Ref ID : 7020
Michael M. Suzuki, Edwin L. Cooper, George S. Eyambe, Arthur J. Goven, Lloyd C. Fitzpatrick, and Barney J. Venables; Polychlorinated Biphenyls (PCBs) depress allogeneic natural cytotoxicity by earthworm coelomocytes. Environmental Toxicology & Chemistry 14(10):1697-1700, 1995
Reprint
In File
Notes
Coelomocytes of the earthworm Lumbricus terrestris caused significant spontaneous allogeneic cytotoxicity in a 24-hr trypan blue assay, but not in an assay using lactate dehydrogenase (LDH) release. Allogeneic cytotoxicity assay using cells from worms exposed to polychlorinated biphenyls (PCBs) suggest that PCBs can suppress a natural killing (NK-like) reaction. The implications of this worms are twofold: unerstanding the evolution of natural killing (NK-like) activity and providing preliminary information on how spontaneous killing, a component of cellular immunity, may be compromised by pollutants.