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The World of Protozoa, Rotifera, Nematoda and Oligochaeta

Ref ID : 7394

Phillip E. Ryals and Xiangli Yang; Effects of Dichloroisoproterenol on Macromolecular Synthesis and Differentiation in Tetrahymena vorax. J.Eukaryot.Microbiol. 44(1):43-45, 1997

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The effect of dichloroisoproterenol on macrostomal cell formation in Tetrahymena vorax was examined and the drug was found to be 50% inhibitory at a concentration of 88 µM. Cellular uptake and incorporation of a variety of radiolabelled precursors was monitored in the presence of dichloroisoproterenol. The results demonstrate a strong, concentration-dependent inhibitory effect on RNA and protein biosynthesis, with a lesser inhibition observed for lipid biosynthesis. These data indicate that dichloroisoproterenol's reported effects on vacuole formation and processing in Tetrahymena are nonspecific with regard to phagocytic processes, but result from a general suppression of macromolecular synthesis.