Ref ID : 1981
Anna Marie Pyle, Felicia L. Murphy, and Thomas R. Cech; RNA substrate binding site in the catalytic core of the Tetrahymena ribozome. Nature 358:123-128, 1992
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In catalysis by group I introns, the helix (P1) containing the RNA cleavage site must be positioned next to the guanosine binding site. We have identified a conserved adenine in the catalytic core that contributes to the stability of this arrangement and propose that it accepts a hydrogen bond from a specific 2'-OH in P1. Such base-backbone tertiary interactions may be generally important to the organization of RNA tertiary structure.