Ref ID : 3963
Joseph Donald Smith, Jeffery C. King, and Eric C. Holland; Phosphonoacetic Acid: Effect on and Disposition by Tetrahymena. J.Protozool. 29(1):103-105, 1982
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The antiviral agent phosphonoacetic acid inhibits growth of Tetrahymena thermophila at concentrations comparable to those inhibiting growth of other eukaryotic cells, with 50% inhibition at 0.5 mM phosphonoacetic acid. The compound is cytotoxic to Tetrahymena at concentrations greater than 2.0 mM. When a culture of Tetrahymena the growth of which was totally inhibited by 2.0 mM phosphonoacetic acid was diluted with fresh medium, growth resumed in an exponential, rather than synchronous, fashion. [2-14C]phosphonoacetic acid is not metabolized by Tetrahymena.