Ref ID : 3351
Janine Dupy-Blanc, Claude-Alain Groliere, Rached Berrada, and Lucien David; [Action Comparee de deux Antibiotiques Ionophores (Nigericine et Epinigericine) sur les Teneurs en ADN Macronucleaire du Cilie Tetrahymena pyriformis GL, en Culture Synchrone]. Europ.J.Protistol. 24(2):138-144, 1989
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Antibiotics (30 mg/l) added at T 60 mn. lead, in a part of the population, to an increase of the macronuclear DNA content resulting from DNA activity during a phase S2 which begins after the phase G2. The largest cells have the highest DNA content and the longest generation time. The results are confirmed by autoradiography with tritiated thymidine. The percentage of macronuclear labelling increases from T 150 to a maximum at T 180, and it is greater with nigericin (46%) than with epinigericin (37%). Thus, epinigericin is less toxic than nigericin.