Ref ID : 7081
Gernot Glockner, Ludwig Eichinger, Karol Szafranski, Justin A. Pachebat, Alan T. Bankier, Paul H. Dear, Rudiger Lehmann, Cornelia Baumgart, Genis Parra, Josep F. Abril, Roderic Guigo, Kal Kumpf, Budi Tunggal, The Dictyostelium Genome Sequencing Consortium, Edward Cox, Michael A. Quail, Matthias Platzer, Andre Rosenthal, and Angelika A. Noegel; Sequence and analysis of chromosome 2 of Dictyostelium discoideum. Nature 418(4):79-85, 2002
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The genome of the lower eukaryote Dictyostelium discoideum comprises six chromosomes. Here we report the sequence of the largest, chromosome 2, which at 8 megabases (Mb) represents about 25% of the genome. Despite an A+T content of nearly 80%, the chromosome codes for 2,799 predicted protein coding genes and 73 transfer RNA genes. This gene density, about 1 gene per 2.6 kilobases (kb), is surpassed only by Saccharomyces cerevisiae (one per 2 kb) and is similar to that of Schizosaccharomyces pombe (one per 2.5 kb). If we assume that the other chromosomes have a similar gene density, we can expect around 11,000 genes in the D. discoideum genome. A significant number of the genes show higher similarities to genes of vertebrates than to those of other fully sequenced eukaryotes. This analysis strengthens the view that the evolutionary position of D. discoideum is located before the branching of metazoa and fungi but after the divergence of the plant kingdom, placing it close to the base of metazoan evolution.