Latest Update：2024/08/31 11:04:40

KOIKE Eiko

Researcher Name: KOIKE Eiko

Div (Section) name/title: Health and Environmental Risk Division／Deputy Director

Research Subject: Studies on the cellular and molecular mechanisms of the effects of environmental chemicals on inflammatory disease

Degree(s): PhD

Professional Qualification(s): Medicine,Biology

Environmental Speciality Field: Environmental medicine,Immuno toxicology

Keyword(s): Chemicals,Health effects,Inflammation,Allergy,Obesity,Immune cells

Membership of Academic Society: Japanese Society of Allergology,Japanese Society of Immunotoxicology,Japanese Society for Atmospheric Environment,The Japanese Society of Toxicology

Research Subject

Fiscal Year: 2024
- 26803 : Comprehensive Environmental Risk Research Program
- 26829 : Research project on the health hazard assessment considering the real-life environment and vulnerability
- 26835 : Research on the development of comprehensive indexes of health risk and ecological risk
- 26950 : Research on the effects of low-dose combined exposure to chemicals from the living environment on allergic diseases
- 26965 : Study on the exposure and health hazards of chemicals derived from plastic products focusing on isocyanates
- 26966 : Basic research on the effects of environmental factors on the onset/progression of diseases
Fiscal Year: 2023
- 26403 : Comprehensive Environmental Risk Research Program
- 26420 : Research project on the health hazard assessment considering the real-life environment and vulnerability
- 26424 : Research on the development of comprehensive indexes of health risk and ecological risk
- 26542 : Research on the effects of low-dose combined exposure to chemicals from the living environment on allergic diseases
- 26550 : Study on the exposure and health hazards of chemicals derived from plastic products focusing on isocyanates
- 26551 : Basic research on the effects of environmental factors on the onset/progression of diseases
- 26786 : Commission on investigation of health risk assessment methods for hazardous air pollutants
- 26788 : Implementation of initial risk assessment of environmental chemicals
Fiscal Year: 2022
- 25972 : Comprehensive Environmental Risk Research Program
- 25973 : Research project on the health hazard assessment considering the real-life environment and vulnerability
- 25977 : Research on the development of comprehensive indexes of health risk and ecological risk
- 26052 : Study on the exposure and health hazards of chemicals derived from plastic products focusing on isocyanates
- 26082 : Analysis of pathogenic mechanism of allergic inflammation via the activation of eye immunity due to exposure to environmental chemicals
- 26083 : Basic research on the effects of environmental factors on the onset/progression of diseases
- 26201 : Integration of sub-themes in S17 through development of risk management system, and development of risk assessment methodology under non-steady state environment by disaster and accidents
- 26281 : Commission on investigation of health risk assessment methods for hazardous air pollutants
- 26284 : Implementation of initial risk assessment of environmental chemicals
Fiscal Year: 2021
- 25501 : Comprehensive environmental risk research program
- 25517 : Research on the health hazard assessment considering the real-life environment and vulnerability
- 25521 : Research on the development of comprehensive indexes of health risk and ecological risk
- 25738 : Basic research on the effects of environmental factors on the onset/progression of diseases
- 25743 : Analysis of pathogenic mechanism of allergic inflammation via the activation of eye immunity due to exposure to environmental chemicals
- 25940 : Integration of sub-themes in S17 through development of risk management system, and development of risk assessment methodology under non-steady state environment by disaster and accidents
- 25948 : Commission on investigation of health risk assessment methods for hazardous air pollutants
- 25950 : Implementation of initial risk assessment of environmental chemicals
Fiscal Year: 2020
- 25099 : Research Program on Health and Environmental Safety
- 25141 : Research Project on Health Impacts of Chemicals on Children and Future Generations
- 25148 : Research Project on the Scientific and Social Framework of Risk Assessment and Management
- 25243 : Comprehensive and systematic study for control/eradication of allergic diseases via environmental and medical approaches
- 25250 : Studies on the Effects of Environmental Factors on the Onset/progression of Diseases
- 25300 : Analysis of pathogenic mechanism of allergic inflammation via the activation of eye immunity due to exposure to environmental chemicals
- 25354 : Integration of sub-themes in S17 through development of risk management system, and development of risk assessment methodology under non-steady state environment by disaster and accidents
- 25422 : Commission on investigation of health risk assessment methods for hazardous air pollutants
- 25423 : Implementation of initial risk assessment of environmental chemicals
Fiscal Year: 2019
- 24696 : Research Program on Health and Environmental Safety
- 24721 : Research Project on Health Impacts of Chemicals on Children and Future Generations
- 24728 : Research Project on the Scientific and Social Framework of Risk Assessment and Management
- 24819 : Study on the relationship between changes in gut microbiota induced by chemicals in house dust and the disturbance of higher-order biological function.
- 24824 : Comprehensive and systematic study for control/eradication of allergic diseases via environmental and medical approaches
- 24891 : Studies on the Effects of Environmental Factors on the Onset/progression of Diseases
- 24897 : Commission on consideration of health risk assessment methods for hazardous air pollutants
- 24901 : Implementation of initial risk assessment of environmental chemicals in FY2019
- 24979 : Integration of sub-themes in S17 through development of risk management system, and development of risk assessment methodology under non-steady state environment by disaster and accidents
Fiscal Year: 2018
- 24304 : Research project on health impacts of chemicals on children and future generations
- 24311 : Research project on the scientific and social framework of risk assessment and management
- 24355 : Research program on health and environmental safety
- 24445 : Comprehensive and systematic study for control/eradication of allergic diseases via environmental and medical approaches
- 24504 : Studies on the effects of environmental factors on the onset/progression of diseases
- 24516 : Study on the relationship between changes in gut microbiota induced by chemicals in house dust and the disturbance of higher-order biological function.
- 24582 : Implementation of initial risk assessment of environmental chemicals in FY2018
Fiscal Year: 2017
- 23817 : Research project on the scientific and social framework of risk assessment and management
- 23824 : Research project on health impacts of chemicals on children and future generations
- 23847 : Research program on health and environmental safety
- 23896 : Study on the effects of exposure to flame retardants to the onset and/or progression of allergic asthma in obese subjects.
- 23899 : The relationship between the gut microbiota and modern diseases
- 23900 : Impact of brominated flame retardants in obesity and obesity-related metabolic disorders
- 23902 : Study on the relationship between changes in gut microbiota induced by chemicals in house dust and the disturbance of higher-order biological function.
- 23948 : Studies on the effects of environmental factors on the onset/progression of diseases
- 23949 : Comprehensive and systematic study for control/eradication of allergic diseases via environmental and medical approaches
- 24198 : Study on the health impacts of environmental heat exposure and differences in the susceptibility
Fiscal Year: 2016
- 23414 : Research program on health and environmental safety
- 23415 : Research project on health impacts of chemicals on children and future generations
- 23422 : Research project on the scientific and social framework of risk assessment and management
- 23524 : The effects of environmental pollutants on the gut microbiota.
- 23525 : Impact of brominated flame retardants in obesity and obesity-related metabolic disorders.
- 23528 : Study on the effects of exposure to flame retardants to the onset and/or progression of allergic asthma in obese subjects.
- 23558 : Studies on the effects of environmental factors on the onset/progression of diseases
- 23743 : Comprehensive and systematic study for control/eradication of allergic diseases via environmental and medical approaches
- 23745 : Study on the health impacts of environmental heat exposure and differences in the susceptibility
Fiscal Year: 2015
- 23018 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 23065 : Effects of brominated flame retardants on the differentiation and activation of macrophages induced by saturated fatty acid
- 23082 : Impact of brominated flame retardants in obesity and obesity-related metabolic disorders.
Fiscal Year: 2014
- 22606 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 22685 : Effects of brominated flame retardants on the differentiation and activation of macrophages induced by saturated fatty acid
- 22706 : Impact of brominated flame retardants in obesity and obesity-related metabolic disorders.
Fiscal Year: 2013
- 22190 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 22277 : Effects of Asian dust aerosol on respiratory, reproductive, and immune systems.
- 22278 : Studies on the mechanisms via which environmental pollutants enhance allergy, with special emphasis on the intercellular and intracellular networks
- 22279 : Studies on the effects of environmental chemicals on nervous and immunological systems during developmental period
- 22314 : Impact of brominated flame retardants in obesity and obesity-related metabolic disorders.
- 22377 : Chemical exposure assessment of tsunami stricken areas using bioassay and chemical analysis--from the early phase through recovery activities
Fiscal Year: 2012
- 21761 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 21805 : Studies on the mechanisms via which environmental pollutants enhance allergy, with special emphasis on the intercellular and intracellular networks
- 21806 : Evaluation of biological effects of aerosol
- 21807 : Effects of Asian dust aerosol on respiratory, reproductive, and immune systems.
- 21808 : Studies on the effects of environmental chemicals on nervous and immunological systems during developmental period
- 22012 : Chemical exposure assessment of tsunami stricken areas using bioassay and chemical analysis--from the early phase through recovery activities.
Fiscal Year: 2011
- 21270 : Evaluation of biological effects of aerosol
- 21271 : International comparison study on waste management and recycle institutions, and integrated system analysis of chemical substance management
- 21272 : Studies on the mechanisms via which environmental pollutants enhance allergy, with special emphasis on the intercellular and intracellular networks
- 21273 : Studies on the effects of environmental chemicals on nervous and immunological systems during developmental period
- 21319 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 21661 : Effects of Asian dust aerosol on respiratory, reproductive, and immune systems.
- 21708 : Chemical exposure assessment of tsunami stricken areas using bioassay and chemical analysis--from the early phase through recovery activities.
Fiscal Year: 2010
- 21019 : Evaluation of biological effects of aerosol
- 21020 : International comparison study on waste management and recycle institutions, and integrated system analysis of chemical substance management
- 21022 : Study of the effects of environmental chemicals on immune cells
- 21029 : Studies on the mechanisms via which environmental pollutants enhance allergy, with special emphasis on the intercellular and intracellular networks
- 21031 : Studies on the effects of environmental chemicals on nervous and immunological systems during developmental period
Fiscal Year: 2009
- 20400 : evaluation of biological aeffects of aerosol
- 20447 : Study on lung function and cytokine production in pulmonary emphysema models of rodents and evaluation of effects of environmental pollutants
- 20448 : Adverse impacts of environmental nanoparticles on sensitive respiratory disorders
- 20460 : Study on the mechanisms of aggravation of allergy by dendritic cells exposed to environmental chemicals
- 20461 : Study of the effects of environmental chemicals on immune cells
- 20799 : International comparison study on waste management and recycle institutions, and integrated system analysis of chemical substance management
Fiscal Year: 2008
- 20036 : Study of the effects of environmental chemicals on immune cells
- 20037 : Study on the mechanisms of aggravation of allergy by dendritic cells exposed to environmental chemicals
- 20147 : Development of evaluation system which can predict the effects of environmental chemicals on hypersensitive subjects with atopy using dendritic cells
- 20153 : respiratory and immunological effects of <br>nanoparticles and nanomaterials
- 20355 : Study on lung function and cytokine production in pulmonary emphysema models of rodents and evaluation of effects of environmental pollutants
Fiscal Year: 2007
- 10421 : Development and evaluation of the in vivo model which elucidate the effects of environmental chemicasls on allergic disordes
- 10667 : Evaluation of the effects of environmental chemicals on the differentiation and function of bone marrow-derived dendritic cells.
- 10677 : Development of evaluation system which can predict the effects of environmental chemicals on hypersensitive subjects with atopy using dendritic cells
Fiscal Year: 2005
- 9349 : Study on environmental behavior and health effects of airborne fine particulate matter such as PM2.5 and DEP
- 9471 : Study on health effects, characteristics and environmental behavior of nano- particles
- 9496 : Oxidative stress of particulate matter, and the effect on immune system.
- 9640 : Development and evaluation of the in vivo model which elucidate the effects of environmental chemicasls on allergic disordes
Fiscal Year: 2004
- 8985 : Study on environmental behavior and health effects of airborne fine particulate matter such as PM2.5 and DEP
- 9144 : Study on the effect of particulate matter including DEP on immune system and the mechanisms.
- 9189 : Study on health effects, characteristics and environmental behavior of nano- particles
- 9247 : Oxidative stress of particulate matter, and the effect on immune system.
Fiscal Year: 2003
- 8604 : Studies on the antigen presenting cells in airway
- 8702 : Study on environmental behavior and health effects of airborne fine particulate matter such as PM2.5 and DEP
- 8881 : Study on the effect of particulate matter including DEP on immune system and the mechanisms.
- 8919 : Study on health effects, characteristics and environmental behavior of nano- particles
Fiscal Year: 2002
- 8333 : Studies on the antigen presenting cells in airway
- 8371 : Studies on the development of the methods to evaluate the health effects of particles
- 8485 : Study on environmental behavior and health effects of airborne fine particulate matter such as PM2.5 and DEP

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Research Result (Publication)

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Original Paper

Original Paper
Effects of styrene monomer on a mouse model of atopic dermatitis

Presenter : Tanaka M., Inoue K.I., Honda A., Miyasaka N., Koike E., Yanagisawa R., Takano H.
Title : , Immunopharmacology and Immunotoxicology , 45(4):455-460 (2023)
Original Paper
Dietary exposure to flame retardant tris (2-butoxyethyl) phos-phate altered neurobehavior and neuroinflammatory responses in a mouse model of allergic asthma

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Lwin T.T., Kawakami F., Koike E., Takano H.
Title : , International Journal Of Molecular Sciences, 23(655):1-15 (2022)
Original Paper
Benzo[a]pyrene aggravates atopic dermatitis-like skin lesions in mice

Presenter : Yanagisawa R., Koike E., Takano H.
Title : , Human & Experimental Toxicology, 40(12):S269-S277 (2022)
Original Paper
Effects of oral exposure to low-dose bisphenol S on allergic asthma in mice

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Takano H.
Title : , International Journal of Molecular Sciences , 23(10790):1-17 (2022)
Original Paper
Toxicological effects of Tris (1,3-dichloro-2-propyl) phosphate exposure in adult male rats differ depending on the history of exposure in the neonatal period

Presenter : Akimoto T., Kobayashi S., Nakayama A., Isobe A., Abe K., Hatakeyama T., Ohta R., Yanagisawa R., Koike E., Suzuki N., Kawaguchi M.
Title : , Journal of Applied Toxicology, 42(9):1503-1509 (2022)
Original Paper
Novel toxicity of tris(1,3-dichloro-2-propyl) phosphate in adult male rats

Presenter : Shohei Kobayashi, Kodai Abe, Anna Isobe, Airi Nakayama, Takahiro Akimoto, Taichi Hatakeyama, Yoshiaki Saito, Yanagisawa R., Koike E., Suzuki N., Maiko Kawaguchi, Ryo Ohta
Title : , Journal of Applied Toxicology, 41(6):987-992 (2021)
Original Paper
Dietary exposure to bisphenol A affects memory function and neuroimmune biomarkers in allergic asthmatic mice

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Takano H.
Title : , Journal of Applied Toxicology, 1-10 (2021)
Original Paper
Impact of dietary exposure to low-dose tris(1,3-dichloro-2-propyl)phosphate in allergic asthmatic mice

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Maiko Kawaguchi, Hirohisa Takano
Title : , IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 13:1-12 (2021)
Original Paper
The impact of oral exposure to low-dose tris(2-butoxyethyl)phosphate in allergic asthmatic mice

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Kawaguchi M., Takano H.
Title : , Journal of Applied Toxicology, 40(11):1498-1510 (2020)
Original Paper
Decabromodiphenyl ether exacerbates hyperglycemia in diet-induced obese mice

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Hirohisa Takano
Title : , Toxicology, 15(412):12-18 (2019)
Original Paper
Memory function, neurological and immunological biomarkers in allergic asthmatic mice intratracheally exposed to bisphenol A

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Takano H
Title : , International Journal of Environmental Research and Public Health, 16(3770):1-16 (2019)
Original Paper
Oral exposure to low dose bisphenol A aggravates allergic airway inflammation in mice

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Hirohisa Takano
Title : , Toxicology Reports, 6:1253-1262 (2019)
Original Paper
Effects of lactational exposure to low-dose BaP on allergic and non-allergic immune responses in mice offspring

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Ichinose T., Takano H.
Title : , Journal of Immunotoxicology , 15(1):31-40 (2018)
Original Paper
Exposure to low-dose bisphenol A during the juvenile period of development disrupts the immune system and aggravates allergic airway inflammation in mice

Presenter : Koike E., Yanagisawa R., Tin-Tin-Win-Shwe, Takano H.
Title : , International Journal of Immunopathology and Pharmacology, 32:1-14 (2018)
Original Paper
Brominated flame retardants, hexabromocyclododecane and tetrabromobisphenol A, affect proinflammatory protein expression in human bronchial epithelial cells via disruption of intracellular signaling

Presenter : Koike E., Yanagisawa R., Takano H.
Title : , Toxicology in Vitro, 32:212-219 (2016)
Original Paper
Low-dose benzo[a]pyrene aggravates allergic airway inflammation in mice

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Ichinose T., Takano H.
Title : , Journal of Applied Toxicology, 36:1496-1504 (2016)
Original Paper
Penta- and octa-bromodiphenyl ethers promote proinflammatory protein expression in human bronchial epithelial cells in vitro

Presenter : Koike E., Yanagisawa R., Takigami H., Takano H.
Title : , Toxicology in Vitro, 28:327-333 (2014)
Original Paper
Impaired Lipid and Glucose Homeostasis in Hexabromocyclododecane-Exposed Mice Fed a High-Fat Diet

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Megumi Y., Takano H.
Title : , Environmental Health Perspectives, 122(3):277-283 (2014)
Original Paper
Effects of Asian sand dust particles on the respiratory and immune system

Presenter : Honda A, Matsuda Y, Murayama R, Tsuji K, Nishikawa M., Koike E., Yoshida S, Ichinose T, Takano H
Title : , Journal of Applied Toxicology, 34(3):250-257 (2014)
Original Paper
Toxicological effects of polycyclic aromatic hydrocarbons and their derivatives on respiratory cells

Presenter : Koike E., Yanagisawa R., Takano H.
Title : , Atmospheric Environment, 97:529-536 (2014)
Original Paper
Effects of oral administration of di-(2-ethylhexyl) and diisononyl phthalates on atopic dermatitis in NC/Nga mice.

Presenter : Sadakane K., Ichinose T., Takano H., Yanagisawa R., Koike E.
Title : , Immunopharmacology and Immunotoxicology, 36(1):61-69 (2014)
Original Paper
Expression levels of neuroimmune biomarkers in hypothalamus of allergic mice after phthalate exposure

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Nitta H., Takano H.
Title : , Journal of Applied Toxicology , 33(10):1071-1078 (2013)
Original Paper
Brominated flame retardants stimulate mouse immune cells in vitro

Presenter : Koike E., Yanagisawa R., Takigami H., Takano H.
Title : , Journal of applied toxicology , 33(12):1451-1459 (2013)
Original Paper
Streamer discharge reduces pollen-induced inflammatory responses and injury in human airway epithelial cells

Presenter : Honda A, Murayama R, Tsuji K, Matsuda Y, Koike E., Okamoto Y, Shirasawa N, Takano H
Title : , Experimental Biology and Medicine, 238(2):187-192 (2013)
Original Paper
The alkylphenols 4-nonylphenol, 4-tert-octylphenol and 4-tert-butylphenol aggravate atopic dermatitis-like skin lesions in NC/Nga mice

Presenter : Sadakane K., Ichinose T., Takano H., Yanagisawa R., Koike E., Inoue K.
Title : , Journal of Applied Toxicology, 34(8):893-902 (2013)
Original Paper
Peroxiredoxin I null mice exhibits reduced acute lung inflammation following ozone exposure.

Presenter : Yanagisawa R., Warabi E., Inoue K., Yanagawa T., Koike E., Ichinose T., Takano H., Ishii T
Title : , The Journal of Biochemistry, 152(6):595-601 (2012)
Original Paper
Size effects of polystyrene nanoparticles on atopic Dermatitis-Like skin lesions in NC/Nga mice

Presenter : Yanagisawa R., Takano H., Inoue Ken-ichiro, Koike E., Sadakane K., Ichinose T.
Title : , Int.J.Immunopathol.Pharmacol., 23(1):131-141 (2010)
Original Paper
Effects of diisononyl phthalate on atopic dermatitis in vivo and immunologic responses in vitro

Presenter : Koike E., Yanagisawa R., Sadakane K., Inoue Ken-ichiro, Ichinose T., Takano H.
Title : , Environ.Health Perspect., 118(4):472-478 (2010)
Original Paper
Extensive analysis of elastase-induced pulmonary emphysema in rats: ALP in the lung, a new biomarker for disease progression?

Presenter : Inoue Ken-ichiro, Koike E., Yanagisawa R., Takano H.
Title : , J.Clin.Biochem.Nutr., 46(2):168-176 (2010)
Original Paper
Size effects of latex nanomaterials on lung inflammation in mice

Presenter : Inoue Ken-ichiro, Takano H., Yanagisawa R., Koike E., Shimada A
Title : , Toxicol.Appl.Pharmacol., 234(1):68-76 (2009)
Original Paper
Effects of pulmonary exposure to diesel exhaust particles on extrathoracic CD4 polarization in asthmatic mice

Presenter : Inoue Ken-ichiro, Koike E., Yanagisawa R., Takano H.
Title : , Immunopharmacol.Immunotoxicol., 31(1):71-74 (2009)
Original Paper
Effects of diesel exhaust particles on antigen-presenting cells and antigen-specific Th immunity in mice

Presenter : Inoue Ken-ichiro, Koike E., Takano H., Yanagisawa R., Ichinose T., Yoshikawa T
Title : , Exp.Biol.Med., 234:200-209 (2009)
Original Paper
Titanium dioxide nanoparticles aggravate atopic dermatitis-like skin lesions in NC/Nga mice

Presenter : Yanagisawa R., Takano H., Inoue Ken-ichiro, Koike E., Kamachi T., Sadakane K., Ichinose T.
Title : , Exp.Biol.Med., 234:314-322 (2009)
Original Paper
Di-(2-ethylhexyl) phthalate affects immune cells from atopic prone mice in vitro

Presenter : Koike E., Inoue Ken-ichiro, Yanagisawa R., Takano H.
Title : , Toxicology, 259(1/2):54-60 (2009)
Original Paper
Pulmonary exposure to soluble cell wall beta-(1, 3)-glucan of aspergillus induces proinflammatory response in mice

Presenter : Inoue Ken-ichiro, Koike E., Yanagisawa R., Adachi Y., Ishibashi K., Ohno N., Takano H.
Title : , Int.J.Immunopathol.Pharmacol., 22(2):287-297 (2009)
Original Paper
Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation model

Presenter : Inoue Ken-ichiro, Koike E., Yanagisawa R., Hirano S., Nishikawa M., Takano H.
Title : , Toxicol.Appl.Pharmacol., 237(3):306-316 (2009)
Original Paper
Microarray analysis of gene expression in rat alveolar epithelial cells exposed to fractionated organic extracts of diesel exhaust particles

Presenter : Omura S, Koike E., Kobayashi T.
Title : , Toxicology, 262(1):65-72 (2009)
Original Paper
Peroxiredoxin ? is a negative regulator of Th2-dominant allergic asthma

Presenter : Inoue Ken-ichiro, Takano H., Koike E., Warabi E., Yanagawa T., Yanagisawa R., Ishii T.
Title : , Int.Immunopharmacol., 9(11):1281-1288 (2009)
Original Paper
Candida soluble cell wall β-glucan facilitates ovalbumin-induced allergic airway inflammation in mice: Possible role of antigen-presenting cells

Presenter : Inoue Ken-ichiro, Takano H., Koike E., Yanagisawa R., Oda T., Tamura H., Adachi Y., Ishibashi K., Ohno N.
Title : , Respir.Res., 10(68):1-12 (2009)
Original Paper
Pulmonary exposure to soluble cell wall β-(1, 3)-glucan of aspergillus induces proinflammatory response in mice

Presenter : Inoue Ken-ichiro, Koike E., Yanagisawa R., Adachi Y., Ishibashi K., Ohno N., Takano H.
Title : , Int.J.Immunopathol.Pharmacol., 22(2):287-297 (2009)
Original Paper
Pulmonary exposure to carbon black nanoparticles increases the number of antigen-presenting cells in murine lung

Presenter : Koike E., Takano H., Inoue Ken-ichiro, Yanagisawa R., Aoyagi H., Shinohara R., Kobayashi T.
Title : , Int.J.Immunopathol.Pharmacol., 21(1):35-42 (2008)
Original Paper
Effects of maternal exposure to Di-(2-ethylhexyl) phthalate during fetal and/or neonatal periods on atopic dermatitis in male offspring

Presenter : Yanagisawa R., Takano H., Inoue Ken-ichiro, Koike E., Sadakane.K, Ichinose.T
Title : , Environ.Health Perspect., 116(9):1136-1141 (2008)
Original Paper
Effects of pulmonary exposure to carbon nanotubes on lung and systemic inflammation with coagulatory disturbance induced by lipopolysaccharide in mice

Presenter : Inoue Ken-ichiro, Takano H., Koike E., Yanagisawa R., Tasaka S, Ishizaka A, Shimada A
Title : , Soc.Exp.Biol.Med., 233:1583-1590 (2008)
Original Paper
Impact of diesel exhaust particles on Th2 response in the lung in asthmatic mice

Presenter : Inoue Ken-ichiro, Koike E., Yanagisawa R., Takano H.
Title : , J.Clin.Biochem.Nutr., 43:199-200 (2008)
Original Paper
Carbon black nanoparticles promote the maturation and function of mouse bone marrow-derived dendritic cells

Presenter : Koike E., Takano H., Inoue Ken-ichiro, Yanagisawa R., Kobayashi T.
Title : , Chemosphere, 73(3):371-376 (2008)
Original Paper
Accelerated differentiation of bone marrow-derived dendritic cells in atopic prone mice

Presenter : Koike E., Takano H., Inoue Ken-ichiro, Yanagisawa R.
Title : , Int.Immunopharmacol., 8(-1314):1737-1743 (2008)
Induction of oxidative stress and inhibition of plasminogen activator inhibitor-1 production in endothelial cells following exposure to organic extracts of diesel exhaust particles and urban fine particles

Presenter : , , , Koike E.
Title : , Arch.Toxicol., 80:154-162 (2006)
Oxidative ability and toxicity of n-Hexane insoluble fraction of diesel exhaust particles

Presenter : , Koike E.
Title : , Toxicol.Sci., 91(1):218-226 (2006)
Exposure to ozone enhances antigen-presenting activity concentration dependently in rats

Presenter : Koike E., Watanabe H.(*1), Kobayashi T.
Title : , Toxicology, 197(1):37-46 (2004)
Ozone exposure enhances antigen-presenting activity of interstitial lung cells in rats

Presenter : Koike E., Kobayashi T.
Title : , Toxicology, 196:217-227 (2004)
cDNA microarray analysis of rat alveolar epithelial cells following exposure to organic extract of diesel exhaust particles

Presenter : , , , Koike E.
Title : , Toxicol.Appl.Pharmacol., 201(2):178-185 (2004)
Oxidative-stress potency of organic extracts of diesel exhaust and urban fine particles in rat heart microvessel endothelial cells

Presenter : , , , Koike E.
Title : , Toxicology, 187:161-170 (2003)
cDNA microarray analysis of gene expression in rat alveolar macrophages in response to organic extract of diesel exhaust particles

Presenter : , , Koike E.
Title : , Toxicol.Sci., 67:241-246 (2002)
Ozone exposure enhances expression of cell-surface molecules associated with antigen-presenting activity on bronchoalveolar lavage cells in rats

Presenter : , Koike E.
Title : , Toxicol.Sci., 63:115-124 (2001)
Effect of exposure to nitrogen dioxide on alveolar macrophage-mediated immunosuppressive activity in rats

Presenter : , Koike E.
Title : , Toxicol.Lett., 121:135-143 (2001)
Effect of aging on nitric oxide production by rat alveolar macrophages

Presenter : , , Koike E.
Title : , Eex.Gerontol., 34:889‐894 (1999)
Effect of Ozone Exposure on Alveolar Macrophage-Mediated Immunosuppressive Activity in Rats

Presenter : , Koike E.
Title : , Toxicol.Sci., 41:217‐223 (1998)

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Effects of styrene monomer on a mouse model of atopic dermatitis

Presenter : Tanaka M., Inoue K.I., Honda A., Miyasaka N., Koike E., Yanagisawa R., Takano H.
Title : , Immunopharmacology and Immunotoxicology , 45(4):455-460 (2023)
Dietary exposure to flame retardant tris (2-butoxyethyl) phos-phate altered neurobehavior and neuroinflammatory responses in a mouse model of allergic asthma

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Lwin T.T., Kawakami F., Koike E., Takano H.
Title : , International Journal Of Molecular Sciences, 23(655):1-15 (2022)
Benzo[a]pyrene aggravates atopic dermatitis-like skin lesions in mice

Presenter : Yanagisawa R., Koike E., Takano H.
Title : , Human & Experimental Toxicology, 40(12):S269-S277 (2022)
Effects of oral exposure to low-dose bisphenol S on allergic asthma in mice

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Takano H.
Title : , International Journal of Molecular Sciences , 23(10790):1-17 (2022)
Toxicological effects of Tris (1,3-dichloro-2-propyl) phosphate exposure in adult male rats differ depending on the history of exposure in the neonatal period

Presenter : Akimoto T., Kobayashi S., Nakayama A., Isobe A., Abe K., Hatakeyama T., Ohta R., Yanagisawa R., Koike E., Suzuki N., Kawaguchi M.
Title : , Journal of Applied Toxicology, 42(9):1503-1509 (2022)
Novel toxicity of tris(1,3-dichloro-2-propyl) phosphate in adult male rats

Presenter : Shohei Kobayashi, Kodai Abe, Anna Isobe, Airi Nakayama, Takahiro Akimoto, Taichi Hatakeyama, Yoshiaki Saito, Yanagisawa R., Koike E., Suzuki N., Maiko Kawaguchi, Ryo Ohta
Title : , Journal of Applied Toxicology, 41(6):987-992 (2021)
Dietary exposure to bisphenol A affects memory function and neuroimmune biomarkers in allergic asthmatic mice

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Takano H.
Title : , Journal of Applied Toxicology, 1-10 (2021)
Impact of dietary exposure to low-dose tris(1,3-dichloro-2-propyl)phosphate in allergic asthmatic mice

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Maiko Kawaguchi, Hirohisa Takano
Title : , IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 13:1-12 (2021)
The impact of oral exposure to low-dose tris(2-butoxyethyl)phosphate in allergic asthmatic mice

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Kawaguchi M., Takano H.
Title : , Journal of Applied Toxicology, 40(11):1498-1510 (2020)
Decabromodiphenyl ether exacerbates hyperglycemia in diet-induced obese mice

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Hirohisa Takano
Title : , Toxicology, 15(412):12-18 (2019)
Memory function, neurological and immunological biomarkers in allergic asthmatic mice intratracheally exposed to bisphenol A

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Takano H
Title : , International Journal of Environmental Research and Public Health, 16(3770):1-16 (2019)
Oral exposure to low dose bisphenol A aggravates allergic airway inflammation in mice

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Hirohisa Takano
Title : , Toxicology Reports, 6:1253-1262 (2019)
Effects of lactational exposure to low-dose BaP on allergic and non-allergic immune responses in mice offspring

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Ichinose T., Takano H.
Title : , Journal of Immunotoxicology , 15(1):31-40 (2018)
Exposure to low-dose bisphenol A during the juvenile period of development disrupts the immune system and aggravates allergic airway inflammation in mice

Presenter : Koike E., Yanagisawa R., Tin-Tin-Win-Shwe, Takano H.
Title : , International Journal of Immunopathology and Pharmacology, 32:1-14 (2018)
Brominated flame retardants, hexabromocyclododecane and tetrabromobisphenol A, affect proinflammatory protein expression in human bronchial epithelial cells via disruption of intracellular signaling

Presenter : Koike E., Yanagisawa R., Takano H.
Title : , Toxicology in Vitro, 32:212-219 (2016)
Low-dose benzo[a]pyrene aggravates allergic airway inflammation in mice

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Ichinose T., Takano H.
Title : , Journal of Applied Toxicology, 36:1496-1504 (2016)
Penta- and octa-bromodiphenyl ethers promote proinflammatory protein expression in human bronchial epithelial cells in vitro

Presenter : Koike E., Yanagisawa R., Takigami H., Takano H.
Title : , Toxicology in Vitro, 28:327-333 (2014)
Impaired Lipid and Glucose Homeostasis in Hexabromocyclododecane-Exposed Mice Fed a High-Fat Diet

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Megumi Y., Takano H.
Title : , Environmental Health Perspectives, 122(3):277-283 (2014)
Effects of Asian sand dust particles on the respiratory and immune system

Presenter : Honda A, Matsuda Y, Murayama R, Tsuji K, Nishikawa M., Koike E., Yoshida S, Ichinose T, Takano H
Title : , Journal of Applied Toxicology, 34(3):250-257 (2014)
Toxicological effects of polycyclic aromatic hydrocarbons and their derivatives on respiratory cells

Presenter : Koike E., Yanagisawa R., Takano H.
Title : , Atmospheric Environment, 97:529-536 (2014)
Effects of oral administration of di-(2-ethylhexyl) and diisononyl phthalates on atopic dermatitis in NC/Nga mice.

Presenter : Sadakane K., Ichinose T., Takano H., Yanagisawa R., Koike E.
Title : , Immunopharmacology and Immunotoxicology, 36(1):61-69 (2014)
Expression levels of neuroimmune biomarkers in hypothalamus of allergic mice after phthalate exposure

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Nitta H., Takano H.
Title : , Journal of Applied Toxicology , 33(10):1071-1078 (2013)
Brominated flame retardants stimulate mouse immune cells in vitro

Presenter : Koike E., Yanagisawa R., Takigami H., Takano H.
Title : , Journal of applied toxicology , 33(12):1451-1459 (2013)
Streamer discharge reduces pollen-induced inflammatory responses and injury in human airway epithelial cells

Presenter : Honda A, Murayama R, Tsuji K, Matsuda Y, Koike E., Okamoto Y, Shirasawa N, Takano H
Title : , Experimental Biology and Medicine, 238(2):187-192 (2013)
The alkylphenols 4-nonylphenol, 4-tert-octylphenol and 4-tert-butylphenol aggravate atopic dermatitis-like skin lesions in NC/Nga mice

Presenter : Sadakane K., Ichinose T., Takano H., Yanagisawa R., Koike E., Inoue K.
Title : , Journal of Applied Toxicology, 34(8):893-902 (2013)
Peroxiredoxin I null mice exhibits reduced acute lung inflammation following ozone exposure.

Presenter : Yanagisawa R., Warabi E., Inoue K., Yanagawa T., Koike E., Ichinose T., Takano H., Ishii T
Title : , The Journal of Biochemistry, 152(6):595-601 (2012)
Size effects of polystyrene nanoparticles on atopic Dermatitis-Like skin lesions in NC/Nga mice

Presenter : Yanagisawa R., Takano H., Inoue Ken-ichiro, Koike E., Sadakane K., Ichinose T.
Title : , Int.J.Immunopathol.Pharmacol., 23(1):131-141 (2010)
Effects of diisononyl phthalate on atopic dermatitis in vivo and immunologic responses in vitro

Presenter : Koike E., Yanagisawa R., Sadakane K., Inoue Ken-ichiro, Ichinose T., Takano H.
Title : , Environ.Health Perspect., 118(4):472-478 (2010)
Extensive analysis of elastase-induced pulmonary emphysema in rats: ALP in the lung, a new biomarker for disease progression?

Presenter : Inoue Ken-ichiro, Koike E., Yanagisawa R., Takano H.
Title : , J.Clin.Biochem.Nutr., 46(2):168-176 (2010)
Size effects of latex nanomaterials on lung inflammation in mice

Presenter : Inoue Ken-ichiro, Takano H., Yanagisawa R., Koike E., Shimada A
Title : , Toxicol.Appl.Pharmacol., 234(1):68-76 (2009)
Effects of pulmonary exposure to diesel exhaust particles on extrathoracic CD4 polarization in asthmatic mice

Presenter : Inoue Ken-ichiro, Koike E., Yanagisawa R., Takano H.
Title : , Immunopharmacol.Immunotoxicol., 31(1):71-74 (2009)
Effects of diesel exhaust particles on antigen-presenting cells and antigen-specific Th immunity in mice

Presenter : Inoue Ken-ichiro, Koike E., Takano H., Yanagisawa R., Ichinose T., Yoshikawa T
Title : , Exp.Biol.Med., 234:200-209 (2009)
Titanium dioxide nanoparticles aggravate atopic dermatitis-like skin lesions in NC/Nga mice

Presenter : Yanagisawa R., Takano H., Inoue Ken-ichiro, Koike E., Kamachi T., Sadakane K., Ichinose T.
Title : , Exp.Biol.Med., 234:314-322 (2009)
Di-(2-ethylhexyl) phthalate affects immune cells from atopic prone mice in vitro

Presenter : Koike E., Inoue Ken-ichiro, Yanagisawa R., Takano H.
Title : , Toxicology, 259(1/2):54-60 (2009)
Pulmonary exposure to soluble cell wall beta-(1, 3)-glucan of aspergillus induces proinflammatory response in mice

Presenter : Inoue Ken-ichiro, Koike E., Yanagisawa R., Adachi Y., Ishibashi K., Ohno N., Takano H.
Title : , Int.J.Immunopathol.Pharmacol., 22(2):287-297 (2009)
Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation model

Presenter : Inoue Ken-ichiro, Koike E., Yanagisawa R., Hirano S., Nishikawa M., Takano H.
Title : , Toxicol.Appl.Pharmacol., 237(3):306-316 (2009)
Microarray analysis of gene expression in rat alveolar epithelial cells exposed to fractionated organic extracts of diesel exhaust particles

Presenter : Omura S, Koike E., Kobayashi T.
Title : , Toxicology, 262(1):65-72 (2009)
Peroxiredoxin ? is a negative regulator of Th2-dominant allergic asthma

Presenter : Inoue Ken-ichiro, Takano H., Koike E., Warabi E., Yanagawa T., Yanagisawa R., Ishii T.
Title : , Int.Immunopharmacol., 9(11):1281-1288 (2009)
Candida soluble cell wall β-glucan facilitates ovalbumin-induced allergic airway inflammation in mice: Possible role of antigen-presenting cells

Presenter : Inoue Ken-ichiro, Takano H., Koike E., Yanagisawa R., Oda T., Tamura H., Adachi Y., Ishibashi K., Ohno N.
Title : , Respir.Res., 10(68):1-12 (2009)
Pulmonary exposure to soluble cell wall β-(1, 3)-glucan of aspergillus induces proinflammatory response in mice

Presenter : Inoue Ken-ichiro, Koike E., Yanagisawa R., Adachi Y., Ishibashi K., Ohno N., Takano H.
Title : , Int.J.Immunopathol.Pharmacol., 22(2):287-297 (2009)
Pulmonary exposure to carbon black nanoparticles increases the number of antigen-presenting cells in murine lung

Presenter : Koike E., Takano H., Inoue Ken-ichiro, Yanagisawa R., Aoyagi H., Shinohara R., Kobayashi T.
Title : , Int.J.Immunopathol.Pharmacol., 21(1):35-42 (2008)
Effects of maternal exposure to Di-(2-ethylhexyl) phthalate during fetal and/or neonatal periods on atopic dermatitis in male offspring

Presenter : Yanagisawa R., Takano H., Inoue Ken-ichiro, Koike E., Sadakane.K, Ichinose.T
Title : , Environ.Health Perspect., 116(9):1136-1141 (2008)
Effects of pulmonary exposure to carbon nanotubes on lung and systemic inflammation with coagulatory disturbance induced by lipopolysaccharide in mice

Presenter : Inoue Ken-ichiro, Takano H., Koike E., Yanagisawa R., Tasaka S, Ishizaka A, Shimada A
Title : , Soc.Exp.Biol.Med., 233:1583-1590 (2008)
Impact of diesel exhaust particles on Th2 response in the lung in asthmatic mice

Presenter : Inoue Ken-ichiro, Koike E., Yanagisawa R., Takano H.
Title : , J.Clin.Biochem.Nutr., 43:199-200 (2008)
Carbon black nanoparticles promote the maturation and function of mouse bone marrow-derived dendritic cells

Presenter : Koike E., Takano H., Inoue Ken-ichiro, Yanagisawa R., Kobayashi T.
Title : , Chemosphere, 73(3):371-376 (2008)
Accelerated differentiation of bone marrow-derived dendritic cells in atopic prone mice

Presenter : Koike E., Takano H., Inoue Ken-ichiro, Yanagisawa R.
Title : , Int.Immunopharmacol., 8(-1314):1737-1743 (2008)

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Research Result (Presentation)

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Research Presentation
Research Lecture

Research Lecture
Assessment of immunotoxicity of chemicals considering vulnerability: Focus on Bisphenols

Presenter : Koike E., Yanagisawa R., Tin-Tin-Win-Shwe
Name of Society : The 50th Annual Meeting of the Japanese Society of Toxicology (2023)
Name of Proceedings : Japanese Society of Toxicology, 48:S31
Research Presentation
PSTR352.18 / II5 - Exposure to tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) at periods of juvenile and adult suppresses sexual behavior, but not neonatal and adult in male rats

Presenter : Iwata S., Kato F., Sato K., Hatakeyama T., Watanabe G., Ohta R., Yanagisawa R., Koike E., Suzuki N., Kawaguchi M.
Name of Society : Neuroscience 2023 (2023)
Name of Proceedings : -
Research Presentation
Effects of bisphenol S exposure on neuroinflammation and cognitive impairment through dysregulation of autophagy and synaptic plasticity in allergic asthmatic mice

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E.
Name of Society : 28th Japan Society of Immunotoxicology Meeting (2022)
Name of Proceedings : Abstracts Poster PN-02, 82
Research Presentation
Assessment of neurotoxic and immunotoxic effects of flame retardant [tris (2-butoxyethyl) phosphate] in a mouse model of allergic asthma

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Hirohisa Takano
Name of Society : 6th Virtual Edition of Polymers, Plastics and Composites (2022)
Name of Proceedings : Abstracts
Research Presentation
Oral exposure to bisphenol S altered neurobehaviors and related gene expressions in allergic asthmatic mice

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E.
Name of Society : The 28th Meeting of the Japanese Society of Immunotoxicology (2021)
Name of Proceedings : Abstract (P-02), 80
Research Presentation
Dietary exposure to tris(1,3-dichloro-2-propyl) phosphate affects central nervous system in allergic asthmatic mice

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Takano H
Name of Society : 27th Japan Society of Immunotoxicology Meeting (2020)
Name of Proceedings : Abstract, 56-56
Research Presentation
Toxicological effects in adult male rats of two-hit exposure to tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) at neonatal and adult stages

Presenter : Akimoto T., Kobayashi S., Hatakeyama T., Ohta R., Yanagisawa R., Koike E., Suzuki N., Kawaguchi M.
Name of Society : The 47th Annual Meeting of the Japanese Society of Toxicology (2020)
Name of Proceedings : -
Research Presentation
Exposure to flame retardant tris (2-butoxyethyl) phosphate induces memory deficit and neuroinflammatory responses in a mouse model of allergic asthma

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Takano H
Name of Society : 55th Congress of the European Societies of Toxicology (2019)
Name of Proceedings : Abstract, S213-S214
Research Presentation
Decabromodiphenyl ether impairs glucose homeostasis in mice fed a high-fat diet

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe
Name of Society : 15th International Congress of Toxicology (2019)
Name of Proceedings : Abstracts, 186
Research Presentation
Decabromodiphenyl ether affects immune response in obese mice and in adipocyte-macrophage co-culture system

Presenter : Koike E., Yanagisawa R., Tin-Tin-Win-Shwe, Takano H.
Name of Society : 15th International Congress of Toxicology (2019)
Name of Proceedings : Abstracts, 188
Research Presentation
Dietary exposure to flame retardant tris (2-butoxyethyl) phosphate alters cognitive function and inflammatory markers in brain of a mouse model of allergic asthma

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Takano H
Name of Society : The 41st Annual Meeting of the Japan Neuroscience Society (2018)
Name of Proceedings : Abstract, 242
Research Presentation
Oral exposure to bisphenol A impairs allergic asthma in mice

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Hirohisa Takano, Takano H.
Name of Society : The 67th Annual Meeting of Japanese Society of Allergology (2018)
Name of Proceedings : Japanese Journal of Allergology, 67(4.5):506
Research Presentation
Effects of lactational exposure to low-dose benzo[a]pyrene on allergic airway inflammation in mice offspring

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Hirohisa Takano
Name of Society : The Joint Congress of the Asia Pacific Association of Allergy, Asthma and Clinical Immunology & the Asia Pacific Association of Pediatric Allergy, Respirology and Immunology (2018)
Name of Proceedings : -
Research Presentation
Exposure to low-dose bisphenol A during the juvenile period of development disrupts the immune system and aggravates allergic airway inflammation in mice

Presenter : Koike E., Yanagisawa R., Tin-Tin-Win-Shwe, Takano H.
Name of Society : Joint Congress of the Asia Pacific Association of Allergy, Asthma and Clinical Immunology & the Asia Pacific Association of Pediatric Allergy, Respirology and Immunology (2018)
Name of Proceedings : - (mobile application)
Research Presentation
Exposure to bisphenol A on novel object recognition ability and neuroimmune biomarkers in allergic asthmatic mice

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Takano H
Name of Society : Asia Pacific Association of Allergy, Asthma and Immunology (APAAACI) (2018)
Name of Proceedings : Abstract P-23 (3rd day)
Research Presentation
Effects of exposure to bisphenol A on memory function and neuroimmune biomarkers in allergic asthmatic mice

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Takano H
Name of Society : 24th Annual Meeting of the Japanese Society of Immunotoxicology (2017)
Name of Proceedings : Abstracts, 84
Research Presentation
Lactational exposure to benzo[a]pyrene (BaP) on neuroimmune biomarkers in hippocampus of an allergic asthmatic mouse model

Presenter : Tin-Tin-Win-Shwe, Htike N.T.T., Tsukahara S., Koike E., Yanagisawa R.
Name of Society : The 39th Annual Meeting of the Japan neuroscience Society (2016)
Name of Proceedings : Abstract, 189
Research Presentation
NEUROTOXICITY IN ALLERGIC MICE AFTER EARLY PHTHALATE EXPOSURE

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Nitta H., Takano H.
Name of Society : International Conference of Asian Environmental Chemistry 2014 (2014)
Name of Proceedings : Abstract, 318
Research Presentation
Impact of hexabromocyclododecane on lipid and glucose metabolism in high-fat diet-induced obese mice

Presenter : YANAGISAWA Rie, TIN-TIN-Win-Shwe, KOIKE Eiko
Name of Society : 49th Congress of the European Societies of Toxicology (2013)
Name of Proceedings : Abstracts o the 49th Congress of the European Societies of Toxicology (EUROTOX), 221S:S252-S252
Research Presentation
Brominated flame retardants stimulate immune response in vitro

Presenter : Koike E., Yanagisawa R., Takano H
Name of Society : 49th Congress of the European Societies of Toxicology (2013)
Name of Proceedings : Toxicol. Lett. Abstracts o the 49th Congress of the European Societies of Toxicology (EUROTOX), 221S:S134-S134
Research Presentation
Expression of neuroimmune biomarkers in hypothalamus of allergic mice after early phthalate exposure

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Nakajima D., Takano H., Nitta H.
Name of Society : Annual Meeding of Society of Indoor Environment Japan 2012 (2012)
Name of Proceedings : Abstracts, 118-119
Research Presentation
Effects of maternal exposure to Di-(2-ethylhexyl) phthalate during fetal and/or neonatal periods on atopic dermatitis in male offspring

Presenter : Yanagisawa R., Takano H., Inoue Ken-ichiro, Koike E., Sadakane K., Ichinose T.
Name of Society : Int.Symp.Occup.Environ.Allerg.Immune Dis.2010(ISOEAID’10) (2010)
Name of Proceedings : Abstracts, 53
Research Presentation
Effects of Di-isononyl phthalate on atopic dermatitis in vivo and immunological responses in vitro

Presenter : Koike E., Yanagisawa R., Sadakane K., Inoue Ken-ichiro, Ichinose T., Takano H.
Name of Society : Int.Symp.Occup.Environ.Allerg.Immune Dis.2010(ISOEAID’10) (2010)
Name of Proceedings : Abstracts, 52
Research Presentation
Impacts of latex nanomaterials on sensitive lung inflammation

Presenter : Inoue Ken-ichiro, Takano H., Yanagisawa R., Koike E., Shimada A
Name of Society : HORIBA/CDBIM Symp. -21st Century Adv.Mol.Toxicol.Environ.Chem.Pathog.Dis.- (2009)
Name of Proceedings : Abstracts, 175
Research Presentation
Effects of diesel exhaust particles on antigen-presenting cells and antigen-specific Th2 immunity in mice

Presenter : Yanagisawa R., Inoue Ken-ichiro, Koike E., Takano H., Ichinose.T, Yoshino S, Yamaki K, Yoshikawa T
Name of Society : 10th Int.Symp.Dendritic Cells (2008)
Name of Proceedings : Abstracts, 142
Research Presentation
Candida soluble cell wall β-D-glucan facilitates allergic lung inflammation via activation of antigen-presenting cells in mice

Presenter : Inoue Ken-ichiro, Takano H., Koike E., Yanagisawa R., Oda T, Tamura H, Adachi Y, Ishibashi K, Ohno N
Name of Society : 10th Int.Symp.Dendritic Cells (2008)
Name of Proceedings : Abstracts, 144
Research Presentation
Microarray analysis of murine lungs following pulmonary exposure to diesel exhaust particles

Presenter : Yanagisawa R., Takano H., Koike E.
Name of Society : 47th Annu.Meet.ToxExpo(Poster Session) (2008)
Name of Proceedings : Program
Research Presentation
Exposure to carbon black nanoparticles activates antigen-presenting cells in vivo and in vitro

Presenter : Koike E., Yanagisawa R., Takano H.
Name of Society : 47th Annu.Meet.ToxExpo(Poster Session) (2008)
Name of Proceedings : Program
Research Presentation
Phthalate esters modulate the differentiation of mouse peripheral blood mononuclear cells-derived dendritic cells

Presenter : Ito T., Inoue Ken-ichiro, Koike E., Yanagisawa R., Nishimura N., Takano H.
Name of Society : 45th Congr.Eur.Soc.Toxicol. (2008)
Name of Proceedings : Toxicol.Lett., 180S:S117
Research Presentation
Low dose effects of phthalates and other environmental chemicals on atopic dermatitis-like skin lesions in mice

Presenter : Takano H., Yanagisawa R., Inoue Ken-ichiro., Koike E.
Name of Society : 2nd Workshop Low Dose Eff.Chem.Spec.Consideration Phthalates (2007)
Name of Proceedings : Abstracts
Research Presentation
Size dependent chemical compositions of diesel exhaust particles in steady state and transient cycle

Presenter : Fujitani Y., , , Koike E.
Name of Society : 16th Reg.Conf.Clean Air Environ.Asian Pac.Area(Poster Session) (2005)
Name of Proceedings : Abstracts
Research Presentation
Chemical characteristics and toxicity of polar organic extract of diesel exhaust particles

Presenter : Koike E.
Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
Name of Proceedings : Abstracts
Research Presentation
Organic extract of diesel exhaust particles stimulates expression of ia and costimulatory molecules associated with antigen presentation in rat peripheral blood monocytes but not aleveolar macrophages

Presenter : Koike E.
Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
Name of Proceedings : Abstracts
Research Presentation
Analysis of gene expression in rat alveolar epithelial cells in response to organic extravct of diesel exhaust particles

Presenter : Koike E.
Name of Society : Soc.Toxicol.43rd Annu.Meet. (2004)
Name of Proceedings : Toxicologist, 78(1/5)(1-5):146-146
Research Presentation
Basement membrane attenuates oxidative stress caused by organic extracts of diesel exhaust particles in rat lung microvessel endothelial cells

Presenter : Hirano S., Mochitate K., Furuyama A., Koike E.
Name of Society : 5th Pan Pac.Connect.Tissue Soc.Symp. (2003)
Name of Proceedings : Abstracts, 82
Exposure of ozone to rats enhances antigen-presenting activity of cells in lung tissue

Presenter : Koike E., Kobayashi T.
Name of Society : 9th Int.Congr.Toxicol. (2001)
Name of Proceedings : Toxicol., 164(1/3)

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Assessment of neurotoxic and immunotoxic effects of flame retardant [tris (2-butoxyethyl) phosphate] in a mouse model of allergic asthma

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Hirohisa Takano
Name of Society : 6th Virtual Edition of Polymers, Plastics and Composites (2022)
Name of Proceedings : Abstracts
Oral exposure to bisphenol A impairs allergic asthma in mice

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Hirohisa Takano, Takano H.
Name of Society : The 67th Annual Meeting of Japanese Society of Allergology (2018)
Name of Proceedings : Japanese Journal of Allergology, 67(4.5):506
Expression of neuroimmune biomarkers in hypothalamus of allergic mice after early phthalate exposure

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Nakajima D., Takano H., Nitta H.
Name of Society : Annual Meeding of Society of Indoor Environment Japan 2012 (2012)
Name of Proceedings : Abstracts, 118-119
Candida soluble cell wall β-D-glucan facilitates allergic lung inflammation via activation of antigen-presenting cells in mice

Presenter : Inoue Ken-ichiro, Takano H., Koike E., Yanagisawa R., Oda T, Tamura H, Adachi Y, Ishibashi K, Ohno N
Name of Society : 10th Int.Symp.Dendritic Cells (2008)
Name of Proceedings : Abstracts, 144
Microarray analysis of murine lungs following pulmonary exposure to diesel exhaust particles

Presenter : Yanagisawa R., Takano H., Koike E.
Name of Society : 47th Annu.Meet.ToxExpo(Poster Session) (2008)
Name of Proceedings : Program
Exposure to carbon black nanoparticles activates antigen-presenting cells in vivo and in vitro

Presenter : Koike E., Yanagisawa R., Takano H.
Name of Society : 47th Annu.Meet.ToxExpo(Poster Session) (2008)
Name of Proceedings : Program
Low dose effects of phthalates and other environmental chemicals on atopic dermatitis-like skin lesions in mice

Presenter : Takano H., Yanagisawa R., Inoue Ken-ichiro., Koike E.
Name of Society : 2nd Workshop Low Dose Eff.Chem.Spec.Consideration Phthalates (2007)
Name of Proceedings : Abstracts
Size dependent chemical compositions of diesel exhaust particles in steady state and transient cycle

Presenter : Fujitani Y., , , Koike E.
Name of Society : 16th Reg.Conf.Clean Air Environ.Asian Pac.Area(Poster Session) (2005)
Name of Proceedings : Abstracts
Chemical characteristics and toxicity of polar organic extract of diesel exhaust particles

Presenter : Koike E.
Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
Name of Proceedings : Abstracts
Organic extract of diesel exhaust particles stimulates expression of ia and costimulatory molecules associated with antigen presentation in rat peripheral blood monocytes but not aleveolar macrophages

Presenter : Koike E.
Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
Name of Proceedings : Abstracts
Analysis of gene expression in rat alveolar epithelial cells in response to organic extravct of diesel exhaust particles

Presenter : Koike E.
Name of Society : Soc.Toxicol.43rd Annu.Meet. (2004)
Name of Proceedings : Toxicologist, 78(1/5)(1-5):146-146
Basement membrane attenuates oxidative stress caused by organic extracts of diesel exhaust particles in rat lung microvessel endothelial cells

Presenter : Hirano S., Mochitate K., Furuyama A., Koike E.
Name of Society : 5th Pan Pac.Connect.Tissue Soc.Symp. (2003)
Name of Proceedings : Abstracts, 82
PSTR352.18 / II5 - Exposure to tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) at periods of juvenile and adult suppresses sexual behavior, but not neonatal and adult in male rats

Presenter : Iwata S., Kato F., Sato K., Hatakeyama T., Watanabe G., Ohta R., Yanagisawa R., Koike E., Suzuki N., Kawaguchi M.
Name of Society : Neuroscience 2023 (2023)
Name of Proceedings : -
Effects of bisphenol S exposure on neuroinflammation and cognitive impairment through dysregulation of autophagy and synaptic plasticity in allergic asthmatic mice

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E.
Name of Society : 28th Japan Society of Immunotoxicology Meeting (2022)
Name of Proceedings : Abstracts Poster PN-02, 82
Oral exposure to bisphenol S altered neurobehaviors and related gene expressions in allergic asthmatic mice

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E.
Name of Society : The 28th Meeting of the Japanese Society of Immunotoxicology (2021)
Name of Proceedings : Abstract (P-02), 80
Dietary exposure to tris(1,3-dichloro-2-propyl) phosphate affects central nervous system in allergic asthmatic mice

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Takano H
Name of Society : 27th Japan Society of Immunotoxicology Meeting (2020)
Name of Proceedings : Abstract, 56-56
Toxicological effects in adult male rats of two-hit exposure to tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) at neonatal and adult stages

Presenter : Akimoto T., Kobayashi S., Hatakeyama T., Ohta R., Yanagisawa R., Koike E., Suzuki N., Kawaguchi M.
Name of Society : The 47th Annual Meeting of the Japanese Society of Toxicology (2020)
Name of Proceedings : -
Exposure to flame retardant tris (2-butoxyethyl) phosphate induces memory deficit and neuroinflammatory responses in a mouse model of allergic asthma

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Takano H
Name of Society : 55th Congress of the European Societies of Toxicology (2019)
Name of Proceedings : Abstract, S213-S214
Decabromodiphenyl ether impairs glucose homeostasis in mice fed a high-fat diet

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe
Name of Society : 15th International Congress of Toxicology (2019)
Name of Proceedings : Abstracts, 186
Decabromodiphenyl ether affects immune response in obese mice and in adipocyte-macrophage co-culture system

Presenter : Koike E., Yanagisawa R., Tin-Tin-Win-Shwe, Takano H.
Name of Society : 15th International Congress of Toxicology (2019)
Name of Proceedings : Abstracts, 188
Dietary exposure to flame retardant tris (2-butoxyethyl) phosphate alters cognitive function and inflammatory markers in brain of a mouse model of allergic asthma

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Takano H
Name of Society : The 41st Annual Meeting of the Japan Neuroscience Society (2018)
Name of Proceedings : Abstract, 242
Effects of lactational exposure to low-dose benzo[a]pyrene on allergic airway inflammation in mice offspring

Presenter : Yanagisawa R., Koike E., Tin-Tin-Win-Shwe, Hirohisa Takano
Name of Society : The Joint Congress of the Asia Pacific Association of Allergy, Asthma and Clinical Immunology & the Asia Pacific Association of Pediatric Allergy, Respirology and Immunology (2018)
Name of Proceedings : -
Exposure to low-dose bisphenol A during the juvenile period of development disrupts the immune system and aggravates allergic airway inflammation in mice

Presenter : Koike E., Yanagisawa R., Tin-Tin-Win-Shwe, Takano H.
Name of Society : Joint Congress of the Asia Pacific Association of Allergy, Asthma and Clinical Immunology & the Asia Pacific Association of Pediatric Allergy, Respirology and Immunology (2018)
Name of Proceedings : - (mobile application)
Exposure to bisphenol A on novel object recognition ability and neuroimmune biomarkers in allergic asthmatic mice

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Takano H
Name of Society : Asia Pacific Association of Allergy, Asthma and Immunology (APAAACI) (2018)
Name of Proceedings : Abstract P-23 (3rd day)
Effects of exposure to bisphenol A on memory function and neuroimmune biomarkers in allergic asthmatic mice

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Takano H
Name of Society : 24th Annual Meeting of the Japanese Society of Immunotoxicology (2017)
Name of Proceedings : Abstracts, 84
Lactational exposure to benzo[a]pyrene (BaP) on neuroimmune biomarkers in hippocampus of an allergic asthmatic mouse model

Presenter : Tin-Tin-Win-Shwe, Htike N.T.T., Tsukahara S., Koike E., Yanagisawa R.
Name of Society : The 39th Annual Meeting of the Japan neuroscience Society (2016)
Name of Proceedings : Abstract, 189
NEUROTOXICITY IN ALLERGIC MICE AFTER EARLY PHTHALATE EXPOSURE

Presenter : Tin-Tin-Win-Shwe, Yanagisawa R., Koike E., Nitta H., Takano H.
Name of Society : International Conference of Asian Environmental Chemistry 2014 (2014)
Name of Proceedings : Abstract, 318
Impact of hexabromocyclododecane on lipid and glucose metabolism in high-fat diet-induced obese mice

Presenter : YANAGISAWA Rie, TIN-TIN-Win-Shwe, KOIKE Eiko
Name of Society : 49th Congress of the European Societies of Toxicology (2013)
Name of Proceedings : Abstracts o the 49th Congress of the European Societies of Toxicology (EUROTOX), 221S:S252-S252
Brominated flame retardants stimulate immune response in vitro

Presenter : Koike E., Yanagisawa R., Takano H
Name of Society : 49th Congress of the European Societies of Toxicology (2013)
Name of Proceedings : Toxicol. Lett. Abstracts o the 49th Congress of the European Societies of Toxicology (EUROTOX), 221S:S134-S134
Effects of maternal exposure to Di-(2-ethylhexyl) phthalate during fetal and/or neonatal periods on atopic dermatitis in male offspring

Presenter : Yanagisawa R., Takano H., Inoue Ken-ichiro, Koike E., Sadakane K., Ichinose T.
Name of Society : Int.Symp.Occup.Environ.Allerg.Immune Dis.2010(ISOEAID’10) (2010)
Name of Proceedings : Abstracts, 53
Effects of Di-isononyl phthalate on atopic dermatitis in vivo and immunological responses in vitro

Presenter : Koike E., Yanagisawa R., Sadakane K., Inoue Ken-ichiro, Ichinose T., Takano H.
Name of Society : Int.Symp.Occup.Environ.Allerg.Immune Dis.2010(ISOEAID’10) (2010)
Name of Proceedings : Abstracts, 52
Impacts of latex nanomaterials on sensitive lung inflammation

Presenter : Inoue Ken-ichiro, Takano H., Yanagisawa R., Koike E., Shimada A
Name of Society : HORIBA/CDBIM Symp. -21st Century Adv.Mol.Toxicol.Environ.Chem.Pathog.Dis.- (2009)
Name of Proceedings : Abstracts, 175
Effects of diesel exhaust particles on antigen-presenting cells and antigen-specific Th2 immunity in mice

Presenter : Yanagisawa R., Inoue Ken-ichiro, Koike E., Takano H., Ichinose.T, Yoshino S, Yamaki K, Yoshikawa T
Name of Society : 10th Int.Symp.Dendritic Cells (2008)
Name of Proceedings : Abstracts, 142
Phthalate esters modulate the differentiation of mouse peripheral blood mononuclear cells-derived dendritic cells

Presenter : Ito T., Inoue Ken-ichiro, Koike E., Yanagisawa R., Nishimura N., Takano H.
Name of Society : 45th Congr.Eur.Soc.Toxicol. (2008)
Name of Proceedings : Toxicol.Lett., 180S:S117

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Assessment of immunotoxicity of chemicals considering vulnerability: Focus on Bisphenols

Presenter : Koike E., Yanagisawa R., Tin-Tin-Win-Shwe
Name of Society : The 50th Annual Meeting of the Japanese Society of Toxicology (2023)
Name of Proceedings : Japanese Society of Toxicology, 48:S31

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KOIKE Eiko

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