Latest Update:2017/10/05 16:16:24

ITO Tomohiro

Researcher Name
ITO Tomohiro
Div (Section) name/title
Center for Health and Environmental Risk Research(Health Effect Assessment Section)/Senior Researcher
Research Subject
Studies on the effects of environmental chemicals on immune cells and their mechanisms
Degree(s)
Ph.D. (Environmental Science)
Professional Qualification(s)
Pharmacy,Biochemistry
Environmental Speciality Field
Environmental toxicology
Keyword(s)
Immunology,Dioxin,Cell culture,Gene recombination,Flow cytometry,Molecular biology,Microarray,RNA interference,Dendritic cells
Membership of Academic Society
Japan Society of Endocrine Disrupters Research (JSEDR),The Molecular Biology Society of Japan,The pharmaceutical society of japan
Research Subject
  • Fiscal Year: 2017
    • 23823 : Project to develop integrated approaches to detecting and assessment of multiple and unknown chemicals, and building environmental monitoring networks
    • 23824 : Research project on health impacts of chemicals on children and future generations
    • 23847 : Research program on health and environmental safety
    • 23975 : A fundamental study for evaluating health impact of environmental factors
    • 23986 : Effective development of iPS cells into alveolar epithelium by utilization of basement membrane substratum
    • 24009 : Source apportionment of various toxicities by atmospheric organic aerosols
    • 24107 : Detection of chemical substances with epigenetic activity to protect environmental risk by the adverse outcome pathway approach
  • Fiscal Year: 2016
    • 23414 : Research program on health and environmental safety
    • 23415 : Research project on health impacts of chemicals on children and future generations
    • 23416 : Project to develop integrated approaches to detecting and assessment of multiple and unknown chemicals, and building environmental monitoring networks
    • 23640 : Development of in vitro hazard testing systems using iPS cells
    • 23641 : Detection of chemical substances with epigenetic activity to protect environmental risk by the adverse outcome pathway approach
    • 23659 : A fundamental study for evaluating health impact of environmental factors
    • 23680 : Effective development of iPS cells into alveolar epithelium by utilization of basement membrane substratum
    • 23684 : Effects of airborne particulates in China on lung cells
  • Fiscal Year: 2015
    • 23018 : Mechanism and evaluation system of the developmental health effects of environmental factors
    • 23170 : Development of in vitro hazard testing systems using iPS cells
    • 23172 : Detection of chemical substances with epigenetic activity to protect environmental risk by the adverse outcome pathway approach
    • 23202 : Effects of airborne particulates in China on lung cells
    • 23203 : Study for toxicities of environmental pollutants by using pluripotent stem cells
  • Fiscal Year: 2014
    • 22606 : Mechanism and evaluation system of the developmental health effects of environmental factors
    • 22894 : Development of in vitro hazard testing systems using iPS cells
    • 22895 : Study for toxicities of environmental pollutants by using pluripotent stem cells
    • 22958 : Effects of airborne particulates in China on lung cells
  • Fiscal Year: 2013
    • 22190 : Mechanism and evaluation system of the developmental health effects of environmental factors
    • 22550 : Study for toxicities of environmental pollutants by using pluripotent stem cells
    • 22570 : Health effects of secondary organic aerosols derived from diesel exhaust.
  • Fiscal Year: 2012
    • 21761 : Mechanism and evaluation system of the developmental health effects of environmental factors
  • Fiscal Year: 2011
    • 21319 : Mechanism and evaluation system of the developmental health effects of environmental factors
  • Fiscal Year: 2010
    • 20844 : Effects of environmental chemicals on antigen-presenting cells
    • 20921 : Estimating of toxicities of environmental pollutants on hematopoietic stem cells using iPS cells
  • Fiscal Year: 2009
    • 20764 : in vitro evaluation of effects of diesel exhaust particles using iPS-derived cardiomyocytes
    • 20765 : Effects of environmental chemicals on antigen-presenting cells
  • Fiscal Year: 2008
    • 20147 : Development of evaluation system which can predict the effects of environmental chemicals on hypersensitive subjects with atopy using dendritic cells
  • Fiscal Year: 2007
    • 10650 : Effect of environmental pollutants on the skin immunity by using langerhans cells
    • 10677 : Development of evaluation system which can predict the effects of environmental chemicals on hypersensitive subjects with atopy using dendritic cells
  • Fiscal Year: 2006
    • 10050 : Studies on application of toxicogenomics for risk assessment of environmental pollutants
  • Fiscal Year: 2005
    • 9521 : Studies on application of toxicogenomics for risk assessment of environmental pollutants
  • Fiscal Year: 2004
    • 9050 : Studies on the health effects of endocrine disrupters
    • 9217 : Identification of causal genes responsible for dioxin-induced immunosuppression using RNAi
    • 9272 : Studies on application of toxicogenomics for risk assessment of environmental pollutants
  • Fiscal Year: 2003
    • 8610 : Elucidation of endocrine disrupting mechanism of dioxin and related compounds for health risk assessment
Research Result (Publication)
  • all
  • Original Paper
Research Result (Presentation)
  • all
  • Research Presentation
  • Presenter : Nishimura N., Nishimura H., Ito T., Fujimaki H., Matsumura F.
    Name of Society : HORIBA/CDBIM Symp. -21st Century Adv.Mol.Toxicol.Environ.Chem.Pathog.Dis.- (2009)
    Name of Proceedings : Abstracts, 158
  • Research Presentation
    Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on born development in mouse pups
    Presenter : Nishimura N., Ito T., Izumi K., Nishimura H., Fujimaki H.
    Name of Society : Eurotox 2008 (2008)
    Name of Proceedings : Toxicol.Lett., 180S:S194
  • Research Presentation
    Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin bone mineralization the growing mouse
    Presenter : , , Ito T.
    Name of Society : SOT 2008 (2008)
    Name of Proceedings : Abstracts
  • Presenter : Nishimura N., Ito T., Fujimaki H., Izumi K., Nishimura H.
    Name of Society : 5th SETAC World Congr. (2008)
    Name of Proceedings : Abstracts
  • Research Presentation
    Defect of mineralization as a possible cause of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced bone toxicity in early postnatal development in mice
    Presenter : Nishimura N., Ito T., Fujimaki H., Nishimura H.
    Name of Society : 28th Int.Symp.Halogenat.Persistent Org.Pollut.-DIOXIN 2008 (2008)
    Name of Proceedings : Organohalogen Compd., 70:1924-1927
  • Research Presentation
    Phthalate esters modulate the differentiation of mouse peripheral blood mononuclear cells-derived dendritic cells
    Presenter : Ito T., Inoue Ken-ichiro, Koike E., Yanagisawa R., Nishimura N., Takano H.
    Name of Society : 45th Congr.Eur.Soc.Toxicol. (2008)
    Name of Proceedings : Toxicol.Lett., 180S:S117
  • Research Presentation
    Up-regulation of 25-hydroxyvitamin D3 1α-hydroxylase and disruption of calcium metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing mouse kidney
    Presenter : , , Ito T.
    Name of Society : 27th Int.Symp.Halogenat.Persistent Org.Pollut.-DIOXIN 2007 (2007)
    Name of Proceedings : Organohalogen Compd., 69
  • Research Presentation
    Changes of gene expression involved in vitamin D metabolism and transcellular CA2+ transport by 2,3,7,8-tetrachlorodibenzo-p-dioxin in developing mouse kidney
    Presenter : , , Ito T.
    Name of Society : Int.Congr.Toxicol.(Poster Session) (2007)
    Name of Proceedings : Abstracts
  • Research Presentation
    Search for genes involved in the growth inhibition of Jurkat T cells by a constitutively active arylhydrocarbon receptor
    Presenter : Ito T.
    Name of Society : 20th IUBMB Int.Congr.Biochem.Mol.Biol.11th FAOBMB Congr.(Poster Session) (2006)
    Name of Proceedings : Abstracts
  • Research Presentation
    Distinctive gene expression patterns in thymuses exposed to atrophy-inducing chemicals
    Presenter : , Ito T.
    Name of Society : SOT Annu.Meet.2006(Poster Session) (2006)
    Name of Proceedings : Toxicologist, 90
  • Research Presentation
    Comparison of the TCDD-induced CYP1A1 gene expression profile in lymphocytes from mice,rats and humans
    Presenter : , Ito T.
    Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
    Name of Proceedings : Toxicologist, 84
  • Research Presentation
    Gene expression changes in fetal thymus exposed to organic compounds extracted from diesel exhaust particles.
    Presenter : Tohyama C., Ito T.
    Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
    Name of Proceedings : Toxicologist, 84
  • Research Presentation
    Activation of arylhydrocarbon receptor(AhR) in T lineage cells inhibits cellular growth.
    Presenter : , Ito T.
    Name of Society : 24th Int.Symp.Halogenat.Environ.Org.Pollut.POPs; DIOXIN 2004 (2004)
    Name of Proceedings : Organohalogen Compd., 66
  • Research Presentation
    Thymocyte alterations in CD2-driven constitutively active arylhydrocarbon receptor(AHR) transgenic mice
    Presenter : , Ito T.
    Name of Society : Soc.Toxicol.42nd Annu.Meet. (2003)
    Name of Proceedings : Toxicologist, 72:362
  • Research Presentation
    A constitutively active aryl hydrocarbon receptor induces growth inhibition by cell cycle arrest and apoptosis in jurkat T cells
    Presenter : , Ito T.
    Name of Society : Soc.Toxicol.42nd Annu.Meet. (2003)
    Name of Proceedings : Toxicologist, 72:367
  • The effects of TCDD on germinal center formation in the spleen of C57BL/6 mice
    Presenter : Inouye K., Ito T., Fujimaki H., Tohyama C., Nohara K.
    Name of Society : Soc.Toxicol.: 41st Annu.Meet. (2002)
    Name of Proceedings : Toxicologist, 61
  • Suppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) on Th2-derived cytokine production in primary immune reaction of mice
    Presenter : Nohara K., Ito T., Inouye K., Fujimaki H., Tohyama C.
    Name of Society : Soc.Toxicol.: 41st Annu.Meet. (2002)
    Name of Proceedings : Toxicologist, 61
  • Alteration of B cell development in the spleen of C57B1/6 mice by TCDD treatment
    Presenter : Inouye K., Ito T., Fujimaki H., Tohyama C., Nohara K.
    Name of Society : 4th Annu.Meet.Jpn.Soc.Endocr.Disrupters Res. (2001)
    Name of Proceedings : Program & Abstracts
  • Mechanisms for 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)- induced suppression of antigen-specific antibody production
    Presenter : Ito T., Inouye K., Fujimaki H., Tohyama C., Nohara K.
    Name of Society : 4th Annu.Meet.Jpn.Soc.Endocr.Disrupters Res. (2001)
    Name of Proceedings : Program & Abstracts
  • Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin bone mineralization the growing mouse
    Presenter : , , Ito T.
    Name of Society : SOT 2008 (2008)
    Name of Proceedings : Abstracts
  • Presenter : Nishimura N., Ito T., Fujimaki H., Izumi K., Nishimura H.
    Name of Society : 5th SETAC World Congr. (2008)
    Name of Proceedings : Abstracts
  • Up-regulation of 25-hydroxyvitamin D3 1α-hydroxylase and disruption of calcium metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing mouse kidney
    Presenter : , , Ito T.
    Name of Society : 27th Int.Symp.Halogenat.Persistent Org.Pollut.-DIOXIN 2007 (2007)
    Name of Proceedings : Organohalogen Compd., 69
  • Changes of gene expression involved in vitamin D metabolism and transcellular CA2+ transport by 2,3,7,8-tetrachlorodibenzo-p-dioxin in developing mouse kidney
    Presenter : , , Ito T.
    Name of Society : Int.Congr.Toxicol.(Poster Session) (2007)
    Name of Proceedings : Abstracts
  • Search for genes involved in the growth inhibition of Jurkat T cells by a constitutively active arylhydrocarbon receptor
    Presenter : Ito T.
    Name of Society : 20th IUBMB Int.Congr.Biochem.Mol.Biol.11th FAOBMB Congr.(Poster Session) (2006)
    Name of Proceedings : Abstracts
  • Distinctive gene expression patterns in thymuses exposed to atrophy-inducing chemicals
    Presenter : , Ito T.
    Name of Society : SOT Annu.Meet.2006(Poster Session) (2006)
    Name of Proceedings : Toxicologist, 90
  • Comparison of the TCDD-induced CYP1A1 gene expression profile in lymphocytes from mice,rats and humans
    Presenter : , Ito T.
    Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
    Name of Proceedings : Toxicologist, 84
  • Gene expression changes in fetal thymus exposed to organic compounds extracted from diesel exhaust particles.
    Presenter : Tohyama C., Ito T.
    Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
    Name of Proceedings : Toxicologist, 84
  • Activation of arylhydrocarbon receptor(AhR) in T lineage cells inhibits cellular growth.
    Presenter : , Ito T.
    Name of Society : 24th Int.Symp.Halogenat.Environ.Org.Pollut.POPs; DIOXIN 2004 (2004)
    Name of Proceedings : Organohalogen Compd., 66
  • Thymocyte alterations in CD2-driven constitutively active arylhydrocarbon receptor(AHR) transgenic mice
    Presenter : , Ito T.
    Name of Society : Soc.Toxicol.42nd Annu.Meet. (2003)
    Name of Proceedings : Toxicologist, 72:362
  • A constitutively active aryl hydrocarbon receptor induces growth inhibition by cell cycle arrest and apoptosis in jurkat T cells
    Presenter : , Ito T.
    Name of Society : Soc.Toxicol.42nd Annu.Meet. (2003)
    Name of Proceedings : Toxicologist, 72:367
  • Presenter : Nishimura N., Nishimura H., Ito T., Fujimaki H., Matsumura F.
    Name of Society : HORIBA/CDBIM Symp. -21st Century Adv.Mol.Toxicol.Environ.Chem.Pathog.Dis.- (2009)
    Name of Proceedings : Abstracts, 158
  • Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on born development in mouse pups
    Presenter : Nishimura N., Ito T., Izumi K., Nishimura H., Fujimaki H.
    Name of Society : Eurotox 2008 (2008)
    Name of Proceedings : Toxicol.Lett., 180S:S194
  • Defect of mineralization as a possible cause of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced bone toxicity in early postnatal development in mice
    Presenter : Nishimura N., Ito T., Fujimaki H., Nishimura H.
    Name of Society : 28th Int.Symp.Halogenat.Persistent Org.Pollut.-DIOXIN 2008 (2008)
    Name of Proceedings : Organohalogen Compd., 70:1924-1927
  • Phthalate esters modulate the differentiation of mouse peripheral blood mononuclear cells-derived dendritic cells
    Presenter : Ito T., Inoue Ken-ichiro, Koike E., Yanagisawa R., Nishimura N., Takano H.
    Name of Society : 45th Congr.Eur.Soc.Toxicol. (2008)
    Name of Proceedings : Toxicol.Lett., 180S:S117