Seishiro Hirano, Ph. D.

Independent Senior Researcher

Environmental Health Sciences

National Institute for Environmental Studies

16-2 Onogawa, Tsukuba, Ibaraki 305-0053,JAPAN

Phone: +81-298-50-2512 Fax: +81-298-50-2512

E-mail:seishiro@nies.go.jp

Research Interest

Inflammatory responses of alveolar macrophages and pulmonary epithelial cells to heavy metals and particulate substances.

Discipline　Environmental Toxicology

Selected Publications

  1. Anuradha C. D., Kanno S., Hirano S.
    Fluoride induces apoptosis by caspase-3 activation in human leukemia HL-60 cells. Arch Toxicol(2000) 74 : 226-230
  2. Hirano, S. Anuradha, C. D. and Kanno, S.
    Transcription of krox-20/egr-2 is upregulated after exposure to fibrous particles and adhesion in rat alveolar macrophages. Am. J. Respir. Cell Mol. Biol. (2000) 23, 313-319
  3. Kitajima, H., Hirano, S. and Suzuki, K. T.
    Upregulation of heme oxygenase gene expression in rat lung epithelial cells following exposure to cadmium. Arch Toxicol. (1999) 73, 410-412
  4. Hirano, S. and Kanno, S.
    Sky and paxillin are differentially phosphorylated following adhesion to the plastic substrate in rat alveolar macrophages. Immunology (1999) 97, 414-419
  5. Hirano, S., Ando, M. and Kanno, S.
    Inflammatory responses of rat alveolar macrophages following exposure to fluoride
    Arch. Toxicol. (1999) 73, 310-315
  6. S. Hirano and S. Kanno (1999) Syk and paxillin are differentailly
    phosphorylated following adhesion to the plastic substrate in rat
    alveolar macrophages. Immunology, 97, 414-419.
  7. S. Hirano (1998) Nitric oxide-mediated cytotoxic effects of alveolar
    macrophages on transformed lung epithelial cells are independent of the
    beta2 integrin-mediated intercellular adhesion. Immunology, 93, 102-108.

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