Latest Update:2017/12/06 19:21:42

AOKI Yasunobu

AOKI Yasunobu
Researcher Name
AOKI Yasunobu
Div (Section) name/title
Center for Health and Environmental Risk Research/Fellow
Research Subject
Risk assessment of chemicals, Mechanism of in vivo mutagenesis by exposure of environmental chemicals and its evaluation
Degree(s)
Ph.D.
Professional Qualification(s)
Pharmacy,Biochemistry,Biology
Environmental Speciality Field
hazardous chemical substance,health effect,risk assessment
Keyword(s)
environmental mutagen,dioxins,transgenic aminal,zebrafish,in vivo mutagenesis,gene expression analysis,diesel exhaust,air pollutant,bioassay
Brief Description of Research
(あとから)
Career
1982 March, Graduated from Univ. Tokyo, Graduate School of Pharmacuetical Sciences, Ph.D Course
1982 Dec., Reseacher, Basic Medical Science Division, National Institute for Environmental Studies (NIES)
1988 Jan., Research Associate, Univ. Maryland, Toxicology Program
1988 Apr. , Senior Reseacher, Environmental Health Science Division, NIES
1993 Apr. , Research Coordinator, NIES
1995 Feb. , Section Chief, Environmental Health Science Division, NIES
2001 Apr., Visiting Professor, Univ Chiba, Graduate School of Pharmacuetical Sciences
2001 Oct. , Section Chief, Research Center for Environmental Risk, NIES
2006 May, Director of Environment and Energy, Council of Science and Technology Policy, Cabnet Office
2009 Apr., Duputy Director, Research Center for Environmental Risk, NIES
Membership of Academic Society
The pharmaceutical society of japan,The Japanese Environmental Mutagen Society (JEMS) ,The Japanese Biochemical Society (JBS),Society of Toxicology
Research Subject
  • Fiscal Year: 2017
    • 23824 : Research project on health impacts of chemicals on children and future generations
    • 23847 : Research program on health and environmental safety
    • 24038 : Commission on Consideration of Health Risk Assessment Methods for Hazardous Air Pollutants
    • 24060 : Estimation of Intake of acrylamide in Japanese
    • 24073 : Fundamental study on the basis of health and environmental risk research
    • 24097 : Implementation of initial risk assessment of environmental chemicals in FY2017
    • 24118 : Characterization of mutation as a marker for carcinogenesis induced by oxidative stress: identification of mutation hotspot
  • Fiscal Year: 2016
    • 23414 : Research program on health and environmental safety
    • 23415 : Research project on health impacts of chemicals on children and future generations
    • 23711 : Fundamental study on the basis of health and environmental risk research
    • 23713 : The Study about a New Evaluation System of the Ecological Effect with Chemicals.
    • 23744 : Characterization of mutation as a marker for carcinogenesis induced by oxidative stress: identification of mutation hotspot
    • 23756 : Implementation of initial risk assessment of environmental chemicals in FY2016
    • 23777 : Commission on Consideration of Health Risk Assessment Methods for Hazardous Air Pollutants
    • 23787 : Estimation of Intake of acrylamide in Japanese
  • Fiscal Year: 2015
    • 23002 : Study on strategic approach of chemical risk management and control
    • 23018 : Mechanism and evaluation system of the developmental health effects of environmental factors
    • 23028 : Reference laboratory for ecotoxicity test, chemical database for environmental risk
    • 23148 : Development of methodology for predicting ecotoxicity for risk assessment/management of chemicals
    • 23230 : Development and publication of databases of chemical information
    • 23241 : The Study about a New Evaluation System of the Ecological Effect with Chemicals.
    • 23242 : The reinforcement as the standard organization about the examination for ecological effect (Reference Laboratory)
    • 23331 : Commission on Consideration of Health Risk Assessment Methods for Hazardous Air Pollutants
    • 23332 : Development of Bioassay method based on mode of action of chemical
    • 23333 : Pulmonary carcinogenic risk assessment of past exposure of suspended particulate matter in ambient air
  • Fiscal Year: 2014
    • 22573 : Environmental Risk Research
    • 22587 : Research Program on Risk Assessment and Control of Environmental Chemicals
    • 22590 : Study on strategic approach of chemical risk management and control
    • 22606 : Mechanism and evaluation system of the developmental health effects of environmental factors
    • 22616 : Reference laboratory for ecotoxicity test, chemical database for environmental risk
    • 22766 : Development of methodology for predicting ecotoxicity for risk assessment/management of chemicals
    • 22799 : Development and publication of databases of chemical information
    • 22836 : The reinforcement as the standard organization about the examination for ecological effect (Reference Laboratory)
    • 22903 : Investigation on water environment management method using biological responses
    • 22918 : Measurement and genotoxic evaluation of the organic pollutants in particulate matter 2.5 (PM2.5)
    • 22927 : Commission on Consideration of Health Risk Assessment Methods for Hazardous Air Pollutants
    • 22931 : Pulmonary carcinogenic risk assessment of past exposure of suspended particulate matter in ambient air
    • 22932 : Development of Bioassay method based on mode of action of chemical
    • 22933 : Implementation of initial risk assessment of environmental chemicals in FY 2014
    • 22934 : Implementation of Risk assessment in CSCL and investigation on the advanced procedure in 2014FY
    • 22937 : Investigation on QSAR for eco-toxicity in FY 2014
  • Fiscal Year: 2013
    • 22157 : Environmental Risk Research
    • 22171 : Research Program on Risk Assessment and Control of Environmental Chemicals
    • 22174 : Study on strategic approach of chemical risk management and control
    • 22190 : Mechanism and evaluation system of the developmental health effects of environmental factors
    • 22200 : Reference laboratory for ecotoxicity test, chemical database for environmental risk
    • 22315 : Development of methodology for predicting ecotoxicity for risk assessment/management of chemicals
    • 22344 : Implementation of initial risk assessment of environmental chemicals in FY 2013
    • 22358 : Measurement and genotoxic evaluation of the organic pollutants in particulate matter 2.5 (PM2.5)
    • 22364 : The reinforcement as the standard organization about the examination for ecological effect (Reference Laboratory)
    • 22437 : Development and publication of databases of chemical information
    • 22480 : Low dose-response analysis of oxidative stress inducing genotoxic substance
    • 22481 : Development of Bioassay method based on mode of action of chemical
    • 22482 : Pulmonary carcinogenic risk assessment of past exposure of suspended particulate matter in ambient air
    • 22484 : Fundamental research for risk assessment of chemicals
    • 22506 : Involvement of oxidative stress in the epigenetic changes induced by environmental chemicals
    • 22546 : Investigation on Improvement of Risk assessment of chemicals under CSCL in 2013 FY
    • 22554 : Commission on Consideration of Health Risk Assessment Methods for Hazardous Air Pollutants
    • 22562 : Investigation on QSAR for eco-toxicity in FY 2013
    • 22564 : Investigation on water environment management method using biological responses
  • Fiscal Year: 2012
    • 21745 : Study on strategic approach of chemical risk management and control
    • 21761 : Mechanism and evaluation system of the developmental health effects of environmental factors
    • 21771 : Reference laboratory for ecotoxicity test, chemical database for environmental risk
    • 21977 : Development and publication of databases of chemical information
    • 21985 : Involvement of oxidative stress in the epigenetic changes induced by environmental chemicals
    • 22082 : Development of Bioassay method based on mode of action of chemical
    • 22083 : Development of methodology for predicting ecotoxicity for risk assessment/management of chemicals
    • 22084 : Fundamental research for risk assessment of chemicals
    • 22085 : The reinforcement as the standard organization about the examination for ecological effect (Reference Laboratory)
    • 22088 : Investigation on water environment management method using biological responses
    • 22089 : Commission on Preparing Guidelines on Health Risk Assessment Methods for Hazardous Air Pollutants
    • 22132 : Implementation of Initial Risk Assessment of Environmental chemicals in FY 2012
    • 22210 : Low dose-response analysis of oxidative stress inducing genotoxic substance
  • Fiscal Year: 2011
    • 21302 : Study on strategic approach of chemical risk management and control
    • 21319 : Mechanism and evaluation system of the developmental health effects of environmental factors
    • 21329 : Reference laboratory for ecotoxicity test, chemical database for environmental risk
    • 21461 : Infrastructure of environmental risk evaluation methods for congenital malformation: developments of biomarkers based on genetic susceptibility to persistent organic pollutant
    • 21470 : Involvement of oxidative stress in the epigenetic changes induced by environmental chemicals
    • 21482 : Development and publication of databases of chemical information
    • 21494 : The reinforcement as the standard organization about the examination for ecological effect (Reference Laboratory)
    • 21510 : Fundamental research for risk assessment of chemicals
    • 21533 : Development of methodology for predicting ecotoxicity for risk assessment/management of chemicals
    • 21534 : Development of Bioassay method based on mode of action of chemical
    • 21541 : Study/investigation of the aqueous environment control procedure by the WET program
    • 21546 : Investigation on subjects associated with implementation of Chemical control law in FY 2011
    • 21583 : Assessment of in vivo mutagenicity and trans-generational effect of compounds contained in suspended particulate matter in urban air
    • 21584 : Studies on safety evaluation of genotoxic carcinogens in food additives
    • 21709 : Commission of Preparing Guidelines on Health Risk Assessment Methods for Hazardous Air Pollutants
  • Fiscal Year: 2010
    • 20978 : Study on Environmental Risk Assessment for Regulatory Objectives and Communication of Environmental Risks
    • 21098 : Development of the prediction method for the carcinogenicity evaluation
    • 21104 : Studies on safety evaluation of genotoxic carcinogens in food additives
    • 21108 : Development of method for risk assessment of genotoxicity on germ cells by environmental chemicals
    • 21111 : Studies on setting a guideline for health risk assessment of hazadous air pollutants
    • 21114 : Infrastructure of environmental risk evaluation methods for congenital malformation: developments of biomarkers based on genetic susceptibility to persistent organic pollutant
    • 21125 : Assessment of in vivo mutagenicity and trans-generational effect of compounds contained in suspended particulate matter in urban air
  • Fiscal Year: 2009
    • 20498 : Study on Environmental Risk Assessment for Regulatory Objectives and Communication of Environmental Risks
    • 20524 : Assessment of in vivo mutagenicity and trans-generational effect of compounds contained in suspended particulate matter in urban air
    • 20531 : Development of method for risk assessment of genotoxicity on germ cells by environmental chemicals
    • 20532 : Development of the prediction method for the carcinogenicity evaluation
    • 20818 : Infrastructure of environmental risk evaluation methods for congenital malformation: developments of biomarkers based on genetic susceptibility to persistent organic pollutant
    • 20833 : Studies on setting a guideline for health risk assessment of hazadous air pollutants
    • 20834 : Studies on safety evaluation of genotoxic carcinogens in food additives
  • Fiscal Year: 2008
    • 20106 : Development of the prediction method for the carcinogenicity evaluation
    • 20108 : Studies on susceptibility factors for toxic chemicals and drug-metabolizing system
  • Fiscal Year: 2006
    • 10015 : Endocrine disrupting effect of low-dose irradiation on spermatogenesis
    • 10087 : Mutagenesis in zebrafish by the exposure of space-radiation
    • 10097 : Studies on susceptibility factors for toxic chemicals and drug-metabolizing system
    • 10122 : Evaluation of sensitivity of aged animal tp mutagens in ambient air
    • 10354 : Development of the prediction method for the carcinogenicity evaluation
  • Fiscal Year: 2005
    • 9333 : Exposure and health effects assessment of dioxins
    • 9430 : Endocrine disrupting effect of low-dose irradiation on spermatogenesis
    • 9446 : Study on the establishment of scientific and technical foundation for assessment of sources, development of destruction method and elucidation of pollution status of POPs-like compounds, especially organofluorine chemicals
    • 9454 : Studies on the effect of genetically modified organisms on biodiversity and its gene behavior in environment
    • 9466 : Studies on quantitative structure-activity relationship for risk assessment of chemicals --- A study on three dimensional structure-activity relationship modeling based on repeat dose toxicity test
    • 9521 : Studies on application of toxicogenomics for risk assessment of environmental pollutants
    • 9558 : Mutagenesis in zebrafish by the exposure of space-radiation
    • 9565 : Studies on susceptibility factors for toxic chemicals and drug-metabolizing system
  • Fiscal Year: 2004
    • 8958 : Exposure and health effects assessment of dioxins
    • 9081 : Sensitive sensing for exposure of mutagens in ambient air by gene-knockout mouse and evaluation of their effects
    • 9113 : Endocrine disrupting effect of low-dose irradiation on spermatogenesis
    • 9163 : Study on the establishment of scientific and technical foundation for assessment of sources, development of destruction method and elucidation of pollution status of POPs-like compounds, especially organofluorine chemicals
    • 9171 : Studies on the effect of genetically modified organisms on biodiversity and its gene behavior in environment
    • 9184 : Studies on quantitative structure-activity relationship for risk assessment of chemicals --- A study on three dimensional structure-activity relationship modeling based on repeat dose toxicity test
    • 9209 : Risk analysis of dioxin using mathematical and biological model.
    • 9272 : Studies on application of toxicogenomics for risk assessment of environmental pollutants
    • 9307 : Analysis of health risk of dioxin to humans using mathematical and biological model.
    • 9308 : Mutagenesis in zebrafish by the exposure of space-radiation
    • 9315 : Studies on susceptibility factors for toxic chemicals and drug-metabolizing system
  • Fiscal Year: 2003
    • 8610 : Elucidation of endocrine disrupting mechanism of dioxin and related compounds for health risk assessment
    • 8636 : Exposure and health effects assessment of dioxins
    • 8801 : Sensitive sensing for exposure of mutagens in ambient air by gene-knockout mouse and evaluation of their effects
    • 8827 : Endocrine disrupting effect of low-dose irradiation on spermatogenesis
    • 8898 : Study on the establishment of scientific and technical foundation for assessment of sources, development of destruction method and elucidation of pollution status of POPs-like compounds, especially organofluorine chemicals
    • 8906 : Studies on the effect of genetically modified organisms on biodiversity and its gene behavior in environment
  • Fiscal Year: 2002
    • 8324 : Effects of environmental pollutants on male reproductive function
    • 8339 : Elucidation of endocrine disrupting mechanism of dioxin and related compounds for health risk assessment
    • 8343 : Studies for estimating health effects of oxidative stresses induced by environmental chemicals
    • 8375 : Development of a bioassay system for the estimation of the toxicity of polluted water using transgenic zebrafish
    • 8386 : Analysis of alteration of placental functions associated with the fetal growth abnormalities by environmental toxic substances
    • 8399 : Exposure and health effects assessment of dioxins
    • 8598 : Radiative transfer analysis for satellite remoto sensing date of atmospheres
  • Fiscal Year: 2001
    • 8031 : Effects of environmental pollutants on male reproductive function
    • 8056 : A-4  Studies on the risk assessment of ultraviolet radiation and the establishment of preventive measures A-4(2) Prediction of ultraviolet radiation change and assessment of its health risks
    • 8084 : Elucidation of endocrine disrupting mechanism of dioxin and related compounds for health risk assessment
    • 8096 : Studies for estimating health effects of oxidative stresses induced by environmental chemicals
    • 8129 : Development of a bioassay system for the estimation of the toxicity of polluted water using transgenic zebrafish
    • 8139 : Analysis of alteration of placental functions associated with the fetal growth abnormalities by environmental toxic substances
    • 8152 : Exposure and health effects assessment of dioxins
Research Result (Publication)
  • all
  • Original Paper
  • Review
  • Book
  • Presenter : Furuhama A., Hasunuma K., Aoki Y.
    Title : , SAR and QSAR in Environmental Research, 27(3):245-247 (2016)
  • Book
    Nrf2 as a possible determinant of the threshold for carcinogenesis
    Presenter : Aoki Y.
    Title : , Thresholds of genotoxic carcinogens: From mechanisms to regulation (2016)
  • Presenter : Furuhama A., Hasunuma K., Aoki Y.
    Title : , SAR and QSAR in Environmental Research, 26(4):301-323 (2015)
  • Presenter : Furuhama A., Hasunuma K., Aoki Y.
    Title : , SAR and QSAR in Environmental Research, 26(10):809-830 (2015)
  • Presenter : Jagiello K., Mostrag-Szlichtyng A., Gajewicz A., Kawai T., Imaizumi Y., Sakurai T., Yamamoto H., Tatarazako N., Mizukawa K., Aoki Y., Suzuki N., Watanabe H., Puzyn T.
    Title : , Environmental Modelling & Software, 72:147-154 (2015)
  • Presenter : Aoki Y., Hashimoto A.H., Sugawara Y., Hiyoshi-Arai K., Goto S., Masumura K., Nohmi T.
    Title : , Genes and Environment, 37(7): (2015)
  • Presenter : Takumi S., Aoki Y., Sano T., Suzuki T., Nohmi T., Nohara K.
    Title : , Mutation Research, 760:42-47 (2014)
  • Presenter : Takumi S., Aoki Y., Sano T., Suzuki T., Nohmi T., Nohara K.
    Title : , Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 760:42-47 (2014)
  • Original Paper
    Effect of exposure to nanoparticle-rich or delpeted diesel exhaust on allergic pathophysiology in the murine lung
    Presenter : Tanaka M., Aoki Y., Takano H., Fujitani Y., Hirano S., Nakamura R., Sone Y., Kiyono M., Ichinose T., Itoh T., Inoue K.
    Title : , Journal of Toxicological Sciences, 38(1):35-48 (2013)
  • Presenter : Furuhama A., Aoki Y., Shiraishi H.
    Title : , SAR and QSAR in Environmental Research, 23(1-2):169-184 (2012)
  • Presenter : Furuhama A., Aoki Y., Shiraishi H.
    Title : , SAR and QSAR in Environmental Research, 23(7-8):731-749 (2012)
  • Review
    Health risk assessment of air pollutants: Air pollutant genotoxicity and its enhancement by suppression of phase II drug-metabolizing enzymes
    Presenter : Aoki Y.
    Title : , Genes and Environment, 34(4):186-190 (2012)
  • Original Paper
    Estimation of the respiratory ventilation rate of preschool children in daily life using accelerometers
    Presenter : Kawahara J., Tanaka C., Tanaka C., Hikihara Y., Aoki Y., Yonemoto J.
    Title : , J.Air Waste Manag.Assoc., 61(1):46-54 (2011)
  • Presenter : Furuhama A., Hasunuma K., Aoki Y., Yoshioka Y., Shiraishi H.
    Title : , SAR and QSAR in Environmental Research, 22(5-6):505-523 (2011)
  • Presenter : Kawahara J., Tanaka S., Tanaka C., Aoki Y., Yonemoto J.
    Title : , Science of the Total Environment , 409(16):3073-3077 (2011)
  • Book
    Chapter7: Potency of air pollutants at DNA adduct formation and assessment by in vivo mutagenesis
    Presenter : Aoki Y., Hashimoto A.H., Sato H. , Matsumoto M.
    Title : , DNA Adducts: Formation, Detection and Mutagenesis (2010)
  • Presenter : Furuhama A., Toida T., Nishikawa N., Aoki Y., Yoshioka Y., Shiraishi H.
    Title : , SAR QSAR Environ.Res. , 21(5/6):403-413 (2010)
  • Original Paper
    In vivo mutagenesis caused by diesel exhaust in the testis of gpt delta transgenic mice
    Presenter : Hashimoto A.H, Amanuma K., Masumura K., Nohmi T., Aoki Y.
    Title : , Genes Environ., 31(1):1-8 (2009)
  • Original Paper
    Examination of integrated pML4 DNA transfer from genetically modified zebrafish to bacteria
    Presenter : Hashimoto A.H., Amanuma K., Iwasaki K., Aoki Y.
    Title : , J.Environ.Biotechnol., 9(1):31-36 (2009)
  • Presenter : Aoki Y.
    Title : , J.Health Sci., 55(6):857-859 (2009)
  • Original Paper
    Genetically modified red fluorescent zebrafish: detection crossing, inheritance of red fluorescence, and tolerance to low temperatures
    Presenter : Amanuma K., Nakajima N., Hashimoto A.H, Aoki Y.
    Title : , J.Environ.Biotechnol., 8(2):105-110 (2008)
  • Presenter : Hashimoto A.H., Amanuma K., Hiyoshi K., Sugawara Y., Goto S., Yanagisawa R., Takano H., Masumura K., Nohmi T., Aoki Y.
    Title : , Environ.Mol.Mutagen., 48(8):682-693 (2007)
  • Presenter : Hashimoto A.H., Amanuma K., Hiyoshi K.(*1), Takano H., Masumura K-i.(*2), Nohmi T.(*2), Aoki Y.
    Title : , Environ.Mol.Mutagen., 47:277-283 (2006)
  • Presenter : Maruyama W., Aoki Y.
    Title : , Toxicol.Appl.Pharmacol., 214:188-198 (2006)
  • Suppression of carbonic anhydrase III mRNA level by an aryl hydrocarbon receptor ligand in primary cultured hepatocytes of rat
    Presenter : Ishii Y.(*1), Akazawa D.(*1), Aoki Y., Yamada H.(*1), Oguri K.(*1)
    Title : , Biol.Pharm.Bull., 28(6):1087-1090 (2005)
  • In Vivo mutagenesis induced by benzo[a]pyrene instilled into the lung of gpt delta transgenic Mice
    Presenter : , Aoki Y.
    Title : , Environ.Mol.Mutagen., 45:365-373 (2005)
  • Presenter : Maruyama W., Yoshida K.(*1), Aoki Y.
    Title : , Environ.Toxicol.Pharmacol., 18:21-37 (2004)
  • DNA-adduct formation in lungs,nasal mucosa,and livers of rats exposed to urban roadside air in Kawasaki City,Japan
    Presenter : Sato H.(*1), Suzuki K.T.(*1), Sone H., Yamano Y.(*2), Kagawa J.(*2), Aoki Y.
    Title : , Environ.Res., 93:36-44 (2003)
  • Fffects of 3,3',4,4',5-pentachlorobiphenyl,a coplanar polychlorinated biphenyl congener,on cultured neonatal mouse testis
    Presenter : , Aoki Y.
    Title : , Toxicol.Vitro, 17:259-269 (2003)
  • Altered protein profile and possible hypoxia in the placenta of 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed rats
    Presenter : , , Aoki Y.
    Title : , Toxicol.Appl.Pharmacol., 185:197-206 (2003)
  • Distinct response to dioxin in an arylhydrocarbon receptor(AHR)-humanized mouse
    Presenter : , Nishimura N., Aoki Y.
    Title : , PNAS, 100(10):5652-5657 (2003)
  • Mutational spectra of benzo[a]pyrene and MeIQx in rpsL transgenic zebrafish embryos
    Presenter : Aoki Y.
    Title : , Mutat.Res., 513:83-92 (2002)
  • Cloning and sequences of beta-actin genes from rhodeus notatus and the silver carp Hypophthalmichthys molitrix(Cyprinidae) and the phylogeny of cyprinid fishes inferred from beta-actin genes
    Presenter : Hwang U.W.(*1), Han M.S.(*2), Kim I.C.(*2), Lee Y.S.(*2), Aoki Y., Lee J.S.(*2)
    Title : , DNA Sequence, 13(3):153-159 (2002)
  • Mutagenesis by environmental pollutants and bio-monitoring of environmental mutagens
    Presenter : Aoki Y.
    Title : , Curr.Drug Metab., 3(3):311-319 (2002)
  • Increased glycogen content and glucose transporter 3 mRNA level in the placenta of Holtzman rats after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Presenter : , , , Aoki Y.
    Title : , Toxicol.Appl.Pharmacol., 178:161-171 (2002)
  • Mutational spectra of benzo[a]pyrene and MeIQx in rpsL transgenic zebrafish embryos
    Presenter : Aoki Y.
    Title : , Mutat.Res., 513:83-92 (2002)
  • Paradoxical increase of heat-shock response with age in a substrain of F344 rats-comparison between F344/DuCrj and F344/Jcl
    Presenter : Takahashi R.(*1), Toyoda E.(*1), Aoki Y., Suzuki K.T.(*2), Goto S.(*1)
    Title : , Mech.Ageing Develop., 123:1605-1615 (2002)
  • Bisphenol-A affects spermatogenesis in the adult rat even at a low dose
    Presenter : , Ishimura R., , Aoki Y.
    Title : , J.Occup.Health, 43(4):185-190 (2001)
  • Quantitative changes in glycosaminoglycans in the lungs of rats exposed to diesel exhaust
    Presenter : Sato H.(*1), Onose J.(*1), Toyoda H.(*1), Toida T.(*1), Imanari T.(*1), Sagai M.(*2), Nishimura N., Aoki Y.
    Title : , Toxicology, 166:119-128 (2001)
  • Induction of metallothionein in the livers of female Sprague-Dawley rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Presenter : , , , Suzuki J., Aoki Y.
    Title : , Life Sci., 69:1291-1303 (2001)
  • Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust
    Presenter : , , Aoki Y.
    Title : , Toxicol.Appl.Pharmacol., 173:154-160 (2001)
  • Polychlorinated biphenyls,polychlorinated dibenzo-p-dioxins,and polychlorinated dibenzofurans as endocrine disrupters-What we have learned from Yusho disease
    Presenter : Aoki Y.
    Title : , Environ.Res.Sect.A, 86:2-11 (2001)
  • Inhibitory effect of 2,3,7,8- tetrachlorodibenzo-p-dioxin on cAMP-induced differentiation of rat C6 glial cell line
    Presenter : Takanaga H.(*1), Kunimoto M., Adachi T., Tohyama C., Aoki Y.
    Title : , J.Neurosci.Res., 64:402-409 (2001)
  • Maternal Exposure to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) suppressed the development of reproductive organs of male rats:
    Presenter : , , SONE Hideko, Aoki Y.
    Title : , Toxicol.Sci., 60(1):132‐143 (2001)
  • Induction of cytochrome P450 1B1 in lung,liver and kidney of rats exposed to diesel exhaust
    Presenter : Hatakeyama N.(*1), Yamazaki H.(*1), Kizu R.(*1), Hayakawa K.(*1), Aoki Y., Iwanari M.(*1), Nakajima M.(*1), Yokoi T.(*1)
    Title : , Carcinogenesis, 22(12):2033-2038 (2001)
  • Heart shock protein 73 and transferrin as early biomarkers for UV-B-induced response in the skin of hairless mice
    Presenter : , Aoki Y.
    Title : , Environ.Sci., 7(4):259-267 (2000)
  • Epidermal growth factor regulation of glutathione S-transferase gene expression in the rat is mediated by class Pi glutathione S-transferase enhancer I
    Presenter : Matsumoto M., Aoki Y.
    Title : , Biochem.J., 349:225‐230 (2000)
  • Increase in mutation frequency in lung of Big Blue rat by exposure to diesel exhaust
    Presenter : SONE Hideko, Aoki Y.
    Title : , Carcinogenesis, 21(4):653‐661 (2000)
  • Transgenic zebrafish for detecting mutations caused by compounds in aquatic environments
    Presenter : Aoki Y.
    Title : , Nat.Biotechnol., 18(1):62‐65 (2000)
  • Identification,by cDNA microarray,of A-raf and proliferating cell nuclear antigen as genes induced in rat lung by exposure to diesel exhaust
    Presenter : Aoki Y.
    Title : , Res.Commun.Mol.Patho;Pharmacol., 105(1&2):77‐86 (1999)
  • Cytotoxicity and Mutagenicity of UVB Assessed Using Cultured Rat Fibroblast
    Presenter : Aoki Y.
    Title : , J.Epidemiol., 9(6 Suppl.):72‐77 (1999)
  • Identification of an enhancer element of class Pi glutathione S-transferase gene required for expression by a co-planar polychlorinated biphenyl
    Presenter : Matsumoto M., Aoki Y.
    Title : , Biochem.J., 338:599‐605 (1999)
  • Risk assessment of the flavonoids,quercetin as an endocrine modifier
    Presenter : , , SONE Hideko, Aoki Y.
    Title : , J.Risk Res., 2(2):151‐166 (1999)
  • Metallothionein Deficiency Promotes Mouse Skin Carcinogenesis Induced by 7,12-Dimethylbenz(a)anthracene
    Presenter : , , SONE Hideko, Suzuki J., Aoki Y.
    Title : , Cancer Res., 58:4044‐4046 (1998)
  • MEIC Evaluation of Acute Systemic Toxicity
    Presenter : Aoki Y.
    Title : , ATLA, (26):131‐183 (1998)
  • Expression of Glutathione S-Transferase P by Coplanar PCB in Rat Hepatocytes
    Presenter : Matsumoto M., Aoki Y.
    Title : , Jpn.J.Toxicol.Environ.Health, 44(1):P・47 (1998)
  • Modulated cytokine production from cervical lymph node cells treated with B[a]P and PCB
    Presenter : , , Aoki Y.
    Title : , Chemosphere, 34(5-7):1487‐1493 (1997)
  • Protective role of metallothionein in renal toxicity of cisplatinum
    Presenter : , Aoki Y.
    Title : , Cancer Chemother.Pharmacol., 40:358‐362 (1997)
  • Protective Role of Metallothionein in Cisplatin-Caused Renal Toxicity
    Presenter : , Aoki Y.
    Title : , Trace Elements in Man and Animals-9(Fisher P.W.F.,L'Abbe M.R.,Cockell K.A.,Gibson R.S.ed.,NRC Research Press,667p.), 572‐573 (1997)
  • Methods of Metal Toxicology 1.3.1 Cell Cultures
    Presenter : Aoki Y.
    Title : , Handbook of Human Toxicology (Massaro E.J.ed.,CRC Press,1111p.), 88‐103 (1997)
  • Methods of Metal Toxicology 1.1.7 Western Blotting Methods
    Presenter : Aoki Y.
    Title : , Handbook of Human Toxicology (Massaro E.J.ed.,CRC Press, 1111p.), 32‐35 (1997)
  • Characterization of mutations induced by 300 and 300 nm UV radiation in a rat fibroblast cell line
    Presenter : Aoki Y.
    Title : , Mutat.Res., 372:119‐131 (1996)
  • Phosphorylation of c-Jun stimulated in primary cultured rat liver parenchymal cells by a coplanar polychlorinated biphenyl
    Presenter : Aoki Y.
    Title : , Biochem.J., 313:863‐860 (1996)
  • Copper metabolism leading to and following acute hepatitis in LEC rats
    Presenter : Aoki Y.
    Title : , Toxicology, 97:81‐92 (1995)
  • Induction of glutathione S-transferase II in mouse liver parenchymal cells by 3453'4'-pentachlorobiphenyl-comparison between C57BL strain and DBA strain
    Presenter : Matsumoto M., Aoki Y.
    Title : , Jpn.J.Toxicol.Environ.Health., 41:33 (1995)
  • Enhanced synthesis of metallothionein as a possible cause of abnormal copper accumulation in LEC rats
    Presenter : Suzuki J., Aoki Y.
    Title : , J.Inorg.Biochem., 56:117‐125 (1994)
  • Mechanisms for removal of copper from metallothionein by tetrathiomolybdate
    Presenter : Aoki Y.
    Title : , J.Inorg.Biochem., 54:157‐165 (1994)
  • Altered protein synthesis in rat kidney cells exposed to semiconductor materials
    Presenter : Aoki Y.
    Title : , Appl.Organomet.Chem., 8:253‐258 (1994)
  • Accumulation of copper in the liver as the cause of acute hepatitis in LEC rats
    Presenter : Aoki Y.
    Title : , Metal Ions in Biol. and Med.(John Libbey,585p.), 3:187‐192 (1994)
  • Induction of glutathione S-Transferase-P by chlorinated biphenyls and dibenzofurans, and inhibitory effect of dexamethasone on the induction
    Presenter : Matsumoto M., Aoki Y.
    Title : , Jpn.J.Toxicol.Environ.Health, 40:P‐15 (1994)
  • -
    Presenter : AOKI Yasunobu
    Title : , トキシコロジー用語集(薬業時報社,311p.) (1993)
  • Selective removal of copper bound to metallothionein in the liver of LEC rats by tetrathiomolybdate
    Presenter : Aoki Y.
    Title : , Toxicology, 83:149‐158 (1993)
  • Expression of glutathione S-transferase P-form in primary cultured rat liver parenchymal cells by coplanar polychlorinated biphenyl congeners is suppressed by protein kinase inhibitors and dexamethasone
    Presenter : Matsumoto M., Aoki Y.
    Title : , FEBS Lett., 333:114‐118 (1993)
  • Induction of glutathione S-Transferase P-Form in rat hepatocytes by coplanar polychlorinated biphenyl congeners and its mechanism
    Presenter : Matsumoto M., Aoki Y.
    Title : , Jpn.J.Toxicol.Environ.Health, 39:P‐24 (1993)
  • ATP-dependent strontium uptake by basolateral membrane vesicles from rat renal cortex in the absence or presence of calcium
    Presenter : Aoki Y.
    Title : , Biol.Trace Elem.Res., 34:45‐54 (1992)
  • Differential cytotoxic effects of methylmercury and organotin compounds on mature and immature neuronal cells and non-neuronal cells in vitro
    Presenter : Aoki Y.
    Title : , Toxicol.in Vitro, 6(4):349‐355 (1992)
  • Induction of glutathione S-transferase P-form in primary cultured rat liver parenchymal cells by co-planar polychlorinated biphenyl congeners
    Presenter : Aoki Y.
    Title : , Biochem.J., 281:539‐543 (1992)
  • Binding of cadmium to alcohol dehydrogenase in the liver before induction of metallothionein
    Presenter : Aoki Y.
    Title : , Res.Commun.Chem.Pathol.Pharmacol., 74:223‐236 (1991)
  • A simple method for in situ freezing of anchorage-dependent cells including rat liver parenchymal cells
    Presenter : Aoki Y.
    Title : , Cytotechnology, 5:273‐277 (1991)
  • Detection of metallothionein by western blotting
    Presenter : Aoki Y.
    Title : , Methods Enzymol.(Acad.Press,681p.), 108‐114 (1991)
  • Different distribution of cadmium in the liver supernatant between in vivo and in vitro
    Presenter : Aoki Y.
    Title : , Res.Commun.Chem.Pathol.Pharmacol., 74:215‐222 (1991)
  • A western blotting procedure for detection of metallothionein
    Presenter : , Aoki Y.
    Title : , J.Biochem.Biophys.Methods, 23:207‐216 (1991)
  • Alteration in protein synthesis in primary cultures of rat kidney proximal tubule epithelial cells by exposure to gallium, indium, and arsenite
    Presenter : Aoki Y.
    Title : , Toxicol.Appl.Pharmacol., 106:462‐468 (1990)
  • Induction of protein synthesis by exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in primary cultured rat liver parenchymal cells and rat livers
    Presenter : Aoki Y.
    Title : , Eisei Kagaku, 36:22p. (1990)
  • Comparison of cadmium-binding protein induction among mayfly larvae of heavy metal resistant (Baetis Thermicus) and susceptible species (B.Yoshinensis and B.Sahoensis)
    Presenter : Aoki Y.
    Title : , Comp.Biochem.Physiol., 93C:345‐347 (1989)
  • Inhibitory effects of cadmium on rat ornithine carbamoyltransferase and urea synthesis in the rat liver parenchymal cells
    Presenter : Aoki Y.
    Title : , Res.Commun.Chem.Pathol.Pharmacol., 63:411‐422 (1989)
  • The major cadmium-binding protein before induction of metallothionein in the rat liver is alcohol dehydrogenase
    Presenter : Aoki Y.
    Title : , Eisei Kagaku, 35:S‐21 (1989)
  • Binding of cadmium and copper in the mayfly baetis thermicus larvae that inhabit a river polluted with heavy metals
    Presenter : , Aoki Y.
    Title : , Comp.Biochem.Physiol., 91C:487‐492 (1988)
  • A cadmium-binding protein in rat liver identified as ornithine carbamoyl transferase
    Presenter : Aoki Y.
    Title : , Biochem.J., 250:735‐742 (1988)
  • Accumulation of newly synthesized serum proteins by cadmium in cultured rat liver parenchymal cells
    Presenter : Aoki Y.
    Title : , Biochem.Pharmacol., 36:3657‐3661 (1987)
  • Cadmium inhibits protein secretion from cultured rat liver parenchymal cells
    Presenter : Aoki Y.
    Title : , Biochem.Pharmacol., 36:2647‐2652 (1987)
  • Cadmium-induced inhibition of protein secretion from liver: pretreatment effect and specificity among cadmium, copper and zinc
    Presenter : Aoki Y.
    Title : , Biochem.Pharmacol., 36(13):2225‐2227 (1987)
  • Detection of a zinc-containing protein as the primary cadmium-binding protein before induction of metallothionein in rat liver
    Presenter : Aoki Y.
    Title : , EISEI KAGAKU, 33(6):423‐430 (1987)
  • Identification of cadmium-binding proteins using western blotting technique
    Presenter : SHIBATA Yasuyuki, Aoki Y.
    Title : , Toxicology of Metals: Clinical and Experimental Research (Brown S.S. & Kodama Y. ed.,EllisHorwood,448p.), 301‐302 (1987)
  • Characterization of cadmium-binding proteins detected in rat liver by the western blotting technique
    Presenter : Aoki Y., Suzuki K.T.
    Title : , J.Biochem.Toxicol., 2:67‐71 (1987)
  • Detection of metallothionein on nitrocellulose membrane using western blotting technique and its application to identification of cadmium-binding proteins
    Presenter : SHIBATA Yasuyuki, Aoki Y.
    Title : , Anal.Biochem., 157:117‐122 (1986)
  • Effect of cadmium on secretion of proteins from rat liver
    Presenter : Mitane Y., Aoki Y., Uehara H., Takano Y., Suzuki K.T.
    Title : , Eisei Kagaku, 32:P‐27 (1986)
  • Inhibition of protein secretion from liver by cadmium
    Presenter : Suzuki K.T., Uehara H., Takano Y., Aoki Y.
    Title : , Biochem.Pharmacol., 34:4171‐4173 (1985)
  • Depression of serum cholinesterase activity by cadmium
    Presenter : Uehara H., Aoki Y., Shimojo N., Suzuki K.T.
    Title : , Toxicology, 36:131‐138 (1985)
  • Excretion process of copper from copper pre-loaded rat liver parenchymal cells
    Presenter : Aoki Y., Suzuki K.T.
    Title : , Biochem.Pharmacol., 34:1713‐1716 (1985)
  • Effects of diet on tissue accumulation of cadmium and its toxicological indicators
    Presenter : , Aoki Y.
    Title : , Eisei Kagaku, 31:P‐50 (1985)
  • Difference in tolerance mechanism to cadmium among three insect larvae (midge, fleshfly and silkworm)
    Presenter : Suzuki K.T., Yamamura M., Hatakeyama S., Aoki Y., Masui H., Matsubara F., Sumi Y., Suzuki T.
    Title : , J.Pharmacobio-Dyn., 8:S25 (1985)
  • Effect of cadmium-feeding on tissue concentrations of elements in germ-free silkworm (bombyx mori) larvae and distribution of cadmium in the alimentary canal
    Presenter : , Aoki Y.
    Title : , Comp.Biochem.Physiol., 79C:249‐253 (1984)
  • Excretion of cadmium and change in the relative ratio of iso-cadmium-binding proteins during metamorphosis of fleshfly (Sarcophaga peregrina)
    Presenter : Aoki Y., Suzuki K.T.
    Title : , Comp.Biochem.Physiol., 78C:315‐317 (1984)
  • Accumulation of cadmium and induction of its binding protein in the digestive tract of fleshfly (Sarcophaga peregrina) larvae
    Presenter : Aoki Y., Suzuki K.T., Kubota K.
    Title : , Comp.Biochem.Physiol., 77C:279‐282 (1984)
  • Separation of metallothionein on gel permeation, ion exchange and reversed-phase columns by HPLC-AAS
    Presenter : Suzuki K.T., Sunaga H., Aoki Y., Yamamura M.
    Title : , J.Pharm.Dyn., 7:S‐5 (1984)
  • Gel permeation, ion-exchange and reversed-phase columns for separation of metallothioneins by high-performance liquid chromatography-atomic absorption spectrophotometry
    Presenter : Suzuki K.T., Sunaga H., Aoki Y., Yamamura M.
    Title : , J.Chromatogr., 281:159‐166 (1983)
  • Health risk assessment of air pollutants: Air pollutant genotoxicity and its enhancement by suppression of phase II drug-metabolizing enzymes
    Presenter : Aoki Y.
    Title : , Genes and Environment, 34(4):186-190 (2012)
  • Nrf2 as a possible determinant of the threshold for carcinogenesis
    Presenter : Aoki Y.
    Title : , Thresholds of genotoxic carcinogens: From mechanisms to regulation (2016)
  • Chapter7: Potency of air pollutants at DNA adduct formation and assessment by in vivo mutagenesis
    Presenter : Aoki Y., Hashimoto A.H., Sato H. , Matsumoto M.
    Title : , DNA Adducts: Formation, Detection and Mutagenesis (2010)
Research Result (Presentation)
  • all
  • Research Presentation
  • Research Lecture
  • Presenter : Udagawa O., KATO A., Kobayashi Y., Aoki Y., Hirano S.
    Name of Society : 2015 Cellular & Molecular Mechanisms of Toxicity Gordon Research Conference (2015)
    Name of Proceedings : Abstracts, 16
  • Research Presentation
    Threshold of mutagenesis induced by a reactive oxygen species-generating compound, potassium bromate, in the small intestine of gpt delta mice
    Presenter : Aoki Y.
    Name of Society : Gordon Research Conference on Cellular & Molecular Mechanism of Toxicity (2015)
    Name of Proceedings : Abstract
  • Presenter : Furuhama A., Hasunuma K., Aoki Y.
    Name of Society : 8th International Symposium on Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (CMTPI-2015) (2015)
    Name of Proceedings : Abstracts, 35
  • Presenter : Furuhama A., Hasunuma K., Aoki Y.
    Name of Society : 16th International Workshop on Quantitative Structure-Activity Relationships in Environmental and Health Sciences (QSAR2014) (2014)
    Name of Proceedings : Abstracts, 134
  • Presenter : Takumi S., Aoki Y., Sano T., Suzuki T., Nohmi T., Nohara K.
    Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
    Name of Proceedings : Abstracts
  • Research Lecture
    Transgenic animal models as a tool for risk assessment of environmental mutagens
    Presenter : Aoki Y.
    Name of Society : 4th Asian Conference on Environmental Mutagens (2014)
    Name of Proceedings : Abstract
  • Research Presentation
    CONTRIBUTION OF BENZO[A]PYRENE TO MUTAGENICITY IN AMBIENT AIR COLLECTED AT 11 SITES IN JAPAN FROM 2007 TO 2009
    Presenter : Goto S., Yagishita M., Kageyama S., Shiraishi F., Aoki Y., Wang Q., Mineki S., Ohshima S., Nakajima D.
    Name of Society : 2013 International Symposium of Polycyclic Aromatic Compounds (2013)
    Name of Proceedings : Abstracts
  • Research Presentation
    CONCENTRATIONS OF PAHs, O-PAHs AND PASHs IN TOTAL SUSPENDED PARTICULATE AND GASEOUS PHASE IN JAPAN
    Presenter : Yagishita M., Kageyama S., Shiraishi F., Terasaki M., Aoki Y., Wang Q., Ohshima S., Goto S., Nakajima D.
    Name of Society : 2013 International Symposium of Polycyclic Aromatic Compounds (2013)
    Name of Proceedings : Abstracts
  • Research Lecture
    Environmental and human health impacts of pollutants generated by energy production
    Presenter : Aoki Y.
    Name of Society : Harvard Project for Asia and International Relations 2013 Asia Conference (2013)
    Name of Proceedings : -
  • Research Lecture
    Risk Assessment of Environmental Chemicals
    Presenter : Aoki Y.
    Name of Society : ILSI HESI Workshop (2013)
    Name of Proceedings : -
  • Presenter : Furuhama A., Aoki Y., Shiraishi H.
    Name of Society : 5th JCS International Symposium on Theoretical Chemistry (2013)
    Name of Proceedings : Abstract
  • Research Presentation
    In Vivo Mutagenicity of Arsenic
    Presenter : Takumi S., Aoki Y., Nohara K.
    Name of Society : NIES Arsenic Workshop 2013 (2013)
    Name of Proceedings : Abstracts, 17
  • Research Lecture
    In vivo mutagenesis resulting from oxidative stress in mice with suppressed phase II drug-metabolizing enzyme expression
    Presenter : Aoki Y.
    Name of Society : 11th International conference on environmental mutagens (2013)
    Name of Proceedings : Abstract
  • Research Presentation
    Comparison of Risk Assessment Values of Hazardous Chemicals Estimated Based on Animal Inhalation Studies with the Guideline Values for Ambient Air Based on Epidemiological Studies
    Presenter : Matsumoto M., Matsumoto Y., Aoki Y.
    Name of Society : The 6th International Congress of Asian Society of Toxicology (2012)
    Name of Proceedings : The Journal of Toxicological Sciences (The 6th International Congress of Asian Society of Toxicology, Program and Abstracts), 37(Suppl. ?):S 412
  • Research Presentation
    Manganese protects against cadmium cytotoxicity via a lower expression of ZIP8 and ZIP14 in vascular endothelial cells
    Presenter : Ando R., Takahashi S., Yamamoto C., Aoki Y., Kaji T.
    Name of Society : 6th International Congress of Asian Society of Toxicology (2012)
    Name of Proceedings : Abstracts
  • Presenter : Furuhama A., Aoki Y., Shiraishi H.
    Name of Society : The 15th International Workshop on Quantitative Structure-Activity Relationships (QSAR2012) in Environmental and Health Sciences (2012)
    Name of Proceedings : Abstracts, 62
  • Research Presentation
    Comparative study on the utilities of animal experimental data for risk assessment of inhalation exposure of chemicals
    Presenter : Aoki Y., Matsumoto Y., Matsumoto M.
    Name of Society : SOT 2012 Annual Meeting (2012)
    Name of Proceedings : Abstract of SOT 2012 Annual Meeting, 27
  • Research Presentation
    Distribution of polycyclic aromatic sulfur heterocycles in total suspended particle and gaseous phase in Japan
    Presenter : Yagishita M., Kageyama S., Takemura T., Shiraishi F., Aoki Y., Shiraishi H., Wang Q., Ohshima S., Goto S., Nakajima D.
    Name of Society : International Symposium on Aerosols in East Asia and Their Impacts on Plants and Human Health (2012)
    Name of Proceedings : Abstracts, 144-145
  • Presenter : Furuhama A., Aoki Y., Shiraishi H.
    Name of Society : Ninth Triennial Congress of the WORLD ASSOCIATION OF THEORETICAL AND COMPUTATIONAL CHEMISTS WATOC 2011 (2011)
    Name of Proceedings : Abstracts of Ninth Triennial Congress of the WORLD ASSOCIATION OF THEORETICAL AND COMPUTATIONAL CHEMISTS WATOC 2011
  • Presenter : Aoki Y.
    Name of Society : Environmental Health 2011 Oral programme (2011)
  • Research Lecture
    Health risk assessemnt of air pollutants: Air pollutant genotoxicity and its enhancement on suppression of phase II drug-metabolizing enzymes
    Presenter : Aoki Y.
    Name of Society : International Symposium on Genotoxic and Carcinogenic Thresholds (2011)
    Name of Proceedings : Abstract, 28
  • Research Presentation
    Functional prediction analysis based on global gene expression by using Nrf2 Knockout mouse liver exposed to TCDD
    Presenter : Sato H. , Matsumoto M., Aoki Y., Itoh K., Yamamoto M.
    Name of Society : 12th Int.Congr.Toxicol. (2010)
    Name of Proceedings : Toxicol.Lett., 196(Suppl.1):S208
  • Presenter : Furuhama A., Hasunuma K., Aoki Y., Yoshioka Y., Shiraishi H.
    Name of Society : 14th Int.Workshop QSARs Environ.Health Sci. (2010)
    Name of Proceedings : Abstracts, 40
  • Research Presentation
    In vivo mutagenicity of ambient air in the lungs of gpt delta transgenic mice;A case study in Tsukuba city,Japan
    Presenter : Sato H. , Nakajima D., Kageyama S., Sakashita Y. , Yanagisawa R., Masumura K., Nohmi T., Aoki Y.
    Name of Society : 2nd Asian Conf.Environ.Mutagens (2010)
    Name of Proceedings : Abstracts
  • Research Presentation
    External validation of ecotoxicity prediction QSAR system,“KAshinhou Tool for Ecotoxicity” (KATE)
    Presenter : Hasunuma K., Furuhama A., Aoki Y., Sugaya Y., Yoshioka Y., Shiraishi H.
    Name of Society : 2nd Korea-Jpn.Symp.Environ.Chem./韓国環境分析学会秋季学術大会 (2010)
    Name of Proceedings : Abstracts, 249
  • Presenter : Aoki Y.
    Name of Society : 10th Int.Conf.Environ.Mutagens(ICEM) (2009)
    Name of Proceedings : Abstracts, 70
  • Presenter : Aoki Y., Hashimoto A.H., Matsumoto M., Sugawara Y., Goto S., Masumura K., Nohmi T.
    Name of Society : CCT Meet.PPTOXII: Role of Environmental Stressors in the Developmental Origins of Disease (2009)
    Name of Proceedings : Abstracts, VI.15
  • Research Presentation
    In vivo mutagenesis induced by the air pollutants in the testis of gpt delta transgenic mice
    Presenter : Aoki Y., Hashimoto A.H., Amanuma K., Matsumoto M., Masumura K., Nohmi T.
    Name of Society : 21st Cent.Adv.Mol.Toxicol.Environ.Chem.Pathog.Dis. (2009)
    Name of Proceedings : Abstracts, 173
  • Research Presentation
    Assessment of in vivo mutagenesis induced by environmental chemicals using transgenic animals for detecting mutagens
    Presenter : Aoki Y.
    Name of Society : 2nd Int.Conf.Environ.Health Sci. (2009)
    Name of Proceedings : Speaker's Presentation Materials, 189-196
  • Research Presentation
    In vivo mutagenesis induced in the testis of gpt delta transgenic mice by inhalation of diesel exhuast
    Presenter : Aoki Y., Hashimoto A.H., Amanuma K., Masumura K., Nohmi T.
    Name of Society : Gordon Res.Conf.Mech.Toxicity (2008)
    Name of Proceedings : -
  • Research Presentation
    Risk assessment of chlorinated organic compounds using immortalized rat hepatocytes and toxicological information
    Presenter : Tanno K.(*1), Minota S.(*1), Aoki Y., Yonemoto J., Sone H
    Name of Society : 27th Int.Symp.Halogenat.Persistent Org.Pollut.-DIOXIN 2007(Poster Session) (2007)
    Name of Proceedings : Organohalogen Compd., 69
  • Research Presentation
    Spectra of wateborne Benzo [a] pyrene-induced mutations in the gill and hepatopancreas of rpsL transgenic zebrafish
    Presenter : Amanuma K., Tone S.(*1), Nagaya M., Aoki Y.
    Name of Society : 11th Int.Congr.Toxicol.(Poster Session) (2007)
    Name of Proceedings : Abstracts
  • Research Presentation
    Comprehensive gene expression analysis in male Nrf2KO mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)
    Presenter : Sato H.(*1), Matsumoto M., Itoh K.(*2), Yamamoto, M.(*2), Aoki Y.
    Name of Society : SOT.46th Annu.Meet. (2007)
    Name of Proceedings : Abstracts(CD-ROM)
  • Research Presentation
    In vivo mutations by 3,6-dinitrobenzo[e]pyrene instilled into the lung of gpt delta transgenic mice
    Presenter : Matsumoto M., Takano H., Amanuma K., Yanagisawa R., Aoki Y.
    Name of Society : 1st Asian Conf.Environ.Mutagens/36th Annu.Meet.Jpn.Environ.Mutagen Soc.(Poster Session) (2007)
    Name of Proceedings : Program & Abstracts
  • Research Presentation
    N-methyl-N'-nitro-N-nitorosoguanidine-induced mutations in adults and embryos of RPSL transgenic zebrafish
    Presenter : Amanuma K., Nakamura T., Nagaya M., Aoki Y.
    Name of Society : 9th Int.Conf.Environ.Mutagens/36th Annu.Meet.Environ.Mutagen Soc. (2005)
    Name of Proceedings : Abstracts
  • Research Presentation
    Development of in vivo mutagenicity assay system using rpsL transgenic zebrafish for monitoring environmental mutagens
    Presenter : Aoki Y., Amanuma K.
    Name of Society : 9th Int.Conf.Environ.Mutagens/36th Annu.Meet.Environ.Mutagen Soc. (2005)
    Name of Proceedings : Abstracts
  • Research Presentation
    In vivo mutagebusuty of diesel exhaust and its components,benzo[a]Pyrene and 1,6-dinitripyrene,in the lungs of gpt delta mice
    Presenter : Aoki Y., Hashimoto A.H., Amanuma K., Hiyoshi K.(*1), Yanagisawa R., Takano H., Masumura K.(*2), Nohmi T.(*2)
    Name of Society : 9th Int.Conf.Environ.Mutagens/36th Annu.Meet.Environ.Mutagen Soc. (2005)
    Name of Proceedings : Abstracts
  • Research Presentation
    Mutagenic activity of airborne particles in central metropolition Tokyo over the past 20years
    Presenter : NAKAJIMA Daisuke, Aoki Y.
    Name of Society : 9th Int.Conf.Environ.Mutagens/36th Annu.Meet.Environ.Mutagen Soc. (2005)
    Name of Proceedings : Abstracts
  • Research Presentation
    Alterations in gene expression by 2378-tetrachloro-p-dibenzodioxin (TCDD) in livers of Nrf2 knockout mice
    Presenter : Matsumoto M., Aoki Y.
    Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
    Name of Proceedings : Abstracts(CD-ROM)
  • Research Presentation
    Relative potencies of three dioxin congeners based on liver foci formation assay and liver concentrations in rat and human estimated PBPK models
    Presenter : Maruyama W., Aoki Y.
    Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
    Name of Proceedings : Abstracts
  • Research Presentation
    Enhanced mutagenesis in the lung of Nuf2 knockout gpt delta mice
    Presenter : Aoki Y., Hashimoto A.H.(*1), Amanuma K., Matsumoto M., Hiyoshi K.(*1), Takano H., Masumura K.(*1), Itoh K.(*1), Nohmi T.(*1), Yamamoto M.
    Name of Society : JST-ERATO: yamamoto Environ. Response Proj. Int. Symp. 'Molecular Mechanism of Environmental Response to Food & Oxygen' (2005)
    Name of Proceedings : Abstracts
  • Research Presentation
    Detection of N-methyl-N'-nitro-N-nitrosoguanidine-induced mutations in gill and hepatopancreas of rpsL transgenic
    Presenter : Amanuma K., Nakamura T., Aoki Y.
    Name of Society : Soc.Toxicol.43rd Annu.Meet. (2004)
    Name of Proceedings : Toxicologist(CD-ROM), 78
  • Research Presentation
    Accelerated DNA adduct formation in lung,nasal mucosa,and liver of rats exposed to urbun air in Kawasaki,Japan
    Presenter : Sato H.(*1), Suzuki K.T.(*1), Sone H., Yamano Y.(*2), Kagawa J.(*2), Aoki Y.
    Name of Society : Soc.Toxicol.43rd Annu.Meet. (2004)
    Name of Proceedings : Toxicologist(CD-ROM), 78
  • Research Presentation
    Increased susceptibility of Nrf2 knockout mice to diesel exhaust-acceleratedDNA adduct formation in the lung and mutagenicity(Poster session)
    Presenter : , Aoki Y.
    Name of Society : JBS Bio-Front.Symp.2003 (2003)
    Name of Proceedings : -
  • 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) affects glucose kinetics in rat placenta
    Presenter : Ishimura R., Kawakami T., Aoki Y., Yonemoto J., Tohyama C., Ohsako S.
    Name of Society : 21st Int.Symp.Halogenat.Environ.Org.Pollut.& POPs (2001)
    Name of Proceedings : Organohalogen Compd., 53
  • Coplanar polychrolinated biphenyl(co-PCB) affects steroidgenic enzyme mRNA expression in the neonatal mouse testis in vitro
    Presenter : Fukuzawa N.H.(*1), Nagano R.(*2), Baba T.(*1), Aoki Y., Tohyama C., Ohsako S.
    Name of Society : 21st Int.Symp.Halogenat.Environ.Org.Pollut.& POPs (2001)
    Name of Proceedings : Organohalogen Compd., 53
  • Detection and characterization of TCDD-inducible protein(HSP27) in the rat placenta
    Presenter : Ishimura R., Ohsako S., Aoki Y., Tohyama C.
    Name of Society : Endocr.Soc.83rd Annu.Meet. (2001)
    Name of Proceedings : Abstracts
  • Detection of mutations caused by compounds in aquatic environments using rpsL transgenic zebrafish
    Presenter : Amanuma K., Aoki Y.
    Name of Society : 8th Int.Conf.Environ.Mutagens (2001)
    Name of Proceedings : Mutation Res., 483(Suppl.1)
  • Mutational spectra of chemical agent-induced mutations in the embryos of rpsL transgenic zebrafish
    Presenter : Amanuma K., Aoki Y.
    Name of Society : 8th Int.Conf.Environ.Mutagens (2001)
    Name of Proceedings : Mutation Res., 483(Suppl.1)
  • Induction of cytochrome P450 1B1 in lung,liver,and kindney of rats exposed to diesel exhaust
    Presenter : Aoki Y., Nakajima M.
    Name of Society : 8th Int.Conf.Environ.Mutagens (2001)
    Name of Proceedings : Mutation Res., 483(Suppl.1)
  • Decrease of androgen sensitivity in the ventral prostate of male rats exposed maternally to 2,3,7,8-tetrachlorodebenzo-p-dioxin(TCDD)
    Presenter : Ohsako S., Ishimura R., Aoki Y., Tohyama C., Yonemoto J.
    Name of Society : 20th Int.Symp.Halogenat.Environ.Org.Pollut.& POPs (2000)
    Name of Proceedings : Organohalogen Compd., 49
  • Presenter : Furuhama A., Hasunuma K., Aoki Y.
    Name of Society : 8th International Symposium on Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (CMTPI-2015) (2015)
    Name of Proceedings : Abstracts, 35
  • CONCENTRATIONS OF PAHs, O-PAHs AND PASHs IN TOTAL SUSPENDED PARTICULATE AND GASEOUS PHASE IN JAPAN
    Presenter : Yagishita M., Kageyama S., Shiraishi F., Terasaki M., Aoki Y., Wang Q., Ohshima S., Goto S., Nakajima D.
    Name of Society : 2013 International Symposium of Polycyclic Aromatic Compounds (2013)
    Name of Proceedings : Abstracts
  • In Vivo Mutagenicity of Arsenic
    Presenter : Takumi S., Aoki Y., Nohara K.
    Name of Society : NIES Arsenic Workshop 2013 (2013)
    Name of Proceedings : Abstracts, 17
  • Presenter : Furuhama A., Aoki Y., Shiraishi H.
    Name of Society : The 15th International Workshop on Quantitative Structure-Activity Relationships (QSAR2012) in Environmental and Health Sciences (2012)
    Name of Proceedings : Abstracts, 62
  • Functional prediction analysis based on global gene expression by using Nrf2 Knockout mouse liver exposed to TCDD
    Presenter : Sato H. , Matsumoto M., Aoki Y., Itoh K., Yamamoto M.
    Name of Society : 12th Int.Congr.Toxicol. (2010)
    Name of Proceedings : Toxicol.Lett., 196(Suppl.1):S208
  • In vivo mutagenicity of ambient air in the lungs of gpt delta transgenic mice;A case study in Tsukuba city,Japan
    Presenter : Sato H. , Nakajima D., Kageyama S., Sakashita Y. , Yanagisawa R., Masumura K., Nohmi T., Aoki Y.
    Name of Society : 2nd Asian Conf.Environ.Mutagens (2010)
    Name of Proceedings : Abstracts
  • Presenter : Aoki Y.
    Name of Society : 10th Int.Conf.Environ.Mutagens(ICEM) (2009)
    Name of Proceedings : Abstracts, 70
  • Assessment of in vivo mutagenesis induced by environmental chemicals using transgenic animals for detecting mutagens
    Presenter : Aoki Y.
    Name of Society : 2nd Int.Conf.Environ.Health Sci. (2009)
    Name of Proceedings : Speaker's Presentation Materials, 189-196
  • In vivo mutagenesis induced in the testis of gpt delta transgenic mice by inhalation of diesel exhuast
    Presenter : Aoki Y., Hashimoto A.H., Amanuma K., Masumura K., Nohmi T.
    Name of Society : Gordon Res.Conf.Mech.Toxicity (2008)
    Name of Proceedings : -
  • Risk assessment of chlorinated organic compounds using immortalized rat hepatocytes and toxicological information
    Presenter : Tanno K.(*1), Minota S.(*1), Aoki Y., Yonemoto J., Sone H
    Name of Society : 27th Int.Symp.Halogenat.Persistent Org.Pollut.-DIOXIN 2007(Poster Session) (2007)
    Name of Proceedings : Organohalogen Compd., 69
  • Spectra of wateborne Benzo [a] pyrene-induced mutations in the gill and hepatopancreas of rpsL transgenic zebrafish
    Presenter : Amanuma K., Tone S.(*1), Nagaya M., Aoki Y.
    Name of Society : 11th Int.Congr.Toxicol.(Poster Session) (2007)
    Name of Proceedings : Abstracts
  • Comprehensive gene expression analysis in male Nrf2KO mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)
    Presenter : Sato H.(*1), Matsumoto M., Itoh K.(*2), Yamamoto, M.(*2), Aoki Y.
    Name of Society : SOT.46th Annu.Meet. (2007)
    Name of Proceedings : Abstracts(CD-ROM)
  • In vivo mutations by 3,6-dinitrobenzo[e]pyrene instilled into the lung of gpt delta transgenic mice
    Presenter : Matsumoto M., Takano H., Amanuma K., Yanagisawa R., Aoki Y.
    Name of Society : 1st Asian Conf.Environ.Mutagens/36th Annu.Meet.Jpn.Environ.Mutagen Soc.(Poster Session) (2007)
    Name of Proceedings : Program & Abstracts
  • N-methyl-N'-nitro-N-nitorosoguanidine-induced mutations in adults and embryos of RPSL transgenic zebrafish
    Presenter : Amanuma K., Nakamura T., Nagaya M., Aoki Y.
    Name of Society : 9th Int.Conf.Environ.Mutagens/36th Annu.Meet.Environ.Mutagen Soc. (2005)
    Name of Proceedings : Abstracts
  • Development of in vivo mutagenicity assay system using rpsL transgenic zebrafish for monitoring environmental mutagens
    Presenter : Aoki Y., Amanuma K.
    Name of Society : 9th Int.Conf.Environ.Mutagens/36th Annu.Meet.Environ.Mutagen Soc. (2005)
    Name of Proceedings : Abstracts
  • In vivo mutagebusuty of diesel exhaust and its components,benzo[a]Pyrene and 1,6-dinitripyrene,in the lungs of gpt delta mice
    Presenter : Aoki Y., Hashimoto A.H., Amanuma K., Hiyoshi K.(*1), Yanagisawa R., Takano H., Masumura K.(*2), Nohmi T.(*2)
    Name of Society : 9th Int.Conf.Environ.Mutagens/36th Annu.Meet.Environ.Mutagen Soc. (2005)
    Name of Proceedings : Abstracts
  • Mutagenic activity of airborne particles in central metropolition Tokyo over the past 20years
    Presenter : NAKAJIMA Daisuke, Aoki Y.
    Name of Society : 9th Int.Conf.Environ.Mutagens/36th Annu.Meet.Environ.Mutagen Soc. (2005)
    Name of Proceedings : Abstracts
  • Alterations in gene expression by 2378-tetrachloro-p-dibenzodioxin (TCDD) in livers of Nrf2 knockout mice
    Presenter : Matsumoto M., Aoki Y.
    Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
    Name of Proceedings : Abstracts(CD-ROM)
  • Relative potencies of three dioxin congeners based on liver foci formation assay and liver concentrations in rat and human estimated PBPK models
    Presenter : Maruyama W., Aoki Y.
    Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
    Name of Proceedings : Abstracts
  • Enhanced mutagenesis in the lung of Nuf2 knockout gpt delta mice
    Presenter : Aoki Y., Hashimoto A.H.(*1), Amanuma K., Matsumoto M., Hiyoshi K.(*1), Takano H., Masumura K.(*1), Itoh K.(*1), Nohmi T.(*1), Yamamoto M.
    Name of Society : JST-ERATO: yamamoto Environ. Response Proj. Int. Symp. 'Molecular Mechanism of Environmental Response to Food & Oxygen' (2005)
    Name of Proceedings : Abstracts
  • Detection of N-methyl-N'-nitro-N-nitrosoguanidine-induced mutations in gill and hepatopancreas of rpsL transgenic
    Presenter : Amanuma K., Nakamura T., Aoki Y.
    Name of Society : Soc.Toxicol.43rd Annu.Meet. (2004)
    Name of Proceedings : Toxicologist(CD-ROM), 78
  • Accelerated DNA adduct formation in lung,nasal mucosa,and liver of rats exposed to urbun air in Kawasaki,Japan
    Presenter : Sato H.(*1), Suzuki K.T.(*1), Sone H., Yamano Y.(*2), Kagawa J.(*2), Aoki Y.
    Name of Society : Soc.Toxicol.43rd Annu.Meet. (2004)
    Name of Proceedings : Toxicologist(CD-ROM), 78
  • Increased susceptibility of Nrf2 knockout mice to diesel exhaust-acceleratedDNA adduct formation in the lung and mutagenicity(Poster session)
    Presenter : , Aoki Y.
    Name of Society : JBS Bio-Front.Symp.2003 (2003)
    Name of Proceedings : -
  • Presenter : Udagawa O., KATO A., Kobayashi Y., Aoki Y., Hirano S.
    Name of Society : 2015 Cellular & Molecular Mechanisms of Toxicity Gordon Research Conference (2015)
    Name of Proceedings : Abstracts, 16
  • Threshold of mutagenesis induced by a reactive oxygen species-generating compound, potassium bromate, in the small intestine of gpt delta mice
    Presenter : Aoki Y.
    Name of Society : Gordon Research Conference on Cellular & Molecular Mechanism of Toxicity (2015)
    Name of Proceedings : Abstract
  • Presenter : Furuhama A., Hasunuma K., Aoki Y.
    Name of Society : 16th International Workshop on Quantitative Structure-Activity Relationships in Environmental and Health Sciences (QSAR2014) (2014)
    Name of Proceedings : Abstracts, 134
  • Presenter : Takumi S., Aoki Y., Sano T., Suzuki T., Nohmi T., Nohara K.
    Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
    Name of Proceedings : Abstracts
  • CONTRIBUTION OF BENZO[A]PYRENE TO MUTAGENICITY IN AMBIENT AIR COLLECTED AT 11 SITES IN JAPAN FROM 2007 TO 2009
    Presenter : Goto S., Yagishita M., Kageyama S., Shiraishi F., Aoki Y., Wang Q., Mineki S., Ohshima S., Nakajima D.
    Name of Society : 2013 International Symposium of Polycyclic Aromatic Compounds (2013)
    Name of Proceedings : Abstracts
  • Comparison of Risk Assessment Values of Hazardous Chemicals Estimated Based on Animal Inhalation Studies with the Guideline Values for Ambient Air Based on Epidemiological Studies
    Presenter : Matsumoto M., Matsumoto Y., Aoki Y.
    Name of Society : The 6th International Congress of Asian Society of Toxicology (2012)
    Name of Proceedings : The Journal of Toxicological Sciences (The 6th International Congress of Asian Society of Toxicology, Program and Abstracts), 37(Suppl. ?):S 412
  • Manganese protects against cadmium cytotoxicity via a lower expression of ZIP8 and ZIP14 in vascular endothelial cells
    Presenter : Ando R., Takahashi S., Yamamoto C., Aoki Y., Kaji T.
    Name of Society : 6th International Congress of Asian Society of Toxicology (2012)
    Name of Proceedings : Abstracts
  • Comparative study on the utilities of animal experimental data for risk assessment of inhalation exposure of chemicals
    Presenter : Aoki Y., Matsumoto Y., Matsumoto M.
    Name of Society : SOT 2012 Annual Meeting (2012)
    Name of Proceedings : Abstract of SOT 2012 Annual Meeting, 27
  • Distribution of polycyclic aromatic sulfur heterocycles in total suspended particle and gaseous phase in Japan
    Presenter : Yagishita M., Kageyama S., Takemura T., Shiraishi F., Aoki Y., Shiraishi H., Wang Q., Ohshima S., Goto S., Nakajima D.
    Name of Society : International Symposium on Aerosols in East Asia and Their Impacts on Plants and Human Health (2012)
    Name of Proceedings : Abstracts, 144-145
  • Presenter : Furuhama A., Aoki Y., Shiraishi H.
    Name of Society : Ninth Triennial Congress of the WORLD ASSOCIATION OF THEORETICAL AND COMPUTATIONAL CHEMISTS WATOC 2011 (2011)
    Name of Proceedings : Abstracts of Ninth Triennial Congress of the WORLD ASSOCIATION OF THEORETICAL AND COMPUTATIONAL CHEMISTS WATOC 2011
  • Presenter : Furuhama A., Hasunuma K., Aoki Y., Yoshioka Y., Shiraishi H.
    Name of Society : 14th Int.Workshop QSARs Environ.Health Sci. (2010)
    Name of Proceedings : Abstracts, 40
  • External validation of ecotoxicity prediction QSAR system,“KAshinhou Tool for Ecotoxicity” (KATE)
    Presenter : Hasunuma K., Furuhama A., Aoki Y., Sugaya Y., Yoshioka Y., Shiraishi H.
    Name of Society : 2nd Korea-Jpn.Symp.Environ.Chem./韓国環境分析学会秋季学術大会 (2010)
    Name of Proceedings : Abstracts, 249
  • Presenter : Aoki Y., Hashimoto A.H., Matsumoto M., Sugawara Y., Goto S., Masumura K., Nohmi T.
    Name of Society : CCT Meet.PPTOXII: Role of Environmental Stressors in the Developmental Origins of Disease (2009)
    Name of Proceedings : Abstracts, VI.15
  • In vivo mutagenesis induced by the air pollutants in the testis of gpt delta transgenic mice
    Presenter : Aoki Y., Hashimoto A.H., Amanuma K., Matsumoto M., Masumura K., Nohmi T.
    Name of Society : 21st Cent.Adv.Mol.Toxicol.Environ.Chem.Pathog.Dis. (2009)
    Name of Proceedings : Abstracts, 173
  • Environmental and human health impacts of pollutants generated by energy production
    Presenter : Aoki Y.
    Name of Society : Harvard Project for Asia and International Relations 2013 Asia Conference (2013)
    Name of Proceedings : -
  • Risk Assessment of Environmental Chemicals
    Presenter : Aoki Y.
    Name of Society : ILSI HESI Workshop (2013)
    Name of Proceedings : -
  • Presenter : Furuhama A., Aoki Y., Shiraishi H.
    Name of Society : 5th JCS International Symposium on Theoretical Chemistry (2013)
    Name of Proceedings : Abstract
  • In vivo mutagenesis resulting from oxidative stress in mice with suppressed phase II drug-metabolizing enzyme expression
    Presenter : Aoki Y.
    Name of Society : 11th International conference on environmental mutagens (2013)
    Name of Proceedings : Abstract
  • Health risk assessemnt of air pollutants: Air pollutant genotoxicity and its enhancement on suppression of phase II drug-metabolizing enzymes
    Presenter : Aoki Y.
    Name of Society : International Symposium on Genotoxic and Carcinogenic Thresholds (2011)
    Name of Proceedings : Abstract, 28
  • Transgenic animal models as a tool for risk assessment of environmental mutagens
    Presenter : Aoki Y.
    Name of Society : 4th Asian Conference on Environmental Mutagens (2014)
    Name of Proceedings : Abstract
  • Presenter : Aoki Y.
    Name of Society : Environmental Health 2011 Oral programme (2011)