Ref ID : 3982
Jeffrey J. Seilhamer and Thomas J. Byers; ATPase-Associated Oligomycin Resistance in Acanthamoeba castellanii. J.Protozool. 29(3):394-397, 1982
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The multiplication rate of "wild-type" (WT) populations of Acanthamoeba castellanii was inhibited 50% by ~3 µg oligomycin/ml; Oli(R2), an oligomycin resistant cell line, required ~7 µg/ml for the same inhibition. ATPase solubilized from Oli(R2) mitochondrial fractions required 3-10-fold higher concentrations of oligomycin than did identical WT fractions to achieve 50% inhibition of activity. Resistance was correlated with altered mitochondrial ATPase sensitivity to oligomycin.