Ref ID : 1668
Thomas Nogrady and Toby L.A. Rowe; Comparative laboratory studies of narcosis in Brachionus plicatilis. Hydrobiologia 255/256:51-56, 1993
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The effect of twelve drugs and chemical compounds on the narcosis of Brachionus plicatilis was studied using standardized laboratory conditions. Drug efficacy was compared by calculating EC50 (effective concentration causing narcosis in 50% of animals), time necessary to reach narcosis in 50% of animals, concentration range of activity, and degree of extension after preservation. The local anesthetic Bupivacaine was found to be most effective by all criteria. Our previous data and preliminary field experiments indicated that drug sensitivity varies widely, even between congeneric taxa. The anesthetic effect of carbonated water was also investigated.