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The World of Protozoa, Rotifera, Nematoda and Oligochaeta

Ref ID : 4200

Michael Cline, Richard Carchman, and Francine Marciano-Cabral; Movement of Naegleria fowleri Stimulated by Mammalian Cells in Vitro. J.Protozool. 33(1):10-13, 1986

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Naegleria fowleri amebae, but not those of N. australiensis, N. gruberi, or N. lovaniensis, demonstrated enhanced motility when placed in proximity to mammalian cells. Amebae of nonpathogenic species of Naegleria, however, were more motile in cell culture medium than the amebae of N. fowleri. The locomotory response of highly pathogenic mouse-passaged N. fowleri amebae to nerve cells was greater than axenically cultured amebae. The enhanced mobility elicited by whole nerve cells or distrupted nerve cells was not directed migration but chemokinetic. Naegleria fowleri responded to disrupted neuroblastoma cells more vigorously than to disrupted African green monkey kidney (Vero) cells.