Latest Update：2024/04/12 14:28:08

UMEZU Toyoshi

Researcher Name: UMEZU Toyoshi

Div (Section) name/title: Health and Environmental Risk Division／Senior Research Associate

Research Subject: Studies on effects of chemicals on Central Nervous system

Degree(s): Ph.D

Professional Qualification(s): Medicine,Pharmacy,Physiology

Environmental Speciality Field: risk assessment,hazardous chemical substances,Aroma Environment

Keyword(s): Behavioral sciences,Neurochemistry,Neurotoxicity,Neuropyschiatric disorders,Developmental diseases,Neuropharmacology,Aromatherapy,smell/fragrance

Brief Description of Research: Since we humans are exposed to various kinds of environmental chemicals, their safety have been concerned. Health risk assessment on various chemicals have been proceeded, however, shortage of information on neurotoxicity of chemicals is remarkable, thus their impact have hardly been elucidated. I am working on development of new methods and arrangement of test batteries for evaluating neurotoxicity and application of them to various chemicals to provide neurotoxicity data of various environmental chemicals. My special interest is on development and application of new behavioral methods and test batteries for evaluating neurotoxicity of environmental chemicals and providing neurotoxicity data using those methods. I am also interested in good effects of environmental chemicals on mental function, and working on neuropharmacological effects of aromatic and/or odor chemicals.

Career: 1980~1984　College of Biological Sciences, Second Cluster of College, University of Tsukuba
1984~1986 Graduate School of Environmental Sciences, University of Tsukuba
1986~1990 Graduate School of Medicine, Gunnma University
1990~ National Institute for Environmental Studies
1995~1997 University of Virginia (Visiting Researcher)

URL: http://www.nies.go.jp/gaiyo/bunya/chem-e.html

Membership of Academic Society: Japanese Pharmacological Society (JPS),The pharmaceutical society of japan,Japanese Society of Neuropsychopharmacology,Japan Society of Endocrine Disrupters Research (JSEDR),Japanese Society for Chronobiology,Japanese Society of Behavioral Medicine

Research Subject

Fiscal Year: 2023
- 26420 : Research project on the health hazard assessment considering the real-life environment and vulnerability
Fiscal Year: 2022
- 25973 : Research project on the health hazard assessment considering the real-life environment and vulnerability
Fiscal Year: 2021
- 25517 : Research on the health hazard assessment considering the real-life environment and vulnerability
- 25625 : A fundamental study for evaluating health impact of environmental factors
- 25650 : A study on psychoactive effects of plant-derived substances for developing healthy aroma environment
Fiscal Year: 2020
- 25099 : Research Program on Health and Environmental Safety
- 25141 : Research Project on Health Impacts of Chemicals on Children and Future Generations
- 25218 : A study on psychoactive effects of plant-derived substances for developing healthy aroma environment
- 25236 : A Fundamental Study for Evaluating Health Impact of Environmental Factors
Fiscal Year: 2019
- 24696 : Research Program on Health and Environmental Safety
- 24721 : Research Project on Health Impacts of Chemicals on Children and Future Generations
- 24926 : A Fundamental Study for Evaluating Health Impact of Environmental Factors
- 24927 : A study on psychoactive effects of plant-derived substances for developing healthy aroma environment
Fiscal Year: 2018
- 24304 : Research project on health impacts of chemicals on children and future generations
- 24355 : Research program on health and environmental safety
- 24447 : A study on psychoactive effects of plant-derived substances for developing healthy aroma environment
- 24531 : A fundamental study for evaluating health impact of environmental factors
Fiscal Year: 2017
- 23824 : Research project on health impacts of chemicals on children and future generations
- 23847 : Research program on health and environmental safety
- 23975 : A fundamental study for evaluating health impact of environmental factors
- 23976 : A study on psychoactive effects of plant-derived substances for developing healthy aroma environment
Fiscal Year: 2016
- 23414 : Research program on health and environmental safety
- 23415 : Research project on health impacts of chemicals on children and future generations
- 23598 : A study on psychoactive effects of plant-derived substances for developing healthy aroma environment
- 23659 : A fundamental study for evaluating health impact of environmental factors
Fiscal Year: 2015
- 23110 : A study on systematization of neurobehavioral methods for evaluating health effects of environmental chemicals
- 23111 : A study on psychoactive effects of plant-derived substances for developing healthy aroma environment
Fiscal Year: 2014
- 22880 : A study on systematization of neurobehavioral methods for evaluating health effects of environmental chemicals
- 22884 : A study on psychoactive effects of plant-derived substances for developing healthy aroma environment
Fiscal Year: 2013
- 22461 : A study on psychoactive effects of plant-derived substances for developing healthy aroma environment
- 22462 : A study on systematization of neurobehavioral methods for evaluating health effects of environmental chemicals
Fiscal Year: 2012
- 22031 : A study on psychoactive effects of plant-derived substances for developing healthy aroma environment
- 22034 : A study on systematization of neurobehavioral methods for evaluating health effects of environmental chemicals
Fiscal Year: 2011
- 21405 : Research for monitoring and risk assessment of cyanotoxin microcystin
- 21556 : Neuropharmacological study for effects of nicotine and menthol on depression symptom
- 21557 : A study on psychoactive effects of plant-derived substances for developing healthy aroma environment
- 21564 : A study on systematization of neurobehavioral methods for evaluating health effects of environmental chemicals
Fiscal Year: 2010
- 21071 : Study on establishment of behavioral tests system for evaluation of health effects of environmental chemicals
- 21072 : Neuropharmacological study for effects of nicotine and menthol on depression symptom
- 21073 : A study on psychoactive effects of plant-derived substances for developing healthy aroma environment
Fiscal Year: 2009
- 20509 : Quantification of ferritin, an iron storage protein in vivo and its application to molecular imaging
- 20632 : Study on establishment of behavioral tests system for evaluation of health effects of environmental chemicals
- 20633 : Neuropharmacological study for effects of nicotine and menthol on depression symptom
- 20634 : A study on psychoactive effects of plant-derived substances for developing healthy aroma environment
Fiscal Year: 2008
- 20103 : Quantification of ferritin, an iron storage protein in vivo and its application to molecular imaging
- 20225 : Study on establishment of behavioral tests system for evaluation of health effects of environmental chemicals
Fiscal Year: 2007
- 10477 : Behavioral toxicological study for developmental effects of diphenylarsinic acid
- 10605 : Study on establishment of behavioral tests system for evaluation of health effects of environmental chemicals
- 10723 : Quantification of ferritin, an iron storage protein in vivo and its application to molecular imaging
Fiscal Year: 2006
- 10081 : Study on the metabolism underlying brain function using an ultra high field multinuclear MRI system
- 10221 : Behavioral toxicological study for developmental effects of diphenylarsinic acid
- 10338 : Study on establishment of behavioral tests system for evaluation of health effects of environmental chemicals
Fiscal Year: 2005
- 9337 : MRI, behavioral and neurochemical study on the effect of endocrine disrupting chemicals on the nervous system.
- 9341 : Study on the effect of endocrine disrupting chemicals to the reproductive and immune system.
- 9388 : Study on establishment of behavioral tests system for evaluation of health effects of environmental chemicals
- 9554 : Study on the metabolism underlying brain function using an ultra high field multinuclear MRI system
Fiscal Year: 2004
- 8972 : MRI, behavioral and neurochemical study on the effect of endocrine disrupting chemicals on the nervous system.
- 8976 : Study on the effect of endocrine disrupting chemicals to the reproductive and immune system.
- 9022 : Study on establishment of behavioral tests system for evaluation of health effects of environmental chemicals
- 9305 : Study on the metabolism underlying brain function using an ultra high field multinuclear MRI system
Fiscal Year: 2003
- 8675 : Development of ultrahighfieldmultinuclear MRI system for human measurements
- 8689 : MRI, behavioral and neurochemical study on the effect of endocrine disrupting chemicals on the nervous system.
- 8693 : Study on the effect of endocrine disrupting chemicals to the reproductive and immune system.
- 8740 : Study on establishment of behavioral tests system for evaluation of health effects of environmental chemicals
Fiscal Year: 2002
- 8459 : Development of ultra high field multinuclear MRI system for human measurements
- 8474 : MRI, behavioral and neurochemical study on the effect of endocrine disrupting chemicals on the nervous system.
- 8522 : Study on establishment of behavioral tests system for evaluation of health effects of environmental chemicals
- 8538 : Study on the effect of endocrine disrupting chemicals to the reproductive and immune system.
Fiscal Year: 2001
- 8236 : Development of ultra high field multinuclear MRI system for human measurements
- 8252 : MRI, behavioral and neurochemical study on the effect of endocrine disrupting chemicals on the nervous system.
- 8284 : Study on establishment of behavioral tests system for evaluation of health effects of environmental chemicals

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Research Result (Publication)

all
Original Paper

Original Paper
Toxicokinetic characteristics and effects of diphenylarsinic acid on dopamine in the striatum of free-moving mice

Presenter : Umezu T., Shibata Y.
Title : , Neurotoxicology, 83:106-115 (2021)
Original Paper
Identification of novel target molecules of l-menthol

Presenter : Umezu T.
Title : , Heliyon, 7:e07329 (2021)
Original Paper
l-Menthol increases extracellular dopamine and c-Fos-like immunoreactivity in the dorsal striatum, and promotes ambulatory activity in mice

Presenter : Umezu T., Sano T., Hayashi J.
Title : , PLOS ONE, 16(11):e0260713 (2021)
Original Paper
Dataset on effects of perinatal exposure to propylthiouracil on serum T4, body weight gain, day of eye opening and brain monoamine contents in offspring mice

Presenter : Umezu T., Kita T., Morita M.
Title : , Data in brief, 28:104900 (2020)
Original Paper
Simultaneous blood and brain microdialysis in a free-moving mouse to test blood-brain barrier permeability of chemicals

Presenter : Umezu T., Sano T., Hayashi J., Shibata Y.
Title : , Toxicology Reports, 7:1542-1550 (2020)
Original Paper
Hyperactive behavioral phenotypes and an altered brain monoaminergic state in male offspring mice with perinatal hypothyroidism

Presenter : Umezu T., Kita T., Morita M.
Title : , Toxicology Reports, 1031-1039 (2019)
Original Paper
Identification of isobutyl angelate, isoamyl angelate and 2‐methylbutyl isobutyrate as active constituents in Roman chamomile essential oil that promotes mouse ambulation

Presenter : Umezu T., Sano T., Hayashi J., Yoshikawa Y., Shibata Y.
Title : , Flavour and Fragrance Journal (2017)
Original Paper
Brain regions and monoaminergic neurotransmitters that are involved in mouse ambulatory activity promoted by bupropion

Presenter : Umezu T., Shibata Y.
Title : , Toxicology Reports, 3:552-562 (2016)
Original Paper
Different behavioral effect dose-response profiles in mice exposed to two-carbon chlorinated hydrocarbons: Influence of structural and physical properties

Presenter : Umezu T., Shibata Y.
Title : , Toxicology and Applied Pharmacology, 279:103-112 (2014)
Original Paper
Evaluation of central nervous system acting effects of plant-derived essential oils using ambulatory activity in mice

Presenter : Umezu T.
Title : , Pharmacology and Pharmacy, 4(2):160-170 (2013)
Original Paper
Diphenylarsinic acid produces behavioral effects in mice relevant to symptoms observed in citizens who ingested polluted well water

Presenter : Umezu T., Nakamiya K., Kita K, Ochi T, Shibata Y., Morita M.
Title : , Neurotoxicology and Teratology, 34(1):143-151 (2012)
Original Paper
Unusual effects of nicotine as a psychostimulant on ambulatory activity in mice

Presenter : Umezu T.
Title : , ISRN Pharmacology, 2012:170981 (2012)
Original Paper
Evaluation of the effects of plant-derived essential oils on central nervous system function using discrete shuttle-type conditioned avoidance response in mice

Presenter : Umezu T.
Title : , Phytotherapy research, 26(6):884-891 (2012)
Original Paper
Anxiolytic-like effect of essential oil extracted from Abies sachalinensis

Presenter : Satou T., Matsuura M., Takahashi M., Umezu T., Hayashi S., Sadamoto K., Koike K.
Title : , Flavour and Fragrance Journal, 26(6):416-420 (2011)
Original Paper
Evidence for dopamine involvement in ambulation promoted by pulegone in mice

Presenter : Umezu T.
Title : , Pharmacol.Biochem.Behav., 94(4):497-502 (2010)
Original Paper
Evidence for dopamine involvement in ambulation promoted by menthone in mice

Presenter : Umezu T.
Title : , Pharmacol.Biochem.Behav., 91(3):315-320 (2009)
Anticonflict effects of lavender oil and identification of its active constituents

Presenter : Morita M., Ito H., Umezu T., Nagano K.
Title : , Pharmacol.,Biochem.Behav., 85:713-721 (2006)
Uterotrophic effects of benzophenone derivatives and a p-hydroxybenzoate used in ultraviolet screens

Presenter : , Kamata R., UMEZU Toyoshi
Title : , Environ.Res., 98:40-45 (2005)
RNA constitution and estrogen-responsive gene expression in the ovariectomized rat uterus

Presenter : , Kamata R., UMEZU Toyoshi
Title : , Anal.Biochem., 341(1):131-140 (2005)
Behavioral pharmacology of plant-derived essential oils

Presenter : Umezu T.
Title : , Curr.Top.Pharmacol., 7(1):17-31 (2003)
Evidence for the involvement of dopamine in ambulation promoted by menthol in mice

Presenter : Umezu T., Morita M.
Title : , J.Pharmacol.Sci., 91:125-135 (2003)
Anticonflict effects of rose oil and identification of its active constituents

Presenter : Nagano K., Umezu T., Ito H., Nagano K., Yamakoshi M.(*1), Oouchi H.(*1), Sakaniwa M.(*1), Morita M.
Title : , Life Sci., 72:91-102 (2002)
Ambulation-promoting effect of peppermint oil and identification of its active constituents

Presenter : Umezu T., Sakata A., Ito H.
Title : , Parmacol.Biochem. Behav., 69:383-390 (2001)
Behavioral Effects of Plant-Derived Essential Oils in the Geller Type Conflict Test in Mice

Presenter : UMEZU Toyoshi
Title : , Jpn.J.Pharmacol., 83:150‐153 (2000)
Anticonflict Effects of Plant-Derived Essential Oils

Presenter : UMEZU Toyoshi
Title : , Pharmacol.Biochem.Bihav., 64(1):35‐40 (1999)
Effects of Psychoactive Drugs in the Vogel Conflict Test in Mice

Presenter : UMEZU Toyoshi
Title : , Jpn.J.Pharmacol., 80:111‐118 (1999)
Circadian Behavior and Plasticity of Light-Induced c-fos Expression in SCN of tau Mutant Hamsters

Presenter : UMEZU Toyoshi
Title : , J.Biol.Rhythms, 13(4):305‐314 (1998)
Tris(2-chloroethyl)phosphate Increases Ambulatory Activity in Mice:Pharmacological Analyses of Its Neurochemical Mechanism

Presenter : UMEZU Toyoshi,
Title : , Toxicol.Appl.Pharmacol., 148:109‐116 (1998)
Behavioral Effects of Trichloroethylene and Tetrachloroethylene in Mice

Presenter : UMEZU Toyoshi,
Title : , Pharmacol.Biochem.Behav., 58(3):665‐671 (1997)
Development of tolerance against ozone effects on drinking and eating behaviors in rats by intermittent exposures

Presenter : UMEZU Toyoshi
Title : , Inhal.Toxicol., 6:289‐302 (1994)
Effects of ozone and Nitrogen dioxide on drinking and eating behaviors in mice

Presenter : UMEZU Toyoshi,
Title : , Neurobehavioral Methods & Effects in Occupational Health (Academic press,1020p.), 949‐965 (1994)
Long-continuous observation of the effects of methamphetamine on wheel-running and drinking in mice

Presenter : UMEZU Toyoshi
Title : , Prog.Neuro-Psycho-pharmacol.& Biol.Psychiat., 18:397‐407 (1994)
Effects of ozone and nitrogen dioxide on drinking and eating behaviors in mice

Presenter : UMEZU Toyoshi,
Title : , Environ.Res., 61(1):51‐67 (1993)
Effect of ozone toxicity in the drinking behavior of rats

Presenter : UMEZU Toyoshi,
Title : , Arch.Environ.Health, 42(1):58‐62 (1987)

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Toxicokinetic characteristics and effects of diphenylarsinic acid on dopamine in the striatum of free-moving mice

Presenter : Umezu T., Shibata Y.
Title : , Neurotoxicology, 83:106-115 (2021)
Identification of novel target molecules of l-menthol

Presenter : Umezu T.
Title : , Heliyon, 7:e07329 (2021)
l-Menthol increases extracellular dopamine and c-Fos-like immunoreactivity in the dorsal striatum, and promotes ambulatory activity in mice

Presenter : Umezu T., Sano T., Hayashi J.
Title : , PLOS ONE, 16(11):e0260713 (2021)
Dataset on effects of perinatal exposure to propylthiouracil on serum T4, body weight gain, day of eye opening and brain monoamine contents in offspring mice

Presenter : Umezu T., Kita T., Morita M.
Title : , Data in brief, 28:104900 (2020)
Simultaneous blood and brain microdialysis in a free-moving mouse to test blood-brain barrier permeability of chemicals

Presenter : Umezu T., Sano T., Hayashi J., Shibata Y.
Title : , Toxicology Reports, 7:1542-1550 (2020)
Hyperactive behavioral phenotypes and an altered brain monoaminergic state in male offspring mice with perinatal hypothyroidism

Presenter : Umezu T., Kita T., Morita M.
Title : , Toxicology Reports, 1031-1039 (2019)
Identification of isobutyl angelate, isoamyl angelate and 2‐methylbutyl isobutyrate as active constituents in Roman chamomile essential oil that promotes mouse ambulation

Presenter : Umezu T., Sano T., Hayashi J., Yoshikawa Y., Shibata Y.
Title : , Flavour and Fragrance Journal (2017)
Brain regions and monoaminergic neurotransmitters that are involved in mouse ambulatory activity promoted by bupropion

Presenter : Umezu T., Shibata Y.
Title : , Toxicology Reports, 3:552-562 (2016)
Different behavioral effect dose-response profiles in mice exposed to two-carbon chlorinated hydrocarbons: Influence of structural and physical properties

Presenter : Umezu T., Shibata Y.
Title : , Toxicology and Applied Pharmacology, 279:103-112 (2014)
Evaluation of central nervous system acting effects of plant-derived essential oils using ambulatory activity in mice

Presenter : Umezu T.
Title : , Pharmacology and Pharmacy, 4(2):160-170 (2013)
Diphenylarsinic acid produces behavioral effects in mice relevant to symptoms observed in citizens who ingested polluted well water

Presenter : Umezu T., Nakamiya K., Kita K, Ochi T, Shibata Y., Morita M.
Title : , Neurotoxicology and Teratology, 34(1):143-151 (2012)
Unusual effects of nicotine as a psychostimulant on ambulatory activity in mice

Presenter : Umezu T.
Title : , ISRN Pharmacology, 2012:170981 (2012)
Evaluation of the effects of plant-derived essential oils on central nervous system function using discrete shuttle-type conditioned avoidance response in mice

Presenter : Umezu T.
Title : , Phytotherapy research, 26(6):884-891 (2012)
Anxiolytic-like effect of essential oil extracted from Abies sachalinensis

Presenter : Satou T., Matsuura M., Takahashi M., Umezu T., Hayashi S., Sadamoto K., Koike K.
Title : , Flavour and Fragrance Journal, 26(6):416-420 (2011)
Evidence for dopamine involvement in ambulation promoted by pulegone in mice

Presenter : Umezu T.
Title : , Pharmacol.Biochem.Behav., 94(4):497-502 (2010)
Evidence for dopamine involvement in ambulation promoted by menthone in mice

Presenter : Umezu T.
Title : , Pharmacol.Biochem.Behav., 91(3):315-320 (2009)

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Research Result (Presentation)

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Research Presentation

Research Presentation
Behavioral pharmacology of plant-derived substances (29): Identification of active constituents of Thyme and tea tree essential oils that promote mouse ambulation

Presenter : Umezu T., Sano T., Hayashi J., Yoshikawa Y.
Name of Society : WCP2018 KYOTO / 18th WORLD CONGRESS OF BASIC AND CLINICAL PHARMACOLOGY (2018)
Name of Proceedings : WCP2018 KYOTO / 18th WORLD CONGRESS OF BASIC AND CLINICAL PHARMACOLOGY/MICEnavi Program and Proceedings
Research Presentation
Rapid transport of diphenylarsinic acid into brain through blood-brain barrier as revealed by microdialysis combined with LCMSMS

Presenter : Shibata Y., Umezu T., Hosoya T., Takagi M. , Nakamiya K.
Name of Society : Metallomics 2013 (2013)
Name of Proceedings : Abstracts
Research Presentation
Behavioral pharmacology of plant-derived substances(15): Effects of mentol on extracellular dopamine,serotonine,norepinephrine and their metabolites in mouse striatum.Comparison with effects of bupropion,methylphenidate and cffeine

Presenter : UMEZU Toyoshi
Name of Society : 79th Annu.Meet.Jpn.Pharmacol.Soc. (2006)
Name of Proceedings : Abstracts
Research Presentation
Behavioral pharmacology of plant-derived subustances(14): Interaction between menthol and nicotine on ambulation in mice

Presenter : Umezu T., Morita M.
Name of Society : 78th Annu.Meet.Jpn.Pharm.Soc. (2005)
Name of Proceedings : J.Pharm.Sci., 97(Suppl.1)
Research Presentation
Behaviral pharmacology of plant-derived substances (13): anticonflict effects of lavender oil and identification of its active constituent

Presenter : Umezu T., Ito H., Morita M., Nagano K.
Name of Society : 24th CINP Congr.2004 (2004)
Name of Proceedings : Abstracts, 7(Suppl.1)
Research Presentation
Behavioral pharmacology of plant-derived substances(10)-behavioral effects of 2-phenethyl alcohol and citronellol in mice.Comparison with diazepam

Presenter : Umezu T., Sato C.(*1), Yamada M.(*1), Sakaniwa M.(*1), Morita M.
Name of Society : 76th Annu.Meet.Jpn.Pharmacol.Soc. (2003)
Name of Proceedings : J.Pharmacol.Sci., 91(Suppl.1)(Suppl.1):91
Behavioral pharmacology of plant-derived substances(8): effects of plant-derived essential oils on the discrete shuttle type avoidance response in mice

Presenter : Umezu T.
Name of Society : 75th Annu.Meet.Jpn.Pharmocol.Soc. (2002)
Name of Proceedings : Jpn.J.Pharmacol., 88(Suppl.1)

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Rapid transport of diphenylarsinic acid into brain through blood-brain barrier as revealed by microdialysis combined with LCMSMS

Presenter : Shibata Y., Umezu T., Hosoya T., Takagi M. , Nakamiya K.
Name of Society : Metallomics 2013 (2013)
Name of Proceedings : Abstracts
Behavioral pharmacology of plant-derived substances(15): Effects of mentol on extracellular dopamine,serotonine,norepinephrine and their metabolites in mouse striatum.Comparison with effects of bupropion,methylphenidate and cffeine

Presenter : UMEZU Toyoshi
Name of Society : 79th Annu.Meet.Jpn.Pharmacol.Soc. (2006)
Name of Proceedings : Abstracts
Behavioral pharmacology of plant-derived subustances(14): Interaction between menthol and nicotine on ambulation in mice

Presenter : Umezu T., Morita M.
Name of Society : 78th Annu.Meet.Jpn.Pharm.Soc. (2005)
Name of Proceedings : J.Pharm.Sci., 97(Suppl.1)
Behaviral pharmacology of plant-derived substances (13): anticonflict effects of lavender oil and identification of its active constituent

Presenter : Umezu T., Ito H., Morita M., Nagano K.
Name of Society : 24th CINP Congr.2004 (2004)
Name of Proceedings : Abstracts, 7(Suppl.1)
Behavioral pharmacology of plant-derived substances(10)-behavioral effects of 2-phenethyl alcohol and citronellol in mice.Comparison with diazepam

Presenter : Umezu T., Sato C.(*1), Yamada M.(*1), Sakaniwa M.(*1), Morita M.
Name of Society : 76th Annu.Meet.Jpn.Pharmacol.Soc. (2003)
Name of Proceedings : J.Pharmacol.Sci., 91(Suppl.1)(Suppl.1):91
Behavioral pharmacology of plant-derived substances (29): Identification of active constituents of Thyme and tea tree essential oils that promote mouse ambulation

Presenter : Umezu T., Sano T., Hayashi J., Yoshikawa Y.
Name of Society : WCP2018 KYOTO / 18th WORLD CONGRESS OF BASIC AND CLINICAL PHARMACOLOGY (2018)
Name of Proceedings : WCP2018 KYOTO / 18th WORLD CONGRESS OF BASIC AND CLINICAL PHARMACOLOGY/MICEnavi Program and Proceedings

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UMEZU Toyoshi

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