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The World of Protozoa, Rotifera, Nematoda and Oligochaeta

Ref ID : 4762

Rached Berrada, C.A. Groliere, Janine Dupy-Blanc, and Lucien David; [Action Comparee de Deux Antibiotiques Polyethers Carboxyliques Epimeres (Nigericine et Epinigericine) sur les Populations de Tetrahymena pyriformis en Croissance Exponentielle ou Synchronisees] (Comparative Action of Two Epimeric Polyether Carboxylic Antibiotics (Nigericin and Epinigericin) on the Tetrahymena pyriformis Population Dynamics in Exponential Cultures or Synchronous Cultures). Arch.Protistenk 136:317-326, 1988

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This study gives the comparative action of two epimeric polyether carboxylic antibiotics, nigericin and epinigericin on the Tetrahymena pyriformis population dynamic in exponential cultures or synchronous cultures obtained by the thermicshock method. DMSO was used dissolve there (not soluble in water). The dynamics of the both populations are not altered in these experimental conditions (0.5% DMSO). With exponential cultures, the addition of ionophorous antibiotics leads to an extension of generation time. The CI50 is 6.2 mg/l for nigericin and 12.7 mg/l for epinigericin. Epinigericin is less toxic than nigericin. With synchronous cultures, the addition of the both antibiotics during the synthesis time S leads to an stronger alteration than during the post-synthetic time G2. At all conditions, the modifications obtained are more important with nigericin than with epinigericin.