Publication@List


‚`. Original Articles

2004

Ito T., Tsukumo S., Suzuki N., Motohashi H., Yamamoto M., Fujii-Kuriyama Y., Mimura J., Lin T-M., Peterson R.E., Tohyama C., and Nohara K. A constitutively active arylhydrocarbon receptor inhibits growth of Jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest. J. Biol. Chem. (2004, in press)

Wu Q., Ohsako S., Ishimura R., Suzuki J. S., and Tohyama C. Exposure of Mouse Preimplantation Embryos to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters the Methylation Status of Imprinted Genes H19 and Igf2.  Biol. Reproduction (2004, in press)

Fukuzawa N. H., Ohsako S. , Wu Q., Sakaue M., Fujii-Kuriyama Y., Baba T., and Tohyama C.  Testicular cytochrome P450scc and LHR as possible targets of 2,3,7,8-tetrachlorodibenzo-p-diosin (TCDD) in the mouse. Mol. Cell. Endocrinol. (2004, in press)

Kusumegi T., Tanaka J., Kawano M., Yonemoto J., Tohyama C.,  and Sone H.  MP7/ActRIIB regulates estrogen-dependent apoptosis: New biomarkers for environmental estrogens.  J. Biochem. Mol. Toxicol. 18: 1-11 ,2004.

2003

Ishizuka M., Yonemoto J., Zaha H., Tohyama C., and Sone H. Perinatal exposure to low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin alters sex-dependent expression of hepatic CYP2C11. J. Biochem. Toxicol. 17:, 278-2,2003.

Ohsako S., Kubota K., Kurosawa S., Takeda K., Wu Q., Ishimura R., and TohyamaC.:. Alterations of gene expression in adult male rat testis and pituitary shortly after subacute administration of the antiandrogen flutamide. J Reprod Dev, 49, 275-290, (2003).

Kubota K., Ohsako S., Kurosawa S., Takeda K., Wu Q., Sakaue M., Kawakami T., Ishimura R., and
TohyamaC.: Effects of vinclozolin administration on sperm production and testosterone biosynthetic pathway in adult male rat. J Reprod Dev, 49: 403-412, 2003.

Inouye K, Ito T, Fujimaki H, Takahashi Y, Takemori T, Pan X,
Tohyama C, Nohara K.: Suppressive Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)on the High-Affinity Antibody Response in C57BL/6 Mice.Toxicol. Sci. 74: 315-324, 2003.

Suzuki JS, Nishimura N, Zhang BX, Nakatsuru Y, Kobayashi S, Satoh M,
TohyamaC.: Metallothionein deficiency enhances skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate in metallothionein-null mice. Carcinogenesis. 24 (6): 1123-1132, 2003.

Doi H, Baba T,
Tohyama C, Nohara K. Functional activation of arylhydrocarbon receptor (AhR) in primary T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chemosphere. 52 (4): 655-662, 2003.

Arisawa K, Matsumura T,
Tohyama C, Saito H, Satoh H, Nagai M, Morita M, Suzuki T. Fish intake, plasma omega-3 polyunsaturated fatty acids, and polychlorinated dibenzo-p-dioxins/polychlorinated dibenzo-furans and co-planar polychlorinated biphenyls in the blood of the Japanese population . Int Arch Occ Env Hea. 76 (3): 205-21, 2003.

Moriguchi T, Motohashi H, Hosoya T, Nakajima O, Takahashi S, Ohsako S, Aoki Y, Nishimura N,
Tohyama C, Fujii-Kuriyama Y, Yamamoto M. Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse. P Natl Acad Sci USA. 100 (10): 5652-5657, 2003

Ohtake F, Takeyama K, Matsumoto T, Kitagawa H, Yamamoto Y, Nohara K,
Tohyama C, Krust A, Mimura J, Chambon P, Yanagisawa J, Fujii-Kuriyama Y, Kato S. Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature. 423 (6939): 545-550, 2003

Murata M, Nishimura N, Zhang BX, Satoh M,
Tohyama C. Interleukin-6 protects skin legion caused by 7,12-dimethylbenz[a]anthracene. J Vet Med Sci. 65 (4): 511-513, 2003

Nishimura N., Yonemoto J., Miyabara Y., Sato M. and
Tohyama, C. Rat Thyroid Hyperplasia Induced by Gestational and Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. Endocrinol. 144 (5): 2075-2083, 2003

Fukuzawa H. N., Ohsako S., Nagano R., Sakaue M., Baba T., Aoki Y. and
Tohyama C. Effects of 3,3',4,4',5-Pentachlorobiphenyl, a Coplanar Polychlorinated Biphenyl Congener, on Cultured Neonatal Mouse Testis. Toxicology in vitro, 17(3): 259-269, 2003

Kakeyama M, Sone H, Miyabara Y and
Tohyama C. Perinatal exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters activity dependent expression of BDNF mRNA in the Neocortex and male rat sexual behavior in adulthood. NeuroToxicology 24:207-21, 2003

Kakeyama M, Sone H, Miyabara Y and Tohyama C. Perinatal exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters activity dependent expression of BDNF mRNA in the Neocortex and male rat sexual behavior in adulthood. NeuroToxicology 24:207-217, 2003

2002

Wu Q, Ohsako S, Baba T, Miyamoto K, Tohyama C. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on preimplantation mouse embryos. Toxicology 174 (2): 119-129 (2002)

Ishimura R, Ohsako S, Kawakami T, Sakaue M, Aoki Y,
TohyamaC. Altered protein profile and possible hypoxia in the placenta of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposed rats. Toxicol Appl pharmacol., 2002 in press

Ito, T., Inouye, K., Fujimaki, H., Tohyama, C. and Nohara, K. : Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced suppression of antibody production: Effect on T cell-derived cytokine production in the primary immune reaction of mice, Toxicol. Sci., 2002 in press

Tsukumo, S., Iwata, M., Tohyama, C. and Nohara, K. : Skewed differentiation of thymocytes toward CD8 T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires activation of the extracellular signal-related kinase pathway, Arch. Toxicol., 76, 335-343, 2002.

Buchanan DL, Ohsako S.,
Tohyama C, Cooke PS, Iguchi T.: 2,3,7,8-Tetrachrolodibenzo-p-dioxin (TCDD) inhibition of estrogen-induced mouse uterine epithelial mitogenesis involves changes in cyclin and transforming growth factor-beta expression. Toxicol Sci., 66: 62-68, 2002.

Ohsako S, Miyabara Y, Sakaue M, Ishimura R, Kakeyama M, Izumi H, Yonemoto J,
Tohyama C.: Developmental Stage-Specific Effects of Perinatal 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure on Reproductive Organs of Male Rat Offspring. Toxicol Sci., 66: 283-292, 2002.

Ishimura R, Ohsako S, Miyabara Y, Sakaue M, Kawakami T, Aoki Y, Yonemoto J,
Tohyama C.: Increased glycogen content and glucose transporter 3 (GLUT3) mRNA level in the placenta of Holtzman rats after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl pharmacol., 178: 161-171, 2002.

Sakaue M, Ishimura R, Kurosawa S, Fukuzawa HN, Kurohmaru M, Hayashi Y,
Tohyama C, Ohsako S.: Administration of estradiol-3-benzoate down-regulates the expression of testicular steroidogenic enzyme genes for testosterone production in the adult rat. J Vet Med Sci., 64: 107-113, 2002

Nishimura,N., Miyabara, Y., Sato, M., Yonemoto, J. and Tohyama, C.: Immunohistochemical localization of thyroid stimulating hormone induced by a low oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats. Toxicology., 171, 73-82, 2002.

Nohara, K., Fujimaki, H., Tsukumo, S., Inouye, K., Sone, H. and Tohyama, C.: Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on T cell-derived cytokine production in ovalbumin (OVA)-immunized C57Bl/6 mice, Toxicology, 172, 49-58, 2002.

Fujimaki, H., Nohara, K., Kobayashi, T., Suzuki, K., Eguchi-Kasai, K., Tsukumo, S., Kijima, M. and Tohyama, C.: Effect of a single oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin on immune function in male NC/Nga mice, Toxicol. Sci., 66, 117-124, 2002.
.
2002, in press.

Nohara, K.,
Izumi, H., Tamura, S., Nagata, R. and Tohyama, C.: Effect of low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on influenza A virus-induced mortality in mice, Toxicology, 170, 131-138, 2002.

2001

Fukada, K., Nagano, S., Satoh, M.,
Tohyama, C., Nakanishi, T., Shimizu, A., Yanagihara, T. and Sakoda, S. Stabilization of mutant Cu/Zn superoxide dismutase (SOD1) protein by co-expressed wild SOD1 protein accelerates the disease progression in familial amyotrophic lateral sclerosis mice. Eur. J. Neurosci., 14, 2032-2036, 2001.

Kakeyama, M., Sone, H.,
Tohyama, C. Changes in expression of NMDA receptor subunit mRNA by perinatal exposure to dioxin. Neuroreport., 12: 4009-4012, 2001.

Nishimura, N., Miyabara, Y., Suzuki, J.S., Sato, M., Yonemoto, J., Satoh, M., Aoki, Y. and
Tohyama, C.: Induction of metallothionein in the livers of female sprague dawley rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Life Sci., 69, 1291-1303, 2001.

Sakaue, M.,
Ohsako, S., Ishimura, R., Kurosawa, S., Kurohmaru, M., Hayashi, Y., Aoki ,Y., Yonemoto, J. and Tohyama, C. Bisphenol-A affects spermatogenesis in the mature rat even at a low dose. J Occupational Health, 43, 185-190, 2001.

Nagano, S., Satoh, M., Sumi, H., Fujimura, H.,
Tohyama, C., Yanagihara, T. and Sakoda, S. Reduction of metallothioneins promotes the disease expression of familial amyotrophic lateral sclerosis mice in a dose-dependent manner. Eur. J. Neurosci., 13, 1363-1370, 2001..

Ohsako, S., Miyabara, Y., Nishimura, N., Kurosawa, S., Sakaue, M., Ishimura, R., Sato, M., Takeda, K., Aoki, Y., Sone, H.,
Tohyama, C. and Yonemoto, J.: Maternal Exposure to A Low Dose of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Suppressed the Development of Reproductive Organs of Male Rats:Dose-Dependent Increase of mRNA Levels of 5a-Reductase Type 2 in Contrast to A Decrease of Androgen Receptor in the Pubertal Ventral Prostate. Toxicological Sciences., 60, 132-143, 2001.

2000

Jana, N. R., Sarkar, S., Ishizuka, M, Yonemoto, J, Tohyama, C. and Sone, H.: Comparative effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on MCF-7, RL95-2, and LNCaP cells: Role of target steroid hormones in cellular responsiveness to CYP1A1 induction. Mol. Cell Biol. Res. Commun. 4, 174-180, 2000.

Molotkov, A., Satoh, M. and
Tohyama, C.: Induction of hepatic metallothioneins in tumour-bearing IL-6-null mice. Oncol. Res., 12, 169-172, 2000. press.

Satoh, M., Shimada, A., Zhang, B. and
Tohyama, C.: Renal toxicity caused by cisplatinum in glutathione-depleted metallothionein-null mice. Biochem. Pharmacol., 60, 1729-1734, 2000.

Nohara, K.,
Fujimaki, H., Tsukumo, S., Ushio, H., Miyabara, Y., Kijima, M., Tohyama, C. and Yonemoto, J. : The effect of perinatal exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin on immune organs in rats, Toxicology, 154, 123-133, 2000.

Nohara, K., Ushio, H., Tsukumo, S., Kobayashi, T., Kijima, M., Tohyama, C. and Fujimaki, H.: Alterations of thymocyte development, thymic emigrants and peripheral T cell population in rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology., 145, 227-235, 2000.

Takano, H., Satoh, M., Shimada, A., Sagai, M., Yoshikawa. T. and Tohyama, C.: Cytoprotection by metallothionein against gastroduodenal mucosal injury caused by ethanol in mice. Laboratory Investigation., 80, 371-377, 2000.

Nishimura, N., Reeve, V. E., Nishimura, H., Satoh, M. and Tohyama, C.: Cutaneous metallothionein induction by ultraviolet B irradiation in interleukin-6-null mice. J. Invest. Dermatol., 114, 343-348, 2000.

Molotkov, A., Nishimura, N., Satoh, M. and Tohyama, C.: Role of interleukin-6 in the induction of hepatic metallothionein in mice after partial hepatectomy. Life Sci., 66, 963-970, 2000.

1999

Yoshida, M., Satoh, M., Yasutake, A., Shimada, A., Sumi, Y. and Tohyama, C.: Distribution and retention of mercury in metallothionein-null mice after exposure to mercury vapor. Toxicology., 139, 129-136, 1999.

Jana, N. R., Sarkar, S., Ishizuka, M., Yonemoto, J., Tohyama, C. and Sone, H.: Role of Estradiol Receptor-a in
Differential Expression of 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Inducible Genes in the RL95-2 and KLE Human Endometrial Cancer Cell Lines, Arch Biochem Biophys, 368: 31-39, 1999.

Jana,N.R., Sarkar, S., Ishizuka, M., Yonemoto, J., Tohyama, C. and Sone, H.: Cross-talk between 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Testosterone Signal Transduction Pathways in LNCaP Prostate Cancer Cells. Biochem Biophy Res Commun, 256: 462-468, 1999.

Sone, H., Tohyama, C., Aoki, Y. and Yonemoto, J.: Risk assessment of the flavonoids, quercetin as an endocrine modifier. Journal of Risk Research., 2: 151-166, 1999.

Tohyama, C., Suzuki, J. S., Nishimura, H. and Nishimura, N.: Metallothionein and male genital organs. C. Klaassen (ed.). MetallothioneinúM. pp. 295-300. Birkheuuser Verlag Basel/Switzerland. 1999.

Yasutake, A., Satoh, M., Tohyama, C.: and Hirayama, K. Selective and simple quantification of metallothionein III in mouse brain. J. Health Sci., 45(4), 222-225, 1999.

Yoshida, M., Satoh, M., Shimada, A., Yasutake, A., Sumi, Y. and Tohyama, C.: Pulmonary toxicity caused by acute exposure to mercury vapor is enhanced in metallothionein-null mice. Life Sci., 64, 1861-1867, 1999.

Cai, L., Satoh, M., Tohyama, C. and Cherian, M. G. Metallothionein in radiation biology: Its induction and protective role. Toxicology., 132, 85-98, 1999.

Nishimura, N., Tohyama, C., Satoh, M., Nishimura, H. and Reeve, V. E. Defective immune response and severe skin damage following UVB-irradiation in interleukin-6-deficient mice. Immunology., 97, 77-83, 1999.

Satoh, M. and Tohyama, C.: Susceptibility to metals and radical-inducing chemicals of metallothionein-null mice. C. Klaassen (ed.). Metallothionein úM. pp. 541-546. Birkheuuser Verlag Basel/Switzerland. 1999.

Zhang, B., Satoh, M. and Tohyama, C.: A Protective Role for Metallothionein in Acetaminophen-caused Liver Toxicity via Oxidative Stress. Journal of Health Science., 45: 15-19. 1999.

1998

Molotkov, A., Satoh, M. and Tohyama, C.: Tumor growth and food intake in interleukin-6 gene knock-out mice. Cancer Lett., 132, 187-192,@1998

Tsutsumi, O., Uechi, H., Sone, H., Yonemoto, J., Takai, Y., Momoeda, M., Tohyama, C., Hashimoto, S., Morita, M. and Taketani, Y.: Presence of dioxins in human follicular fluid: Their possible stage-specific action on the development of preimplantation mouse embryos Biochem. Biophys. Res. Commun., 250F498-501, 1998

Zhang, B., Satoh, M., Nishimura, N., Suzuki, J.S., Sone, H. Aoki, Y. and Tohyama, C.: Metallothionein Deficiency Promotes Mouse Skin Tumorigenesis Induced by 7,12-Dimethylbenz[a]anthracene. Cancer Res., 58:4044-4046,1998

Suzuki, J.S., Kodama, N., Molotkov, A., Aoki, E. and Tohyama, C.: Isolation and identification of metallothionein isoforms (MT-1 and MT-2) in the rat testis. Biochem. J., 334: 695-701,1998.

Jana,N.R.,Sarkar,S.,Yonemoto,J.,Tohyama,C. and Sone,H.: Strain Differences in Cytochrome P4501A1 Gene Expression Caused by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in the rat liver: Role of the aryl hydrocarbon receptor and its nuclear translaocator. Biochem. Biophys. Res. Commun., 248: 554-558,1998

1997

Satoh, M., Nishimura, N., Kanayama, Y., Naganuma, A., Suzuki, T. and Tohyama, C.: Enhanced renal toxicity by inorganic mercury in metallothionein-null mice. J. Pharmacol. Exp. Ther., 283, 1529-1533,1997

Satoh, M., Aoki, Y. and Tohyama, C.: Protective role of metallothionein in renal toxicity of cisplatinum. Cancer Chemother. Pharmacol., 40, 358-362,1997

Apostolova, M. D. , Choo, K. H. A. , Michalska, A. E. and Tohyama, C. Analysis of possible protective role of metallothionein in streptozotocin-induced diabetes usingmetallothionein-null mice. J. Trace Elements Med. Biol. 11: 1-7,1997.

Sato, H., Suzuki, J.S., Tanaka, M., Ogiso, M., Tohyama, C., Kobayashi, S., Gene@expression in skin tumors induced in hairless mice by chronic exposure to@ultraviolet. B irradiation. Photochem. Photobiol. 65: 908-914,1997.

Homma-T. S., Ishido, M. and Tohyama, C.: Cadmium-induced apoptosis in the proximaltubules of rat kidney. J. Occup. Health 39: 242-243,1997

1996

Homma S. T., Shinyashiki, M., Nakai, I., Tohyama, C. and Shimojo, N. Direct@detection of mercury-bound metalloproteins (metallothionein and Cu, Zn-superoxide@ dismutase) using a combination of gel electrophoresis and one dimensional synchrotron radiation X-ray fluorescence analysis. Anal. Lett., 29: 601-611,1996

Nishimura, N., Cam, G. R., Nishimura, H., Tohyama, C., Saitoh, Y., and Adelson, D.L. Evidence for developmentally regulated transcriptional, translational and@post-translational control of metallothionein gene expression in hair follicles.@Reprod. Fertil. Dev., 8: 1089-1096,1996

Kobayashi, S. , Takehana, M. and Tohyama, C. Glutathione isopropyl ester reduces@UVB-induced skin damage in hairless mice. Photochem. Photobiol. 63: 106-110,1996

Tohyama, C., Suzuki, J. S., Homma, S., Karasawa, M., Kuroki, T., Nishimura, H. and Nishimura, N. Testosterone-dependent induction of metallothionein in genital organsof male rats. Biochem. J. 317: 97-102,1996

Tohyama, C., Satoh, M., Kodama, N., Nishimura, H. , Choo, A., Michalska, A., Kanayama, Y. and Naganuma, A. Reduced retention of cadmium in the liver of@metallothionein-null mice. Environ. Toxicol. Pharmacol. 1: 213-216,1996

Sato, M., Apostolova, M. D., Hamaya, M., Yamaki, J., Choo, K. H. A., Michalska, A.E., Kodama, N. and Tohyama, C. Susceptibility of metallothionein-null mice to@paraquat. Environ. Toxicol. Pharmacol. 1: 221-225,1996

1995

Abe, T., Ohtsuka, R., Hongo, T., Suzuki, T., Tohyama, C., Nakano, A., Akagi, H.and Akimichi, T. High hair and urinary mercury levels of fish eaters in the@nonpolluted environment of Papua New Guinea. Arch. Environ. Health. 50: 367-373,1995

Zhang, B., Suzuki, J. S., Nishimura, N. and Tohyama, C. Difference in cadmium cytotoxicity in two kidney cell lines (LLC-PK1 and MDCK) with special reference to@metallothionein. Toxicol. In Vitro. 9: 765-772,1995

Ishido, M., Homma, S. T., Leung, P. S. and Tohyama, C. Cadmium-induced DNA@fragmentation is inhibitable by zinc in porcine kidney LLC-PK1 cells. Life. Sci. 56: 351-356,1995

Kawada, T., Tohyama, C. and Suzuki, S. Effects of cadmium and lead exposure on urinary N-acetyl- -D-glucosaminidase, 2-microglobulin and metallothionein of@workers. Asia Pacific J. Public Health, 8: 91-94, 1995

1994

Kobayashi, S., Hirota, Y., Sayato-Suzuki, J., Takehana, M., Nishimura, H.,@Nishimura,N. and Tohyama, C. Possible role of metallothionein in the cellular defense mechanism against UVB irradiation in neonatal human skin fibroblasts. Photochem. Photobiol. 59: 650-656,1994

Hongo, T., Ohtsuka, R., Inaoka, T., Kawabe, T., Akimichi, T., Kuchikura, Y.,@Suda, K.,Tohyama, C. and Suzuki, T. Health status comparison by urinalysis (dipstick test) among four populations in Papua New Guinea. Asia Pacific. J. Public Health. 7: 165-172,1994

Tohyama, C., Nishimura, N., Suzuki, J. S., Karasawa, M. and Nishimura, H.@Metallothionein mRNA in the testis and prostate of the rat detected by digoxigenin-labeled riboprobe. Histochemistry. 101: 341-346,1994

1993

Tohyama, C., Suzuki, J. S., Hemelraad, J., Nishimura, N. and Nishimura, H.@Inductionof@metallothionein and its localization in the nucleus of rat hepatocytes after partial hepatectomy. Hepatology. 18: 1193-1201,1993

Watanabe, K., Hasegawa, K., Ohtake, H., Tohyama, C. and Koga, M. Inhibition of DNAsynthesis by EDTA and its cancellation by zinc in primary cultures of adult rat@hepatocytes. Biomed.Res., ‚P‚S: 99-100,1993


‚a. Review Articles

2004

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2003

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2002

èG–è—˜K, ¬ŽR@—m. ²“¡‰ë•F. ‰“ŽRçt.@’á—p—ʃJƒhƒ~ƒEƒ€”˜˜I‚ÆŒ’N‰e‹¿i‚Qj¶ŠˆKŠµ•a‚Ɛ¶B“Ő«. “ú–{‰q¶ŠwŽGŽ. 57(3)F556-563, 2002

¬ŽR@—m, ‹S“ª‰p–¾. ²“¡‰ë•F.
‰“ŽRçt. ’á—p—ʃJƒhƒ~ƒEƒ€”˜˜I‚ÆŒ’N‰e‹¿i‚Pjˆâ“`ŽqŠQ«‚Æ”­‚ª‚ñ«. “ú–{‰q¶ŠwŽGŽ. 57(3)F547-555, 2002.


‰“ŽRçt. Low-Dose Exposure to Dioxin, Its Toxicities and Health Risk Assessment. Environemal Sciences., 9F37-50, 2002.

2001

Ishimura R, Kawakami T, Aoki Y, Yonemoto J, Tohyama C, Ohsako S. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affects glucose kinetics in rat placenta. Organohalogen Compounds, 53, 300-302, 2001.

ŠÔ³—Œb,@‰“ŽRçt. •Ä‘ŠÂ‹«•ÛŒì’¡iU.S.EPAj‚É‚æ‚éƒ_ƒCƒIƒLƒVƒ“—ÞƒŠƒXƒNÄ•]‰¿‚Ì“®Œü. “ú–{ƒŠƒXƒNŒ¤‹†Šw‰ïŽ. 12(2)F54-63, 2001.

2000

‰“ŽRçt,@
ŠÂ‹«‚ÆŒ’NA@u¶–½‚̉Ȋw\\‚Q‚P¢‹I‚̈ãŠw‚ª–ÚŽw‚·‚à‚́vi‹T“cŽ¡’j‚ç•ÒjAƒƒfƒBƒRƒsƒA‘æ‚S‚PŠªApp. 58-74., ”­s@•xŽmƒŒƒrƒIA2000.

¼‘º“TŽq, ‹{Œ´—Tˆê. —é–؏ƒŽq. ²“¡‰ë•F. ²“¡–¤Šì•v. •ÄŒ³ƒŽO. Â–؍N“W.
‰“ŽRçt. ƒ_ƒCƒIƒLƒVƒ““Š—^ƒ‰ƒbƒgŠÌ‘Ÿ‚É‚¨‚¯‚郁ƒ^ƒƒ`ƒIƒlƒCƒ“‚Ì—U“±‚Əd‹à‘®‚Ì•Ï“®. Biomed. Res. Trace Elements., 11, 387-388, 2000.@@

²“¡‰ë•F, ¼‘º“TŽq. ‘º“c”ü‰h. ¼‘º‹v—Y.
‰“ŽRçt. ŠÌÄ¶‚É‚¨‚¯‚郁ƒ^ƒƒ`ƒIƒlƒCƒ“‚Ì–ðŠ„. Biomed. Res. Trace Elements., 11, 385-386, 2000.@

‰“ŽRçt, ‘å”—½ˆê˜Y, Î‘º—²‘¾. “à•ª”坘—‰»Šw•¨Ž¿‚ÌŒ’NƒŠƒXƒNƒAƒZƒXƒƒ“ƒg. “ú–{—Տ°, 58(12): 19-26, 2000.

ƒpƒIƒ ƒ‚ƒbƒJƒŒƒŠ, ‰“ŽRçt. ƒZƒxƒ\‚É‚¨‚¯‚éƒ_ƒCƒIƒLƒVƒ“’†“ł̏Ǐó. Ž¡—Êw, 34(5): 96-99, 2000.

²“¡‰ë•F,
‰“ŽRçt. RŽîᇈöŽqFƒTƒCƒgƒJƒCƒ“. ¶‘̂̉Ȋw iƒmƒbƒNƒAƒEƒgƒ}ƒEƒXƒŠƒXƒgj, 51: 490, 2000.

²“¡‰ë•F,
‰“ŽRçt. Á‰»ŠÇF‚y‚Ž•ª”åE‰ŠÇ–hŒä. ¶‘̂̉Ȋw iƒmƒbƒNƒAƒEƒgƒ}ƒEƒXƒŠƒXƒgj,@51: 464-465, 2000.

Î‘º—²‘¾, ‘å”—½ˆê˜Y,
‰“ŽRçt. “à•ª”坘—•¨Ž¿‚ÌŒ’NƒŠƒXƒN•]‰¿. BIO Clinica, 15(2): 43-48, 2000.

²“¡‰ë•F,
‰“ŽRçt. “Ë‘R•ÏˆÙ‚¨‚æ‚Ñ”­‚ª‚ñ‚É‚¨‚¯‚郁ƒ^ƒƒ`ƒIƒlƒCƒ“‚Ì–ðŠ„. Biomed. Res. Trace Elements., 11, 138-144, 2000.

1999

‰“ŽRçt
, ‘]ªGŽq. •ÄŒ³ƒŽO. ƒ_ƒCƒIƒLƒVƒ“‚ÌŒ’NƒŠƒXƒN•]‰¿. —Տ°ŠÂ‹«ˆãŠw, 8(2): 51-61, 1999.

‹{Œ´—Tˆê,
‰“ŽRçt. ƒ_ƒCƒIƒLƒVƒ“—Þ‚Ì“à•ª”坘—ì—p‚ƓŐ«. ŒŽŠ§ƒGƒRƒCƒ“ƒ_ƒXƒgƒŠ[, 4(8): 5-12, 1999.

²“¡‰ë•F,
‰“ŽRçt. ƒƒ^ƒƒ`ƒIƒlƒCƒ“Œ‡‘¹ƒ}ƒEƒX‚É‚¨‚¯‚éd‹à‘®‚̓Ő«‚Æ“®‘Ô. Biomed. Res. Trace Elements., 10, 147-148, 1999.

‘\ªGŽq, ‰“ŽRçt. ¶B‚Æ“à•ª”坘—•¨Ž¿@‚PD“à•ª”坘—•¨Ž¿‚ÆŒ’NƒŠƒXƒN. ŽY‰È‚Æ•wl‰È, 66(2): 189-199, 1999

Î’ː^—R”ü, ‰“ŽRçt. ŠÂ‹«ƒzƒ‹ƒ‚ƒ“A“ú–{•a‰@–òÜŽt‰ïŽGŽ, 35(2): 7-11, 1999

²“¡‰ë•F, ‰“ŽRçt. ŠÂ‹«‰˜õƒoƒCƒIƒ}[ƒJ[‚Æ‚µ‚Ẵƒ^ƒƒ`ƒIƒlƒCƒ“‚Ì—L—p«. ŠÂ‹«“Ő«ŠwŽ, 2, 27-34, 1999.

1998

‰“ŽRçt
@ “à•ª”åŠh—•¨Ž¿‚ÌŒ’NƒŠƒXƒN‚Ì•]‰¿ @‘æ112‰ñ“ú–{ˆãŠw‰ïƒVƒ“ƒ|ƒWƒEƒ€‹L˜^W, 72-78, 1998.

Î’ː^—R”ü,
‰“ŽRçt@ŠÂ‹«ƒzƒ‹ƒ‚ƒ“Œ¤‹†‚Ì“®ŒüA‰»Šw‚Æ‹³ˆç 46(9): 564-565,1998

‰“ŽRçt@H•i‚¨‚æ‚ъ‹«¶‘ÔŒn‚É‚¨‚¯‚é“à•ª”坘—•¨Ž¿A46: 517-528,1998@

‰“ŽRçt@ƒ_ƒCƒIƒLƒVƒ“‚ÆŒ’NA“d‹C•]˜_@‚UŒŽ†A66-67,1998

1997

²“¡‰ë•F, ‰“ŽRçt@Metallothionein. In: ƒmƒbƒNƒAƒEƒgƒ}ƒEƒXEƒf[ƒ^ƒuƒbƒN (–ìŒû@–Î, •½ˆä‹vŠÛ), ’†ŽR‘“X, “Œ‹ž, pp320-321, (Molecular Medicine. Vol. 34, —ÕŽž‘Š§†), 1997.

Satoh, M., Aoki, Y. and Tohyama, C. Protective role of metallothionein in cisplatin-caused renal toxicity. In: Trace Elements in Man and Animals (Fischer, P. W. F., L'Abbe, m. R., Cockell, K. A. and Gibson, R. S., eds), NRC Research Press, Ottawa, pp572-573, 1997.

1996

•P–쐽ˆê˜Y, ‰“ŽRçt@”÷—ÊŒ³‘fiˆŸ‰”‚ƃZƒŒƒ“jDu‰h—{|•]‰¿‚ÆŽ¡—Áv,

ƒƒfƒBƒJƒ‹ƒŒƒrƒ…[ŽÐC13F289-295,1996

1995

Â–؍N“W, ‰“ŽRçt@ŽÀŒ±Œn‚É‚¨‚¯‚鎇ŠOü‚̉e‹¿.@ƒIƒ]ƒ“‘w”j‰ó‚Æ‚»‚̉e‹¿A (ŠÂ‹«’¡AiŽÐjŠÂ‹«î•ñ‰ÈŠwƒZƒ“ƒ^[A209p.) 98-108,1995

West, A. K., Stennard, F. A. and Tohyama, C. Metallothioneins: New tricks for an@old dog. Today's Life Sci. 7 (7) : 46-49,1995

1994

‰“ŽRçt, —é–ØŒp”ü @’n‹…‹CŒó•Ï“®‚ÆŒ’N. ˜J“­‚̉Ȋw, 49: 580-584,1994

–{ŠÔŽu”T, ‰“ŽRçt Cu (“º). Toxicology Today- --- ’†“ÅŠw‚©‚琶‘Ì–hŒä‚̉Ȋw‚Ö (²“¡ —m, ‹à–F“°380p.) : 63-70,1994

1993

‰“ŽRçt. ‰h—{‚ƓŐ«. ƒtƒ@ƒ‹ƒ}ƒVƒA, 29: 39-43,1993

Tohyama, C., Suzuki, J. S., Homma, S. T.,Nishimura, N. and Nishimura,H. Regulation of metallothionein biosynthesis in genital organs of male rats.@In Metallothionein III (Suzuki, K. T., Imura, N.,Kimura, M., Eds., Birkhauser Verlag,479p.) : 443-456,1993



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