Ref ID : 3884
Jacob J. Blum; Effect of Chlorpromazine on Active Transport of Amino Acids in Tetrahymena. J.Protozool. 27(4):498-502, 1980
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Low concentrations of chlorpromazine (~0.01 mM) inhibit growth and nucleic acid synthesis in the ciliate Tetrahymena pyriformis. Brief exposure of the cells to, e.g. 0.018 mM chlorpromazine, had very little effect on [14C]O2 production or on label incorporation into glycogen from [1-14C]acetate, [6-14C]glucose, [1-14C]leucine, but 7-hr exposure of stationary phase cultures to this drug caused marked alterations in metabolism, including an almost complete loss of ability to decarboxylate L-[1-14C]leucine and L-[1-14C]tyrosine. It was shown that loss of ability to decarboxylate these amino acids results from loss of ability to transport them.