Latest Update：2020/06/30 18:24:20

NOHARA Keiko

Researcher Name: NOHARA Keiko

Div (Section) name/title: Center for Health and Environmental Risk Research／Fellow

Research Subject: Late-onset and transgenerational effects of environmental chaemicals with particular focus on inorganic arsenic, and their molecular mechanisms including epigenentics. effects and epigenetic effects of environmental chemicals

Degree(s): PhD

Professional Qualification(s): Medicine,Biochemistry,Bioengineering

Environmental Speciality Field: environmental chemicals

Keyword(s): dioxin,immunotoxicology,arylhydrocarbon receptor,arsenic,epigenetics,DNA methylation,hisotone modification,carcinogenesis

Membership of Academic Society: Japanese Society of Immunotoxicology,The Molecular Biology Society of Japan,The Japanese Society for Hygiene,Society of Toxicology,The Japanese Cancer Association,The Japanese Society for Epigenetics,The Japanese Society for DOHaD

Research Subject

Fiscal Year: 2019
- 24696 : Research Program on Health and Environmental Safety
- 24721 : Research Project on Health Impacts of Chemicals on Children and Future Generations
- 24837 : Identification of sperm small RNAs involved in multigenerational health effects of environmental chemicals
- 24838 : Inheritance of environmental impacts on DNA methylation through sperm to the next generation embryos
- 24977 : Fundamental Study on the Basis of Health and Environmental Risk Research
Fiscal Year: 2018
- 24304 : Research project on health impacts of chemicals on children and future generations
- 24355 : Research program on health and environmental safety
- 24455 : Identification of sperm small RNAs involved in multigenerational health effects of environmental chemicals
- 24553 : Fundamental study on the basis of health and environmental risk research
Fiscal Year: 2017
- 23824 : Research project on health impacts of chemicals on children and future generations
- 23847 : Research program on health and environmental safety
- 23967 : Identification of sperm small RNAs involved in multigenerational health effects of environmental chemicals
- 23969 : Development of new in vitro methods for detecting toxicity of chemicals
- 24073 : Fundamental study on the basis of health and environmental risk research
- 24118 : Characterization of mutation as a marker for carcinogenesis induced by oxidative stress: identification of mutation hotspot
Fiscal Year: 2016
- 23414 : Research program on health and environmental safety
- 23415 : Research project on health impacts of chemicals on children and future generations
- 23593 : Studies on epimutations that are involved in the transgenerational effects of environmental chemicals in mice
- 23594 : Genome-wide DNA methylation analysis of sperm to explore the mechanism of hepatic tumor augmentation in the F2 by gestational arsenite exposure of F0 pregnant female
- 23711 : Fundamental study on the basis of health and environmental risk research
- 23744 : Characterization of mutation as a marker for carcinogenesis induced by oxidative stress: identification of mutation hotspot
- 23756 : Implementation of initial risk assessment of environmental chemicals in FY2016
Fiscal Year: 2015
- 23016 : Research Program on Environmental Health for Children and Future Generations
- 23018 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 23256 : Studies on multigenerational late-onset effects of environmental chemicals
- 23257 : Studies on epimutations that are involved in the transgenerational effects of environmental chemicals in mice
- 23258 : Genome-wide DNA methylation analysis of sperm to explore the mechanism of hepatic tumor augmentation in the F2 by gestational arsenite exposure of F0 pregnant female
- 23277 : Establishment of an international cooperation for promoting arsenic research
Fiscal Year: 2014
- 22606 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 22718 : Studies on lead- and arsenic-exposure from food and their health impacts
- 22719 : Studies on multigenerational late-onset effects of environmental chemicals
- 22721 : Studies on epimutations that are involved in the transgenerational effects of environmental chemicals in mice
- 22722 : Establishment of an international cooperation for promoting arsenic research
Fiscal Year: 2013
- 22190 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 22475 : Exploration of molecular epidemiological indexes to health effects of environmental factors focusing on genetic and epigenetic mutation
- 22506 : Involvement of oxidative stress in the epigenetic changes induced by environmental chemicals
- 22507 : Studies on multigenerational late-onset effects of environmental chemicals
- 22508 : Studies on lead- and arsenic-exposure from food and their health impacts
- 22544 : Establishment of an international cooperation for promoting arsenic research
Fiscal Year: 2012
- 21761 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 21985 : Involvement of oxidative stress in the epigenetic changes induced by environmental chemicals
- 21986 : Studies of factors contributing to the regulation of epigenetics
Fiscal Year: 2011
- 21319 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 21470 : Involvement of oxidative stress in the epigenetic changes induced by environmental chemicals
- 21480 : Studies of factors contributing to the regulation of epigenetics
- 21481 : Studies on the mechanism of transcription factor dependent effects of environmental chemicals
Fiscal Year: 2010
- 20977 : Health risk assessment methods of environmental chemicals that cause sensitivity
- 21051 : Studies to evaluate toxicityies of environmental chemicals focusing on their epigenetic effects
- 21053 : Studies of factors contributing to the regulation of epigenetics
- 21055 : Studies on the mechanism of transcription factor dependent effects of environmental chemicals
Fiscal Year: 2009
- 20482 : Studies on method for detection of epigenetics effects of environmental chemicals focusing on global changes of DNA methylation
- 20483 : Studies to evaluate toxicityies of environmental chemicals focusing on their epigenetic effects
- 20490 : Studies on the mechanism of transcription factor dependent effects of environmental chemicals
- 20536 : Health risk assessment methods of environmental chemicals that cause sensitivity
Fiscal Year: 2008
- 20078 : Studies on the role of transcription factors that mediate organ- and cell-specific toxicity of environmental chemicals
- 20124 : Studies on the effect of arsenic on transcripiton factors in immune cells
- 20139 : Studies to evaluate toxicityies of environmental chemicals focusing on their epigenetic effects
- 20281 : Health risk assessment methods of environmental chemicals that cause sensitivity
- 20362 : Studies on method for detection of epigenetics effects of environmental chemicals focusing on global changes of DNA methylation
Fiscal Year: 2007
- 10383 : Development of methods for health effect assessment of hazardous chemicals using DNA chip
- 10516 : Studies on the role of transcription factors that mediate organ- and cell-specific toxicity of environmental chemicals
- 10583 : Health risk assessment methods of environmental chemicals that cause sensitivity
- 10684 : Studies on the effect of arsenic on transcripiton factors in immune cells
- 10739 : Studies to evaluate toxicityies of environmental chemicals focusing on their epigenetic effects
Fiscal Year: 2006
- 10030 : Development of methods for health effect assessment of hazardous chemicals using DNA chip
- 10050 : Studies on application of toxicogenomics for risk assessment of environmental pollutants
- 10257 : Studies on the role of transcription factors that mediate organ- and cell-specific toxicity of environmental chemicals
Fiscal Year: 2005
- 9521 : Studies on application of toxicogenomics for risk assessment of environmental pollutants
Fiscal Year: 2004
- 9050 : Studies on the health effects of endocrine disrupters
- 9091 : Establishement for methodology to implement tolerable intake of dioxins by characterizing non-TCDD toxicities of coplanar PCBs
- 9272 : Studies on application of toxicogenomics for risk assessment of environmental pollutants
Fiscal Year: 2003
- 8610 : Elucidation of endocrine disrupting mechanism of dioxin and related compounds for health risk assessment
- 8776 : Studies on the health effects of endocrine disrupters
- 8811 : Establishement for methodology to implement tolerable intake of dioxins by characterizing non-TCDD toxicities of coplanar PCBs
- 8899 : Studies on evaluation of memory function for exposure to environmental chemicals and the development of the tool for risk evaluation in mice
- 8908 : Development of new methodologies for health risk evaluation through exploring regulatory genes determining sensitivities against environmental pollutants.
Fiscal Year: 2002
- 8339 : Elucidation of endocrine disrupting mechanism of dioxin and related compounds for health risk assessment
- 8571 : Studies on the health effects of endocrine disrupters
Fiscal Year: 2001
- 8084 : Elucidation of endocrine disrupting mechanism of dioxin and related compounds for health risk assessment
- 8094 : Studies on the interaction of T cell development with antigen presenting cells

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Research Result (Publication)

all
Original Paper
Review

Original Paper
Association between chronic arsenic exposure and the characteristic features of asthma

Presenter : Siddique A.E., Rahman M., Hossain M.I., Karim Y., Hasibuzzaman M.M., Biswas S., Islam M.S., Rahman A., Hossen F., Mondal V., Banna H.U., Huda N., Hossain M., Sultana P., Nikkon F., Saud Z.A., Haque A., Nohara K., Xin L., Himeno S., Hossain K.
Title : , Chemosphere, 246: (2020)
Review
Arsenic Exposure and Reproductive Toxicity

Presenter : Udagawa O., Okamura K., Suzuki T., Nohara K.
Title : , Arsenic Contamination in Asia. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore, 29-42 (2019)
Original Paper
Hijiki seaweed consumption elevates levels of inorganic arsenic intake in Japanese children and pregnant women

Presenter : Nathan Mise, Mayumi Ohtsu, Akihiko Ikegami, Atsuko Mizuno, Xiaoyi Cui, Kobayashi Y., Yoshihiko Nakagi, Nohara K., Takahiko Yoshida, Fujio Kayama
Title : , FOOD ADDITIVES & CONTAMINANTS: PART A, 36(1):84-95 (2019)
Original Paper
Developmental Arsenic Exposure on Social Behavior and Related Gene Expressions in C3H Adult Male Mice

Presenter : Htway S.M., Nohara K., Tin-Tin-Win-Shwe
Title : , International Journalof Environmental Research and Public Health, 16(174):1-12 (2019)
Original Paper
DNA methylation changes involved in the tumor increase in F2 males born to gestationally arsenite-exposed F1 male mice

Presenter : Okamura K., Nakabayashi K., Kawai T., Suzuki T., Sano T., Hata K., Nohara K.
Title : , Cancer Science, 110:2629-2642 (2019)
Original Paper
Oral exposure to lead for Japanese childrenand pregnant women, estimated usingduplicate food portions and house dustanalyses

Presenter : Ohtsu M., Mise N., Ikegami A., Mizuno A., Kobayashi Y., Nakagi Y., Nohara K., Yoshida T., Kayama F.
Title : , Environmental Health and Preventive Medicine, 24(1):72-81 (2019)
Review
Epigenetics as a mechanism linking developmental exposures to long-term toxicity

Presenter : Barouki R., Melen E., Herceg Z., Beckers J., Chen J., Karagas M., Puga A., Xia Y., Chadwick L., Yan W., Audouze K., Slama R., Heindel J., Grandjean P., Kawamoto T., Nohara K.
Title : , Environment International , 114:77-86 (2018)
Original Paper
The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes

Presenter : Matsushita J., Okamura K., Nakabayashi K, Suzuki T., Horibe Y., Kawai T., Sakurai T., Yamashita S., Higami Y., Ichihara G., Hata K., Nohara K.
Title : , BMC Cancer, 18:317 (2018)
Original Paper
Chronic exposure to arsenic, LINE-1 hypomethylation, and blood pressure: a cross-sectional study in Bangladesh

Presenter : Hossain K., Suzuki T., Hasibuzzaman M.M., Islam M.S., Rahman A., Paul S.K., Tanu T., Hossain S., Saud Z.A., Rahman M., Nikkon F., Miyataka H., Himeno S., Nohara K.
Title : , Environmental Health, 16:20 (2017)
Review
Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice

Presenter : Nohara K., Suzuki T., Okamura K., Matsushita J., Takumi S.
Title : , Genes and Environment, 39(3): (2017)
Original Paper
Prenatal Exposure to Arsenic Impairs Behavioral Flexibility and Cortical Structure in Mice

Presenter : Aung K.H., Kyi-Tha-ThuC, Sano K., Nakamura K., Tanoue A., Nohara K., Kakeyama M., Tohyama C., Tsukahara S., Maekawa F.
Title : , Frontiers in Neuroscience, 10(137): (2016)
Original Paper
Long-term arsenite exposure induces premature senescence in B cell lymphoma A20 cells

Presenter : Okamura K., Nohara K.
Title : , Archives of Toxicology, 90(4):793-803 (2016)
Original Paper
Exposure assessment of lead from food and airborne dusts and biomonitoring in pregnant mothers, their fetus and siblings in Karachi, Pakistan and Shimotsuke, Japan

Presenter : Kayama F., Fatmi Z., Ikegami A., Mizuno A., Ohtsu M, Mise N., Cui X., Ogawa M., Sakamoto T., Nakagi Y., Yoshida T., Sahito A., Naeem S., Ghias K., Zuberi H., Tariq K., Kobayashi Y., Nohara K.
Title : , Reviews on Environmental Health, 31(1):33-35 (2016)
Original Paper
In utero and Lactational Exposure to Acetamiprid Induces Abnormalities in Socio-Sexual and Anxiety-Related Behaviors of Male Mice

Presenter : Sano K., Isobe T., Yang J., Tin-Tin-Win-Shwe, Yoshikane M., Nakayama S., Kawashima T., Suzuki G., Hashimoto S., Nohara K., Tohyama C., Maekawa F.
Title : , Frontiers in Neuroscience, 10(228): (2016)
Review
Role of Environmental Chemical Insult in Neuronal Cell Death and Cytoskeleton Damage

Presenter : Aung KH., Tsukahara S., Maekawa F., Nohara K., Nakamura K., Tanoue A.
Title : , Biological and Pharmaceutical Bulletin, 38(8):1109-1112 (2015)
Original Paper
Augmenting effects of gestational arsenite exposure of C3H mice on the hepatic tumors of the F2 male offspring via the F1 male offspring

Presenter : Nohara K., Okamura K., Suzuki T., Murai H., Michikawa T., Ito T., Shinjo K., Takumi S., Kondo Y., Hata K.
Title : , Journal of Applied Toxicology, 36(1):105-112 (2015)
Review
The mechanisms underlying sexual differentiation of behavior and physiology in mammals and birds: relative contributions of sex steroids and sex chromosomes

Presenter : Maekawa F., Tsukahara S., Kawashima T., Nohara K., Ohki-Hamazaki H.
Title : , Frontiers in Neuroscience, 8(242): (2014)
Original Paper
In vivo mutagenicity of arsenite in the livers of gpt delta transgenic mice.

Presenter : Takumi S., Aoki Y., Sano T., Suzuki T., Nohmi T., Nohara K.
Title : , Mutation Research, 760:42-47 (2014)
Original Paper
In vivo mutagenicity of arsenite in the livers of gpt deltatransgenic mice

Presenter : Takumi S., Aoki Y., Sano T., Suzuki T., Nohmi T., Nohara K.
Title : , Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 760:42-47 (2014)
Original Paper
The effect of a methyl-deficient diet on the global DNA methylation and the DNA methylation regulatory pathways

Presenter : Takumi S., Okamura K., Yanagisawa H., Sano T., Kobayashi Y., Nohara K.
Title : , Journal of Applied Toxicology, 760:1550-1556 (2014)
Original Paper
Inhibition of neurite outgrowth and alteration of cytoskeletal gene expression by sodium arsenite

Presenter : Aung K.H., Kurihara R., Nakashima S., Maekawa F., Nohara K., Kobayashi T., Tsukahara S.
Title : , Neuro Toxicology, 34:226-235 (2013)
Original Paper
Effects of sodium arsenite on neurite outgrowth and glutamate AMPA receptor expression in mouse cortical neurons.

Presenter : Maekawa F., Tsuboi T., Oya M., Aung K.H., Tsukahara S., Pellerin L., Nohara K.
Title : , NeuroToxicology, 37:197-206 (2013)
Original Paper
Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto-Kakizaki rats.

Presenter : Maekawa F., Fujiwara K., Toriya M., Maejima Y., Nishio T., Toyoda Y., Nohara K., Yashiro T., Yada T.
Title : , Frontiers in Synaptic Neuroscience, 5(7): (2013)
Original Paper
Long-term arsenic exposure induces histone H3 Lys9 dimethylation without altering DNA methylation in the promoter region of p16INK4a and down-regulates its expression in the liver of mice

Presenter : Suzuki T., Nohara K.
Title : , Journal of Applied Toxicology, 33(9):951-958 (2013)
Original Paper
Inorganic arsenic exposure induces E2F-dependent G0/G1 arrest via an increase in retinoblastoma family protein p130 in B-cell lymphoma A20 cells.

Presenter : Okamura K., Miki D., Nohara K.
Title : , Genes to Cells, 18(10):839-849 (2013)
Original Paper
Genome-wide analysis of DNA methylation changes induced by gestational arsenic exposure in liver tumors

Presenter : Suzuki T., Yamashita S, Ushijima T, Takumi S, Sano T., Michikawa T., Nohara K.
Title : , Cancer Science, 104(12):1575-1585 (2013)
Original Paper
A Methyl-Deficient Diet Modifies Early B Cell Development

Presenter : Kurogi T., Inoue H., Guo Y., Nobukiyo A, Nohara K., Kanno M.
Title : , Pathobiology, 209-218 (2012)
Original Paper
Diurnal expression of Dnmt3b mRNA in mouse liver is regulated by feeding and hepatic clockwork

Presenter : Maekawa F., Shimba S., Takumi S., Sano T., Suzuki T., Bao J., Ohwada M., Ehara T., Ogawa Y., Nohara K.
Title : , Epigenetics, 1046-1056 (2012)
Original Paper
Late-onset Increases in Oxidative Stress and Other Tumorigenic Activities and Tumors With a Ha-ras Mutation in the Liver of Adult Male C3H Mice Gestationally Exposed to Arsenic

Presenter : Nohara K., Tateishi Y., Suzuki T., Okamura K., Murai H., Takumi S., Maekawa F., Nishimura N., Kobori M., Ito T.
Title : , Toxicological Sciences, 129:293-304 (2012)
Original Paper
Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis

Presenter : Nakahama T., Kimura A., Nguyen N.T., Chinen I., Hanieh H., Nohara K., Fujii-Kuriyama Y., Kishimoto T.
Title : , Proceedings of the National Academy of Sciences of the United States of America, 108(34):14222-14227 (2011)
Original Paper
Aryl hydrocarbon receptor negatively regulated dendritic cell immunogenicity via a kynurenine-dependent mechanism

Presenter : Nguyen N.T., Kimura A., Nakahama T., Chinen I., Masuda K., Nohara K., Fujii-Kuriyama Y., Kishimoto T.
Title : , Proc.Natl.Acad.Sci.USA, 107(46):19961-19966 (2010)
Original Paper
Comparison of immunotoxicity among tetrachloro-, pentachloro-, tetrabromo-and pentabromo-dibenzo-p-dioxins in mice

Presenter : Ao k., Suzuki T., Murai H., Matsumoto M., Nagai H., Miyamoto Y., Tohyama C, Nohara K.
Title : , Toxicology, 256(1/2):25-31 (2009)
Original Paper
Constitutively active aryl hydrocarbon receptor expressed in T cells increases immunization-induced IFN-γ production in mice but does not suppress Th2-cytokine production or antibody production

Presenter : Nohara K., Suzuki T., Ao K., Murai H., Miyamoto Y., Inouye K., Pan X., Motohashi H., Fujii-Kuriyama Y., Yamamoto M., Tohyama C.
Title : , Int.Immunol., 21(7):769-777 (2009)
Original Paper
Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses

Presenter : Kimura A., Naka T., Nakahama T., Chinen I., Masuda K., Nohara K., Fujii-Kuriyama Y., Kishimoto T.
Title : , J.Exp.Med., 206(9):2027-2035 (2009)
Original Paper
Expression of constitutively-active aryl hydrocarbon receptor in T-cells enhances the down-regulation of CD62L, but does not alter expression of CD25 or suppress the allogeneic CTL response

Presenter : Funatake C.J., Ao K, Suzuki T., Murai H., Yamamoto M., Fujii-Kuriyama Y., Kerkvliet N.I., Nohara K.
Title : , J.Immunotoxicol., 6(3):194-203 (2009)
Original Paper
TCDD exposure exacerbates atopic dermatitis-related inflammation in NC/Nga mice

Presenter : Ito T., Nohara K., Fujimaki H.
Title : , Toxicol.Lett., 177(1):31-37 (2008)
Original Paper
Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells

Presenter : Kimura A., Naka T., Nohara K., Fujii-Kuriyama Y., Kishimoto T.
Title : , Proc.Natl.Acad.Sci.USA, 105(28):9721-9726 (2008)
Arsenite-Induced thymus atrophy is mediated by cell cycle arrest: A characteristic downregulation of E2F-Related genes revealed by a microarray approach

Presenter : Nohara K., Ao K., Miyamoto Y., Suzuki T., Imaizumi S., Tateishi Y., Omura S., Tohyama C., Kobayashi T.
Title : , Toxicol.Sci., 101:226-238 (2008)
Regulatory factors involved in species-specific modulation of arylhydrocarbon receptor(AhR)-dependent gene expression in humans and mice

Presenter : Suzuki T., Nohara K.
Title : , J.Biochem., 142:443-452 (2007)
Dioxin receptor is a ligand-dependent E3 ubiquitin ligase

Presenter : Ohtake F.(*1)(*2), Baba A.(*2), Takada I.(*2), Okada M.(*2), Iwasaki K.(*1), Miki H.(*2), Takahashi S.(*2), Kouzmenko A.(*1)(*2), Nohara K., Chiba T.(*3)
Title : , Nature, 446:562-566 (2007)
Organic chemicals adsorbed onto diesel exhaust particles directly alter the differentiation of fetal thymocytes through arylhydrocarbon receptor but not oxidative stress responses

Presenter : Ito T., Nagai H., Lin T.M., Peterson R.E., Tohyama C., Kobayashi T., Nohara K.
Title : , J.Immunotoxicol., 3:21-30 (2006)
Suppressive effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vascular remodeling that takes place in the normal labyrinth zone of rat placenta during late gestation

Presenter : Ishimura R., Kawakami T.(*1), Ohsako S.(*2), Nohara K., Tohyama C.(*2)
Title : , Toxicol.Sci., 91(1):265-274 (2006)
Constitutive activation of the aryl hydrocarbon receptor in T-lineage cells induces thymus involution independently of the Fas/Fas ligand signaling pathway

Presenter : Nagai H., Kubo M.(*1), Abe R.(*2), Yamamoto M.(*3), Nohara K.
Title : , Int.Immunopharmacol., 6:279-286 (2006)
Differential susceptibilities of Holtzman and Sprague-Dawley rats to fetal death and placental dysfunction induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) despite the identical primary structure of the aryl hydrocarbon receptor

Presenter : Kawakami T., Ishimura R., Nohara K., Tabata K., Tohyama C., Ohsako S.
Title : , Toxicol.Appl.Pharmacol., 212:224-236 (2006)
Comparison of the 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)-induced CYP1A1gene expression profile in lymphocytes from mice,rats,and humans: Most potent induction in humans

Presenter : Nohara K., Ao K., Miyamoto Y., Ito T., Suzuki T., Toyoshiba H., Tohyama C.
Title : , Toxicology, 225:204-213 (2006)
Search for the target genes involved in the suppression of antibody production by TCDD in C57BL/6 mice

Presenter : Nagai H.(*1), Takei T.(*2), Tohyama C., Kubo M.(*3), Abe R.(*1), Nohara K.
Title : , Int.Immunopharmacol., 5:331-343 (2005)
T cell-derived IL-5 production is a sensitive target of 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)

Presenter : Inouye K., Pan X., Imai N., Ito T., Takei T., Tohyama C., Nohara K.
Title : , Chemosphere, 60:907-913 (2005)
Constitutively active aryl hydrocarbon receptor expressed specifically in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytes

Presenter : Nohara K., Pan X., Tsukumo S., Hida A., Ito T., Nagai H., Inouye K., Motohashi H., Yamamoto M., Fujii-Kuriyama Y., Tohyama C.
Title : , J.Immunol., 174:2770-2777 (2005)
A constitutively active arylhydrocarbon receptor induces growth inhibition of Jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest

Presenter : Ito T., Tsukumo S., Suzuki N., Motohashi H., Yamamto M., Fujii-Kuriyama Y., Mimura J., Lin T.M., Peterson R.E., Tohyama C., Nohara K.
Title : , J.Biol.Chem., 279(24):25204-25210 (2004)
Evaluation of relative potencies of PCB126 and PCB169 for the immunotoxicities in ovalbumin(OVA)-immunized mice

Presenter : Pan X., Inouye K., Ito T., Nagai H., Takeuchi Y., Miyabara Y., Tohyama C., Nohara K.
Title : , Toxicology, 204:51-60 (2004)
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor

Presenter : Ohtake F.(*1), Takeyama K.(*1)(*2), Matsumoto T.(*1), Kitagawa H.(*1), Yamamoto Y.(*3), Nohara K., Tohyama C., Krust A.(*4), Mimura J.(*5)(*6), Chambon P.(*4),
Title : , Nature, 423(6939):545-550 (2003)
Suppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) on the high-affinity antibody response in C57BL/6 mice

Presenter : Inouye K., Ito T., Fujimaki H., Takahashi Y., Takemori T., Pan X., Tohyama C., Nohara K.
Title : , Toxicol.Sci., 74:315-324 (2003)
Functional activation of arylhydrocarbon receptor(AhR) in primary T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin

Presenter : Doi H., Baba T., Tohyama C., Nohara K.
Title : , Chemosphere, 52:655-662 (2003)
Skewed differentiation of thymocytes toward CD8 T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires activation of the extracellular signal-related kinase pathway

Presenter : Tsukumo S., Iwata M.(*1), Tohyama C., Nohara K.
Title : , Arch.Toxicol., 76:335-343 (2002)
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) on T cell-derived cytokine production in ovalbumin(OVA)-immunized C57B1/6 mice

Presenter : Nohara K., Fujimaki H., Tsukumo S.(*1),, Inouye K.(*1), Sone H., Tohyama C.
Title : , Toxicol., 172:49-58 (2002)
Effect of low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) on influenza A virus-induced mortality in mice

Presenter : Nohara K., Izumi H.(*1), Tamura S.(*2), Nagata R.(*1), Tohyama C.
Title : , Toxicology, 170:131-138 (2002)
Mechanism of TCDD-induced suppression of antibody production: effect on T cell-derived cytokine production in the primary immune reaction of mice

Presenter : Ito T., Inouye K., Fujimaki H., Tohyama C., Nohara K.
Title : , Toxicol.Sci., 70:46-54 (2002)
Induction of the imbalance of helper T-cell functions in mice exposed to diesel exhaust

Presenter : Fujimaki H., Ushio H., Nohara K., Ui N.
Title : , Sci.Total Environ., 270:113-121 (2001)
Role of CD4+ and CD8+ T cellsin adjuvant activity of diesel exhaust particles in mice

Presenter : Fujimaki H., Ui N., Usio N., Nohara K., Endo T.
Title : , Int.Arch.Allergy Immunol., 124:485-496 (2001)
Alterations of thymocyte development,thymic emigrants and peripheral T cell population in rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Presenter : , , NOHARA Keiko,
Title : , Toxicology, 145:227‐235 (2000)
Induction of apoptosis in mouse thymocytes by cadmium

Presenter : NOHARA Keiko, , ISHIDO Masami
Title : , Toxicol.Lett., 115:99‐105 (2000)
The effects of perinatal exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin on immune organs in rats

Presenter : Nohara K., Fujimaki H., Tsukumo S., Ushio H., Miyabara Y., Kijima M., Tohyama C., Yonemoto J.
Title : , Toxicology, 154:123‐133 (2000)
Effect of environmental pollutants on the production of pro-inflammatory cytokines by normal human dermal keratinocytes

Presenter : NOHARA Keiko,
Title : , Toxicol.Lett., 105:17‐24 (1999)
Involvement of Focal Adhesion Kinase in Inhibition of Motility of Human Breast Cancer Cells by Sphingosine 1-Phosphate

Presenter : NOHARA Keiko
Title : , Exp.Cell.Res., 247:17‐28 (1999)
Antibody against Ganglioside GD1c Containing NeuGcα2-8NeuGc Cooperates with CD3 and CD4 in Rat T Cell Activation

Presenter : Nohara K., Fujimaki H.
Title : , J.Biochem., 124:194‐199 (1998)
Glycosphingolipid composition of MDA-MB-231 and MCF-7 human breast cancer cell lines

Presenter : NOHARA Keiko
Title : , Breast Cancer Res.Treat., 48(2):149‐157 (1998)
Gangliosides involved in activation of rat T Iineage cells

Presenter : NOHARA Keiko, , SAJI Hikaru
Title : , Biochim.Biophys.Acta, 1345:207‐214 (1997)
Ganglioside GM3 inhibits interleukin-3-dependent bone marrow-derived mast cell proliferation

Presenter : NOHARA Keiko,
Title : , Int.Arch.Allergy Immunol., 107:527‐532 (1995)
Glycosphingolipids of rat T cells. Predominance of Asialo-GM1 and GD1c

Presenter : NOHARA Keiko
Title : , Biochem., 33(15):4661‐4666 (1994)
An activation-associated ganglioside in rat thymocytes

Presenter : NOHARA Keiko, ,
Title : , J.Biol.Chem., 268:24997‐25000 (1993)
A method for micro-determination of total microcystin contentin waterblooms of cyanobacteria (bluegreen algae)

Presenter : NOHARA Keiko, ,
Title : , Intern.J.Environ.Anal.Chem., 49:163‐170 (1992)
A novel disialoganglioside in rat spleen lymphocytes

Presenter : NOHARA Keiko,
Title : , J.Biol.Chem., 267(21):14982‐14986 (1992)
A GM1b-derived disialoganglioside GD1c is the predominant ganglioside of rat thymocytes

Presenter : NOHARA Keiko
Title : , J.Biochem., 110:274‐278 (1991)
A unique fucoganglioside with blood group B determinant in rat spleen

Presenter : , NOHARA Keiko
Title : , J.Biochem., 108:684‐688 (1990)
Identification of novel gangliosides containing lactosaminyl-GM1 structure from rat spleen

Presenter : , NOHARA Keiko
Title : , J.Biol.Chem., 265:14335‐14339 (1990)
2-(7,13-Dihydroxy-2-trans- octadecenoylamino) ethanesulfonic acid (lipotaurine) as an intermediate of taurolipids biosynthesies

Presenter : , NOHARA Keiko
Title : , Biochim.Biophys.Acta, 1042:338‐343 (1990)
Isolation and characterization of major gangliosides from frog liver

Presenter : NOHARA Keiko
Title : , J.Biochem., 102:923‐932 (1987)
Effect of di-n-octylphthalate on fatty acid composition of phosphatidylcholine in tetrahymena

Presenter : NOHARA Keiko
Title : , Chem.-Biol.Interactions, 64:93‐101 (1987)

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Association between chronic arsenic exposure and the characteristic features of asthma

Presenter : Siddique A.E., Rahman M., Hossain M.I., Karim Y., Hasibuzzaman M.M., Biswas S., Islam M.S., Rahman A., Hossen F., Mondal V., Banna H.U., Huda N., Hossain M., Sultana P., Nikkon F., Saud Z.A., Haque A., Nohara K., Xin L., Himeno S., Hossain K.
Title : , Chemosphere, 246: (2020)
Hijiki seaweed consumption elevates levels of inorganic arsenic intake in Japanese children and pregnant women

Presenter : Nathan Mise, Mayumi Ohtsu, Akihiko Ikegami, Atsuko Mizuno, Xiaoyi Cui, Kobayashi Y., Yoshihiko Nakagi, Nohara K., Takahiko Yoshida, Fujio Kayama
Title : , FOOD ADDITIVES & CONTAMINANTS: PART A, 36(1):84-95 (2019)
Developmental Arsenic Exposure on Social Behavior and Related Gene Expressions in C3H Adult Male Mice

Presenter : Htway S.M., Nohara K., Tin-Tin-Win-Shwe
Title : , International Journalof Environmental Research and Public Health, 16(174):1-12 (2019)
DNA methylation changes involved in the tumor increase in F2 males born to gestationally arsenite-exposed F1 male mice

Presenter : Okamura K., Nakabayashi K., Kawai T., Suzuki T., Sano T., Hata K., Nohara K.
Title : , Cancer Science, 110:2629-2642 (2019)
Oral exposure to lead for Japanese childrenand pregnant women, estimated usingduplicate food portions and house dustanalyses

Presenter : Ohtsu M., Mise N., Ikegami A., Mizuno A., Kobayashi Y., Nakagi Y., Nohara K., Yoshida T., Kayama F.
Title : , Environmental Health and Preventive Medicine, 24(1):72-81 (2019)
The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes

Presenter : Matsushita J., Okamura K., Nakabayashi K, Suzuki T., Horibe Y., Kawai T., Sakurai T., Yamashita S., Higami Y., Ichihara G., Hata K., Nohara K.
Title : , BMC Cancer, 18:317 (2018)
Chronic exposure to arsenic, LINE-1 hypomethylation, and blood pressure: a cross-sectional study in Bangladesh

Presenter : Hossain K., Suzuki T., Hasibuzzaman M.M., Islam M.S., Rahman A., Paul S.K., Tanu T., Hossain S., Saud Z.A., Rahman M., Nikkon F., Miyataka H., Himeno S., Nohara K.
Title : , Environmental Health, 16:20 (2017)
Prenatal Exposure to Arsenic Impairs Behavioral Flexibility and Cortical Structure in Mice

Presenter : Aung K.H., Kyi-Tha-ThuC, Sano K., Nakamura K., Tanoue A., Nohara K., Kakeyama M., Tohyama C., Tsukahara S., Maekawa F.
Title : , Frontiers in Neuroscience, 10(137): (2016)
Long-term arsenite exposure induces premature senescence in B cell lymphoma A20 cells

Presenter : Okamura K., Nohara K.
Title : , Archives of Toxicology, 90(4):793-803 (2016)
Exposure assessment of lead from food and airborne dusts and biomonitoring in pregnant mothers, their fetus and siblings in Karachi, Pakistan and Shimotsuke, Japan

Presenter : Kayama F., Fatmi Z., Ikegami A., Mizuno A., Ohtsu M, Mise N., Cui X., Ogawa M., Sakamoto T., Nakagi Y., Yoshida T., Sahito A., Naeem S., Ghias K., Zuberi H., Tariq K., Kobayashi Y., Nohara K.
Title : , Reviews on Environmental Health, 31(1):33-35 (2016)
In utero and Lactational Exposure to Acetamiprid Induces Abnormalities in Socio-Sexual and Anxiety-Related Behaviors of Male Mice

Presenter : Sano K., Isobe T., Yang J., Tin-Tin-Win-Shwe, Yoshikane M., Nakayama S., Kawashima T., Suzuki G., Hashimoto S., Nohara K., Tohyama C., Maekawa F.
Title : , Frontiers in Neuroscience, 10(228): (2016)
Augmenting effects of gestational arsenite exposure of C3H mice on the hepatic tumors of the F2 male offspring via the F1 male offspring

Presenter : Nohara K., Okamura K., Suzuki T., Murai H., Michikawa T., Ito T., Shinjo K., Takumi S., Kondo Y., Hata K.
Title : , Journal of Applied Toxicology, 36(1):105-112 (2015)
In vivo mutagenicity of arsenite in the livers of gpt delta transgenic mice.

Presenter : Takumi S., Aoki Y., Sano T., Suzuki T., Nohmi T., Nohara K.
Title : , Mutation Research, 760:42-47 (2014)
In vivo mutagenicity of arsenite in the livers of gpt deltatransgenic mice

Presenter : Takumi S., Aoki Y., Sano T., Suzuki T., Nohmi T., Nohara K.
Title : , Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 760:42-47 (2014)
The effect of a methyl-deficient diet on the global DNA methylation and the DNA methylation regulatory pathways

Presenter : Takumi S., Okamura K., Yanagisawa H., Sano T., Kobayashi Y., Nohara K.
Title : , Journal of Applied Toxicology, 760:1550-1556 (2014)
Inhibition of neurite outgrowth and alteration of cytoskeletal gene expression by sodium arsenite

Presenter : Aung K.H., Kurihara R., Nakashima S., Maekawa F., Nohara K., Kobayashi T., Tsukahara S.
Title : , Neuro Toxicology, 34:226-235 (2013)
Effects of sodium arsenite on neurite outgrowth and glutamate AMPA receptor expression in mouse cortical neurons.

Presenter : Maekawa F., Tsuboi T., Oya M., Aung K.H., Tsukahara S., Pellerin L., Nohara K.
Title : , NeuroToxicology, 37:197-206 (2013)
Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto-Kakizaki rats.

Presenter : Maekawa F., Fujiwara K., Toriya M., Maejima Y., Nishio T., Toyoda Y., Nohara K., Yashiro T., Yada T.
Title : , Frontiers in Synaptic Neuroscience, 5(7): (2013)
Long-term arsenic exposure induces histone H3 Lys9 dimethylation without altering DNA methylation in the promoter region of p16INK4a and down-regulates its expression in the liver of mice

Presenter : Suzuki T., Nohara K.
Title : , Journal of Applied Toxicology, 33(9):951-958 (2013)
Inorganic arsenic exposure induces E2F-dependent G0/G1 arrest via an increase in retinoblastoma family protein p130 in B-cell lymphoma A20 cells.

Presenter : Okamura K., Miki D., Nohara K.
Title : , Genes to Cells, 18(10):839-849 (2013)
Genome-wide analysis of DNA methylation changes induced by gestational arsenic exposure in liver tumors

Presenter : Suzuki T., Yamashita S, Ushijima T, Takumi S, Sano T., Michikawa T., Nohara K.
Title : , Cancer Science, 104(12):1575-1585 (2013)
A Methyl-Deficient Diet Modifies Early B Cell Development

Presenter : Kurogi T., Inoue H., Guo Y., Nobukiyo A, Nohara K., Kanno M.
Title : , Pathobiology, 209-218 (2012)
Diurnal expression of Dnmt3b mRNA in mouse liver is regulated by feeding and hepatic clockwork

Presenter : Maekawa F., Shimba S., Takumi S., Sano T., Suzuki T., Bao J., Ohwada M., Ehara T., Ogawa Y., Nohara K.
Title : , Epigenetics, 1046-1056 (2012)
Late-onset Increases in Oxidative Stress and Other Tumorigenic Activities and Tumors With a Ha-ras Mutation in the Liver of Adult Male C3H Mice Gestationally Exposed to Arsenic

Presenter : Nohara K., Tateishi Y., Suzuki T., Okamura K., Murai H., Takumi S., Maekawa F., Nishimura N., Kobori M., Ito T.
Title : , Toxicological Sciences, 129:293-304 (2012)
Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis

Presenter : Nakahama T., Kimura A., Nguyen N.T., Chinen I., Hanieh H., Nohara K., Fujii-Kuriyama Y., Kishimoto T.
Title : , Proceedings of the National Academy of Sciences of the United States of America, 108(34):14222-14227 (2011)
Aryl hydrocarbon receptor negatively regulated dendritic cell immunogenicity via a kynurenine-dependent mechanism

Presenter : Nguyen N.T., Kimura A., Nakahama T., Chinen I., Masuda K., Nohara K., Fujii-Kuriyama Y., Kishimoto T.
Title : , Proc.Natl.Acad.Sci.USA, 107(46):19961-19966 (2010)
Comparison of immunotoxicity among tetrachloro-, pentachloro-, tetrabromo-and pentabromo-dibenzo-p-dioxins in mice

Presenter : Ao k., Suzuki T., Murai H., Matsumoto M., Nagai H., Miyamoto Y., Tohyama C, Nohara K.
Title : , Toxicology, 256(1/2):25-31 (2009)
Constitutively active aryl hydrocarbon receptor expressed in T cells increases immunization-induced IFN-γ production in mice but does not suppress Th2-cytokine production or antibody production

Presenter : Nohara K., Suzuki T., Ao K., Murai H., Miyamoto Y., Inouye K., Pan X., Motohashi H., Fujii-Kuriyama Y., Yamamoto M., Tohyama C.
Title : , Int.Immunol., 21(7):769-777 (2009)
Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses

Presenter : Kimura A., Naka T., Nakahama T., Chinen I., Masuda K., Nohara K., Fujii-Kuriyama Y., Kishimoto T.
Title : , J.Exp.Med., 206(9):2027-2035 (2009)
Expression of constitutively-active aryl hydrocarbon receptor in T-cells enhances the down-regulation of CD62L, but does not alter expression of CD25 or suppress the allogeneic CTL response

Presenter : Funatake C.J., Ao K, Suzuki T., Murai H., Yamamoto M., Fujii-Kuriyama Y., Kerkvliet N.I., Nohara K.
Title : , J.Immunotoxicol., 6(3):194-203 (2009)
TCDD exposure exacerbates atopic dermatitis-related inflammation in NC/Nga mice

Presenter : Ito T., Nohara K., Fujimaki H.
Title : , Toxicol.Lett., 177(1):31-37 (2008)
Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells

Presenter : Kimura A., Naka T., Nohara K., Fujii-Kuriyama Y., Kishimoto T.
Title : , Proc.Natl.Acad.Sci.USA, 105(28):9721-9726 (2008)

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Arsenic Exposure and Reproductive Toxicity

Presenter : Udagawa O., Okamura K., Suzuki T., Nohara K.
Title : , Arsenic Contamination in Asia. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore, 29-42 (2019)
Epigenetics as a mechanism linking developmental exposures to long-term toxicity

Presenter : Barouki R., Melen E., Herceg Z., Beckers J., Chen J., Karagas M., Puga A., Xia Y., Chadwick L., Yan W., Audouze K., Slama R., Heindel J., Grandjean P., Kawamoto T., Nohara K.
Title : , Environment International , 114:77-86 (2018)
Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice

Presenter : Nohara K., Suzuki T., Okamura K., Matsushita J., Takumi S.
Title : , Genes and Environment, 39(3): (2017)
Role of Environmental Chemical Insult in Neuronal Cell Death and Cytoskeleton Damage

Presenter : Aung KH., Tsukahara S., Maekawa F., Nohara K., Nakamura K., Tanoue A.
Title : , Biological and Pharmaceutical Bulletin, 38(8):1109-1112 (2015)
The mechanisms underlying sexual differentiation of behavior and physiology in mammals and birds: relative contributions of sex steroids and sex chromosomes

Presenter : Maekawa F., Tsukahara S., Kawashima T., Nohara K., Ohki-Hamazaki H.
Title : , Frontiers in Neuroscience, 8(242): (2014)

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Research Result (Presentation)

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Research Presentation
Research Lecture

Research Presentation
DNA methylation changes in cord blood of pregnant woman in the area of high PM2.5 concentration in Myanmar

Presenter : Suzuki T., Nway N.C., Tin-Tin-Win-Shwe, Nakajima D., Isigaki Y., Mar O., Nohara K.
Name of Society : 5th International Forum in Sustainable Future in Asia (2020)
Name of Proceedings : Abstracts, 80
Research Presentation
Maternal exposure to arsenic on social behavior in 41 and 74-week-old F2 male mice born to arsenic-exposed pregnant mice

Presenter : Htway S.M., Suzuki T., Kyaw S., Nohara K., Tin-Tin-Win-Shwe
Name of Society : 48th Myanmar Health Research Congress (2020)
Name of Proceedings : Abstract, 112
Research Presentation
Social Behavior and Related Gene Expression Changes in F2 Male Mice born to Gestationally Arsenite Exposed F1 Mice

Presenter : HTWAY S.M., Suzuki T., KYAW S., Nohara K., Tin-Tin-Win-Shwe
Name of Society : 5th International Forum in Sustainable Future in Asia, 5th NIES International Forum (2020)
Name of Proceedings : Abstracts, 60
Research Presentation
Developmental arsenic exposure on social behavior and related gene expressions in C3H adult male mice

Presenter : Htway S.M., Sein M.T., Nohara K., Tin-Tin-Win-Shwe
Name of Society : 47th Myanmar Health Research Congress (2019)
Name of Proceedings : Abstract, 136
Research Presentation
Epigenetics and Environment

Presenter : Nohara K.
Name of Society : 47th Myanmer Health Research Congress (2019)
Name of Proceedings : Abstracts, 6-10
Research Presentation
Expression changes of cancer-related genes of the hepatocytes in the F1 and F2 generations of C3H mice maternally exposed to arsenite

Presenter : Suzuki T., Nohara K.
Name of Society : 47th Myanmar Health Research Congress (2019)
Name of Proceedings : Abstracts, 140
Research Presentation
The association between arsenic-related LINE-1 methylation changes and blood pressure in Bangladesh

Presenter : Suzuki T., Nohara K., Hossain K., Hasibuzzaman M.M., Islam M.S., Rahman A., Paul S.K., Himeno S.
Name of Society : 46th MYANMAR HEALTH RESEARCH CONGRESS (2018)
Name of Proceedings : THE REPUBLIC OF THE UNION OF MYANMAR MINISTRY OF HEALTH AND SPORTS, 121-122
Research Presentation
DNA microarray analysis of the hepatocyte of the F1 and F2 generation in C3H mice by gestational arsenite exposure

Presenter : Suzuki T., Nohara K.
Name of Society : 45th MYANMAR HEALTH RESEARCH CONGRESS (2017)
Name of Proceedings : Abstracts, 92
Research Presentation
Novel DNA methylation changes induced by gestational arsenite exposure in hepatic tumors in F2 mice

Presenter : Okamura K., Nakabayashi K., Horibe Y., Kawai T., Suzuki T., Hata K., Nohara K.
Name of Society : The 5th Annual Meeting of the Japan Society for Developmental Origins of Health and Disease (2016)
Name of Proceedings : Abstracts, 5(1):41
Research Lecture
Developmental Origins of Health and Disease (DOHaD) and Toxicology

Presenter : Nohara K.
Name of Society : ICCA-LRI and NIHS Workshop (2016)
Name of Proceedings : -
Research Presentation
DNA Methylation Change of LINE-1 Associated with Chronic Arsenic Exposure through a Cross Sectional Study in Bangladesh

Presenter : Suzuki T., K.Hossain, Himeno, Nohara K.
Name of Society : SOT 55th Annual Meeting and ToxExpo (2016)
Name of Proceedings : Abstracts
Research Presentation
Lead and arsenic exposures assessment among pregnant mother and infants in Pakistan and Japan

Presenter : Kayama F., Fatmi Z., Sahito A., Ikegami A., Mizuno A., Ohtsu M., Mise N., Cui X., Ogawa M., Sakamoto T., Nakagi Y., Yoshida T., Takagi M., Kobayashi Y., Nohara K.
Name of Society : 5th Conference on Prenatal Programming and Toxicity (pptox) (2016)
Name of Proceedings : PPTOX V Abstracts
Research Presentation
DNA methylation changes in hepatic normal tissues and tumor tissues in gestationally arsenite-exposed F2 mice

Presenter : Okamura K., Nohara K.
Name of Society : The 75th Annual Meeting of the Japanese Cancer Association (2016)
Name of Proceedings : Abstracts, 95
Research Presentation
The relationship between chronic arsenic exposure and DNA methylation levels of LINE-1 through a cross sectional study in Bangladesh

Presenter : Suzuki T., Hossain S., Himeno S., Nohara K.
Name of Society : 44th Myanmar Health Research Congress (2016)
Name of Proceedings : Abstracts, 75-76
Research Presentation
Long-term arsenite exposure induces premature senescence via DNA damage accumulation in mouse B lymphoma cell line A20 cells

Presenter : Okamura K., Nohara K.
Name of Society : 44th Myanmar Health Research Congress (2016)
Name of Proceedings : Abstracts, 85
Research Presentation
Diesel engine exhaust origin secondary organic aerosol affects olfactory-based spatial learning performance and related gene expressions in preweaning mice

Presenter : Tin-Tin-Win-Shwe, Fujitani Y., Nohara K., Hirano S.
Name of Society : 第4回日本DOHaD研究会学術集会 (2015)
Name of Proceedings : Abtract, 115
Research Presentation
PRENATAL ARSENIC EXPOSURE IMPAIRED BEHAVIORAL FLEXIBILITY AND MORPHOLOGY OF CORTEX IN MICE

Presenter : Maekawa F., KYAW HTET AUNG, CHAW KYI THA THU, Sano K., NAKAMURA S., Tanoue A., Kakeyama M., Tohyama C., Nohara K., Tsukahara S.
Name of Society : 9th World Congress International Brain Research Organization (2015)
Name of Proceedings : Abstracts, (301)
Research Presentation
Adipose tissue malfunction in prenatally arsenic-exposed mice

Presenter : Sano K., Maekawa F., Murai H., Nohara K.
Name of Society : The Joint Meeting of the 120th Annual Meeting of The Japanese Association of Anatomists, the 92nd Annual Meeting of The Physiological Society of Japan. (2015)
Name of Proceedings : The Journal of Physiological Sciences, 65(Supplement 1):S235
Research Presentation
The Effects of Gestational Arsenite Exposure on the F2 Generation: Role of Epigenetics

Presenter : Nohara K., Okamura K., Suzuki T., Hatada I, Hata K
Name of Society : Society of Toxicology 54th Annual Meeting (2015)
Name of Proceedings : Abstracts, 523
Research Presentation
Gestational Arsenic Exposure Affects Gene Expression in the Kidney and Lung in the F1 and F2 Mice

Presenter : Takumi S, Okamura K., Suzuki T., Hano H, Nohara K., Yanagisawa H
Name of Society : Society of Toxicology 54th Annual Meeting (2015)
Name of Proceedings : Abstracts, 422
Research Presentation
Effect of developmental exposure to acetamiprid on behavioral profiles in mice

Presenter : Sano K., Yang J., Tin-Tin-Win-Shwe, Nohara K., Maekawa F.
Name of Society : The 8th congress of the federation of the asian and oceanian physiological societies (2015)
Name of Proceedings : Abstracts, 65(Supplemental 2):S-A179
Research Presentation
Effects of developmental exposure to diesel engine exhaust origin secondary organic aerosol on social and learning behavior in adult mice

Presenter : Tin-Tin-Win-Shwe, Maekawa F., Chaw Kyi Tha Thu, Fujitani Y., Yanagisawa R., Furuyama A., Tsukahara S, Nohara K., Nitta H., Hirano S.
Name of Society : 37th Annual Meeting of the Japan Neuroscience Society (2014)
Name of Proceedings : Abstract, 131
Research Presentation
Effect of prenatal exposure to arsenic on cell number and morphology of neuron in prelimbic cortex of adult mice

Presenter : Kyaw Htet Aung, Maekawa F., Chaw Kyi Tha Thu, Sano K., Nakamura K, Tanoue A, Kakeyama M, Nohara K., Tsukahara S
Name of Society : 21st Japanese Society for Behavioral Neuroendocrinology (2014)
Name of Proceedings : Abstracts, 17
Research Presentation
Maternal Arsenic Exposure of C3H Mice Increases Hepatic Tumor with an Activating Mutation in the Oncogene Ha-ras in the F2 Generation

Presenter : Nohara K., Okamura K., Suzuki T., Murai H., Ito T., Shinjo K., Kondo Y.
Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
Name of Proceedings : Abstracts
Research Presentation
Identification of DNA Methylation Changes in the Liver Tumors Induced by Gestational Arsenic Exposure Using Genome-Wide Analysis

Presenter : Suzuki T., Yamashita S., Ushijima T., Takumi S., Sano T., Michikawa T., Nohara K.
Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
Name of Proceedings : Abstracts
Research Presentation
Arsenite Exposure-Induced Lymphocytes G0/G1 Arrest Is Attributable to p130 Accumulation via p16 Increase

Presenter : Okamura K., Nohara K.
Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
Name of Proceedings : Abstracts
Research Presentation
In Vivo Mutagenicity Assay of Arsenite Using Gpt Delta Transgenic Mice

Presenter : Takumi S., Aoki Y., Sano T., Suzuki T., Nohmi T., Nohara K.
Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
Name of Proceedings : Abstracts
Research Presentation
Live imaging analysis of sodium arsenite-induced inhibition of neurite outgrowth in Neuro-2a cells

Presenter : Aung K.H., Kurihara R., Nakashima S., Maekawa F., Nohara K., Kobayashi T., Tsukahara S.
Name of Society : 分子予防環境医学研究大会第12回 (2013)
Name of Proceedings : 同予稿集, 35
Research Presentation
Effects of Developmental Arsenic Exposure on Social Behavior and Neuronal Morphology in Mice

Presenter : Tin-Tin-Win-Shwe, Aung K.H., Tsukahara S., Nohara K.
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 22
Research Presentation
The Effects of Gestational Inorganic Arsenic Exposure in the Offspring and Future Generations

Presenter : Nohara K., Suzuki T., Takumi S., Okamura K., Maekawa F.
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 15
Research Presentation
Genome-Wide and Site-Specific Analyses of DNA Methylation Changes Induced by Arsenic Exposure

Presenter : Suzuki T., Nohara K.
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 16
Research Presentation
In Vivo Mutagenicity of Arsenic

Presenter : Takumi S., Aoki Y., Nohara K.
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 17
Research Presentation
Effects of Perinatal Arsenic Exposure on the Development of Mice Brain

Presenter : Maekawa F., Tsukahara S., Nohara K.
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 21
Research Presentation
Multi-centered Epidemiological Study on Dietary Arsenic and Lead Exposure among Mother, Neonates and Infants in Japan and Pakistan

Presenter : Kayama F., Nathan Mise, Ohtsu M., Yoshida T., Nohara K., Zafar Fatmi
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 7
Research Presentation
Evaluation of sodium arsenite-induced inhibition of neurite outgrowth by live cell imaging and alteration of cytoskeletal gene expression in Neuro-2a cells

Presenter : Aung K.H., Kurihara R., Nakashima S., Maekawa F., Nohara K., Kobayashi T., Tsukahara S.
Name of Society : 日本行動神経内分泌研究会第17回 (2012)
Name of Proceedings : 同予稿集, (5-1)
Research Presentation
Late increases in tumorigenic stress and tumors with a Ha-ras mutation in the liver of adult male C3H mice gestationally exposed to arsenic

Presenter : Nohara K., Suzuki T., Tateishi Y., Okamura K., Murai H., Takumi S., Maekawa F., Nishimura N., Ito T.
Name of Society : Prenatal Programming and Toxicity（PPTOX）? Meeting (2012)
Name of Proceedings : Abstracts
Research Presentation
A methyl-deficient diet modifies early B cell development

Presenter : Kanno M., Inoue H., Guo Y., Nobukiyo A, Nohara K., Kurogi T.
Name of Society : 日本エピジェネティクス研究会第6回 (2012)
Name of Proceedings : 同予稿集, (PB-14):103
Research Presentation
Late-onset gene expression changes in the livers of male C3H mice maternally exposed to arsenic: Implications for an increase in hepatic tumor incidence

Presenter : Nohara K., Tateishi Y., Suzuki T., Murai H., Takumi S., Okamura K., Maekawa f. , Nishimura N., Ito T.
Name of Society : SOCIETY OF TOXICOLOGY 51st Annual Meeting (2012)
Name of Proceedings : Abstracts of SOCIETY OF TOXICOLOGY 51st Annual Meeting
Research Presentation
Impairment of glutamate AMPA receptor expression by sodium arsenite is related to the neurite suppression in mouse cortical neurons.

Presenter : Maekawa F., Tsuboi T., Tsukahara S., Nohara K.
Name of Society : NEUROSCIENCE 2012 42nd annual meeting (2012)
Name of Proceedings : -
Research Presentation
The effect of AMPA receptor overexpression on suppressed neurite outgrowth by sodium arsenite in mouse cortical neuron

Presenter : Maekawa f. , Tsuboi T, Nohara K.
Name of Society : The 34th Annual Meeting of the Japan Neuroscience Society (2011)
Name of Proceedings : Abstracts of The 34th Annual Meeting of the Japan Neuroscience Society, s19
Research Presentation
Sex-dependent changes in genomic DNA methylation by methyl deficient diet and inorganic arsenic in the liver of mice

Presenter : Nohara K., Sano T., Murai H., Kobayashi Y., Suzuki T., Tateishi Y., Matsumoto M., Nishimura N., Baba T.
Name of Society : 第9回分子予防環境医学研究会 (2010)
Name of Proceedings : 同予稿集, 38
Research Presentation
The E2F family is a sensitive target of arsenite in the thymus: A characteristic down-regulation of E2F-related genes revealed by immunotoxicogenomics

Presenter : Nohara K.
Name of Society : SOT 2009 (2009)
Name of Proceedings : Abstracts
Research Presentation
Transcriptional changes in immunotoxicology: Transcription factors signal transduction and epigenetics

Presenter : N. Kerkvliet, Nohara K.
Name of Society : SOT 2009 (2009)
Name of Proceedings : Abstracts
Research Presentation
The investigation of tissue-specific modulation of AhR-dependent gene expression

Presenter : Suzuki T., Takamoto S., Nohara K.
Name of Society : SOT 2009 (2009)
Name of Proceedings : Abstracts
Research Presentation
Alteration of global DNA methylation induced by a methyl deficient diet and inorganic arsenic intake in mice

Presenter : Nohara K., Sano T., Murai H., Kobayashi Y., Suzuki T., Tateishi Y., Matsumoto M., Nishimura N., Baba T.
Name of Society : 32nd Annu.Meet.Mol.Biol.Soc.Jpn. (2009)
Name of Proceedings : Abstracts, 149
Research Presentation
Sex-dependent effects of diet and arsenic on genomic DNA methylation

Presenter : Nohara K., Murai H., Sano T., Kobayashi Y., Tateishi Y., Suzuki T., Matsumoto M., Nishimura N., Baba T.
Name of Society : HORIBA/CDBIM Symp. -21st Century Adv.Mol.Toxicol.Environ.Chem.Pathog.Dis.- (2009)
Name of Proceedings : Abstracts, 168
Research Presentation
Histone deacetylases are involved in species-specific modulation of arylhydrocarbon receptor-dependent gene expression in humans and mice

Presenter : Suzuki T., Nohara K.
Name of Society : 27th Int.Symp.Halogenat.Persistent Org.Pollut.-DIOXIN 2007(Poster Session) (2007)
Name of Proceedings : Organohalogen Compd., 69
Research Presentation
Activation of the transcription factor AhR in T cells only is not sufficient to generate CD62L(low)CD25(+)CD4(+) putative regulatory T cells and suppress the allo-CTL response

Presenter : Nohara K.
Name of Society : 37th Annu.Meet.Jpn.Soc.Immunol.(Poster Session) (2007)
Name of Proceedings : Abstracts, 37
Research Presentation
Activation of the transcription factor AhR in T cells causes suppression of the immunization-induced increase in splenocytes but does not suppress Th2-cytokine production

Presenter : Nohara K.
Name of Society : 36th Annu.Meet.Jpn.Soc.Immunol.(Poster Session) (2006)
Name of Proceedings : Abstracts, 36
Suppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) on Th2-derived cytokine production in primary immune reaction of mice

Presenter : Nohara K., Ito T., Inouye K., Fujimaki H., Tohyama C.
Name of Society : Soc.Toxicol.: 41st Annu.Meet. (2002)
Name of Proceedings : Toxicologist, 61
The effects of TCDD on germinal center formation in the spleen of C57BL/6 mice

Presenter : Inouye K., Ito T., Fujimaki H., Tohyama C., Nohara K.
Name of Society : Soc.Toxicol.: 41st Annu.Meet. (2002)
Name of Proceedings : Toxicologist, 61
Fetal and infant body burden of 2,3,7,8-tetrachlorodibenzo-p-dioxin causing a short anogenital distance and immunotoxicity in male Holtzman rats

Presenter : Ohsako S., Nohara K., Tohyama C., Yonemoto J.
Name of Society : 21st Int.Symp.Halogenat.Environ.Org.Pollut.& POPs (2001)
Name of Proceedings : Organohalogen Compd., 53
Host resistance to influenza A virus in mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Presenter : Nohara K., Tohyama C.
Name of Society : 21st Int.Symp.Halogenat.Environ.Org.Pollut.& POPs (2001)
Name of Proceedings : Organohalogen Compd., 53
Primary lymphocytes have a functional aryl hydrocarbon receptor

Presenter : Tohyama C., Nohara K.
Name of Society : 21st Int.Symp.Halogenat.Environ.Org.Pollut.& POPs (2001)
Name of Proceedings : Organohalogen Compd., 53
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)on TH1/TH2 cell differentiation in C57BL/6 mice

Presenter : Nohara K., Fujimaki H., Inouye K., Tohyama C.
Name of Society : Soc.Toxicol.40th.Annu.Meet. (2001)
Name of Proceedings : Toxicologist, 60
Effect of low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin on host resistance to influenza virus in mice

Presenter : Nohara K., Tohyama C.
Name of Society : 4th Annu.Meet.Jpn.Soc.Endocr.Disrupters Res. (2001)
Name of Proceedings : Program & Abstracts
Alteration of B cell development in the spleen of C57B1/6 mice by TCDD treatment

Presenter : Inouye K., Ito T., Fujimaki H., Tohyama C., Nohara K.
Name of Society : 4th Annu.Meet.Jpn.Soc.Endocr.Disrupters Res. (2001)
Name of Proceedings : Program & Abstracts
Mechanisms for 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)- induced suppression of antigen-specific antibody production

Presenter : Ito T., Inouye K., Fujimaki H., Tohyama C., Nohara K.
Name of Society : 4th Annu.Meet.Jpn.Soc.Endocr.Disrupters Res. (2001)
Name of Proceedings : Program & Abstracts

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Epigenetics and Environment

Presenter : Nohara K.
Name of Society : 47th Myanmer Health Research Congress (2019)
Name of Proceedings : Abstracts, 6-10
Novel DNA methylation changes induced by gestational arsenite exposure in hepatic tumors in F2 mice

Presenter : Okamura K., Nakabayashi K., Horibe Y., Kawai T., Suzuki T., Hata K., Nohara K.
Name of Society : The 5th Annual Meeting of the Japan Society for Developmental Origins of Health and Disease (2016)
Name of Proceedings : Abstracts, 5(1):41
DNA Methylation Change of LINE-1 Associated with Chronic Arsenic Exposure through a Cross Sectional Study in Bangladesh

Presenter : Suzuki T., K.Hossain, Himeno, Nohara K.
Name of Society : SOT 55th Annual Meeting and ToxExpo (2016)
Name of Proceedings : Abstracts
Lead and arsenic exposures assessment among pregnant mother and infants in Pakistan and Japan

Presenter : Kayama F., Fatmi Z., Sahito A., Ikegami A., Mizuno A., Ohtsu M., Mise N., Cui X., Ogawa M., Sakamoto T., Nakagi Y., Yoshida T., Takagi M., Kobayashi Y., Nohara K.
Name of Society : 5th Conference on Prenatal Programming and Toxicity (pptox) (2016)
Name of Proceedings : PPTOX V Abstracts
DNA methylation changes in hepatic normal tissues and tumor tissues in gestationally arsenite-exposed F2 mice

Presenter : Okamura K., Nohara K.
Name of Society : The 75th Annual Meeting of the Japanese Cancer Association (2016)
Name of Proceedings : Abstracts, 95
The Effects of Gestational Arsenite Exposure on the F2 Generation: Role of Epigenetics

Presenter : Nohara K., Okamura K., Suzuki T., Hatada I, Hata K
Name of Society : Society of Toxicology 54th Annual Meeting (2015)
Name of Proceedings : Abstracts, 523
Effect of prenatal exposure to arsenic on cell number and morphology of neuron in prelimbic cortex of adult mice

Presenter : Kyaw Htet Aung, Maekawa F., Chaw Kyi Tha Thu, Sano K., Nakamura K, Tanoue A, Kakeyama M, Nohara K., Tsukahara S
Name of Society : 21st Japanese Society for Behavioral Neuroendocrinology (2014)
Name of Proceedings : Abstracts, 17
Arsenite Exposure-Induced Lymphocytes G0/G1 Arrest Is Attributable to p130 Accumulation via p16 Increase

Presenter : Okamura K., Nohara K.
Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
Name of Proceedings : Abstracts
Live imaging analysis of sodium arsenite-induced inhibition of neurite outgrowth in Neuro-2a cells

Presenter : Aung K.H., Kurihara R., Nakashima S., Maekawa F., Nohara K., Kobayashi T., Tsukahara S.
Name of Society : 分子予防環境医学研究大会第12回 (2013)
Name of Proceedings : 同予稿集, 35
Effects of Developmental Arsenic Exposure on Social Behavior and Neuronal Morphology in Mice

Presenter : Tin-Tin-Win-Shwe, Aung K.H., Tsukahara S., Nohara K.
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 22
The Effects of Gestational Inorganic Arsenic Exposure in the Offspring and Future Generations

Presenter : Nohara K., Suzuki T., Takumi S., Okamura K., Maekawa F.
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 15
Genome-Wide and Site-Specific Analyses of DNA Methylation Changes Induced by Arsenic Exposure

Presenter : Suzuki T., Nohara K.
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 16
In Vivo Mutagenicity of Arsenic

Presenter : Takumi S., Aoki Y., Nohara K.
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 17
Effects of Perinatal Arsenic Exposure on the Development of Mice Brain

Presenter : Maekawa F., Tsukahara S., Nohara K.
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 21
Multi-centered Epidemiological Study on Dietary Arsenic and Lead Exposure among Mother, Neonates and Infants in Japan and Pakistan

Presenter : Kayama F., Nathan Mise, Ohtsu M., Yoshida T., Nohara K., Zafar Fatmi
Name of Society : NIES Arsenic Workshop 2013 (2013)
Name of Proceedings : Abstracts, 7
Evaluation of sodium arsenite-induced inhibition of neurite outgrowth by live cell imaging and alteration of cytoskeletal gene expression in Neuro-2a cells

Presenter : Aung K.H., Kurihara R., Nakashima S., Maekawa F., Nohara K., Kobayashi T., Tsukahara S.
Name of Society : 日本行動神経内分泌研究会第17回 (2012)
Name of Proceedings : 同予稿集, (5-1)
Sex-dependent changes in genomic DNA methylation by methyl deficient diet and inorganic arsenic in the liver of mice

Presenter : Nohara K., Sano T., Murai H., Kobayashi Y., Suzuki T., Tateishi Y., Matsumoto M., Nishimura N., Baba T.
Name of Society : 第9回分子予防環境医学研究会 (2010)
Name of Proceedings : 同予稿集, 38
The E2F family is a sensitive target of arsenite in the thymus: A characteristic down-regulation of E2F-related genes revealed by immunotoxicogenomics

Presenter : Nohara K.
Name of Society : SOT 2009 (2009)
Name of Proceedings : Abstracts
Transcriptional changes in immunotoxicology: Transcription factors signal transduction and epigenetics

Presenter : N. Kerkvliet, Nohara K.
Name of Society : SOT 2009 (2009)
Name of Proceedings : Abstracts
Histone deacetylases are involved in species-specific modulation of arylhydrocarbon receptor-dependent gene expression in humans and mice

Presenter : Suzuki T., Nohara K.
Name of Society : 27th Int.Symp.Halogenat.Persistent Org.Pollut.-DIOXIN 2007(Poster Session) (2007)
Name of Proceedings : Organohalogen Compd., 69
Activation of the transcription factor AhR in T cells only is not sufficient to generate CD62L(low)CD25(+)CD4(+) putative regulatory T cells and suppress the allo-CTL response

Presenter : Nohara K.
Name of Society : 37th Annu.Meet.Jpn.Soc.Immunol.(Poster Session) (2007)
Name of Proceedings : Abstracts, 37
Activation of the transcription factor AhR in T cells causes suppression of the immunization-induced increase in splenocytes but does not suppress Th2-cytokine production

Presenter : Nohara K.
Name of Society : 36th Annu.Meet.Jpn.Soc.Immunol.(Poster Session) (2006)
Name of Proceedings : Abstracts, 36
DNA methylation changes in cord blood of pregnant woman in the area of high PM2.5 concentration in Myanmar

Presenter : Suzuki T., Nway N.C., Tin-Tin-Win-Shwe, Nakajima D., Isigaki Y., Mar O., Nohara K.
Name of Society : 5th International Forum in Sustainable Future in Asia (2020)
Name of Proceedings : Abstracts, 80
Maternal exposure to arsenic on social behavior in 41 and 74-week-old F2 male mice born to arsenic-exposed pregnant mice

Presenter : Htway S.M., Suzuki T., Kyaw S., Nohara K., Tin-Tin-Win-Shwe
Name of Society : 48th Myanmar Health Research Congress (2020)
Name of Proceedings : Abstract, 112
Social Behavior and Related Gene Expression Changes in F2 Male Mice born to Gestationally Arsenite Exposed F1 Mice

Presenter : HTWAY S.M., Suzuki T., KYAW S., Nohara K., Tin-Tin-Win-Shwe
Name of Society : 5th International Forum in Sustainable Future in Asia, 5th NIES International Forum (2020)
Name of Proceedings : Abstracts, 60
Developmental arsenic exposure on social behavior and related gene expressions in C3H adult male mice

Presenter : Htway S.M., Sein M.T., Nohara K., Tin-Tin-Win-Shwe
Name of Society : 47th Myanmar Health Research Congress (2019)
Name of Proceedings : Abstract, 136
Expression changes of cancer-related genes of the hepatocytes in the F1 and F2 generations of C3H mice maternally exposed to arsenite

Presenter : Suzuki T., Nohara K.
Name of Society : 47th Myanmar Health Research Congress (2019)
Name of Proceedings : Abstracts, 140
The association between arsenic-related LINE-1 methylation changes and blood pressure in Bangladesh

Presenter : Suzuki T., Nohara K., Hossain K., Hasibuzzaman M.M., Islam M.S., Rahman A., Paul S.K., Himeno S.
Name of Society : 46th MYANMAR HEALTH RESEARCH CONGRESS (2018)
Name of Proceedings : THE REPUBLIC OF THE UNION OF MYANMAR MINISTRY OF HEALTH AND SPORTS, 121-122
DNA microarray analysis of the hepatocyte of the F1 and F2 generation in C3H mice by gestational arsenite exposure

Presenter : Suzuki T., Nohara K.
Name of Society : 45th MYANMAR HEALTH RESEARCH CONGRESS (2017)
Name of Proceedings : Abstracts, 92
The relationship between chronic arsenic exposure and DNA methylation levels of LINE-1 through a cross sectional study in Bangladesh

Presenter : Suzuki T., Hossain S., Himeno S., Nohara K.
Name of Society : 44th Myanmar Health Research Congress (2016)
Name of Proceedings : Abstracts, 75-76
Long-term arsenite exposure induces premature senescence via DNA damage accumulation in mouse B lymphoma cell line A20 cells

Presenter : Okamura K., Nohara K.
Name of Society : 44th Myanmar Health Research Congress (2016)
Name of Proceedings : Abstracts, 85
Diesel engine exhaust origin secondary organic aerosol affects olfactory-based spatial learning performance and related gene expressions in preweaning mice

Presenter : Tin-Tin-Win-Shwe, Fujitani Y., Nohara K., Hirano S.
Name of Society : 第4回日本DOHaD研究会学術集会 (2015)
Name of Proceedings : Abtract, 115
PRENATAL ARSENIC EXPOSURE IMPAIRED BEHAVIORAL FLEXIBILITY AND MORPHOLOGY OF CORTEX IN MICE

Presenter : Maekawa F., KYAW HTET AUNG, CHAW KYI THA THU, Sano K., NAKAMURA S., Tanoue A., Kakeyama M., Tohyama C., Nohara K., Tsukahara S.
Name of Society : 9th World Congress International Brain Research Organization (2015)
Name of Proceedings : Abstracts, (301)
Adipose tissue malfunction in prenatally arsenic-exposed mice

Presenter : Sano K., Maekawa F., Murai H., Nohara K.
Name of Society : The Joint Meeting of the 120th Annual Meeting of The Japanese Association of Anatomists, the 92nd Annual Meeting of The Physiological Society of Japan. (2015)
Name of Proceedings : The Journal of Physiological Sciences, 65(Supplement 1):S235
Gestational Arsenic Exposure Affects Gene Expression in the Kidney and Lung in the F1 and F2 Mice

Presenter : Takumi S, Okamura K., Suzuki T., Hano H, Nohara K., Yanagisawa H
Name of Society : Society of Toxicology 54th Annual Meeting (2015)
Name of Proceedings : Abstracts, 422
Effect of developmental exposure to acetamiprid on behavioral profiles in mice

Presenter : Sano K., Yang J., Tin-Tin-Win-Shwe, Nohara K., Maekawa F.
Name of Society : The 8th congress of the federation of the asian and oceanian physiological societies (2015)
Name of Proceedings : Abstracts, 65(Supplemental 2):S-A179
Effects of developmental exposure to diesel engine exhaust origin secondary organic aerosol on social and learning behavior in adult mice

Presenter : Tin-Tin-Win-Shwe, Maekawa F., Chaw Kyi Tha Thu, Fujitani Y., Yanagisawa R., Furuyama A., Tsukahara S, Nohara K., Nitta H., Hirano S.
Name of Society : 37th Annual Meeting of the Japan Neuroscience Society (2014)
Name of Proceedings : Abstract, 131
Maternal Arsenic Exposure of C3H Mice Increases Hepatic Tumor with an Activating Mutation in the Oncogene Ha-ras in the F2 Generation

Presenter : Nohara K., Okamura K., Suzuki T., Murai H., Ito T., Shinjo K., Kondo Y.
Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
Name of Proceedings : Abstracts
Identification of DNA Methylation Changes in the Liver Tumors Induced by Gestational Arsenic Exposure Using Genome-Wide Analysis

Presenter : Suzuki T., Yamashita S., Ushijima T., Takumi S., Sano T., Michikawa T., Nohara K.
Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
Name of Proceedings : Abstracts
In Vivo Mutagenicity Assay of Arsenite Using Gpt Delta Transgenic Mice

Presenter : Takumi S., Aoki Y., Sano T., Suzuki T., Nohmi T., Nohara K.
Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
Name of Proceedings : Abstracts
Late increases in tumorigenic stress and tumors with a Ha-ras mutation in the liver of adult male C3H mice gestationally exposed to arsenic

Presenter : Nohara K., Suzuki T., Tateishi Y., Okamura K., Murai H., Takumi S., Maekawa F., Nishimura N., Ito T.
Name of Society : Prenatal Programming and Toxicity（PPTOX）? Meeting (2012)
Name of Proceedings : Abstracts
A methyl-deficient diet modifies early B cell development

Presenter : Kanno M., Inoue H., Guo Y., Nobukiyo A, Nohara K., Kurogi T.
Name of Society : 日本エピジェネティクス研究会第6回 (2012)
Name of Proceedings : 同予稿集, (PB-14):103
Late-onset gene expression changes in the livers of male C3H mice maternally exposed to arsenic: Implications for an increase in hepatic tumor incidence

Presenter : Nohara K., Tateishi Y., Suzuki T., Murai H., Takumi S., Okamura K., Maekawa f. , Nishimura N., Ito T.
Name of Society : SOCIETY OF TOXICOLOGY 51st Annual Meeting (2012)
Name of Proceedings : Abstracts of SOCIETY OF TOXICOLOGY 51st Annual Meeting
Impairment of glutamate AMPA receptor expression by sodium arsenite is related to the neurite suppression in mouse cortical neurons.

Presenter : Maekawa F., Tsuboi T., Tsukahara S., Nohara K.
Name of Society : NEUROSCIENCE 2012 42nd annual meeting (2012)
Name of Proceedings : -
The effect of AMPA receptor overexpression on suppressed neurite outgrowth by sodium arsenite in mouse cortical neuron

Presenter : Maekawa f. , Tsuboi T, Nohara K.
Name of Society : The 34th Annual Meeting of the Japan Neuroscience Society (2011)
Name of Proceedings : Abstracts of The 34th Annual Meeting of the Japan Neuroscience Society, s19
The investigation of tissue-specific modulation of AhR-dependent gene expression

Presenter : Suzuki T., Takamoto S., Nohara K.
Name of Society : SOT 2009 (2009)
Name of Proceedings : Abstracts
Alteration of global DNA methylation induced by a methyl deficient diet and inorganic arsenic intake in mice

Presenter : Nohara K., Sano T., Murai H., Kobayashi Y., Suzuki T., Tateishi Y., Matsumoto M., Nishimura N., Baba T.
Name of Society : 32nd Annu.Meet.Mol.Biol.Soc.Jpn. (2009)
Name of Proceedings : Abstracts, 149
Sex-dependent effects of diet and arsenic on genomic DNA methylation

Presenter : Nohara K., Murai H., Sano T., Kobayashi Y., Tateishi Y., Suzuki T., Matsumoto M., Nishimura N., Baba T.
Name of Society : HORIBA/CDBIM Symp. -21st Century Adv.Mol.Toxicol.Environ.Chem.Pathog.Dis.- (2009)
Name of Proceedings : Abstracts, 168

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Developmental Origins of Health and Disease (DOHaD) and Toxicology

Presenter : Nohara K.
Name of Society : ICCA-LRI and NIHS Workshop (2016)
Name of Proceedings : -

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NOHARA Keiko

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