- Researcher Name
- OKAMURA Kazuyuki
- Div (Section) name/title
- Health and Environmental Risk Division(Molecular Pathology Section)/Senior Researcher
- Research Subject
- Clarification of the mechanisms of diseases induction by environmental exposure especially focused on cellular senescence and transgenerational epigenetic inheritance
- Degree(s)
- Doctor of Philosophy in Environmental Studies
- Professional Qualification(s)
- Biochemistry,Science,Medicine
- Environmental Speciality Field
- toxicology,chemical substance,Hygiene
- Keyword(s)
- epigenetics,cellular senescence,arsenic,transgenerational effect,tumor
- Membership of Academic Society
- The Japanese Society for Hygiene,The Japanese Cancer Association,The Molecular Biology Society of Japan,The Japanese Society for Epigenetics,The Japanese Society for DOHaD,Japanese Society of Immunotoxicology,The Japanese Society of Toxicology,Society for Senescence-Accelerated Mouse (SAM) Research
Research Subject
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Fiscal Year: 2025
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27216 : Research project on the health hazard assessment considering the real-life environment and vulnerability
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27382 : Basic research on the effects of environmental factors on the onset/progression of diseases
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27425 : Search for molecular targets to eliminate senescent cells induced by arsenic exposure
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27426 : Experimental study of the effects of LED light control on sleep and lifespan
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Fiscal Year: 2024
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26829 : Research project on the health hazard assessment considering the real-life environment and vulnerability
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26966 : Basic research on the effects of environmental factors on the onset/progression of diseases
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26988 : Elucidation of the mechanisms of arsenic-induced cardiometabolic diseases
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26989 : Search for molecular targets to eliminate senescent cells induced by arsenic exposure
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26990 : Experimental study of the effects of LED light control on sleep and lifespan
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27019 : Analysis of mechanism of DNA methylation changes in next-generation sperm genome induced by gestational arsenic exposure
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Fiscal Year: 2023
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26420 : Research project on the health hazard assessment considering the real-life environment and vulnerability
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26514 : Elucidation of the mechanisms of arsenic-induced cardiometabolic diseases
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26516 : Search for molecular targets to eliminate senescent cells induced by arsenic exposure
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26517 : Experimental study of the effects of LED light control on sleep and lifespan
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26551 : Basic research on the effects of environmental factors on the onset/progression of diseases
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26659 : Analysis of mechanism of DNA methylation changes in next-generation sperm genome induced by gestational arsenic exposure
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Fiscal Year: 2022
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25973 : Research project on the health hazard assessment considering the real-life environment and vulnerability
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26083 : Basic research on the effects of environmental factors on the onset/progression of diseases
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26135 : Elucidation of the mechanism of liver carcinogenesis via premature senescence of hepatocytes induced by arsenite exposure
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26136 : Elucidation of the mechanisms of arsenic-induced cardiometabolic diseases
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26220 : Analysis of mechanism of DNA methylation changes in next-generation sperm genome induced by gestational arsenic exposure
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Fiscal Year: 2021
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25517 : Research on the health hazard assessment considering the real-life environment and vulnerability
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25738 : Basic research on the effects of environmental factors on the onset/progression of diseases
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25741 : Elucidation of the mechanism of liver carcinogenesis via premature senescence of hepatocytes induced by arsenite exposure
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25801 : Analysis of mechanism of DNA methylation changes in next-generation sperm genome induced by gestational arsenic exposure
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25936 : Elucidation of the mechanisms of arsenic-induced cardiometabolic diseases
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Fiscal Year: 2020
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25099 : Research Program on Health and Environmental Safety
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25141 : Research Project on Health Impacts of Chemicals on Children and Future Generations
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25196 : Project for the Promotion of Environmental Genomics Studies
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25250 : Studies on the Effects of Environmental Factors on the Onset/progression of Diseases
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25277 : Inheritance of environmental impacts on DNA methylation through sperm to the next generation embryos
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Fiscal Year: 2019
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24696 : Research Program on Health and Environmental Safety
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24721 : Research Project on Health Impacts of Chemicals on Children and Future Generations
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24837 : Identification of sperm small RNAs involved in multigenerational health effects of environmental chemicals
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24838 : Inheritance of environmental impacts on DNA methylation through sperm to the next generation embryos
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24858 : Project for the Promotion of Environmental Genomics Studies
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24891 : Studies on the Effects of Environmental Factors on the Onset/progression of Diseases
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24955 : Investigation of the mechanisms of arsenic-induced carcinogenesis via cellular senescence of fibroblast
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Fiscal Year: 2018
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24304 : Research project on health impacts of chemicals on children and future generations
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24355 : Research program on health and environmental safety
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24446 : Project for The Promotion of Environmental Genomics studies
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24455 : Identification of sperm small RNAs involved in multigenerational health effects of environmental chemicals
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24498 : Investigation of the mechanisms of arsenic-induced carcinogenesis via cellular senescence of fibroblast
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24504 : Studies on the effects of environmental factors on the onset/progression of diseases
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Fiscal Year: 2017
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23824 : Research project on health impacts of chemicals on children and future generations
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23847 : Research program on health and environmental safety
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23948 : Studies on the effects of environmental factors on the onset/progression of diseases
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23967 : Identification of sperm small RNAs involved in multigenerational health effects of environmental chemicals
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23970 : Project for The Promotion of Environmental Genomics studies
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24016 : The involvement of cellular senescence in hepatic tumors that increase through multiple generations by gestational arsenite exposure
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Fiscal Year: 2016
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23414 : Research program on health and environmental safety
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23415 : Research project on health impacts of chemicals on children and future generations
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23484 : Project for The Promotion of Environmental Genomics studies
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23558 : Studies on the effects of environmental factors on the onset/progression of diseases
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23593 : Studies on epimutations that are involved in the transgenerational effects of environmental chemicals in mice
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23594 : Genome-wide DNA methylation analysis of sperm to explore the mechanism of hepatic tumor augmentation in the F2 by gestational arsenite exposure of F0 pregnant female
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23661 : The involvement of cellular senescence in hepatic tumors that increase through multiple generations by gestational arsenite exposure
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Fiscal Year: 2015
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23018 : Mechanism and evaluation system of the developmental health effects of environmental factors
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23256 : Studies on multigenerational late-onset effects of environmental chemicals
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23257 : Studies on epimutations that are involved in the transgenerational effects of environmental chemicals in mice
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23258 : Genome-wide DNA methylation analysis of sperm to explore the mechanism of hepatic tumor augmentation in the F2 by gestational arsenite exposure of F0 pregnant female
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23259 : The involvement of cellular senescence in hepatic tumors that increase through multiple generations by gestational arsenite exposure
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23277 : Establishment of an international cooperation for promoting arsenic research
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Fiscal Year: 2014
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22606 : Mechanism and evaluation system of the developmental health effects of environmental factors
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22719 : Studies on multigenerational late-onset effects of environmental chemicals
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22721 : Studies on epimutations that are involved in the transgenerational effects of environmental chemicals in mice
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22722 : Establishment of an international cooperation for promoting arsenic research
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Fiscal Year: 2013
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22190 : Mechanism and evaluation system of the developmental health effects of environmental factors
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22507 : Studies on multigenerational late-onset effects of environmental chemicals
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Fiscal Year: 2012
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21761 : Mechanism and evaluation system of the developmental health effects of environmental factors
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21986 : Studies of factors contributing to the regulation of epigenetics
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Fiscal Year: 2011
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21480 : Studies of factors contributing to the regulation of epigenetics
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21481 : Studies on the mechanism of transcription factor dependent effects of environmental chemicals
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Research Result (Publication)
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Original PaperPresenter : Nohara K., Suzuki T., Okamura K., Kawai T., Nakabayashi K.
Title : , Epigenetics & Chromatin (2025) -
Original Paper
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Original PaperArsenite exposure induces premature senescence and senescence-associated secretory phenotype (SASP) in human hepatocyte-derived cell line Huh-7Presenter : Okamura K., Sato M., Suzuki T., Nohara K.
Title : , Environmental Health and Preventive Medicine (2024) -
Original PaperPresenter : KATO K., Okamura K., Hiki K., Kintsu H., Nohara K., Yamagishi T., Nakajima N., Watanabe H., Yamamoto H.
Title : , Aquatic Toxicology, 243(106071): (2022) -
Original PaperPresenter : Okamura K., Sato M., Suzuki T., Nohara K.
Title : , Toxicology and Applied Pharmacology, 454: (2022) -
Original PaperPresenter : Matsushita J., Suzuki T., Okamura K., Ichihara G., Nohara K.
Title : , Environmental Health and Preventive Medicine, 25: (2020) -
Original Paper
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Original Paper
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Original PaperPresenter : Nohara K., Nakabayashi K., Okamura K., Suzuki T., Suzuki S., Hata K.
Title : , Epigenetics & Chromatin, 13(53): (2020) -
ReviewPresenter : Udagawa O., Okamura K., Suzuki T., Nohara K.
Title : , Arsenic Contamination in Asia. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore, 29-42 (2019) -
Original PaperPresenter : Okamura K., Nakabayashi K., Kawai T., Suzuki T., Sano T., Hata K., Nohara K.
Title : , Cancer Science, 110:2629-2642 (2019) -
Original PaperPresenter : Matsushita J., Okamura K., Nakabayashi K, Suzuki T., Horibe Y., Kawai T., Sakurai T., Yamashita S., Higami Y., Ichihara G., Hata K., Nohara K.
Title : , BMC Cancer, 18:317 (2018) -
ReviewPresenter : Nohara K., Suzuki T., Okamura K., Matsushita J., Takumi S.
Title : , Genes and Environment, 39(3): (2017) -
Original Paper
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Original PaperPresenter : Nohara K., Okamura K., Suzuki T., Murai H., Michikawa T., Ito T., Shinjo K., Takumi S., Kondo Y., Hata K.
Title : , Journal of Applied Toxicology, 36(1):105-112 (2015) -
Original PaperPresenter : Takumi S., Okamura K., Yanagisawa H., Sano T., Kobayashi Y., Nohara K.
Title : , Journal of Applied Toxicology, 760:1550-1556 (2014) -
Original Paper
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Original PaperPresenter : Nohara K., Tateishi Y., Suzuki T., Okamura K., Murai H., Takumi S., Maekawa F., Nishimura N., Kobori M., Ito T.
Title : , Toxicological Sciences, 129:293-304 (2012)
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Presenter : Nohara K., Suzuki T., Okamura K., Kawai T., Nakabayashi K.
Title : , Epigenetics & Chromatin (2025) -
-
Arsenite exposure induces premature senescence and senescence-associated secretory phenotype (SASP) in human hepatocyte-derived cell line Huh-7Presenter : Okamura K., Sato M., Suzuki T., Nohara K.
Title : , Environmental Health and Preventive Medicine (2024) -
Presenter : KATO K., Okamura K., Hiki K., Kintsu H., Nohara K., Yamagishi T., Nakajima N., Watanabe H., Yamamoto H.
Title : , Aquatic Toxicology, 243(106071): (2022) -
Presenter : Okamura K., Sato M., Suzuki T., Nohara K.
Title : , Toxicology and Applied Pharmacology, 454: (2022) -
Presenter : Matsushita J., Suzuki T., Okamura K., Ichihara G., Nohara K.
Title : , Environmental Health and Preventive Medicine, 25: (2020) -
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Presenter : Nohara K., Nakabayashi K., Okamura K., Suzuki T., Suzuki S., Hata K.
Title : , Epigenetics & Chromatin, 13(53): (2020) -
Presenter : Okamura K., Nakabayashi K., Kawai T., Suzuki T., Sano T., Hata K., Nohara K.
Title : , Cancer Science, 110:2629-2642 (2019) -
Presenter : Matsushita J., Okamura K., Nakabayashi K, Suzuki T., Horibe Y., Kawai T., Sakurai T., Yamashita S., Higami Y., Ichihara G., Hata K., Nohara K.
Title : , BMC Cancer, 18:317 (2018) -
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Presenter : Nohara K., Okamura K., Suzuki T., Murai H., Michikawa T., Ito T., Shinjo K., Takumi S., Kondo Y., Hata K.
Title : , Journal of Applied Toxicology, 36(1):105-112 (2015) -
Presenter : Takumi S., Okamura K., Yanagisawa H., Sano T., Kobayashi Y., Nohara K.
Title : , Journal of Applied Toxicology, 760:1550-1556 (2014) -
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Presenter : Nohara K., Tateishi Y., Suzuki T., Okamura K., Murai H., Takumi S., Maekawa F., Nishimura N., Kobori M., Ito T.
Title : , Toxicological Sciences, 129:293-304 (2012)
-
Presenter : Udagawa O., Okamura K., Suzuki T., Nohara K.
Title : , Arsenic Contamination in Asia. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore, 29-42 (2019) -
Presenter : Nohara K., Suzuki T., Okamura K., Matsushita J., Takumi S.
Title : , Genes and Environment, 39(3): (2017)
Research Result (Presentation)
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Research PresentationEpigenetic Inheritance of Health Effects by Gestational Exposure to Environmental ChemicalsPresenter : Nohara K., Suzuki T., Okamura K., Tin-Tin-Win-Shwe
Name of Society : 1st International Conference: Environmental Pollution and Health Impact on Future Generation in Asian countries (EPHIF2023) (2023)
Name of Proceedings : Abstracts -
Research PresentationArsenite exposure induces premature senescence in fibroblasts and its association of tumorigenesisPresenter : Okamura K., Suzuki T., Nohara K.
Name of Society : SOT 62nd Annual Meeting (2023)
Name of Proceedings : Abstracts, 3387 -
Research PresentationRising global health issue regarding arsenic contamination: gestational arsenic exposure impacts on neuroimmune markers and anxiety in F1 offspringPresenter : Chaw Kyi Tha Thu, Soe-Minn Htway, Suzuki T., Okamura K., Nohara K., Tin-Tin-Win-Shwe
Name of Society : 5th International Conference on Tropical Medicine and Infectious Diseases (2022)
Name of Proceedings : Abstracts, EP549 -
Research PresentationNovel DNA methylation changes induced by gestational arsenite exposure in hepatic tumors in F2 micePresenter : Okamura K., Nakabayashi K., Horibe Y., Kawai T., Suzuki T., Hata K., Nohara K.
Name of Society : The 5th Annual Meeting of the Japan Society for Developmental Origins of Health and Disease (2016)
Name of Proceedings : Abstracts, 5(1):41 -
Research PresentationDNA methylation changes in hepatic normal tissues and tumor tissues in gestationally arsenite-exposed F2 micePresenter : Okamura K., Nohara K.
Name of Society : The 75th Annual Meeting of the Japanese Cancer Association (2016)
Name of Proceedings : Abstracts, 95 -
Research PresentationLong-term arsenite exposure induces premature senescence via DNA damage accumulation in mouse B lymphoma cell line A20 cellsPresenter : Okamura K., Nohara K.
Name of Society : 44th Myanmar Health Research Congress (2016)
Name of Proceedings : Abstracts, 85 -
Research PresentationPresenter : Nohara K., Okamura K., Suzuki T., Hatada I, Hata K
Name of Society : Society of Toxicology 54th Annual Meeting (2015)
Name of Proceedings : Abstracts, 523 -
Research PresentationPresenter : Takumi S, Okamura K., Suzuki T., Hano H, Nohara K., Yanagisawa H
Name of Society : Society of Toxicology 54th Annual Meeting (2015)
Name of Proceedings : Abstracts, 422 -
Research PresentationPresenter : Nohara K., Okamura K., Suzuki T., Murai H., Ito T., Shinjo K., Kondo Y.
Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
Name of Proceedings : Abstracts -
Research PresentationPresenter : Okamura K., Nohara K.
Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
Name of Proceedings : Abstracts -
Research PresentationThe Effects of Gestational Inorganic Arsenic Exposure in the Offspring and Future GenerationsPresenter : Nohara K., Suzuki T., Takumi S., Okamura K., Maekawa F.
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 15 -
Research PresentationPresenter : Nohara K., Suzuki T., Tateishi Y., Okamura K., Murai H., Takumi S., Maekawa F., Nishimura N., Ito T.
Name of Society : Prenatal Programming and Toxicity(PPTOX)? Meeting (2012)
Name of Proceedings : Abstracts -
Research PresentationPresenter : Nohara K., Tateishi Y., Suzuki T., Murai H., Takumi S., Okamura K., Maekawa f. , Nishimura N., Ito T.
Name of Society : SOCIETY OF TOXICOLOGY 51st Annual Meeting (2012)
Name of Proceedings : Abstracts of SOCIETY OF TOXICOLOGY 51st Annual Meeting
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Epigenetic Inheritance of Health Effects by Gestational Exposure to Environmental ChemicalsPresenter : Nohara K., Suzuki T., Okamura K., Tin-Tin-Win-Shwe
Name of Society : 1st International Conference: Environmental Pollution and Health Impact on Future Generation in Asian countries (EPHIF2023) (2023)
Name of Proceedings : Abstracts -
Novel DNA methylation changes induced by gestational arsenite exposure in hepatic tumors in F2 micePresenter : Okamura K., Nakabayashi K., Horibe Y., Kawai T., Suzuki T., Hata K., Nohara K.
Name of Society : The 5th Annual Meeting of the Japan Society for Developmental Origins of Health and Disease (2016)
Name of Proceedings : Abstracts, 5(1):41 -
DNA methylation changes in hepatic normal tissues and tumor tissues in gestationally arsenite-exposed F2 micePresenter : Okamura K., Nohara K.
Name of Society : The 75th Annual Meeting of the Japanese Cancer Association (2016)
Name of Proceedings : Abstracts, 95 -
Presenter : Nohara K., Okamura K., Suzuki T., Hatada I, Hata K
Name of Society : Society of Toxicology 54th Annual Meeting (2015)
Name of Proceedings : Abstracts, 523 -
Presenter : Okamura K., Nohara K.
Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
Name of Proceedings : Abstracts -
The Effects of Gestational Inorganic Arsenic Exposure in the Offspring and Future GenerationsPresenter : Nohara K., Suzuki T., Takumi S., Okamura K., Maekawa F.
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 15 -
Arsenite exposure induces premature senescence in fibroblasts and its association of tumorigenesisPresenter : Okamura K., Suzuki T., Nohara K.
Name of Society : SOT 62nd Annual Meeting (2023)
Name of Proceedings : Abstracts, 3387 -
Rising global health issue regarding arsenic contamination: gestational arsenic exposure impacts on neuroimmune markers and anxiety in F1 offspringPresenter : Chaw Kyi Tha Thu, Soe-Minn Htway, Suzuki T., Okamura K., Nohara K., Tin-Tin-Win-Shwe
Name of Society : 5th International Conference on Tropical Medicine and Infectious Diseases (2022)
Name of Proceedings : Abstracts, EP549 -
Long-term arsenite exposure induces premature senescence via DNA damage accumulation in mouse B lymphoma cell line A20 cellsPresenter : Okamura K., Nohara K.
Name of Society : 44th Myanmar Health Research Congress (2016)
Name of Proceedings : Abstracts, 85 -
Presenter : Takumi S, Okamura K., Suzuki T., Hano H, Nohara K., Yanagisawa H
Name of Society : Society of Toxicology 54th Annual Meeting (2015)
Name of Proceedings : Abstracts, 422 -
Presenter : Nohara K., Okamura K., Suzuki T., Murai H., Ito T., Shinjo K., Kondo Y.
Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
Name of Proceedings : Abstracts -
Presenter : Nohara K., Suzuki T., Tateishi Y., Okamura K., Murai H., Takumi S., Maekawa F., Nishimura N., Ito T.
Name of Society : Prenatal Programming and Toxicity(PPTOX)? Meeting (2012)
Name of Proceedings : Abstracts -
Presenter : Nohara K., Tateishi Y., Suzuki T., Murai H., Takumi S., Okamura K., Maekawa f. , Nishimura N., Ito T.
Name of Society : SOCIETY OF TOXICOLOGY 51st Annual Meeting (2012)
Name of Proceedings : Abstracts of SOCIETY OF TOXICOLOGY 51st Annual Meeting