Latest Update：2020/06/03 15:56:00

MATSUMOTO Michi

Researcher Name: MATSUMOTO Michi

Div (Section) name/title: Center for Health and Environmental Risk Research／-

Research Subject: Health risk assessment of chemicals, Development of the prediction method for the carcinogenicityevaluation

Degree(s): Doctor of Pharmacy

Professional Qualification(s): Pharmacy,Biochemistry

Environmental Speciality Field: environmental risk,hazardous chemical substance,atmospheric environment

Research Subject

Fiscal Year: 2019
- 24696 : Research Program on Health and Environmental Safety
- 24756 : Risk Assessment Science Collaboration Office
- 24897 : Commission on consideration of health risk assessment methods for hazardous air pollutants
- 24977 : Fundamental Study on the Basis of Health and Environmental Risk Research
Fiscal Year: 2018
- 24339 : Risk Assessment Science Collaboration Office
- 24355 : Research program on health and environmental safety
- 24366 : Commission on Consideration of Health Risk Assessment Methods for Hazardous Air Pollutants
- 24553 : Fundamental study on the basis of health and environmental risk research
Fiscal Year: 2017
- 23847 : Research program on health and environmental safety
- 23860 : Risk Assessment Science Collaboration Office
- 24038 : Commission on Consideration of Health Risk Assessment Methods for Hazardous Air Pollutants
- 24073 : Fundamental study on the basis of health and environmental risk research
- 24118 : Characterization of mutation as a marker for carcinogenesis induced by oxidative stress: identification of mutation hotspot
Fiscal Year: 2016
- 23414 : Research program on health and environmental safety
- 23422 : Research project on the scientific and social framework of risk assessment and management
- 23442 : Risk Assessment Science Collaboration Office
- 23645 : Basic study for strategic risk management
- 23677 : Support study on the environmental risk assessment for management and regulation of chemical substances
- 23744 : Characterization of mutation as a marker for carcinogenesis induced by oxidative stress: identification of mutation hotspot
- 23757 : Literature investigation for setting the standard to reserve registration of pesticide to prevent hazard to fisheries in FY 2016
- 23777 : Commission on Consideration of Health Risk Assessment Methods for Hazardous Air Pollutants
Fiscal Year: 2015
- 23002 : Study on strategic approach of chemical risk management and control
- 23246 : Fundamental research for risk assessment of chemicals
- 23330 : Supporting on the environmental risk assessment of chemical substances for the purpose of control and regulation
- 23331 : Commission on Consideration of Health Risk Assessment Methods for Hazardous Air Pollutants
- 23332 : Development of Bioassay method based on mode of action of chemical
- 23333 : Pulmonary carcinogenic risk assessment of past exposure of suspended particulate matter in ambient air
- 23345 : Literature investigation for setting the standard to reserve registration of pesticide to prevent hazard to fisheries in FY 2015
Fiscal Year: 2014
- 22590 : Study on strategic approach of chemical risk management and control
- 22927 : Commission on Consideration of Health Risk Assessment Methods for Hazardous Air Pollutants
- 22930 : Fundamental research for risk assessment of chemicals
- 22931 : Pulmonary carcinogenic risk assessment of past exposure of suspended particulate matter in ambient air
- 22932 : Development of Bioassay method based on mode of action of chemical
- 22933 : Implementation of initial risk assessment of environmental chemicals in FY 2014
- 22935 : Literature investigation for setting the standard to reserve registration of pesticide to prevent hazard to fisheries in FY 2014
- 22940 : Supporting on the environmental risk assessment of chemical substances for the purpose of control and regulation
Fiscal Year: 2013
- 22174 : Study on strategic approach of chemical risk management and control
- 22335 : Literature investigation for setting the standard to reserve registration of pesticide to prevent hazard to fisheries
- 22337 : Support for monitoring visit on GLP laboratory for ecotoxicity testing in FY 2013
- 22343 : Supporting on the environmental risk assessment of chemical substances for the purpose of control and regulation
- 22344 : Implementation of initial risk assessment of environmental chemicals in FY 2013
- 22349 : Support and Information gathering on harmonization of chemical substance regulation egime among three countries, China, Korea and Japan.
- 22481 : Development of Bioassay method based on mode of action of chemical
- 22482 : Pulmonary carcinogenic risk assessment of past exposure of suspended particulate matter in ambient air
- 22484 : Fundamental research for risk assessment of chemicals
- 22554 : Commission on Consideration of Health Risk Assessment Methods for Hazardous Air Pollutants
Fiscal Year: 2012
- 21745 : Study on strategic approach of chemical risk management and control
- 22082 : Development of Bioassay method based on mode of action of chemical
- 22084 : Fundamental research for risk assessment of chemicals
- 22089 : Commission on Preparing Guidelines on Health Risk Assessment Methods for Hazardous Air Pollutants
- 22132 : Implementation of Initial Risk Assessment of Environmental chemicals in FY 2012
Fiscal Year: 2011
- 21510 : Fundamental research for risk assessment of chemicals
- 21534 : Development of Bioassay method based on mode of action of chemical
- 21583 : Assessment of in vivo mutagenicity and trans-generational effect of compounds contained in suspended particulate matter in urban air
- 21584 : Studies on safety evaluation of genotoxic carcinogens in food additives
- 21709 : Commission of Preparing Guidelines on Health Risk Assessment Methods for Hazardous Air Pollutants
Fiscal Year: 2010
- 20978 : Study on Environmental Risk Assessment for Regulatory Objectives and Communication of Environmental Risks
- 21098 : Development of the prediction method for the carcinogenicity evaluation
- 21104 : Studies on safety evaluation of genotoxic carcinogens in food additives
- 21111 : Studies on setting a guideline for health risk assessment of hazadous air pollutants
- 21125 : Assessment of in vivo mutagenicity and trans-generational effect of compounds contained in suspended particulate matter in urban air
Fiscal Year: 2009
- 20498 : Study on Environmental Risk Assessment for Regulatory Objectives and Communication of Environmental Risks
- 20524 : Assessment of in vivo mutagenicity and trans-generational effect of compounds contained in suspended particulate matter in urban air
- 20532 : Development of the prediction method for the carcinogenicity evaluation
- 20833 : Studies on setting a guideline for health risk assessment of hazadous air pollutants
- 20834 : Studies on safety evaluation of genotoxic carcinogens in food additives
Fiscal Year: 2008
- 20106 : Development of the prediction method for the carcinogenicity evaluation
- 20108 : Studies on susceptibility factors for toxic chemicals and drug-metabolizing system
- 20110 : Study on Environmental Risk Assessment for Regulatory Objectives and Communication of Environmental Risks
Fiscal Year: 2007
- 10402 : Studies on susceptibility factors for toxic chemicals and drug-metabolizing system
- 10620 : Development of the prediction method for the carcinogenicity evaluation
- 10621 : Study on Environmental Risk Assessment for Regulatory Objectives and Communication of Environmental Risks
Fiscal Year: 2006
- 10087 : Mutagenesis in zebrafish by the exposure of space-radiation
- 10097 : Studies on susceptibility factors for toxic chemicals and drug-metabolizing system
- 10122 : Evaluation of sensitivity of aged animal tp mutagens in ambient air
- 10354 : Development of the prediction method for the carcinogenicity evaluation
- 10358 : Study on Environmental Risk Assessment for Regulatory Objectives and Communication of Environmental Risks
Fiscal Year: 2005
- 9565 : Studies on susceptibility factors for toxic chemicals and drug-metabolizing system
Fiscal Year: 2004
- 9081 : Sensitive sensing for exposure of mutagens in ambient air by gene-knockout mouse and evaluation of their effects
- 9315 : Studies on susceptibility factors for toxic chemicals and drug-metabolizing system
Fiscal Year: 2003
- 8801 : Sensitive sensing for exposure of mutagens in ambient air by gene-knockout mouse and evaluation of their effects
Fiscal Year: 2002
- 8343 : Studies for estimating health effects of oxidative stresses induced by environmental chemicals
Fiscal Year: 2001
- 8096 : Studies for estimating health effects of oxidative stresses induced by environmental chemicals
- 8170 : Study on the regulation mechanism of cellular response to oxidative stress by dioxins

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Research Result (Publication)

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Original Paper
Book

Original Paper
Mutant Frequency is not Increased in Mice Orally Exposed to Sodium Dichromate

Presenter : Aoki Y., Matsumoto M., Matsumoto M., Masumura K., Nohmi T.
Title : , Food and Safety, 7(1):2-10 (2019)
Original Paper
Change over time of the mutagenicity in the lungs of gpt delta transgenic mice by extract of airborne particles collected from ambient air in the Tokyo metropolitan area

Presenter : Aoki Y., Nakajima D., Matsumoto M., Yagishita M., Matsumoto M., Yanagisawa R., Goto S., Masumura K., Nohmi T.
Title : , Genes and Environment, 40(25): (2018)
Original Paper
Atmospheric concentration and carcinogenic risk of polycyclic aromatic hydrocarbons including benzo[c]fluorene, cyclopenta[c,d]pyrene, and benzo[j]fluoranthene in Japan

Presenter : YAGISHITA M., kageyama S., Ohshima S., Matsumoto M., Aoki Y., Goto S., Nakajima D.
Title : , Atmospheric Environment, 115:263-268 (2015)
Book
Chapter7: Potency of air pollutants at DNA adduct formation and assessment by in vivo mutagenesis

Presenter : Aoki Y., Hashimoto A.H., Sato H. , Matsumoto M.
Title : , DNA Adducts: Formation, Detection and Mutagenesis (2010)
Original Paper
Mutagenicity of 2-[2-(acetylamino)-4-[bis(2-hydroxyethyl)amino]-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole(PBTA-6) and benzo[a]pyrene(BaP) in the gill and hepatopancreas of rpsL transgenic zebrafish

Presenter : Amanuma K., Tone S., Masato N., Matsumoto M., Watanabe T., Totsuka Y., Wakabayashi K., Aoki Y.
Title : , Mutat.Res., 656:36-43 (2008)
Enhanced spontaneous and benzo(a)pyrene-induced mutations in the lung of Nrf2-derficient gpt delta mice

Presenter : , , Matsumoto M., Aoki Y.
Title : , Cancer Res., 67(12):5643-5648 (2007)
Epidermal growth factor regulation of glutathione S-transferase gene expression in the rat is mediated by class Pi glutathione S-transferase enhancer I

Presenter : Matsumoto M., Aoki Y.
Title : , Biochem.J., 349:225‐230 (2000)
Identification of an enhancer element of class Pi glutathione S-transferase gene required for expression by a co-planar polychlorinated biphenyl

Presenter : Matsumoto M., Aoki Y.
Title : , Biochem.J., 338:599‐605 (1999)
Expression of Glutathione S-Transferase P by Coplanar PCB in Rat Hepatocytes

Presenter : Matsumoto M., Aoki Y.
Title : , Jpn.J.Toxicol.Environ.Health, 44(1):P・47 (1998)
Indoor and outdoor air pollution in Tokyo and Beijing supercities

Presenter : , Matsumoto M.
Title : , Atmos.Environ., 30(5):695‐702 (1995)
Induction of glutathione S-transferase II in mouse liver parenchymal cells by 3453'4'-pentachlorobiphenyl-comparison between C57BL strain and DBA strain

Presenter : Matsumoto M., Aoki Y.
Title : , Jpn.J.Toxicol.Environ.Health., 41:33 (1995)
Induction of glutathione S-Transferase-P by chlorinated biphenyls and dibenzofurans, and inhibitory effect of dexamethasone on the induction

Presenter : Matsumoto M., Aoki Y.
Title : , Jpn.J.Toxicol.Environ.Health, 40:P‐15 (1994)
Expression of glutathione S-transferase P-form in primary cultured rat liver parenchymal cells by coplanar polychlorinated biphenyl congeners is suppressed by protein kinase inhibitors and dexamethasone

Presenter : Matsumoto M., Aoki Y.
Title : , FEBS Lett., 333:114‐118 (1993)
Induction of glutathione S-Transferase P-Form in rat hepatocytes by coplanar polychlorinated biphenyl congeners and its mechanism

Presenter : Matsumoto M., Aoki Y.
Title : , Jpn.J.Toxicol.Environ.Health, 39:P‐24 (1993)
Mutagenicity of 3-chlorodibenzofuran and its metabolic activation

Presenter : Matsumoto M.
Title : , Environ.Mol.Mutagenesis, 17:104‐111 (1991)
Content of essential trace elements in hair from children lived in keshan disease district in China

Presenter : Matsumoto M.
Title : , Proc.Int.Symp.Environ.Life Elem.& Health,Beijin,People's Repub.China(Sci.Press,Beijing,390p.), 158‐160 (1991)
Content of essential trace elements in hair from children lived in Keshan Disease district in China

Presenter : Matsumoto M.
Title : , Trace Nutr.Res., (4):109‐113 (1988)
Mutagenicity of monochlorodibenzofurans detected in the environment

Presenter : Matsumoto M.
Title : , Toxicol.Lett., 40:21‐28 (1988)
Air quality of Tokyo metropolis evaluated by analysis of human lung deposits

Presenter : , Matsumoto M.
Title : , Internal medicine today and tomorrow, Proceedings of 17th International Congress of InternalMedicine (Oda T. et al.,1986 Elsevier Sci.Publ.), 106‐112 (1986)
Urban air quality evaluated by analysis of human lung deposits

Presenter : Matsumoto M.
Title : , Proc.7th World CleanAir Congr., 1:208‐215 (1986)
Dynamic study on animal experiments using N-labeled nitrogen dioxide

Presenter : Matsumoto M., Suzuki A.K.
Title : , Proc.4th Int.Conf.Stable Isotopes, March, 23-27, 1981:557‐561 (1982)

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Mutant Frequency is not Increased in Mice Orally Exposed to Sodium Dichromate

Presenter : Aoki Y., Matsumoto M., Matsumoto M., Masumura K., Nohmi T.
Title : , Food and Safety, 7(1):2-10 (2019)
Change over time of the mutagenicity in the lungs of gpt delta transgenic mice by extract of airborne particles collected from ambient air in the Tokyo metropolitan area

Presenter : Aoki Y., Nakajima D., Matsumoto M., Yagishita M., Matsumoto M., Yanagisawa R., Goto S., Masumura K., Nohmi T.
Title : , Genes and Environment, 40(25): (2018)
Atmospheric concentration and carcinogenic risk of polycyclic aromatic hydrocarbons including benzo[c]fluorene, cyclopenta[c,d]pyrene, and benzo[j]fluoranthene in Japan

Presenter : YAGISHITA M., kageyama S., Ohshima S., Matsumoto M., Aoki Y., Goto S., Nakajima D.
Title : , Atmospheric Environment, 115:263-268 (2015)
Mutagenicity of 2-[2-(acetylamino)-4-[bis(2-hydroxyethyl)amino]-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole(PBTA-6) and benzo[a]pyrene(BaP) in the gill and hepatopancreas of rpsL transgenic zebrafish

Presenter : Amanuma K., Tone S., Masato N., Matsumoto M., Watanabe T., Totsuka Y., Wakabayashi K., Aoki Y.
Title : , Mutat.Res., 656:36-43 (2008)

View all

Chapter7: Potency of air pollutants at DNA adduct formation and assessment by in vivo mutagenesis

Presenter : Aoki Y., Hashimoto A.H., Sato H. , Matsumoto M.
Title : , DNA Adducts: Formation, Detection and Mutagenesis (2010)

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Research Result (Presentation)

all
Research Presentation

Research Presentation
Oral Administration of Hexavalent Chromium DiD Not Increase Mutant Frequency in the Small Intestine of gpt delta mouse

Presenter : Aoki Y., Matsumoto M., Matsumoto M., Masumura K., Nohmi T.
Name of Society : SOT 59th Annual Meeting (2020)
Name of Proceedings : Abstract, 125
Research Presentation
Comparison of Risk Assessment Values of Hazardous Chemicals Estimated Based on Animal Inhalation Studies with the Guideline Values for Ambient Air Based on Epidemiological Studies

Presenter : Matsumoto M., Matsumoto Y., Aoki Y.
Name of Society : The 6th International Congress of Asian Society of Toxicology (2012)
Name of Proceedings : The Journal of Toxicological Sciences (The 6th International Congress of Asian Society of Toxicology, Program and Abstracts), 37(Suppl. ?):S 412
Research Presentation
Comparative study on the utilities of animal experimental data for risk assessment of inhalation exposure of chemicals

Presenter : Aoki Y., Matsumoto Y., Matsumoto M.
Name of Society : SOT 2012 Annual Meeting (2012)
Name of Proceedings : Abstract of SOT 2012 Annual Meeting, 27
Research Presentation
Functional prediction analysis based on global gene expression by using Nrf2 Knockout mouse liver exposed to TCDD

Presenter : Sato H. , Matsumoto M., Aoki Y., Itoh K., Yamamoto M.
Name of Society : 12th Int.Congr.Toxicol. (2010)
Name of Proceedings : Toxicol.Lett., 196(Suppl.1):S208
Research Presentation
Benzo[a]pyrene-Induced mutagenesis in the lungs of young and old mice: Young mice are highly susceptible

Presenter : Aoki Y., Hashimoto A.H., Matsumoto M., Sugawara Y., Goto S., Masumura K., Nohmi T.
Name of Society : CCT Meet.PPTOXII: Role of Environmental Stressors in the Developmental Origins of Disease (2009)
Name of Proceedings : Abstracts, VI.15
Research Presentation
In vivo mutagenesis induced by the air pollutants in the testis of gpt delta transgenic mice

Presenter : Aoki Y., Hashimoto A.H., Amanuma K., Matsumoto M., Masumura K., Nohmi T.
Name of Society : 21st Cent.Adv.Mol.Toxicol.Environ.Chem.Pathog.Dis. (2009)
Name of Proceedings : Abstracts, 173
Research Presentation
Comprehensive gene expression analysis in male Nrf2KO mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)

Presenter : Sato H.(*1), Matsumoto M., Itoh K.(*2), Yamamoto, M.(*2), Aoki Y.
Name of Society : SOT.46th Annu.Meet. (2007)
Name of Proceedings : Abstracts(CD-ROM)
Research Presentation
In vivo mutations by 3,6-dinitrobenzo[e]pyrene instilled into the lung of gpt delta transgenic mice

Presenter : Matsumoto M., Takano H., Amanuma K., Yanagisawa R., Aoki Y.
Name of Society : 1st Asian Conf.Environ.Mutagens/36th Annu.Meet.Jpn.Environ.Mutagen Soc.(Poster Session) (2007)
Name of Proceedings : Program & Abstracts
Research Presentation
Alterations in gene expression by 2378-tetrachloro-p-dibenzodioxin (TCDD) in livers of Nrf2 knockout mice

Presenter : Matsumoto M., Aoki Y.
Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
Name of Proceedings : Abstracts(CD-ROM)
Research Presentation
Enhanced mutagenesis in the lung of Nuf2 knockout gpt delta mice

Presenter : Aoki Y., Hashimoto A.H.(*1), Amanuma K., Matsumoto M., Hiyoshi K.(*1), Takano H., Masumura K.(*1), Itoh K.(*1), Nohmi T.(*1), Yamamoto M.
Name of Society : JST-ERATO: yamamoto Environ. Response Proj. Int. Symp. 'Molecular Mechanism of Environmental Response to Food & Oxygen' (2005)
Name of Proceedings : Abstracts

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Functional prediction analysis based on global gene expression by using Nrf2 Knockout mouse liver exposed to TCDD

Presenter : Sato H. , Matsumoto M., Aoki Y., Itoh K., Yamamoto M.
Name of Society : 12th Int.Congr.Toxicol. (2010)
Name of Proceedings : Toxicol.Lett., 196(Suppl.1):S208
Comprehensive gene expression analysis in male Nrf2KO mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)

Presenter : Sato H.(*1), Matsumoto M., Itoh K.(*2), Yamamoto, M.(*2), Aoki Y.
Name of Society : SOT.46th Annu.Meet. (2007)
Name of Proceedings : Abstracts(CD-ROM)
In vivo mutations by 3,6-dinitrobenzo[e]pyrene instilled into the lung of gpt delta transgenic mice

Presenter : Matsumoto M., Takano H., Amanuma K., Yanagisawa R., Aoki Y.
Name of Society : 1st Asian Conf.Environ.Mutagens/36th Annu.Meet.Jpn.Environ.Mutagen Soc.(Poster Session) (2007)
Name of Proceedings : Program & Abstracts
Alterations in gene expression by 2378-tetrachloro-p-dibenzodioxin (TCDD) in livers of Nrf2 knockout mice

Presenter : Matsumoto M., Aoki Y.
Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
Name of Proceedings : Abstracts(CD-ROM)
Enhanced mutagenesis in the lung of Nuf2 knockout gpt delta mice

Presenter : Aoki Y., Hashimoto A.H.(*1), Amanuma K., Matsumoto M., Hiyoshi K.(*1), Takano H., Masumura K.(*1), Itoh K.(*1), Nohmi T.(*1), Yamamoto M.
Name of Society : JST-ERATO: yamamoto Environ. Response Proj. Int. Symp. 'Molecular Mechanism of Environmental Response to Food & Oxygen' (2005)
Name of Proceedings : Abstracts
Oral Administration of Hexavalent Chromium DiD Not Increase Mutant Frequency in the Small Intestine of gpt delta mouse

Presenter : Aoki Y., Matsumoto M., Matsumoto M., Masumura K., Nohmi T.
Name of Society : SOT 59th Annual Meeting (2020)
Name of Proceedings : Abstract, 125
Comparison of Risk Assessment Values of Hazardous Chemicals Estimated Based on Animal Inhalation Studies with the Guideline Values for Ambient Air Based on Epidemiological Studies

Presenter : Matsumoto M., Matsumoto Y., Aoki Y.
Name of Society : The 6th International Congress of Asian Society of Toxicology (2012)
Name of Proceedings : The Journal of Toxicological Sciences (The 6th International Congress of Asian Society of Toxicology, Program and Abstracts), 37(Suppl. ?):S 412
Comparative study on the utilities of animal experimental data for risk assessment of inhalation exposure of chemicals

Presenter : Aoki Y., Matsumoto Y., Matsumoto M.
Name of Society : SOT 2012 Annual Meeting (2012)
Name of Proceedings : Abstract of SOT 2012 Annual Meeting, 27
Benzo[a]pyrene-Induced mutagenesis in the lungs of young and old mice: Young mice are highly susceptible

Presenter : Aoki Y., Hashimoto A.H., Matsumoto M., Sugawara Y., Goto S., Masumura K., Nohmi T.
Name of Society : CCT Meet.PPTOXII: Role of Environmental Stressors in the Developmental Origins of Disease (2009)
Name of Proceedings : Abstracts, VI.15
In vivo mutagenesis induced by the air pollutants in the testis of gpt delta transgenic mice

Presenter : Aoki Y., Hashimoto A.H., Amanuma K., Matsumoto M., Masumura K., Nohmi T.
Name of Society : 21st Cent.Adv.Mol.Toxicol.Environ.Chem.Pathog.Dis. (2009)
Name of Proceedings : Abstracts, 173

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MATSUMOTO Michi

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