Ref ID : 2633
Jalal Keshmirian and Thomas Nogrady; Rotifer neuropharmacology V. Catecholaminergic pharmacology of the abnormal sessile behaviour of Brachionus plicatilis. Comp.Biochem.Physiol.C. 90(2):367-371, 1988
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1. The catecholaminergic pharmacology of the abnormal sessile behaviour of B. plicatilis was investigated. 2. The effect is stereospecific as (-)norepinephrine (NE) was more potent than (+/-)NE. 3. Phenylephrine and isoproterenol (ISNE) were both partical agonists and may exert their effect via two different mechanisms. 4. Both tolazoline as well as atenolol (alpha- and beta-adrenergic blockers respectively) antagonized NE-induced sessility in a dose-dependent fashion. Thus, abnormal sessile behaviour may be both an alpha- and beta adrenergic effect. 5. Dopaminergic agonists such as 2-amino-6,7-dihydroxyotetraline (ADTN), (-)Apomorphine (APO), and SK&F 38393 all induced sessility. The spectrum of activity of these drugs is different from that of dopamine (DA). 6. Spiperone and haloperidol antagonized DA in a dose-dependent manner. Therefore, a dopaminergic system also seems to be involved in this behavioural response. However a distinction between D-1 and D-2 receptor mediation cannot be made, as the drugs are highly toxic to the rotifers. 7. Cross-reactions between the adrenergic and dopaminergic systems in regulating sessile behaviour were also investigated.