Nitroaromatics and derivatives

Nitroaromatic compounds and their numerous derivatives are of use as explosives and propellants both in the military and industory. A number of studies have shown that nitro compounds, their metabolites of environmental transformation and by-products of their synthesis or incomplete combustion are harmful for the biosphere due to their toxicity. For instance, toxic effects in humans after dermal, oral or respiratory exposure include gastrointestinal, neurological and reproductive disorders, cirrhosis of the liver, hepatitis, cataracts, respiratory and skin irritation, nephrotoxicity, and hematological defects. More over, nitroaromatic compounds are widey used in medicine, industry and agriculture. (ref. ID; 7772)

[2-Amino-4-chloro-5-nitrophenol]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[2-Amino-6-chloro-4-nitrophenol] CAS[6358-09-4]

Chemical formula

C6H5ClN2O3

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[4-Amino-3,5-dinitrobenzamide]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2-Amino-4,6-dinitrotoluene (2-ADNT)] CAS[35572-78-2]

Chemical characteristics

2,4,6-Trinitrotoluene (TNT) metabolites.

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[3-Amino-2,6-dinitrotoluene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2-Amino-4-nitrophenol] CAS[99-57-0]

Chemical formula

H2NC6H3(NO2)OH

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[4-Amino-2-nitrophenol]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[ANTA (3-Nitro-1,2,4-triazol-5-amine)]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2-Bromo-4,6-dinitroaniline] CAS[1817-73-8]

Chemical formula

C6H4BrN3O4

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[6-Bromo-1,3-dinitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[4-Bromo-2-fluoro-6-nitrophenol]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2-Bromo-2'-hydroxy-5'-nitroacetanilide]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[Bromonitrobenzene]

See: Benzene & benzene derivatives

[4-Butoxynitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[4-(tert)Butyl-2,6-dinitrophenol] CAS[4097-49-8]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[4-Chloro-2,6-dinitroaniline]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[6-Chloro-2,4-dinitroaniline] CAS[3531-19-9] UN2237

Chemical formula

ClC6H3(NO2)2NH2

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[1-Chloro-2,4-dinitrobenzene (CDNB)] CAS[97-00-7]

= 2,4-Dinitrochlorobenzene

Chemical formula

C6H3ClN2O4

Test organisms

Protozoa: Spirostomum ambiguum (ref. ID; 6983)
Protozoa: Tetrahymena pyriformis (ref. ID; 7772)
Rotifera: Brachionus calyciflorus (ref. ID; 127)

[4-Chloro-3,5-dinitrobenzonitrile]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[5-Chloro-2,4-dinitrotoluene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[3-Chloro-4-fluoronitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2-Chloromethyl-4-nitrophenol]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[2-Chloro-5-nitroaniline] CAS[6283-25-6] UN2237

Chemical formula

ClC6H3(NO2)NH2

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2-Chloro-6-nitroaniline]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2-Chloro-5-nitrobenzaldehyde] CAS[6361-21-3]

Chemical formula

ClC6H3(NO2)CHO

Chemical characteristics

Log Ko/w 2.25. (ref. ID; 7771)

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7771, 7772)

[2-Chloro-6-nitrobenzaldehyde]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[4-Chloro-6-nitrobenzaldehyde]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[5-Chloro-2-nitrobenzamide]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[Chloronitrobenzene]

See; Benzene & benzene derivatives

[4-Chloro-3-nitrobenzonitrile] CAS[939-80-0]

Chemical formula

C7H3ClN2O2

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[4-Chloro-6-nitromcresol]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[2-Chloro-4-nitrophenol] CAS[619-08-9] UN1759

Chemical formula

ClC6H3(NO2)OH

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[4-Chloro-2-nitrophenol] CAS[89-64-5] UN2811

Chemical formula

ClC6H3(NO2)OH

Chemical characteristics

Logarithm of 1-octanol/water partition coefficient log Kow 2.46. (ref. ID; 6981)

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[4-Chloro-3-nitrophenol] CAS[610-78-6]

Chemical formula

C6H4ClNO3

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2,4-Chloro-6-nitrophenol]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[2-Chloro-6-nitrotoluene] CAS[83-42-1] UN43457

Chemical formula

CH3C6H3(NO2)Cl

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[4-Chloro-2-nitrotoluene] CAS[89-59-8] UN3457

Chemical formula

ClC6H3(NO2)CH3

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[CL-14]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[CL-20]

= 2,4,6,8,10,12-Hexanitro-2,4,6,8,10,12-hexazaisowurtzitane CAS[135285-90-4], = Nitramine

Trade name

CL-20

Purpose for use

Energetic compound (polycyclic nitramine explosive).

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)
Oligochaeta: Eisenia andrei (ref. ID; 4572)

[Diaminoazofurazan]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2,4-Dibromo-6-nitroaniline]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2,5-Dibromonitrobenzene] CAS[3460-18-2]

Chemical formula

C6H3Br2NO2

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[2,6-Dibromo-4-nitrophenol] CAS[99-28-5]

Chemical formula

C6H3Br2NO3

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[2,4-Dichloro-6-nitroaniline] CAS[2683-43-4]

Chemical formula

C6H4Cl2N2O2

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[4,5-Dichloro-2-nitroaniline]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[1,3-Dichloro-4,6-dinitrobenzene] CAS[3698-83-7]

Mode of toxic action

Electro(necleo)phile. (ref. ID; 3327)

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 3327, 7772)

[4,6-Dichloro-1,2-dinitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[Dichloronitrobenzene]

See: Benzene & benzene derivatives

[2,6-Dichloro-4-nitrophenol] CAS[618-80-4]

Chemical formula

Cl2C6H2(NO2)OH

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[1,5-Difluoro-2,4-nitroaniline]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2,5-Difluoronitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[4,5-Difluoro-2-dinitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2,6-Diiodo-4-nitrophenol] CAS[305-85-1]

Chemical formula

C6H3I2NO3

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[1,2-Dimethyl-4-nitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[1,3-Dimethyl-2-nitrobenzene] CAS[81-20-9] UN1665

Chemical formula

(CH3)2C6H3NO2

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[2,3-Dimethylnitrobenzene]

= 1,2-Dimethyl-3-nitrobenzene CAS[83-41-0] UN1665

Chemical formula

(CH3)2C6H3NO2

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[Dimethylnitroterephthalate]

= Dimethyl Nitroterephthalate CAS[5292-45-5]

Chemical fromula

C10H9NO6

Mode of toxic action

Diester. (ref. ID; 3327)

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 3327, 7772)

[Dinitroaniline]

Chemical formula

(O2N)2C6H3NH2

2,4-Dinitroaniline

Test organisms

Protozoa: Spirostomum ambiguum (ref. ID; 6983)
Protozoa: Tetrahymena pyriformis (ref. ID; 7772)
Protozoa: Tetrahymena thermophila (ref. ID; 6010)

2,6-Dinitroaniline

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

3,5-Dinitroaniline

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[Dinitrobenzene]

See; Benzene & benzene derivatives

[3,5-Dinitrobenzonitrile] CAS[4110-35-4]

Chemical formula

C7H3N3O4

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[3,4-Dinitrobenzyl alcohol]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[3,5-Dinitrobenzyl alcohol] CAS[71022-43-0]

Chemical fromula

C7H6N2O5

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2,6-Dinitro-4-cresol]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[3,5-Dinitro-p-cresol]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[4,6-Dinitro-2-cresol] CAS[534-52-1] UN1598

= DNOC

Chemical formula

C7H6N2O5

Purpose for use

Pesticide.

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 3554, 6709, 7772)

[1,2-Dinitro-4,5-dichlorobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[2,4-Dinitro-5-fluoroaniline]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2,4-Dinitro-1-fluorobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[Dinitroglycouril]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2,4-Dinitroimidazole]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[Dinitrophenol]

Chemical formula

(O2N)2C6H3OH

2,3-Dinitrophenol

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

2,4-Dinitrophenol

Chemical characteristics

Lipophilicity log P 1.53. (ref. ID; 6959)

Purpose for use

Fungicide.

Toxicity

2,4-Dinitrophenol uncouples oxidative phosphorylation without blocking oxygen consumption by dissipating the electrochemical gradient across the inner mitochondrial membrane. In early studies on Tetrahymena, DNP was reported to affect dose-depended respiration, phosphate accumulation, endocytosis, fine structure after a 1-hr exposure, and final cell density a 96-hr exposure. Effects were enhanced when DNP was tested at acid pH pointing towards the undissociated DNP molecule being active state. (ref. ID; 7348)

Test organisms

Green algae (formerly including protozoa): Chlamydomonas reinhardtii (ref. ID; 4556)
Protozoa: Spirostomum ambiguum (ref. ID; 6984)
Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7348, 7772)
Oligochaeta: Eisenia fetida (ref. ID; 6959)

2,5-Dinitrophenol

Test organisms

Protozoa: Spirostomum ambiguum (ref. ID; 6984)
Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

2,6-Dinitrophenol

Test organisms

Protozoa: Spirostomum ambiguum (ref. ID; 6984)
Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

3,4-Dinitrophenol

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[Dinitrosobenzene]

See; Benzene & benzene derivatives

[1,3-Dinitro-5-nitroso-1,3,5-triazine]

Test organisms

; Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[1,3-Dinitroso-5-nitro-1,3,5-triazine]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[Dinitrotoluene]

2,3-Dinitrotoluene

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

2,5-Dinitrotoluene

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[EGDN]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[4-Ethoxy-2-nitroaniline]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[4-Ethylnitrobenzene] CAS[100-12-9]

Chemical formula

C8H9NO2

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[Ethyl-4-nitrobenzoate]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[1-Fluoro-3-iodo-5-nitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[4-Fluoronitrobenzene] CAS[350-46-9] UN2811

Chemical formula

FC6H4NO2

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[1-Fluoro-2-nitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[1-Fluoro-3-nitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[3-Fluoro-4-nitrophenol] CAS[394-41-2]

Chemical formula

C6H4FNO3

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[5-Fluoro-2-nitrophenol] CAS[446-36-6]

Chemical formula

C6H4FNO3

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[FOX-7]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[HBT]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[HMX]

= Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) CAS[2691-41-0], = 1,3,5,7-Tetranitro-1,3,5,7-tetrazacyclo-octane (ref. ID; 6865)

Purpose for use

High melting explosive.

Toxicity

This explosive is toxic to some aquatic organisms, including fathead minnows (Pimephales promelas) and the freshwater microcrustacean Daphnia magna, and some terrestrial organisms including mice and rats. But, HMX is not toxic to the bioluminescent bacteria Vibrio fisheri and is not cytotoxic or mutagenic to bacterial and mammalian cells in aqueous solutions of HMX. (ref. ID; 6115)

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)
Oligochaeta: Eisenia andrei (ref. ID; 4958, 6115, 6817)
Oligochaeta: Lumbricus terrestris (ref. ID; 4958)

[1-Hydroxylamino-3,5-dinitro-1,3,5-triazine]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[1-Hydroxylamino-3,5-dinitroso-1,3,5-triazine]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2-Hydroxylamino-4,6-dinitrotoluene]

Chemical characteristics

2,4,6-Trinitrotoluene (TNT) metabolites.

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[4-Hydroxylamino-2,6-dinitrotoluene]

Chemical characteristics

2,4,6-Trinitrotoluene (TNT) metabolites.

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[1-Hydroxylamino-3-nitroso-5-nitro-1,3,5-triazine]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[3-Hydroxy-4-nitrobenzaldehyde]

Chemical characteristics

Log Ko/w 1.47. (ref. ID; 7771)

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7771, 7772)

[4-Hydroxy-3-nitrobenzaldehyde] CAS[3011-34-5]

Chemical formula

C7H5NO4

Chemical characteristics

Log Ko/w 1.48. (ref. ID; 7771)

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7771, 7772)

[5-Hydroxy-2-nitrobenzaldehyde] CAS[42454-06-8]

Chemical formula

C7H5NO4

Chemical characteristics

Log Ko/w 1.75. (ref. ID; 7771)

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7771, 7772)

[6-Iodo-1,3-dinitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[K-55]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[3-Methyl-4-bromonitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[Methyl-4-chloro-2-nitrobenzoate] CAS[42087-80-9]

Mode of toxic action

Electro(necleo)phile. (ref. ID; 3327)

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 3327, 7772)

[5-Methyl-1,2-dinitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[6-Methyl-1,3-dinitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[3-Methyl-2,4-dinitrophenol]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[3-Methyl-4,6-dinitrophenol]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2-Methyl-4-nitroaniline] CAS[99-52-5] UN2660

Chemical formula

CH3C6H3(NO2)NH2

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[4-Methyl-2-nitroaniline] CAS[89-62-3]

Chemical formula

CH3C6H3(NO2)NH2

Chemical characteristics

Log Kow 1.82. (ref. ID; 449)

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 449, 7772)

[Methyl-4-nitrobenzoate]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2-Methyl-3-nitrophenol]

= 3-Nitro-o-cresol CAS[119-33-5] UN2446

Chemical formula

CH3C6H3(NO2)OH

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2-Methyl-5-nitrophenol] CAS[5428-54-6] UN2446

Chemical formula

C7H7NO3

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[3-Methyl-2-nitrophenol] CAS[4920-77-8]

Chemical formula

C7H7NO3

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[3-Methyl-4-nitrophenol] CAS[2581-34-2] UN2446

Chemical formula

C7H7NO3

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[4-Methyl-2-nitrophenol]

= 2-Nitro-p-cresol CAS[119-33-5] UN2446

Chemical formula

CH3C6H3(NO2)OH

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[4-Methyl-3-nitrophenol] CAS[2042-14-0] UN2446

Chemical formula

C7H7NO3

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[5-Methyl-2-nitrophenol] CAS[700-38-9] UN2446

Chemical formula

C7H7NO3

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[3-Nitroacetophenone]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[Nitroaniline]

See; Aniline and -aniline

[Nitrobenzaldehyde]

See; -aldehyde

[Nitrobenzamide]

See; -benzamide

[Nitrobenzene]

See; Benzene & benzene derivatives

[Nitrobenzoic acid]

See; benzoic acid & -benzoic acid

[Nitrobenzonitrile]

See; Benzonitrile and -benzonitrile

[Nitrobenzyl alcohol]

Chemical formula

C7H7NO3

2-Nitrobenzyl alcohol

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

3-Nitrobenzyl alcohol

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

4-Nitrobenzyl alcohol

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

4-Nitrobenzyl chloride

Chemical fromula

H6ClNO2

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[Nitrobiphenyl]

Chemical formula

C12H9NO2

2-Nitrobiphenyl

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

3-Nitrobiphenyl

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[4-Nitro-catechol]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[4-Nitrodiphenylamine] CAS[836-30-6]

= N-phenyl-4-nitroaniline

Chemical fromula

C12H10N2O2

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[Nitroglycerin] CAS[55-63-0]

= Glycerol trinitrate

Chemical formula

C3H5N3O9

Purpose for use

Blasting explosive.

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[3-Nitro-2-hydroxybenzaldehyde]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2-Nitroimino-5-nitro-hexahydro-1,3,5-triazine]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[4-Nitrophenetole]

Chemical formula

C8H9NO3

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[Nitrophenol]

See; Phenols and derivatives

[4-Nitrophenylacetonitrile]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[4-Nitrophenyl-phenyl-ether] CAS[620-88-2]

Mode of toxic action

Electro(nucleo)phile. (ref. ID; 3327)

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 3327, 7772)

[2-Nitroresorcinol]

Chemical fromula

C6H5NO4

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[Nitrosobenzene] CAS[586-96-9]

Chemical formula

C6H5NO

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[Nitrotoluene]

See; Toluene and -toluene

[3-Nitro-1,2,4-triazol-5-ol]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[3-Nitro-1,2,4-triazol-5-one]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[1-Octanol] CAS[111-87-5] UN3082

= Octyl alcochol

Chemical formula

CH3(CH2)6CH2OH

Chemical characteristics

1-octanol/water partition coefficient calculated by MEDCHEM CLOGP version 3.53 (log Kow) 3.15. (ref. ID; 631)

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 631, 990, 6839, 7772)

[2-Octanol] CAS[123-96-6] or CAS[4128-31-8] (ref. ID; 631)

= Capryl alcochol, Methylhexylcarbinol

Chemical formula

CH3(CH2)5CH(OH)CH3

Chemical characteristics

1-octanol/water partition coefficient calculated by MEDCHEM CLOGP version 3.53 (log Kow) 2.77. (ref. ID; 631)

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 631)

[3-Octanol] CAS[589-98-0] or CAS[20296-29-1] (ref. ID; 631)

Chemical formula

CH3(CH2)4CH(OH)CH2CH3

Chemical characteristics

1-octanol/water partition coefficient calculated by MEDCHEM CLOGP version 3.53 (log Kow) 2.77. (ref. ID; 631)

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 631)

[Pentachloronitrobenzene] CAS[608-93-5]

Trade name

Quintozene (J, I, B) or Quintozen: Brassicol, Earthcide, PCNB, Pentagen, Pentrone, Terraclor

Chemical formula

C6Cl5NO2

Purpose for use

Fungicide.

Toxicity

LD50 (oral): rat >12000 mg/kg.

Test organisms

Protozoa: Colpidium campylum (ref. ID; 6784)
Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[Pentafluoronitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[Pentryl]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[RDX]

= 1,3,5-Trinitro-1,3,5-triazacyclohexane (RDX) CAS[121-82-4] (ref. ID; 4958, 6817), = 1,3,5-Trinitro-1,3,5,7-triazacyclohexane (ref. ID; 6865), = Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (ref. ID; 6927)

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)
Oligochaeta: Eisenia andrei (ref. ID; 4958, 6817, 6927)
Oligochaeta: Lumbricus terrestris (ref. ID; 4958)

[2,3,5,6-Tetrachloro-1,4-dinitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[1,2,3,5-Tetrachloro-4-nitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[Tetrachloronitrobenzene]

See; Benzene & benzene derivatives

[2,3,4,6-Tetrafluoronitrobenzene] CAS[314-41-0]

Chemical formula

C6HF4NO2

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[Tetryl]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2,4,5-Trichloro-1,3-dinitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[2,4,6-Trichloro-1,3-dinitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[1,2,3-Trichloro-5-nitrobenzene] CAS[20098-48-0]

Chemical formula

C6H2Cl3NO2

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[1,2,4-Trichloro-3-nitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[1,2,4-Trichloro-6-nitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[Trichloronitrobenzene]

See; Benzene & benzene derivatives

[1,2,3-Trifluoro-4-nitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2,4,6-Trimethylnitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[1,3,5-Trinitrobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[2,4,6-Trinitrophenol] CAS[88-89-1] UN0154

Chemical formula

(O2N)3C6H2OH

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 6709, 7772)

[1,3,5-Trinitrosobenzene]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[1,3,5-Trinitroso-1,3,5-triazine]

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

[Trinitrotoluene]

2,3,4-Trinitrotoluene

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

2,3,6-Trinitrotoluene

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

2,4,5-Trinitrotoluene

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

2,4,6-Trinitrotoluene

Biotransformation of TNT has been demonstrated in bacteria, fungi, plants, mammals and humans. The ntiro-reduction of TNT into monoamino metabolites ([2-ADNT] and [4-ADNT] and then into diamino metabolites [2,4-DANT] and [2,6-DANT]) was the major metabolic pathway observed. (ref. ID; 7030)

Purpose for use

Energetic compounds.
TNT has been identified in soil at sites related to military activities. (ref. ID; 7030)

Toxicity

Mutagenicity/Carcinogenic. (ref. ID; 7030)

Test organisms

Protozoa: Tetrahymena pyriformis (ref. ID; 7772)
Oligochaeta: Eisenia andrei (ref. ID; 4958, 6817, 6865, 7030)
Oligochaeta: Enchytraeus albidus (ref. ID; 6130)
Oligochaeta: Lumbricus terrestris (ref. ID; 4958)