【As of Nov 20, 2025】

UDAGAWA Osamu

Researcher Name: UDAGAWA Osamu

Div (Section) name/title: Health and Environmental Risk Division（Integrated Health Risk Research Section）／Senior Researcher

Research Subject: Inhalation toxicology of fine particles

Degree(s): Ph.D (Pharmaceutical science)

Professional Qualification(s): Biology

Environmental Speciality Field: toxicology

Keyword(s): cell culture

Membership of Academic Society: The Japanese Biochemical Society (JBS),The pharmaceutical society of japan,The Japanese Conference on the Biochemistry of Lipids

Research Subject

Fiscal Year: 2025
- 27216 : Research project on the health hazard assessment considering the real-life environment and vulnerability
- 27294 : Fundamental study of integrated health-risk evaluation
- 27393 : Nanoplastic particles: Preparation of standard materials and their potential health hazards
- 27536 : Observational studies to evaluate the spatio-temporal distribution of ultrafine particles(UFP) and epidemiological and toxicological studies to evaluate their acute effects on olfaction and the central nervous system
Fiscal Year: 2024
- 26829 : Research project on the health hazard assessment considering the real-life environment and vulnerability
- 26891 : Observational studies to evaluate the spatio-temporal distribution of ultrafine particles(UFP) and epidemiological and toxicological studies to evaluate their acute effects on olfaction and the central nervous system
- 26948 : Fundamental study of integrated health-risk evaluation
- 27059 : Nanoplastic particles: Preparation of standard materials and their potential health hazards
- 27060 : Elucidation of environmental chemicals that affect the fertility of oocytes due to organelle clustering
Fiscal Year: 2023
- 26420 : Research project on the health hazard assessment considering the real-life environment and vulnerability
- 26503 : Fundamental study of integrated health-risk evaluation
Fiscal Year: 2022
- 25973 : Research project on the health hazard assessment considering the real-life environment and vulnerability
- 26029 : Fundamental study of integrated health-risk evaluation
- 26146 : Elucidation of environmental chemicals that affect the fertility of oocytes due to organelle clustering
Fiscal Year: 2021
- 25517 : Research on the health hazard assessment considering the real-life environment and vulnerability
- 25783 : Fundamental study of integrated health-risk evaluation
Fiscal Year: 2020
- 25099 : Research Program on Health and Environmental Safety
- 25141 : Research Project on Health Impacts of Chemicals on Children and Future Generations
- 25142 : Project to Develop Integrated Approaches to Detecting and Assessment of Multiple and Unknown Chemicals, and Building Environmental Monitoring Networks
- 25196 : Project for the Promotion of Environmental Genomics Studies
- 25219 : A Fundamental Study on the Integrated Health Risk Evaluation.
- 25277 : Inheritance of environmental impacts on DNA methylation through sperm to the next generation embryos
Fiscal Year: 2019
- 24696 : Research Program on Health and Environmental Safety
- 24721 : Research Project on Health Impacts of Chemicals on Children and Future Generations
- 24722 : Project to Develop Integrated Approaches to Detecting and Assessment of Multiple and Unknown Chemicals, and Building Environmental Monitoring Networks
- 24837 : Identification of sperm small RNAs involved in multigenerational health effects of environmental chemicals
- 24838 : Inheritance of environmental impacts on DNA methylation through sperm to the next generation embryos
- 24858 : Project for the Promotion of Environmental Genomics Studies
- 24879 : A Fundamental Study on the Integrated Health Risk Evaluation.
Fiscal Year: 2018
- 24304 : Research project on health impacts of chemicals on children and future generations
- 24305 : Project to develop integrated approaches to detecting and assessment of multiple and unknown chemicals, and building environmental monitoring networks
- 24355 : Research program on health and environmental safety
- 24446 : Project for The Promotion of Environmental Genomics studies
- 24455 : Identification of sperm small RNAs involved in multigenerational health effects of environmental chemicals
- 24509 : A fundamental study on the integrated health risk evaluation.
Fiscal Year: 2017
- 23823 : Project to develop integrated approaches to detecting and assessment of multiple and unknown chemicals, and building environmental monitoring networks
- 23824 : Research project on health impacts of chemicals on children and future generations
- 23847 : Research program on health and environmental safety
- 23894 : A fundamental study on the integrated health risk evaluation.
- 23967 : Identification of sperm small RNAs involved in multigenerational health effects of environmental chemicals
- 23970 : Project for The Promotion of Environmental Genomics studies
Fiscal Year: 2016
- 23414 : Research program on health and environmental safety
- 23415 : Research project on health impacts of chemicals on children and future generations
- 23416 : Project to develop integrated approaches to detecting and assessment of multiple and unknown chemicals, and building environmental monitoring networks
- 23484 : Project for The Promotion of Environmental Genomics studies
- 23594 : Genome-wide DNA methylation analysis of sperm to explore the mechanism of hepatic tumor augmentation in the F2 by gestational arsenite exposure of F0 pregnant female
- 23660 : A fundamental study on the integrated health risk evaluation.
Fiscal Year: 2015
- 23001 : Development of toxicity and safety evaluation methods for nanomaterials
- 23258 : Genome-wide DNA methylation analysis of sperm to explore the mechanism of hepatic tumor augmentation in the F2 by gestational arsenite exposure of F0 pregnant female
- 23286 : Analysis of the effect of inorganic arsenite on reproductive function
Fiscal Year: 2014
- 22589 : Development of toxicity and safety evaluation methods for nanomaterials
- 22641 : Development of health risk evaluation methods for environmental toxicants on the basis of exposure routes.
- 22908 : Analysis of the effect of inorganic arsenite on reproductive function
- 22948 : Health effects of secondary organic aerosols derived from diesel exhaust.

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Research Result (Publication)

all
Original Paper
Review
Book
Other Publications

Original Paper
Whole-tissue distribution analysis for visualization of nanoplastics in the neonatal mouse brain

Presenter : MI Y., Ito T., Tanaka K., Udagawa O., Kakeyama M., Tsutsumi Y., Maekawa F.
Title : , Journal of Hazardous Materials Advances (2026)
Original Paper
Human neurons are susceptible to the internalization of small-sized nanoplastics

Presenter : Ito T., Ikuno Y., Udagawa O., Tanaka K., Kurokawa Y., Kakeyama M., Maekawa F.
Title : , Environmental Toxicology and Pharmacology, 118:104776 (2025)
Original Paper
Behavior of Assembled Promyelocytic Leukemia Nuclear Bodies upon Asymmetric Division in Mouse Oocytes

Presenter : Udagawa O., Kato A., Hirano S.
Title : , International Journal of Molecular Sciences, 25(16):8656 (2024)
Book
Oocyte Health and Quality: Implication of Mitochondria-related Organelle Interactions.

Presenter : Udagawa O.
Title : , Intercellular and Interorganellar Transfer and Communication in Biology and Medicine. Results and Problems in Cell Differentiation, vol 73. (2024)
Original Paper
SUMOylation regulates the number and size of promyelocytic leukemia-nuclear bodies (PML-NBs) and arsenic perturbs SUMO dynamics on PML by insolubilizing PML in THP-1 cells

Presenter : Hirano S., Udagawa O.
Title : , Archives of Toxicology, 96:545-558 (2022)
Review
How arsenic, an inorganic pollutant, is involved in the physiology of biomolecular condensates in the cell

Presenter : Udagawa O., Hirano S.
Title : , Frontiers in Environmental Chemistry, 3(797966): (2022)
Original Paper
Effects of arsenic on the topology and solubility of promyelocytic leukemia (PML)-nuclear bodies.

Presenter : Hirano S., Udagawa O.
Title : , PLOS ONE, 17(5 (e0268835)):1-22 (2022)
Original Paper
Promyelocytic leukemia nuclear body-like structures can assemble in mouse oocytes

Presenter : Udagawa O., Kato A., Hirano S.
Title : , Biology Open, 11(6):bio059130 (2022)
Review
Mitochondrial dynamics and interorganellar communication in the development and dysmorphism of mammalian oocytes

Presenter : Udagawa O., Ishihara N.
Title : , The Journal of Biochemistry, 167(3):257-266 (2020)
Review
Arsenic Exposure and Reproductive Toxicity

Presenter : Udagawa O., Okamura K., Suzuki T., Nohara K.
Title : , Arsenic Contamination in Asia. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore, 29-42 (2019)
Other Publications
Proposed Key Characteristics of Female Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Data in Hazard Assessment

Presenter : Luderer U., Eskenazi B., Hauser R., Korach K.S., McHale C.M., Moran F., Rieswijk L., Solomon G., Udagawa O., Zhang L., Zlatnik M., Zeise L., Smith M.T.
Title : , Environmental Health Perspectives, 127(7):075001-1-075001-14 (2019)
Original Paper
Effects of diesel exhaust-derived secondary organic aerosol (SOA) on oocytes: Potential risks to meiotic maturation

Presenter : Udagawa O., Furuyama A., Imai K., Fujitani Y., Hirano S.
Title : , Reproductive Toxicology, 75:56-64 (2018)
Original Paper
Solubility changes of promyelocytic leukemia (PML) and SUMO monomers and dynamics of PML nuclear body proteins in arsenite-treated cells

Presenter : Hirano S., Udagawa O., Kobayashi Y., Kato A.
Title : , Toxicology and Applied Pharmacology, 360:150-159 (2018)
Original Paper
Pharmacodynamics of S-dimethylarsino-glutathione, a putative metabolic intermediate of inorganic arsenic, in mice

Presenter : Kato A., Kobayashi Y., Udagawa O., Hirano S.
Title : , Biochemical Pharmacology, 126:79-86 (2017)
Original Paper
Solubility shift and SUMOylaltion of promyelocytic leukemia (PML) protein in response to arsenic(III) and fate of the SUMOylated PML

Presenter : Hirano S., Tadano M., Kobayashi Y., Udagawa O., KATO A.
Title : , Toxicology and Applied Pharmacology, 287:191-201 (2015)
Original Paper
Mitochondrial fission factor Drp1 maintains oocyte quality via dynamic rearrangement of multiple organelles

Presenter : Udagawa O., Ishihara T., Maeda M., Matsunaga Y., Tsukamoto S., Kawano N., Miyado K., Shitara H., Yokota S., Nomura M. , Mihara K., Mizushima N., Ishihara N.
Title : , Current Biology, 24(20):1-8 (2014)

View all

Whole-tissue distribution analysis for visualization of nanoplastics in the neonatal mouse brain

Presenter : MI Y., Ito T., Tanaka K., Udagawa O., Kakeyama M., Tsutsumi Y., Maekawa F.
Title : , Journal of Hazardous Materials Advances (2026)
Human neurons are susceptible to the internalization of small-sized nanoplastics

Presenter : Ito T., Ikuno Y., Udagawa O., Tanaka K., Kurokawa Y., Kakeyama M., Maekawa F.
Title : , Environmental Toxicology and Pharmacology, 118:104776 (2025)
Behavior of Assembled Promyelocytic Leukemia Nuclear Bodies upon Asymmetric Division in Mouse Oocytes

Presenter : Udagawa O., Kato A., Hirano S.
Title : , International Journal of Molecular Sciences, 25(16):8656 (2024)
SUMOylation regulates the number and size of promyelocytic leukemia-nuclear bodies (PML-NBs) and arsenic perturbs SUMO dynamics on PML by insolubilizing PML in THP-1 cells

Presenter : Hirano S., Udagawa O.
Title : , Archives of Toxicology, 96:545-558 (2022)
Effects of arsenic on the topology and solubility of promyelocytic leukemia (PML)-nuclear bodies.

Presenter : Hirano S., Udagawa O.
Title : , PLOS ONE, 17(5 (e0268835)):1-22 (2022)
Promyelocytic leukemia nuclear body-like structures can assemble in mouse oocytes

Presenter : Udagawa O., Kato A., Hirano S.
Title : , Biology Open, 11(6):bio059130 (2022)
Effects of diesel exhaust-derived secondary organic aerosol (SOA) on oocytes: Potential risks to meiotic maturation

Presenter : Udagawa O., Furuyama A., Imai K., Fujitani Y., Hirano S.
Title : , Reproductive Toxicology, 75:56-64 (2018)
Solubility changes of promyelocytic leukemia (PML) and SUMO monomers and dynamics of PML nuclear body proteins in arsenite-treated cells

Presenter : Hirano S., Udagawa O., Kobayashi Y., Kato A.
Title : , Toxicology and Applied Pharmacology, 360:150-159 (2018)
Pharmacodynamics of S-dimethylarsino-glutathione, a putative metabolic intermediate of inorganic arsenic, in mice

Presenter : Kato A., Kobayashi Y., Udagawa O., Hirano S.
Title : , Biochemical Pharmacology, 126:79-86 (2017)
Solubility shift and SUMOylaltion of promyelocytic leukemia (PML) protein in response to arsenic(III) and fate of the SUMOylated PML

Presenter : Hirano S., Tadano M., Kobayashi Y., Udagawa O., KATO A.
Title : , Toxicology and Applied Pharmacology, 287:191-201 (2015)
Mitochondrial fission factor Drp1 maintains oocyte quality via dynamic rearrangement of multiple organelles

Presenter : Udagawa O., Ishihara T., Maeda M., Matsunaga Y., Tsukamoto S., Kawano N., Miyado K., Shitara H., Yokota S., Nomura M. , Mihara K., Mizushima N., Ishihara N.
Title : , Current Biology, 24(20):1-8 (2014)

View all

How arsenic, an inorganic pollutant, is involved in the physiology of biomolecular condensates in the cell

Presenter : Udagawa O., Hirano S.
Title : , Frontiers in Environmental Chemistry, 3(797966): (2022)
Mitochondrial dynamics and interorganellar communication in the development and dysmorphism of mammalian oocytes

Presenter : Udagawa O., Ishihara N.
Title : , The Journal of Biochemistry, 167(3):257-266 (2020)
Arsenic Exposure and Reproductive Toxicity

Presenter : Udagawa O., Okamura K., Suzuki T., Nohara K.
Title : , Arsenic Contamination in Asia. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore, 29-42 (2019)

View all

Oocyte Health and Quality: Implication of Mitochondria-related Organelle Interactions.

Presenter : Udagawa O.
Title : , Intercellular and Interorganellar Transfer and Communication in Biology and Medicine. Results and Problems in Cell Differentiation, vol 73. (2024)

View all

Proposed Key Characteristics of Female Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Data in Hazard Assessment

Presenter : Luderer U., Eskenazi B., Hauser R., Korach K.S., McHale C.M., Moran F., Rieswijk L., Solomon G., Udagawa O., Zhang L., Zlatnik M., Zeise L., Smith M.T.
Title : , Environmental Health Perspectives, 127(7):075001-1-075001-14 (2019)

View all

Research Result (Presentation)

all
Research Presentation

Research Presentation
Combined Exposure to Polystyrene Nanoplastics and Carbon Graphite Nanoparticles Impairs Olfactory Function via Neuroinflammatory and Neurotransmitter Dysregulation in Rats

Presenter : Tin-Tin-Win-Shwe, Chaw Kyi Tha Thu, Fujitani Y., Udagawa O., Takami A.
Name of Society : The 53rd Annual Meeting of the Japanese Society of Toxicology (2026)
Name of Proceedings : 「Abstract」P291, S501
Research Presentation
Investigation of hazardous effects by nanoplastic particles on intracellular signaling dynamics and respiratory functions

Presenter : HARADA K., Udagawa O., Ikuno Y., Tanaka K., Ito T., Maekawa F., Kitaguchi T., Tsuboi T., Fujitani Y.
Name of Society : Microplastics Exposure and Human Health Conference (2026)
Name of Proceedings : Abstracts, 118
Research Presentation
Toxicological study to evaluate the acute effects of carbon graphite nanoparticle exposure on olfactory and cognitive functions in rats

Presenter : Tin-Tin-Win-Shwe, Chaw Kyi Tha Thu, Udagawa O., Fujitani Y., Takami A.
Name of Society : 59th Congress of the European Societies of Toxicology (2025)
Name of Proceedings : Toxicology Letters, 411:S276
Research Presentation
Impact of inhalation exposure to carbon graphite nanoparticle on olfactory-mediated behavior in rats

Presenter : Tin-Tin-Win-Shwe, Fujitani Y., Tha Thu C.K., Udagawa O., Takami A.
Name of Society : 第 66回大気環境学会年会 (2025)
Name of Proceedings : 「Abstracts」, 231
Research Presentation
Effects of Diesel Exhaust-Derived Secondary Organic Aerosol (SOA) on Oocytes: Potential Risks to Meiotic Maturation

Presenter : Udagawa O.
Name of Society : BIT's 6th International Congress of Gynaecology and Obstetrics-2018 (2018)
Name of Proceedings : Abstracts, 112
Research Presentation
Possible key characteristics of reproductive toxicants

Presenter : Udagawa O., Sone H., Furuyama A.
Name of Society : Meeting on Advancing the Key Characteristics Framework to Reproductive Toxicants and Endocrine Disruptors (2018)
Name of Proceedings : -
Research Presentation
Effects of diesel exhaust-derived secondary organic aerosol (SOA) on oocytes in mice

Presenter : Udagawa O., Furuyama A., Imai K., Fujitani Y., Hirano S.
Name of Society : 2017 Advanced Investigation in Mechanistic Toxicology, Gordon Research Conference (2017)
Name of Proceedings : Abstracts, 13
Research Presentation
Distribution and speciation of arsenic in mice intravenously injected with S-dimethylarsino-glutathione

Presenter : KATO A., Kobayashi Y., Udagawa O., Hirano S.
Name of Society : 44th Myanmar health research congress (2016)
Name of Proceedings : Abstracts, 97-98
Research Presentation
Arsenic toxicity on female reproduction in mice; molecular examination on how oocyte quality contributes.

Presenter : Udagawa O., KATO A., Kobayashi Y., Aoki Y., Hirano S.
Name of Society : 2015 Cellular & Molecular Mechanisms of Toxicity Gordon Research Conference (2015)
Name of Proceedings : Abstracts, 16

View all

Effects of Diesel Exhaust-Derived Secondary Organic Aerosol (SOA) on Oocytes: Potential Risks to Meiotic Maturation

Presenter : Udagawa O.
Name of Society : BIT's 6th International Congress of Gynaecology and Obstetrics-2018 (2018)
Name of Proceedings : Abstracts, 112
Possible key characteristics of reproductive toxicants

Presenter : Udagawa O., Sone H., Furuyama A.
Name of Society : Meeting on Advancing the Key Characteristics Framework to Reproductive Toxicants and Endocrine Disruptors (2018)
Name of Proceedings : -
Combined Exposure to Polystyrene Nanoplastics and Carbon Graphite Nanoparticles Impairs Olfactory Function via Neuroinflammatory and Neurotransmitter Dysregulation in Rats

Presenter : Tin-Tin-Win-Shwe, Chaw Kyi Tha Thu, Fujitani Y., Udagawa O., Takami A.
Name of Society : The 53rd Annual Meeting of the Japanese Society of Toxicology (2026)
Name of Proceedings : 「Abstract」P291, S501
Investigation of hazardous effects by nanoplastic particles on intracellular signaling dynamics and respiratory functions

Presenter : HARADA K., Udagawa O., Ikuno Y., Tanaka K., Ito T., Maekawa F., Kitaguchi T., Tsuboi T., Fujitani Y.
Name of Society : Microplastics Exposure and Human Health Conference (2026)
Name of Proceedings : Abstracts, 118
Toxicological study to evaluate the acute effects of carbon graphite nanoparticle exposure on olfactory and cognitive functions in rats

Presenter : Tin-Tin-Win-Shwe, Chaw Kyi Tha Thu, Udagawa O., Fujitani Y., Takami A.
Name of Society : 59th Congress of the European Societies of Toxicology (2025)
Name of Proceedings : Toxicology Letters, 411:S276
Impact of inhalation exposure to carbon graphite nanoparticle on olfactory-mediated behavior in rats

Presenter : Tin-Tin-Win-Shwe, Fujitani Y., Tha Thu C.K., Udagawa O., Takami A.
Name of Society : 第 66回大気環境学会年会 (2025)
Name of Proceedings : 「Abstracts」, 231
Effects of diesel exhaust-derived secondary organic aerosol (SOA) on oocytes in mice

Presenter : Udagawa O., Furuyama A., Imai K., Fujitani Y., Hirano S.
Name of Society : 2017 Advanced Investigation in Mechanistic Toxicology, Gordon Research Conference (2017)
Name of Proceedings : Abstracts, 13
Distribution and speciation of arsenic in mice intravenously injected with S-dimethylarsino-glutathione

Presenter : KATO A., Kobayashi Y., Udagawa O., Hirano S.
Name of Society : 44th Myanmar health research congress (2016)
Name of Proceedings : Abstracts, 97-98
Arsenic toxicity on female reproduction in mice; molecular examination on how oocyte quality contributes.

Presenter : Udagawa O., KATO A., Kobayashi Y., Aoki Y., Hirano S.
Name of Society : 2015 Cellular & Molecular Mechanisms of Toxicity Gordon Research Conference (2015)
Name of Proceedings : Abstracts, 16

View all

UDAGAWA Osamu

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