Ref ID : 3768
Mishima Shoji; Effect of Adenine on Paramecium multimicronucleatum. J.Protozool. 22(3):443-447, 1975
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The addition of adenine to the culture medium of Paramecium multimicronucleatum caused an inhibition of conjugation and fission and also an increase in the number of food vacuoles. The inhibition of conjugation was observed at the stage of adhesion of cell membranes. With adenine, the duration of fission was prolonged and L-shaped cells were formed. Adenine apparently repressed the excretion of food vacuoles and thus caused an accumulation of food vacuoles within the cells. All these effects were observed at similar concentrations of adenine higher than 2 mM. The addition of uridine to the adenine-containing medium reversed the inhibition of fission; conjugation and vacuole accumulation remained unaffected.