • 24926 : A Fundamental Study for Evaluating Health Impact of Environmental Factors

  • Fiscal Year: 2018

    • 24304 : Research project on health impacts of chemicals on children and future generations
    • 24305 : Project to develop integrated approaches to detecting and assessment of multiple and unknown chemicals, and building environmental monitoring networks
    • 24355 : Research program on health and environmental safety
    • 24386 : Source apportionment of various toxicities by atmospheric organic aerosols
    • 24531 : A fundamental study for evaluating health impact of environmental factors
    • 24583 : Detection of chemical substances with epigenetic activity to protect environmental risk by the adverse outcome pathway approach

  • Fiscal Year: 2017

    • 23823 : Project to develop integrated approaches to detecting and assessment of multiple and unknown chemicals, and building environmental monitoring networks
    • 23824 : Research project on health impacts of chemicals on children and future generations
    • 23847 : Research program on health and environmental safety
    • 23975 : A fundamental study for evaluating health impact of environmental factors
    • 23986 : Effective development of iPS cells into alveolar epithelium by utilization of basement membrane substratum
    • 24009 : Source apportionment of various toxicities by atmospheric organic aerosols
    • 24107 : Detection of chemical substances with epigenetic activity to protect environmental risk by the adverse outcome pathway approach

  • Fiscal Year: 2016

    • 23414 : Research program on health and environmental safety
    • 23415 : Research project on health impacts of chemicals on children and future generations
    • 23416 : Project to develop integrated approaches to detecting and assessment of multiple and unknown chemicals, and building environmental monitoring networks
    • 23640 : Development of in vitro hazard testing systems using iPS cells
    • 23641 : Detection of chemical substances with epigenetic activity to protect environmental risk by the adverse outcome pathway approach
    • 23659 : A fundamental study for evaluating health impact of environmental factors
    • 23680 : Effective development of iPS cells into alveolar epithelium by utilization of basement membrane substratum
    • 23684 : Effects of airborne particulates in China on lung cells

  • Fiscal Year: 2015

    • 23018 : Mechanism and evaluation system of the developmental health effects of environmental factors
    • 23170 : Development of in vitro hazard testing systems using iPS cells
    • 23172 : Detection of chemical substances with epigenetic activity to protect environmental risk by the adverse outcome pathway approach
    • 23202 : Effects of airborne particulates in China on lung cells
    • 23203 : Study for toxicities of environmental pollutants by using pluripotent stem cells

  • Fiscal Year: 2014

    • 22606 : Mechanism and evaluation system of the developmental health effects of environmental factors
    • 22894 : Development of in vitro hazard testing systems using iPS cells
    • 22895 : Study for toxicities of environmental pollutants by using pluripotent stem cells
    • 22958 : Effects of airborne particulates in China on lung cells

  • Fiscal Year: 2013

    • 22190 : Mechanism and evaluation system of the developmental health effects of environmental factors
    • 22550 : Study for toxicities of environmental pollutants by using pluripotent stem cells
    • 22570 : Health effects of secondary organic aerosols derived from diesel exhaust.

  • Fiscal Year: 2012

    • 21761 : Mechanism and evaluation system of the developmental health effects of environmental factors

  • Fiscal Year: 2011

    • 21319 : Mechanism and evaluation system of the developmental health effects of environmental factors

  • Fiscal Year: 2010

    • 20844 : Effects of environmental chemicals on antigen-presenting cells
    • 20921 : Estimating of toxicities of environmental pollutants on hematopoietic stem cells using iPS cells

  • Fiscal Year: 2009

    • 20764 : in vitro evaluation of effects of diesel exhaust particles using iPS-derived cardiomyocytes
    • 20765 : Effects of environmental chemicals on antigen-presenting cells

  • Fiscal Year: 2008

    • 20147 : Development of evaluation system which can predict the effects of environmental chemicals on hypersensitive subjects with atopy using dendritic cells

  • Fiscal Year: 2007

    • 10650 : Effect of environmental pollutants on the skin immunity by using langerhans cells
    • 10677 : Development of evaluation system which can predict the effects of environmental chemicals on hypersensitive subjects with atopy using dendritic cells

  • Fiscal Year: 2006

    • 10050 : Studies on application of toxicogenomics for risk assessment of environmental pollutants

  • Fiscal Year: 2005

    • 9521 : Studies on application of toxicogenomics for risk assessment of environmental pollutants

  • Fiscal Year: 2004

    • 9050 : Studies on the health effects of endocrine disrupters
    • 9217 : Identification of causal genes responsible for dioxin-induced immunosuppression using RNAi
    • 9272 : Studies on application of toxicogenomics for risk assessment of environmental pollutants

  • Fiscal Year: 2003

    • 8610 : Elucidation of endocrine disrupting mechanism of dioxin and related compounds for health risk assessment
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Research Result (Publication)

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Research Result (Presentation)

  • Research Presentation
    Neonatal Brain Exposure to Nanoplastics via Oral Route: Size-Dependent Uptake and Regional Localization
    Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
    Name of Society : Microplastics Exposure and Human Health Conference (2026)
    Name of Proceedings : Conference Prpgram, 52
  • Research Presentation
    Investigation of hazardous effects by nanoplastic particles on intracellular signaling dynamics and respiratory functions
    Presenter : HARADA K., Udagawa O., Ikuno Y., Tanaka K., Ito T., Maekawa F., Kitaguchi T., Tsuboi T., Fujitani Y.
    Name of Society : Microplastics Exposure and Human Health Conference (2026)
    Name of Proceedings : Abstracts, 118
  • Research Presentation
    Accumulation of nanoplastics in the neonatal mouse brain visualized by imaging
    Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
    Name of Society : The 96th Annual Meeting of the Zoological Society of Japan (2025)
    Name of Proceedings : Abstracts, 27
  • Research Presentation
    Nanoplastics and the Developing Brain: Early-Life Oral Exposure and Size- Dependent Accumulation
    Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
    Name of Society : The 27th Research Presentation Meeting of the Japan Society of Endocrine Disruptors Research (2025)
    Name of Proceedings : Abstracts
  • Research Presentation
    Analysis of effects of nanoplastic particles on human neurons
    Presenter : Ito T., Maekawa F.
    Name of Society : ISTA21 (21st International Symposium on Toxicity Assessment) (2024)
    Name of Proceedings : Abstracts, 66
  • Research Presentation
    Driver Gene Detection through Bayesian Network Integration of Cellular Phonotypes and Expression Profiles
    Presenter : Sone H., Qin X.Y., Ito T., Kikegawa M.
    Name of Society : 2022年日本バイオインフォマティクス学会年会・第11回生命医薬情報学連合大会（IIBMP2022） (2022)
    Name of Proceedings : 同予稿集
  • Research Presentation
    Source apportionment of multiple toxic potentials of atmospheric organic aerosols
    Presenter : Fushimi A., Nakajima D., Furuyama A., Suzuki G., Ito T., Sato K., Fujitani Y., Kondo Y., Yoshino A., Ramasamy S., Schauer J. J., Fu P., Takahashi Y., Saitoh K., Saito S., Takami A.
    Name of Society : European Aerosol Conference - EAC 2021 (2021)
    Name of Proceedings : Abstracts, (OP P1 - 235)
  • Research Presentation
    Hazard evaluation of air pollution by using the key characteristics approach
    Presenter : Sone H., Miki M., Ito T., Tin-Tin-Win-Shwe, Fujitani Y., Nakajima D.
    Name of Society : 5th NIES International Forum (2020)
    Name of Proceedings : Abstract, 70
  • Research Presentation
    Novel Method for Source Apportionment of Toxicity of Atmospheric Organic Aerosols
    Presenter : Fushimi A., Nakajima D., Furuyama A., Suzuki G., Ito T., Sato K., Fujitani Y., Kondo Y., Yoshino A., Takami A.
    Name of Society : 5th International Forum on Sustainable Future in Asia / 5th NIES International Forum (2020)
    Name of Proceedings : Abstracts, 79
  • Research Presentation
    New approach for source apportionment of toxicity by atmospheric organic aerosols
    Presenter : Fushimi A., Nakajima D., Furuyama A., Suzuki G., Ito T., Sato K., Fujitani Y., Kondo Y., Takami A.
    Name of Society : 37th AAAR (American Association for Aerosol Research) Annual Conference (2019)
    Name of Proceedings : Abstracts, (2AD.5)
  • Research Lecture
    Effect-based Detection of Organic Chemicals in PM2.5 for Their Risk Management
    Presenter : Suzuki G., Michinaka C., Nakajima D., Furuyama A., Ito T., Sato K., Kondo Y., Fujitani Y., Takahashi Y., Yagishita M., Ramasamy S., Takami A., Fushimi A.
    Name of Society : 47th Myanmar Health Research Congress (2019)
    Name of Proceedings : Abstracts, 21-25
  • Research Presentation
    Dioxin-induced up-regulation of vitamin D is the main cause for its inhibitory action on osteoblast activities, leading to developmental bone toxicity
    Presenter : Nishimura N., Nishimura H., Ito T., Fujimaki H., Matsumura F.
    Name of Society : HORIBA/CDBIM Symp. -21st Century Adv.Mol.Toxicol.Environ.Chem.Pathog.Dis.- (2009)
    Name of Proceedings : Abstracts, 158
  • Research Presentation
    Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on born development in mouse pups
    Presenter : Nishimura N., Ito T., Izumi K., Nishimura H., Fujimaki H.
    Name of Society : Eurotox 2008 (2008)
    Name of Proceedings : Toxicol.Lett., 180S:S194
  • Research Presentation
    Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin bone mineralization the growing mouse
    Presenter : , , Ito T.
    Name of Society : SOT 2008 (2008)
    Name of Proceedings : Abstracts
  • Research Presentation
    Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on bone mineralization, vitamin D metabolism and calcium(Ca) homeostasis in the growing mouse
    Presenter : Nishimura N., Ito T., Fujimaki H., Izumi K., Nishimura H.
    Name of Society : 5th SETAC World Congr. (2008)
    Name of Proceedings : Abstracts
  • Research Presentation
    Defect of mineralization as a possible cause of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced bone toxicity in early postnatal development in mice
    Presenter : Nishimura N., Ito T., Fujimaki H., Nishimura H.
    Name of Society : 28th Int.Symp.Halogenat.Persistent Org.Pollut.-DIOXIN 2008 (2008)
    Name of Proceedings : Organohalogen Compd., 70:1924-1927
  • Research Presentation
    Phthalate esters modulate the differentiation of mouse peripheral blood mononuclear cells-derived dendritic cells
    Presenter : Ito T., Inoue Ken-ichiro, Koike E., Yanagisawa R., Nishimura N., Takano H.
    Name of Society : 45th Congr.Eur.Soc.Toxicol. (2008)
    Name of Proceedings : Toxicol.Lett., 180S:S117
  • Research Presentation
    Up-regulation of 25-hydroxyvitamin D3 1α-hydroxylase and disruption of calcium metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing mouse kidney
    Presenter : , , Ito T.
    Name of Society : 27th Int.Symp.Halogenat.Persistent Org.Pollut.-DIOXIN 2007 (2007)
    Name of Proceedings : Organohalogen Compd., 69
  • Research Presentation
    Changes of gene expression involved in vitamin D metabolism and transcellular CA2+ transport by 2,3,7,8-tetrachlorodibenzo-p-dioxin in developing mouse kidney
    Presenter : , , Ito T.
    Name of Society : Int.Congr.Toxicol.(Poster Session) (2007)
    Name of Proceedings : Abstracts
  • Research Presentation
    Search for genes involved in the growth inhibition of Jurkat T cells by a constitutively active arylhydrocarbon receptor
    Presenter : Ito T.
    Name of Society : 20th IUBMB Int.Congr.Biochem.Mol.Biol.11th FAOBMB Congr.(Poster Session) (2006)
    Name of Proceedings : Abstracts
  • Research Presentation
    Distinctive gene expression patterns in thymuses exposed to atrophy-inducing chemicals
    Presenter : , Ito T.
    Name of Society : SOT Annu.Meet.2006(Poster Session) (2006)
    Name of Proceedings : Toxicologist, 90
  • Research Presentation
    Comparison of the TCDD-induced CYP1A1 gene expression profile in lymphocytes from mice,rats and humans
    Presenter : , Ito T.
    Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
    Name of Proceedings : Toxicologist, 84
  • Research Presentation
    Gene expression changes in fetal thymus exposed to organic compounds extracted from diesel exhaust particles.
    Presenter : Tohyama C., Ito T.
    Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
    Name of Proceedings : Toxicologist, 84
  • Research Presentation
    Activation of arylhydrocarbon receptor(AhR) in T lineage cells inhibits cellular growth.
    Presenter : , Ito T.
    Name of Society : 24th Int.Symp.Halogenat.Environ.Org.Pollut.POPs; DIOXIN 2004 (2004)
    Name of Proceedings : Organohalogen Compd., 66
  • Research Presentation
    Thymocyte alterations in CD2-driven constitutively active arylhydrocarbon receptor(AHR) transgenic mice
    Presenter : , Ito T.
    Name of Society : Soc.Toxicol.42nd Annu.Meet. (2003)
    Name of Proceedings : Toxicologist, 72:362
  • Research Presentation
    A constitutively active aryl hydrocarbon receptor induces growth inhibition by cell cycle arrest and apoptosis in jurkat T cells
    Presenter : , Ito T.
    Name of Society : Soc.Toxicol.42nd Annu.Meet. (2003)
    Name of Proceedings : Toxicologist, 72:367
  • The effects of TCDD on germinal center formation in the spleen of C57BL/6 mice
    Presenter : Inouye K., Ito T., Fujimaki H., Tohyama C., Nohara K.
    Name of Society : Soc.Toxicol.: 41st Annu.Meet. (2002)
    Name of Proceedings : Toxicologist, 61
  • Suppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) on Th2-derived cytokine production in primary immune reaction of mice
    Presenter : Nohara K., Ito T., Inouye K., Fujimaki H., Tohyama C.
    Name of Society : Soc.Toxicol.: 41st Annu.Meet. (2002)
    Name of Proceedings : Toxicologist, 61
  • Alteration of B cell development in the spleen of C57B1/6 mice by TCDD treatment
    Presenter : Inouye K., Ito T., Fujimaki H., Tohyama C., Nohara K.
    Name of Society : 4th Annu.Meet.Jpn.Soc.Endocr.Disrupters Res. (2001)
    Name of Proceedings : Program & Abstracts
  • Mechanisms for 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)- induced suppression of antigen-specific antibody production
    Presenter : Ito T., Inouye K., Fujimaki H., Tohyama C., Nohara K.
    Name of Society : 4th Annu.Meet.Jpn.Soc.Endocr.Disrupters Res. (2001)
    Name of Proceedings : Program & Abstracts
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