室長: 野原 恵子(学術博士)
電話：029-850-2500
筑波大学生命環境科学研究科教授（連携大学院）
【研究テーマ】
・ダイオキシン類の免疫毒性とそのメカニズム
・環境汚染物質の転写因子を介した作用メカニズム
・無機ヒ素のエピジェネティクス作用
【論文リスト（1990年以降）】
主な論文
2009
Kimura, A., Naka,T., Nakahama, T., Chinen, I., Masuda, K., Nohara, K.,
Fujii-Kuriyama, Y. and Kishimoto, T. : Aryl hydrocarbon receptor in combination with Stat1 regulates
LPS-induced inflammatory responses. J Exp Med.
206, 2027-2035, 2009
Funatake, CJ., Ao, K., Suzuki, T., Murai, H., Yamamoto, M., Fujii-Kuriyama, Y., Kerkvliet, NI. and Nohara, K. : Expression of
constitutively-active aryl hydrocarbon receptor in T-cells enhances the
down-regulation of CD62L, but does not alter expression of CD25 or suppress the
allogeneic CTL response. J Immunotoxicol. 6, 194-203, 2009
Nohara, K., Suzuki, T., Ao, K., Murai, H., Miyamoto, Y., Inouye,
K., Pan, X., Motohashi, H., Fujii-Kuriyama,
Y., Yamamoto, M and Tohyama, C. : Constitutively active aryl hydrocarbon receptor expressed in T cells increases immunization-induced IFN-γ production in mice but does not suppress Th2-cytokine production or antibody production Int. Immunology. 21, 769-777, 2009
Ao,
K., Suzuki, T., Murai, H., Matsumoto, M., Nagai, H., Miyamoto, Y., Tohyama, C
and Nohara, K.: Comparison of immunotoxicity among tetrachloro-, pentachloro-, tetrabromo- and pentabromo-dibenzo-p-dioxins in mice Toxicology. 256, 25-31, 2009
2008
Kimura, A., Naka, T., Nohara, K., Fujii-Kuriyama, Y. and
Kishimoto, T. : Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development
of Th17 cells. Proc. Natl. Acad. Sci. U. S. A. 105,
9721-9726, 2008
Ito, T., Inouye, K., Nohara, K., Tohyama, C. and Fujimaki, H. : TCDD exposure exacerbates atopic dermatitis-related
inflammation in NC/Nga mice. Toxicol. Lett. 177,
31-37, 2008
Nohara, K., Ao, K., Miyamoto, Y., Suzuki, T., Imaizumi, S., Tateishi, Y., Omura, S., Tohyama, C. and Kobayashi, T. : Arsenite-induced thymus atrophy is mediated by cell cycle arrest :A characteristic down-regulation of E2F-related genes revealed by a microarray approach, Toxicol. Sci. 101, 226-238, 2008
2007
Suzuki, T. and Nohara, K. : Regulatory factors involved in species-specific modulation of arylhydrocarbon receptor (AhR)-dependent gene expression in humans and mice, J. Biochem. 142, 443-452, 2007
Ohtake, F., Baba, A., Takada, Okada, M., Iwasaki, K., Miki, H., Takahashi, S., Kouzmenko, A., Nohara, K., Chiba, T., Fujii-Kuriyama, Y. and Kato, S.: Dioxin receptor is a ligand-dependent E3 ubiquitin ligase, Nature, 446, 562-566, 2007
2006
Nohara, K., Ao, K., Miyamoto, Y., Ito, T., Suzuki, T., Toyoshiba, H. and Tohyama, C. : Comparison of the 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)-induced CYP1A1 gene expression profile in lymphocytes from mice, rats, and humans: Most potent induction in humans, Toxicology, 225, 204-213, 2006
Ishimura, R., Kawakami, T.,
Ohsako, S., Nohara, K. and Tohyama, C. : Suppressive Effect of
2,3,7,8-Tetrachlorodibenzo-p-dioxin on Vascular Remodeling that Takes Place in
the Normal Labyrinth Zone of Rat Placenta During Late Gestation, Toxicol.
Sci., 91, 265-274, 2006
Kawakami, T.,
Ishimura, R.,
Nohara, K., Takeda, K.,
Tohyama, C.
and Ohsako, S.
: Differential susceptibilities of Holtzman and Sprague-Dawley rats to fetal
death and placental dysfunction induced by 2,3,7,8-teterachlorodibenzo-p-dioxin
(TCDD) despite the identical primary structure of the aryl hydrocarbon
receptor, Toxicol. Appl. Pharmacol.,
212, 224-236, 2006
Ito, T., Nagai, H., Lin, T-M., Peterson, R E., Tohyama, C., Kobayashi, T. and Nohara, K. : Organic chemicals adsorbed onto diesel exhaust particles directly alter the differentiation of fetal thymocytes through arylhydrocarbon receptor but not oxidative stress responses, J. Immunotoxicol., 3, 21-30, 2006
Nagai, H., Kubo, M., Abe, R., Yamamoto, M. and Nohara, K. : Constitutive activation of the aryl hydrocarbon receptor in T-lineage cells induces thymus involution independently of the Fas/Fas ligand signaling pathway, Int. Immunopharmacol., 6, 279-286, 2006
野原恵子： ダイオキシンによる免疫細胞での転写因子AhRの活性化と免疫毒性 ファルマシア, 42, 700-704, 2006
2005
Inouye, K., Pan, X.,
Imai, N., Ito, T., Takei, T., Tohyama, C. and Nohara, K.: T cell-derived IL-5 production is a sensitive target of 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD), Chemosphere, 60, 907-913, 2005
Nohara, K., Pan, X., Tsukumo, S., Hida, A., Ito, T., Nagai, H., Inouye, K., Motohashi,
H., Yamamoto, M., Fujii-Kuriyama, Y. and Tohyama, C.: Constitutively-active
aryl hydrocarbon receptor expressed specifically in T-lineage cells causes
thymus involution and suppresses the immunization-induced increase in splenocytes,
J. Immunol.,174, 2770-2777, 2005
Nagai, H., Takei, T., Tohyama, C., Kubo, M., Abe, R.
and Nohara,
K.: Search for the target genes involved in the suppression of antibody
production by TCDD in C57BL/6 mice, Int. Immunopharmacol., 5, 331-343, 2005
野原恵子： 142 ダイオキシン 予防医学事典 325-326, 2005
2004
Pan, X., Inouye, K., Ito, T., Nagai, H., Takeuchi, Y., Miyabara, Y., Tohyama,
C. and Nohara, K.: Evaluation of relative potencies of PCB126 and PCB169
for the immunotoxicities in ovalbumin (OVA)-immunized mice, Toxicology, 204, 51-60, 2004
Ito, T., Tsukumo, S.,
Suzuki, N., Motohashi, H., Yamamoto, M., Fujii-Kuriyama, Y., Mimura, J., Lin,
T-M., Peterson, R. Ｅ.,
Tohyama, C. and Nohara, K.: A constitutively active arylhydrocarbon receptor induces growth inhibition
of Jurkat T cells through changes in the expression of genes related to
apoptosis and cell cycle arrest, J. Biol.Chem., 279, 25204-25210, 2004
2003
Ohtake, F., Takeyama, K.,
Matsumoto, T., Kitagawa, H., Yamamoto, Y., Nohara, K., Tohyama, C., Krust, A.,
Mimura, J., Chambon, P., Yanagisawa, J., Fujii-Kuriyama, Y. and Kato, S.: Modulation
of oestrogen receptor signalling by association with the activated dioxin
receptor, Nature, 423,
545-550, 2003
Inouye, K., Ito, T., Fujimaki, H., Takahashi, Y., Takemori, T., Pan, X.,
Tohyama, C. and Nohara, K.: Suppressive effects of
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the high-affinity antibody
response in C57BL/6 mice, Toxicol. Sci., 74, 315-324, 2003
Doi, H., Baba, T., Tohyama, C. and Nohara, K.: Functional activation of
arylhydrocarbon receptor (AhR) in primary T cells by
2,3,7,8-tetrachlorodibenzo-p-dioxin, Chemosphere, 52, 655-662, 2003
遠山千春、野原恵子： 内分泌撹乱化学物質 ダイオキシン・PCB類 分子予防環境医学 562-570, 2003
2002
Ito, T., Inouye, K., Fujimaki, H., Tohyama, C. and Nohara, K.: Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced suppression of antibody production: Effect on T cell-derived cytokine production in the primary immune reaction of mice, Toxicol. Sci., 70, 46-54, 2002
Tsukumo, S., Iwata, M., Tohyama, C. and Nohara, K.: Skewed differentiation of thymocytes toward CD8 T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin
requires activation of the extracellular signal-related kinase pathway,
Arch. Toxicol., 76, 335-343, 2002
Nohara, K., Fujimaki,
H., Tsukumo, S., Inouye, K., Sone, H. and Tohyama, C.: Effects of
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on T cell-derived cytokine
production in ovalbumin (OVA)-immunized C57Bl/6 mice, Toxicology, 172, 49-58, 2002
Fujimaki, H., Nohara, K.,
Kobayashi, T., Suzuki, K., Eguchi-Kasai, K., Tsukumo, S., Kijima, M. and
Tohyama, C.: Effect of a single oral dose of
2,3,7,8-tetrachlorodibenzo-p-dioxin on immune function in male NC/Nga mice, Toxicol.
Sci., 66, 117-124, 2002
Nohara, K., Izumi, H.,
Tamura, S., Nagata, R. and Tohyama, C.: Effect of low-dose
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on influenza A virus-induced
mortality in mice, Toxicology,
170, 131-138, 2002
2001
Fujimaki, H., Ui, N., Ushio, H., Nohara, K. and Endo, T.: Roles of
CD4+ and CD8+ T cells in adjuvant activity of diesel exhaust particles in mice,
Int. Arch allergy Immunol., 124,
485-496, 2001
Fujimaki, H., Ushio, H., Nokara, K. and Ui, N.: Inductoin of the
imbalance of helper T-cell functions in mice exposed to diesel exhaust, Sci.Total
Environ., 270,
113-121, 2001
2000
Nohara, K., Fujimaki, H.,
Tsukumo, S., Ushio, H., Miyabara, Y., Kijima, M., Tohyama, C. and Yonemoto, J.:
The effect of perinatal exposure to low doses of
2,3,7,8-tetrachlorodibenzo-p-dioxin on immune organs in rats, Toxicology, 154, 123-133, 2000
Fujimaki, H., Ishido, M. and Nohara, K.: Induction of apoptosis in mouse
thymocytes by cadmium, Toxicol. Lett., 115, 99-105, 2000
Nohara, K., Ushio, H., Tsukumo, S., Kobayashi, T.,
Kijima, M., Tohyama, C. and Fujimaki, H.：Alterations of
thymocyte development, thymic emigrants and peripheral T cell population in
rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin, Toxicology, 145, 227-235, 2000
1999
Ushio, H., Nohara, K. and
Fujimaki, H.: Effect of environmental pollutants on the production of
pro-inflammatory cytokines by normal human dermal keratinocytes, Toxicol.
Lett., 105, 17-24,
1999
Wang, F., Nohara, K., Olivera, A., Thompson, E. W. and
Spiegel, S.: Involvement of focal adhesion kinase in inhibition of motility of
human breast cancer cells by sphingosine 1-phosphate, Exp. Cell
Res., 247,
17-28, 1999
野原恵子：ガングリオシドは細胞膜において T細胞の活性化をどのように修飾するか？ 生化学, 71,
337-341, 1999
1998
Nohara, K., Kunimoto, M. and
Fujimaki, H.: Antibody against ganglioside GD1c containing NeuGcα2-8NeuGc
cooperates with CD3 and CD4 in rat T cell activation, J. Biochem., 124, 194-199, 1998
Nohara, K., Wang, F. and
Spiegel, S.: Glycosphingolipid composition of MDA-MB-231 and MCF-7 human breast
cancer cell lines, Breast Cancer Res. Tr., 48, 149-157, 1998
1997
Nohara, K., Ozawa, H., Tai, T.,
Saji, H. and Fujimaki, H.: Gangliosides involved in activation of rat T lineage
cells, Biochim. Biophys. Acta, 1345, 207-214, 1997
野原恵子、藤巻秀和 ： ガングリオシドとTh1/Th2細胞の分化, 臨床免疫, 29, 1090-1093, 1997
1995
Fujimaki, H., Nohara, O., Katayama, N., Abe, T. and Nohara, K.: Ganglioside GM3 inhibits
interleukin-3-dependent bone marrow-derived mast cell proliferation, Int. Arch. Allergy Immunol., 107,
527-532, 1995
1994
Nohara, K., Nakauchi, H. and Spiegel, S.: Glycosphingolipids of rat T cells. Predominance of asialo-GM1 and GD1c, Biochemistry, 33,
461-4666, 1994
1993
Nohara, K., Sano, T. and
Shiraishi, F.: An activation-associated ganglioside in rat thymocytes, J. Biol. Chem., 268,
24997-25000, 1993
1992
Sano, T., Nohara, K., Shiraishi, F. and Kaya, K.: A method for micro-determination of total
microcystin content in waterblooms of cyanobacteria (Blue-green algae),
Intern.
J. Environ. Anal. Chem.,
49, 163-170, 1992
Nohara, K., Suzuki, M.,
Inagaki, F., Sano, T. and Kaya, K.: A novel disialoganglioside in rat spleen
lymphocytes, J. Biol. Chem.,
267, 14982-14986, 1992
1991
Nohara, K., Suzuki, M,.
Inagaki, F. and Kaya, K.: A GM1b-derived disialoganglioside GD1c is the
predominant ganglioside of rat thymocytes, J. Biochem., 110, 274-278, 1991
1990
Kaya, K., Ito, H. and Nohara, K.: 2-(7,13-Dihydroxy-2-trans-octadecenoylamino)ethanesulfonic acid (lipotaurine)
as an intermediate of taurolipids biosynthesis, Biochim. Biophys. Acta., 1042, 338-343, 1990
Nohara, K., Suzuki, M., Inagaki, F., Ito, H. and Kaya, K.: A unique fucoganglioside with blood group B determinant in rat spleen, J. Biochem., 108, 684-688, 1990
Nohara, K., Suzuki, M., Inagaki, F., Ito, H. and Kaya, K.: Identification of novel gangliosides containing lactosaminyl-GM1 structure from rat spleen, J. Biol. Chem., 265, 14335-14339, 1990
Kobayashi, A., Nohara, K., Ohsumi, E. and Yamanishi, T.: Identification of di(1-oxyalkyl)-peroxides in the essential oil of citrus-iyo, Agr. Biol. Chem., 54, 561-562, 1990