Polynitro-organic contaminants (PNOs)

[CL-20]
2,4,6,8,10,12-Hexanitro-2,4,6,8,10,12-hexazaisowurtzitane CAS[135285-90-4]
= Nitramine
Trade name; CL-20
Purpose for use; Energetic compound (polycyclic nitramine explosive).
Test organisms;
Protozoa: Tetrahymena pyriformis (ref. ID; 7772)
Oligochaeta: Eisenia andrei (ref. ID; 4572)


[Monocyclic nitramine explosives]
Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) CAS[2691-41-0]
1,3,5-Trinitro-1,3,5-triazacyclohexane (RDX)
2,4,6-Trinitrotoluene (TXT) CAS[118-96-7]

[HMX]
Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine CAS[2691-41-0]
= 1,3,5,7-Tetranitro-1,3,5,7-tetrazacyclo-octane (ref. ID; 6865)
Purpose for use; High melting explosive.
Toxicity; This explosive is toxic to some aquatic organisms, including fathead minnows (Pimephales promelas) and the freshwater microcrustacean Daphnia magna, and some terrestrial organisms including mice and rats. But, HMX is not toxic to the bioluminescent bacteria Vibrio fisheri and is not cytotoxic or mutagenic to bacterial and mammalian cells in aqueous solutions of HMX. (ref. ID; 6115)
Test organisms;
Protozoa: Tetrahymena pyriformis (ref. ID; 7772)
Oligochaeta: Eisenia andrei (ref. ID; 4958, 6115, 6817)
Oligochaeta: Lumbricus terrestris (ref. ID; 4958)

[RDX]
1,3,5-Trinitro-1,3,5-triazacyclohexane CAS[121-82-4] (ref. ID; 4958, 6817)
= 1,3,5-Trinitro-1,3,5,7-triazacyclohexane (ref. ID; 6865)
= Hexahydro-1,3,5-trinitro-1,3,5-triazine (ref. ID; 6927)
Test organisms;
Protozoa: Tetrahymena pyriformis (ref. ID; 7772)
Oligochaeta: Eisenia andrei (ref. ID; 4958, 6817, 6927)
Oligochaeta: Lumbricus terrestris (ref. ID; 4958)

RDX metabolites:
Hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX) (ref. ID; 6927)
Hexahydro-1,3-dinitroso-5-nitro-1,3,5-triazine (DNX) (ref. ID; 6927)
Hexahydro-1,3,5-trinitroso-1,3,5-triazine (TNX) (ref. ID; 6927)

[TNT]
= 2,4,6-Trinitrotoluene CAS[118-96-7]
TNT metabolites:
2-Amino-4,6-dinitrotoluene (2-ADNT) CAS[35572-78-2]
4-Amino-2,6-dinitrotoluene (4-ADNT) CAS[19406-51-0]
2,4-Diamino-6-nitrotoluene (2,4-DANT) CAS[6629-29-4]
2,6-Diamino-4-nitrotoluene (2,6-DANT) CAS[59229-75-2]
2-Hydroxyamino-4,6-dinitrotoluene (2-HADNT)
4-Hydroxyamino-2,6-dinitrotoluene (4-HADNT)
Biotransformation of TNT has been demonstrated in bacteria, fungi, plants, mammals and humans. The nitro-reduction of TNT into monoamino metabolites ([2-ADNT] and [4-ADNT] and then into diamino metabolites [2,4-DANT] and [2,6-DANT]) was the major metabolic pathway observed. (ref. ID; 7030)
Purpose for use; Energetic compounds.
TNT has been identified in soil at sites related to military activities. (ref. ID; 7030)
Toxicity; Mutagenicity/Carcinogenic. (ref. ID; 7030)
Test organisms;
Protozoa: Tetrahymena pyriformis (ref. ID; 7772)
Oligochaeta: Eisenia andrei (ref. ID; 4958, 6817, 6865, 7030)
Oligochaeta: Enchytraeus albidus (ref. ID; 6130)
Oligochaeta: Lumbricus terrestris (ref. ID; 4958)

2-Amino-4,6-dinitrotoluene (2-ADNT) CAS[35572-78-2]
Test organisms;
Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

2-Hydroxyamino-4,6-dinitrotoluene (2-HADNT)
Test organisms;
Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

4-Hydroxyamino-2,6-dinitrotoluene (4-HADNT)
Test organisms;
Protozoa: Tetrahymena pyriformis (ref. ID; 7772)

Other products of TNT manufacture:
Trinitrobenzene (TNB)
2,4-Dinitrotoluene (2,4-DNT)
2,6-Dinitrotoluene (2,6-DNT)


[Tetryl]
Test organisms;
Protozoa: Tetrahymena pyriformis (ref. ID; 7772)