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The World of Protozoa, Rotifera, Nematoda and Oligochaeta

Ref ID : 631

T. Wayne Schultz and Milon Tichy; Structure-toxicity relationships for unsaturated alcohols to Tetrahymena pyriformis: C5 and C6 analogs and primary propargylic alcohols. Bull.Environ.Contam.Toxicol. 51:681-688, 1993

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Previous investigations have used 1-octanol/water partition coefficient (log Kow) dependent quantitative structure-activity relationships (QSAR) as a basis of predicting toxicity of nonreactive, nonionic narcotics including saturated monoalcohols to the guppy (Poecilia reticulata, Konemann 1981), the fathead minnow (Pimephales promelas, Veith et al. 1983) and ciliate (Tetrahymena pyriformis, Schultz et al. 1990). However, other investigations (Lipnick 1985; Veith et al. 1989; Dawson et al. 1990) have shown selected unsaturated alcohols, especially primary propargylic alcohols, to exhibit excess toxicity to fish and to frog embryo and larvae. Excess toxicity (Te) was defined by the ratio of predicted toxicity to observed toxicity (Lipnick et al. 1987) with predicted toxicity values being calculated by the baseline nonpolar narcosis QSAR. The purposes of this investigation were to: (1) determine the biological response in the Tetrahymena population growth impairment assay of exposure to selected unsaturated monoalcohols; (2) compare the observed and predicted toxicity, and (3) develop a log Kow dependent QSAR for 2-alkyn-1-ols.